Article
Environmental Sciences
Paolo Pastorino, Elisabetta Pizzul, Damia Barcelo, Maria Cesarina Abete, Gabriele Magara, Paola Brizio, Rosa Avolio, Marco Bertoli, Alessandro Dondo, Marino Prearo, Antonia Concetta Elia
Summary: This study investigated the oxidative stress ecology in Danube barbel from the Barbucina creek, analyzing the levels of antioxidant biomarkers and trace elements in the fish. Results indicated a significant association between certain trace elements and enzyme activity, suggesting their role as stressors in the aquatic environment. The study provides insights into the biochemical defensive response of fish to environmental disturbances, advancing our understanding of the effects of environmental factors on oxidative stress in aquatic ecosystems.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
Jose Teixeira, Farhan Basit, Peter H. G. M. Willems, Jori A. Wagenaars, Els van de Westerlo, Ricardo Amorim, Fernando Cagide, Sofia Benfeito, Catarina Oliveira, Fernanda Borges, Paulo J. Oliveira, Werner J. H. Koopman
Summary: The novel mitochondria-targeted variants of gallic and caffeic acid were found to increase ROS levels, stimulate NRF2 expression, and increase SOD2 and GSH levels.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Environmental Sciences
Joanna Maria Drozdz-Afelt, Beata Barbara Koim-Puchowska, Piotr Kaminski
Summary: The study aimed to analyze antioxidant enzyme activity and malondialdehyde concentration in prostate cancer, finding a significant decrease in superoxide dismutase activity, which may be due to a deficiency in the antioxidant defense system.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Shunlong Meng, Xi Chen, Chao Song, Limin Fan, Liping Qiu, Yao Zheng, Jiazhang Chen, Pao Xu
Summary: The study found that lower concentrations of methomyl had no effect on antioxidant levels in the testis of Nile tilapia, while higher concentrations significantly influenced these antioxidants. Recovery tests showed that oxidative damage caused by lower concentrations of methomyl was reversible, whereas damage from higher concentrations was irreversible within 18 days.
APPLIED SCIENCES-BASEL
(2021)
Article
Plant Sciences
Ayushi Mishra, Vipin Kumar, Anchal Singh
Summary: This study evaluated the anti-filarial activity of Ocimum sanctum and identified its bioactive compounds. The ethanol extract of O. sanctum significantly inhibited the motility of adult female Setaria cervi, and several bioactive compounds in O. sanctum showed high binding affinity towards filarial antioxidant proteins. This is the first report of the anti-filarial activity of O. sanctum.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Milena Sciskalska, Halina Milnerowicz
Summary: This study evaluated the impact of SNP rs1695 in the GSTP1 gene on GST and GST-pi activity, as well as the concentrations of glutathione and malonyldialdehyde. The results confirmed the important role of GST-pi in oxidative stress.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, General & Internal
Jin-Yu Gong, Si-Yin Peng, Kai Xing, Li Fan, Sheng-Lan Tan, Zhi-Ying Luo, Hai-Yan Yuan, Ping Xu, Jian-Quan Luo
Summary: The study investigated the association between GSTP1 rs1695 polymorphism and cyclophosphamide-induced toxicities, with results showing increased risks of gastrointestinal toxicity and infection in patients with AG and GG genotypes. Significant associations were found in SLE or lupus nephritis syndrome patients, emphasizing the predictive role of GSTP1 rs1695 polymorphism in cyclophosphamide-induced toxicities. More studies are needed to confirm these findings in the future.
Article
Environmental Sciences
Sabrine Afsa, Giuseppe De Marco, Alessia Giannetto, Vincenzo Parrino, Tiziana Cappello, Hedi ben Mansour, Maria Maisano
Summary: This study aimed to evaluate the impact of salicylic acid (SA) on Mediterranean mussels. The results showed that SA had significant effects on mussel digestive glands, causing hemocytic infiltration and altering the expression levels of oxidative stress related genes.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Namrata Singh, G. R. Sherin, Govindasamy Mugesh
Summary: Nanozymes, nanomaterials with enzyme-mimicking activity, have attracted significant interest in biomedical applications, particularly in oxidative stress-mediated disorders. The challenge lies in designing nanozymes that can selectively differentiate between physiological oxidative stress and pathological oxidative stress and mediate appropriate redox reactions in cells, tissues, and organs. This review summarizes the advancements in redox-active nanozymes and their therapeutic significance in various disease models, such as cancer, neurodegeneration, and cardiovascular diseases. It also discusses the future prospects and challenges associated with the biomedical applications of nanozymes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Ecology
Bruno Serra de Lacerda Valverde, Heidi Samantha Moraes Utsunomiya, Cleoni dos Santos Carvalho, Lilian Franco-Belussi, Classius de Oliveira
Summary: Studies on anurans have been conducted for over 40 years to evaluate the adverse effects of benzo(alpha)pyrene (B alpha P), showing genotoxic, hepatotoxic, and immunotoxic effects. This study aimed to assess whether the route of administration of B alpha P influences its effects on hepatic biomarkers, with morphological biomarkers being more significantly affected than biochemical ones. The exposure pathway and time both modulate the effects of B alpha P on hepatic biomarkers in anurans.
Article
Medicine, General & Internal
Jae Ho Park, Eun-Heui Jin, Jang Hee Hong, Sang-Il Lee, Jae Kyu Sung
Summary: The rs2608053 polymorphism in plasmacytoma variant translocation 1 was associated with a decreased risk in T3 + T4 and stage III gastric cancer subgroups, while the rs13255292 polymorphism was associated with an increased risk in female negative lymph node metastasis gastric cancer subgroup.
Article
Medicine, Research & Experimental
Konrad A. Szychowski, Bartosz Skora, Anna Kryshchyshyn-Dylevych, Danylo Kaminskyy, Dmytro Khyluk, Roman Lesyk
Summary: The study evaluated the impact of three 4-thiazolidinone-based compounds on the expression of antioxidant enzymes in various cancer cell lines. All compounds influenced ROS production, with Les-3640 affecting caspase-3 activity in the cell lines.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Francis Jackson de Oliveira Paludo, Matheus Augusto de Bittencourt Pasquali, Amanda Rodrigues de Vargas, Iara Bezerra de Oliveira, Luzia Valberligia Batista Goncalves, Daniel Pens Gelain, Jose Claudio Fonseca Moreira
Summary: This study focused on the impact of SOD2 polymorphism on sperm motility and vigor, finding that the Val16Ala polymorphism could alter the activity of superoxide dismutase in sperm, affecting sperm physiology and postfertilization processes.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Francisco Javier Martinez-Noguera, Pedro E. Alcaraz, Raquel Ortolano-Rios, Stephane P. Dufour, Cristian Marin-Pagan
Summary: This study compared the differences in endogenous antioxidant enzymes and hemogram between professional and amateur cyclists, finding higher values in CAT, GSSG, and GSSG/GSH ratio and lower values in SOD in the professional group. There was an inverse correlation between power produced at ventilation thresholds 1 and 2 and GSSG/GSH ratio in the professional group, suggesting a relationship between these parameters and moderate and submaximal exercise performance.
Review
Biochemistry & Molecular Biology
Pavlina Hemerkova, Martin Valis
Summary: ALS is a neurodegenerative disease that affects motor neurons and currently has no cure. Free oxygen radicals are known to play a role in the pathogenesis of ALS, while antioxidant enzymes like SOD1 are crucial for antioxidant protection.
Article
Cell Biology
Wen-Jing Lu, Nishant Saxena, John M. Luk, Sunil C. Kaul, Renu Wadhwa
CELL STRESS & CHAPERONES
(2015)
Article
Biochemistry & Molecular Biology
Zheng Zhou, Taishan Hu, Zhiheng Xu, Zhaohu Lin, Zhisen Zhang, Teng Feng, Liangcheng Zhu, Yiping Rong, Hong Shen, John M. Luk, Xiongwen Zhang, Ning Qin
Article
Multidisciplinary Sciences
Meilin Wang, Dongying Gu, Mulong Du, Zhi Xu, Suzhan Zhang, Lingjun Zhu, Jiachun Lu, Rui Zhang, Jinliang Xing, Xiaoping Miao, Haiyan Chu, Zhibin Hu, Lei Yang, Cuiju Tang, Lei Pan, Haina Du, Jian Zhao, Jiangbo Du, Na Tong, Jielin Sun, Hongbing Shen, Jianfeng Xu, Zhengdong Zhang, Jinfei Chen
NATURE COMMUNICATIONS
(2016)
Article
Oncology
Xiaowei Wei, Jin Zhou, Lingzhi Hong, Zhi Xu, Huanyu Zhao, Xiaomin Wu, Jinfei Chen
Article
Cell Biology
Honghong Zhang, Weiyong Zhao, Dongying Gu, Mulong Du, Weida Gong, Yongfei Tan, Meilin Wang, Juan Wen, Yongning Zhai, Zhi Xu
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2018)
Article
Gastroenterology & Hepatology
Felice H. Tsang, Victor Au, Wen-Jing Lu, Felix H. Shek, Angela M. Liu, John M. Luk, Sheung-Tat Fan, Ronnie T. P. Poon, Nikki P. Lee
DIGESTIVE DISEASES AND SCIENCES
(2014)
Review
Pathology
Sarwat Fatima, John M. Luk, Ronnie T. P. Poon, Nikki P. Lee
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2014)
Article
Cell Biology
Junfeng Shi, Yi Chen, Wenxing Chen, Cuiju Tang, Honghong Zhang, Yuetong Chen, Xiuwei Yang, Zhi Xu, Jingsun Wei, Jinfei Chen
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2018)
Article
Biochemistry & Molecular Biology
Gautam Sethi, Snehajyoti Chatterjee, Peramaiyan Rajendran, Feng Li, Muthu K. Shanmugam, Kwong Fai Wong, Alan Prem Kumar, Parijat Senapati, Amit K. Behera, Kam Man Hui, Jeelan Basha, Nagashayana Natesh, John M. Luk, Tapas K. Kundu
Editorial Material
Biochemistry & Molecular Biology
John M. Luk, Kun-Liang Guan
Article
Multidisciplinary Sciences
Angela M. Liu, Zhi Xu, Felix H. Shek, Kwong-Fai Wong, Nikki P. Lee, Ronnie T. Poon, Jinfei Chen, John M. Luk
Article
Multidisciplinary Sciences
Zhi Xu, Xinying Huo, Chuanning Tang, Hua Ye, Vijayalakshmi Nandakumar, Feng Lou, Dandan Zhang, Shouwen Jiang, Hong Sun, Haichao Dong, Guangchun Zhang, Zhiyuan Liu, Zhishou Dong, Baishuai Guo, He Yan, Chaowei Yan, Lu Wang, Ziyi Su, Yangyang Li, Dongying Gu, Xiaojing Zhang, Xiaomin Wu, Xiaowei Wei, Lingzhi Hong, Yangmei Zhang, Jinsong Yang, Yonglin Gong, Cuiju Tang, Lindsey Jones, Xue F. Huang, Si-Yi Chen, Jinfei Chen
SCIENTIFIC REPORTS
(2014)
Article
Biotechnology & Applied Microbiology
Jian Yang, Wei Zheng, Zhi Xu, Jinfei Chen
ONCOTARGETS AND THERAPY
(2019)
Article
Medicine, Research & Experimental
Yick-Liang Lum, John M. Luk, Donald E. Staunton, Dennis K. P. Ng, Wing-Ping Fong
MOLECULAR PHARMACEUTICS
(2020)
Article
Oncology
Zhi Xu, Yi Chen, Dongying Gu, Nikki P. Lee, Stella Sun, Weida Gong, Yongfei Tan, John M. Luk, Jinfei Chen
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2015)