Article
Oncology
Jee Young Sung, June Hyuk Kim, Hyun Guy Kang, Jong Woong Park, Seog-Yun Park, Byung-Kiu Park, Yong-Nyun Kim
Summary: ICSBP regulates PD-L1 expression in osteosarcoma cells, and PD-L1 knockdown combined with doxorubicin treatment could represent a strategy for controlling osteosarcoma expressing ICSBP.
FRONTIERS IN ONCOLOGY
(2022)
Article
Integrative & Complementary Medicine
Shubin Wang, Zongguang Li, Wei Liu, Guojun Wei, Naichun Yu, Guangrong Ji
Summary: Neohesperidin inhibits proliferation and induces apoptosis in osteosarcoma cells, while also triggering autophagy. These effects are associated with an increase in ROS generation and are mediated by the activation of the JNK signaling pathway. Therefore, neohesperidin may be a potential drug candidate for the treatment of osteosarcomas.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Oncology
Bangmin Wang, Zheping Hong, Chen Zhao, Qing Bi, Junhui Yuan, Jihang Chen, Yi Shen
Summary: This study confirmed the overexpression of MEX3A in osteosarcoma tissues and demonstrated the inhibitory effects of MEX3A knockdown on osteosarcoma progression. It was further revealed that MEX3A may be involved in osteosarcoma development by regulating apoptosis-related factors.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Shun-Cheng Yang, Hsuan-Ying Chen, Wan-Ling Chuang, Hui-Chun Wang, Cheng-Pu Hsieh, Yi-Fu Huang
Summary: Hinokitiol exhibits antitumor activities against osteosarcoma cells through inducing senescence in cells with wild-type p53 and apoptosis in cells with mutated p53. Additionally, it induces autophagy in both cell lines, and inhibition of autophagy enhances the senescence effect in U-2 OS cells and promotes apoptosis in MG-63 cells. The analysis of p53 status and co-administration of autophagy inhibitors may provide more precise and efficacious therapies in hinokitiol-related trials for treating osteosarcoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Zhi-Qiang Li, Wei-Jie Liao, Bo-Lin Sun, Zhi-Wen Luo, Nan-Shan Zhong, Jia-Bao Wu, Zhi-Li Liu, Jia-Ming Liu
Summary: LRIG2 is highly expressed in osteosarcoma tissues and cells, and its knockdown inhibits cell proliferation and migration while promoting apoptosis. Silencing LRIG2 also suppresses tumor growth in vivo.
Review
Biochemistry & Molecular Biology
Sara R. Martins-Neves, Gabriela Sampaio-Ribeiro, Celia M. F. Gomes
Summary: Relapse and lack of response in osteosarcoma treatment may be linked to chemoresistant cancer stem cells, highlighting the need for further research and solutions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Qicai Han, Penghui Yan, Ruipeng Song, Feifei Liu, Qing Tian
Summary: The upregulation of mitochondrial protein TIMM13 in human osteosarcoma tissues and cells is essential for mitochondrial integrity and function. Depletion of TIMM13 leads to mitochondrial dysfunction and injury, inhibits cell proliferation and migration, and promotes apoptosis in osteosarcoma cells. TIMM13 represents a novel therapeutic target for osteosarcoma cell growth.
CELL DEATH & DISEASE
(2023)
Article
Genetics & Heredity
Tianfei Ran, Song Ke, Xin Song, Tianying Ma, Yuan Xu, Min Wang
Summary: The study found that WIPI1 promotes osteosarcoma cell proliferation by regulating the expression of multiple cell cycle-related genes. This provides important clues for further exploration of the pathogenesis of osteosarcoma.
Article
Biochemistry & Molecular Biology
Qing Su, Baolin Xu, Zhoubin Tian, Ziling Gong
Summary: The study focused on developing a novel CDK9 inhibitor 5k, which inhibits the growth of osteosarcoma cells in vitro and in vivo by targeting CDK9 activity, inducing apoptosis and cell cycle arrest.
CHEMICAL BIOLOGY & DRUG DESIGN
(2022)
Article
Oncology
Songjia Ni, Jianjun Li, Sujun Qiu, Yingming Xie, Kaiqin Gong, Yang Duan
Summary: The study revealed that KIF21B is upregulated in osteosarcoma and may regulate the proliferation and apoptosis of osteosarcoma cells through the PI3K/AKT pathway.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Medicinal
Angela De Luca, Daniele Bellavia, Lavinia Raimondi, Valeria Carina, Viviana Costa, Milena Fini, Gianluca Giavaresi
Summary: Resveratrol (RSV) exhibits multiple tumor-suppressing activities on osteosarcoma (OS) cell lines, including inhibition of cell growth, promotion of cell differentiation, inhibition of cell migration, and enhancement of cytotoxic effect in combination with chemotherapy.
Article
Pharmacology & Pharmacy
Bin He, Wenkan Zhang, Jiaming He
Summary: The study demonstrated that fraxinellone (FRA) isolated from the D. dasycarpus plant inhibited the proliferation and migration of osteosarcoma cells, induced cell apoptosis, and increased autophagy flux. The pro-apoptotic effect of FRA was achieved through excessive autophagy flux, providing new ideas for future osteosarcoma treatment and offering theoretical support for the anti-cancer mechanism of FRA.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biophysics
Yao Wang, Jing He, Junwei Zhang, Nihui Zhang, Yong Zhou, Fang Wu
Summary: The current design scheme on anti-cancer materials focuses on tuning the mechanical properties of materials and inducing apoptosis in cancer cells through the Rho/ROCK signaling pathway. The study proposes that tuning cell motility could be another important approach to modifying the tumor microenvironment and inducing tumor apoptosis. RGD-modified substrates were used to regulate cell motility, and the effect of motility on tumor cell apoptosis and the involvement of the Wnt signaling pathway were examined. The findings suggest that RGD modification can effectively tune the motility of cancer cells, while high RGD concentration can suppress cell migration and increase the apoptosis rate. The activation of the Wnt-beta-catenin pathway further confirms the critical role of the Wnt pathway in motility-regulated apoptosis of tumor cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Pharmacology & Pharmacy
J. Y. Fu, C. X. Jiang, M. Y. Wu, R. Y. Mei, A. F. Yang, H. P. Tao, X. J. Chen, J. Zhang, L. Huang, X. F. Zhao
Summary: Theabrownin (TB) has shown potential as an antitumor agent in glioma cells by significantly reducing cell viability and inducing cell cycle arrest through modulation of various proteins. Different mechanisms related to c-myc and P53 were proposed for cell cycle arrest in different glioma cell lines. TB could be a novel candidate drug for the treatment of gliomas based on these findings.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Meng Qu, Guoxin Zhang, Han Qu, Alexander Vu, Raymond Wu, Hidekazu Tsukamoto, Zhenyu Jia, Wendong Huang, Heinz-Josef Lenz, Jeremy N. Rich, Steve A. Kay
Summary: Hepatocellular carcinoma (HCC) is a global health challenge with increasing incidence worldwide. The circadian clock has been shown to play a key role in hepatocarcinogenesis, but the cellular and molecular mechanisms underlying the HCC-clock crosstalk are unknown. In this study, we found that HCC cells rely on the circadian clock transcription factors BMAL1 and CLOCK for cell growth, and down-regulation of these factors induces apoptosis and cell cycle arrest. Mechanistically, inhibiting BMAL1/CLOCK dysregulates cell cycle regulators Wee1 and p21, leading to tumor cell death. Our findings provide insights into the cellular impact of clock proteins in HCC oncogenesis and suggest a potential therapeutic approach based on modulation of the circadian clock.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Pharmacology & Pharmacy
Marie Cade, Javier Munoz-Garcia, Antoine Babuty, Marc Fouassier, Marie-Francoise Heymann, Paul E. Monahan, Dominique Heymann
Summary: Hemophilia A is an X-linked hereditary disorder caused by deficient coagulation factor VIII (FVIII) activity, leading to spontaneous bleeding episodes. Treatment with FVIII replacement may lead to inhibitor development, but new drugs like emicizumab aim to restore hemostatic balance. The potential extrahemostatic functions of FVIII could be crucial for future therapies in hemophilia.
DRUG DISCOVERY TODAY
(2022)
Article
Biochemistry & Molecular Biology
Marie Cade, Javier Munoz-Garcia, Antoine Babuty, Louis Pare, Denis Cochonneau, Karim Fekir, Mathias Chatelais, Marie-Francoise Heymann, Anna Lokajczyk, Catherine Boisson-Vidal, Dominique Heymann
Summary: This study discovered that recombinant human FVIII has direct biological activities on endothelial cells, including decreased cell adhesion, regulation of transcriptomic and protein profiles, increased vascular permeability, and enhanced monocyte adhesion. The findings highlight new functions of FVIII in regulating vascular permeability and leukocyte adhesion and migration.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Alejandro Rodriguez-Pena, Estibaliz Armendariz, Alvaro Oyarbide, Xabier Morales, Sergio Ortiz-Espinosa, Borja Ruiz-Fernandez de Cordoba, Denis Cochonneau, Inaki Cornago, Dominique Heymann, Josepmaria Argemi, Delia D'Avola, Bruno Sangro, Fernando Lecanda, Ruben Pio, Ivan Cortes-Dominguez, Carlos Ortiz-de-Solorzano
Summary: This paper presents a double spiral microfluidic device based on inertial separation for efficient enrichment and isolation of circulating tumor cells (CTCs). The device has a fine-tunable cut-off value and better separation results than existing technologies.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Camille Jubelin, Javier Munoz-Garcia, Laurent Griscom, Denis Cochonneau, Emilie Ollivier, Marie-Francoise Heymann, Francois M. Vallette, Lisa Oliver, Dominique Heymann
Summary: Cancer is a complex disease that requires multidimensional models to understand its development and drug response. Three-dimensional cell culture models, compared to traditional two-dimensional cultures, better mimic the biological behavior of tumor cells and provide a better platform for studying therapeutic escape and drug resistance.
CELL AND BIOSCIENCE
(2022)
Article
Oncology
Luc Ollivier, Charles Orione, Paul Bore, Laurent Misery, Delphine Legoupil, Jean-Christophe Leclere, Anne Coste, Gilles Girault, Iona Sicard-Cras, Clemence Kacperek, Francois Lucia, Dinu Stefan, Francois Thillays, Emmanuel Rio, Paul Lesueur, Christian Berthou, Dominique Heymann, Stephane Champiat, Stephane Supiot, Loig Vaugier
Summary: This retrospective study investigated the incidence of abscopal response (AR) in patients with metastatic melanoma who received palliative radiotherapy. The study found that AR is highly prognostic of overall survival, although it is a rare phenomenon. Multiple concurrent treatments with radiotherapy and immunotherapy, as well as acute inflammatory events such as infection, may promote AR.
Correction
Medicine, General & Internal
Hannah C. Beird, Stefan S. Bielack, Adrienne M. Flanagan, Jonathan Gill, Dominique Heymann, Katherine A. Janeway, J. Andrew Livingston, Ryan D. Roberts, Sandra J. Strauss, Richard Gorlick
NATURE REVIEWS DISEASE PRIMERS
(2022)
Article
Medicine, General & Internal
Hannah C. Beird, Stefan S. Bielack, Adrianne M. Flanagan, Jonathan Gill, Dominique Heymann, Katherine A. Janeway, J. Andrew Livingston, Ryan D. Roberts, Sandra J. Strauss, Richard Gorlick
Summary: Osteosarcoma is the most common primary malignant bone tumor with a bimodal incidence peaking at 18 and 60 years of age. It is more common in males and is driven by genetic factors related to bone formation leading to malignant progression and metastasis. Screening is currently focused on high-risk groups, and the prognosis for patients with metastatic disease remains poor.
NATURE REVIEWS DISEASE PRIMERS
(2022)
Letter
Dermatology
Magali Croquette, Alicia Faugeroux, Clemence Fonlupt, Julie Godet, Eric Frouin, Martine Garcia, Francois-Xavier Bernard, Sevda Cordier-Dirikoc, Nathalie Pedretti, Guillaume Larid, Laure Favot, Pascal Roblot, Damien Boutin, Ewa Hainaut-Wierzbicka, Dominique Heymann, Jean-Claude Lecron, Franck Morel, Jean-Francois Jegou
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Review
Endocrinology & Metabolism
Isidora Panez-Toro, Javier W. Munoz-Garcia, Jorge Vargas-Franco, Axelle Renodon-Corniere, Marie-Francoise Heymann, Frederic Lezot, Dominique Heymann
Summary: This article provides an overview of recent developments in the treatment of osteosarcoma, including targeting signaling pathways, immune checkpoint inhibitors, drug delivery strategies, and identification of new therapeutic targets.
CURRENT OSTEOPOROSIS REPORTS
(2023)
Article
Oncology
Lisa Oliver, Arturo alvarez-Arenas, Celine Salaud, Juan Jimenez-Sanchez, Gabriel F. Calvo, Juan Belmonte-Beitia, Stephanie Blandin, Luciano Vidal, Victor Perez, Dominique Heymann, Francois M. Vallette
Summary: Glioblastoma (GBM) is an incurable disease and personalized treatments are expected to be the key to therapeutic success due to the heterogeneity, complexity, and plasticity of GBM tumors. This study developed a 3D biosphere model using patient-derived cells (PDCs) from GBM and cancer-activated fibroblasts (CAFs) to mimic GBM progression and response to treatment. The co-culture of PDCs with CAFs showed similar growth and morphology to patients, and the response to standard therapy (Temozolomide and irradiation) was also consistent with GBM patients. This method provides a simple and reproducible way to obtain 3D cultures and has the potential for precision and personalized medicine.
Article
Biochemistry & Molecular Biology
Perrine Jacquot, Javier Munoz-Garcia, Maurine Fleury, Denis Cochonneau, Remi Gaussin, Elise Enouf, Caroline Roze, Emilie Ollivier, Mathieu Cinier, Dominique Heymann
Summary: Re-education of the tumor microenvironment with immune checkpoint inhibitors (ICI) has been a significant breakthrough in cancer treatment, but low response rates and immune-related adverse events (irAEs) remain challenges. A bispecific Nanofitin was engineered using anti-epidermal growth factor receptor (EGFR) and anti-programmed cell death ligand 1 (PDL1) modules to increase selectivity and safety. The study demonstrated that the bispecific Nanofitin elicited EGFR-directed PDL1 blockade, highlighting its potential in enhancing the safety and selectivity of PDL1 checkpoint inhibition.
Article
Pharmacology & Pharmacy
Nolwenn Dubois, Javier Munoz-Garcia, Dominique Heymann, Axelle Renodon-Corniere
Summary: Consuming high dietary glucose and having hyperglycemia can lead to chronic complications. This study investigated the effects of long-term exposure to high glucose on the intestinal barrier. The results showed that high glucose induced morphological changes and disrupted the structure of junction proteins. It also affected the functionalities of the intestinal barrier, and these alterations were more pronounced in co-culture models.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Oncology
Yi Pu, Lu Li, Haoning Peng, Lunxu Liu, Dominique Heymann, Caroline Robert, Francois Vallette, Shensi Shen
Summary: Drug-tolerant persister (DTP) cell populations have been discovered in antibiotic-resistant bacterial biofilms and have also been identified in cancer cells. They are linked with treatment resistance and targeting these cells may offer new treatment opportunities.
NATURE REVIEWS CLINICAL ONCOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Camille Jubelin, Javier Munoz-Garcia, Denis Cochonneau, Emilie Ollivier, Francois Vallette, Marie-Francoise Heymann, Lisa Oliver, Dominique Heymann
Summary: This study reaffirms the relevance of simpler 3D culture methods, such as the Liquid Overlay Technique (LOT), for producing highly reproducible spheroids in the context of drug cytotoxicity measurements. The morphology of spheroids generated in round-bottom multiwell plates was found to be more repeatable than those generated in flat-bottom plates. The IC50 of doxorubicin on MNNG/HOS cells grown in 3D was significantly higher than in 2D cultures, indicating the potential of 3D models for drug response measurements.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Oncology
Camille Jubelin, Javier Munoz-Garcia, Denis Cochonneau, Emilie Moranton, Marie-Francoise Heymann, Dominique Heymann
Summary: Sarcomas are a family of cancers originating in the mesenchyme, and the presence of CSCs in osteosarcomas plays a crucial role in drug resistance, tumor recurrence, and treatment failure.
CANCER DRUG RESISTANCE
(2022)