Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Filippo Lococo, Vittoria Rufini, Angelina Filice, Massimiliano Paci, Guido Rindi
Summary: SFTPs are rare mesenchymal tumors with difficult preoperative diagnosis. Ga-68-DOTATOC PET/CT imaging can aid in diagnosing SFTP and potentially offer new treatment options in unresectable or metastatic disease.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Philippe Thuillier, Virginia Liberini, Serena Grimaldi, Osvaldo Rampado, Elena Gallio, Bruno De Santi, Emanuela Arvat, Alessandro Piovesan, Roberto Filippi, Ronan Abgral, Filippo Molinari, Desiree Deandreis
Summary: We evaluated the prognostic value of somatostatin receptor tumor burden on Ga-68-DOTATOC PET/CT in patients with well-differentiated neuroendocrine tumors. The SRETVwb and TLSREwb extracted from the PET/CT scans were found to predict time to progression or overall survival, and could be clinically useful in managing these patients.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Sara S. Rinne, Ayman Abouzayed, Katherine Gagnon, Vladimir Tolmachev, Anna Orlova
Summary: This study successfully produced gallium-66 for radiolabeling and investigated the imaging properties of gallium-66 labeled GRPR-antagonist for PET imaging of GRPR expression. The results demonstrated that the radiotracer could clearly visualize GRPR expression, but delayed imaging did not improve contrast.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Jingjing Zhang, Harshad R. Kulkarni, Richard P. Baum
Summary: The case study presented a patient with beta-radiation refractory metastatic thymus NET who demonstrated excellent therapy response after Ac-225-DOTATOC-targeted alpha-therapy, showing molecular and morphological remission as well as significantly improved clinical symptoms, with no adverse effects observed during treatment or follow-up.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Medical Laboratory Technology
Songlin Yu, Danchen Wang, Xiaoli Ma, Yuanyuan Zhang, Dandan Sun, Yutong Zou, Jialei Yu, Fang Zhang, Guohua Yang, Shaowei Xie, Qian Cheng, Xinqi Cheng, Ling Qiu
Summary: A LC-MS/MS method was established to quantify G17 and G34 simultaneously, showing high analytical performance. The method was compared with CLIA and RIA, and it was found to be highly correlated with both methods. The study suggests that G17 may be the most specific biomarker for gastrinoma diagnosis.
CLINICAL CHEMISTRY
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Capucine Richard, Jerome Cros, Romain-David Seban, Laurence Champion, Segolene Hescot
Summary: A 73-year-old woman with a grade 2 pancreatic neuroendocrine tumor underwent Ga-68-DOTATOC PET/CT staging, revealing primary pancreatic tumor, liver and pleural metastases, and high uptake in a triceps muscle mass. Previous F-18-FDG PET/CT and In-111-pentetreotide scans showed low and high uptake in the triceps mass, respectively. The histopathological analysis identified a solitary fibrous tumor with no staining for SSTR-2 and SSTR-5, indicating overexpression of another somatostatin receptor. This case highlights a potential pitfall in Ga-68-DOTATOC PET/CT.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Medicine, General & Internal
Virginia Liberini, Osvaldo Rampado, Elena Gallio, Bruno De Santi, Francesco Ceci, Beatrice Dionisi, Philippe Thuillier, Libero Ciuffreda, Alessandro Piovesan, Federica Fioroni, Annibale Versari, Filippo Molinari, Desiree Deandreis
Summary: This study aimed to evaluate radiomic features extracted from 68Ga-DOTATOC-PET/CT and their association with the response to peptide receptor radionuclide therapy (PRRT) in patients with neuroendocrine tumors (NET). The results suggest that TLSREwb-50 and SRETVwb-50 modifications may predict and assess the PET response to PRRT, with radiomic features potentially playing a role in defining inter-patient heterogeneity and predicting therapy response. Further studies with larger patient populations are needed to confirm the efficacy of these biomarkers.
FRONTIERS IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Dong Yun Lee, Seung Hun Lee, Beom-Jun Kim, Wanlim Kim, Pil Whan Yoon, Sang Ju Lee, Seung Jun Oh, Jung-Min Koh, Jin-Sook Ryu
Summary: Ga-68-DOTATOC PET/CT is a useful imaging modality for detecting potential culprit tumors in patients with suspected TIO, providing valuable information for surgical excision.
SCIENTIFIC REPORTS
(2021)
Review
Oncology
Ludovica Magi, Matteo Marasco, Maria Rinzivillo, Antongiulio Faggiano, Francesco Panzuto
Summary: Functional pancreatic neuroendocrine neoplasms (pNENs) are rare and heterogeneous diseases that secrete hormones or peptides, causing various symptoms. Surgery is the main treatment for local disease, while non-resectable cases have multiple therapeutic options. This review provides a summary of the clinical management and therapeutic approaches for functional pNENs.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2023)
Article
Oncology
Elena Trevisi, Ivan Facilissimo, Stefano Taraglio, Maria Brizzi
Summary: Mesenteric fibromatosis is a locally aggressive fibroblastic lesion with a high recurrence rate. This study found that the tumor cells express somatostatin receptors and suggested that it could be one of the potential causes of false-positive results in 68Ga PET/CT.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2022)
Article
Oncology
Janet H. Pollard, Yusuf Menda, K. D. Zamba, Mark Madsen, M. Sue O'Dorisio, Thomas O'Dorisio, David Bushnell
Summary: This pilot imaging study focused on midgut neuroendocrine carcinoma metastatic to the liver, evaluating the effect of pretreatment with the HDAC inhibitor vorinostat on uptake of I-123-MIBG and Ga-68-DOTATOC. The study found a statistically significant increase in SUVmax on Ga-68-DOTATOC PET/CT imaging in some hepatic neuroendocrine tumor metastases after a short course of vorinostat, suggesting potential therapeutic implications for somatostatin analogs.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Paola Mapelli, Carolina Bezzi, Francesca Muffatti, Samuele Ghezzo, Francesco Baldassi, Marco Schiavo Lena, Valentina Andreasi, Carla Canevari, Patrizia Magnani, Francesco De Cobelli, Luigi Gianolli, Stefano Partelli, Massimo Falconi, Maria Picchio
Summary: The study aims to evaluate the role of Ga-68-DOTATOC PET parameters in predicting the loss of DAXX/ATRX expression in patients with Pancreatic neuroendocrine tumors (PanNET) candidate to surgery. The results showed that SRD and TLSRD could predict the loss of DAXX expression. When evaluating SRD in combination with radiological diameter, only SRD maintained statistical significance.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Plant Sciences
Liuping Wang, Shiyuan Xie, Xuan Jiang, Caini Xu, Youqiong Wang, Jianfang Feng, Bin Yang
Summary: This study investigated the therapeutic effect of Bombax ceiba flower aqueous extracts (BCE) against loperamide-induced constipation and characterized the chemical composition of BCE. The results showed that BCE treatment could increase faecal water and number, improve gastrointestinal transit rate, and reduce first black-stool defecation time, suggesting its potential for the treatment of constipation.
PHARMACEUTICAL BIOLOGY
(2023)
Editorial Material
Medicine, General & Internal
Anna Herden, Deema Sabtan, Katja Warnecke, Christian Doll, Christian Furth
Summary: This case report presents the clinical findings of a patient with a rare neoplastic syndrome, who was diagnosed with a rare benign tumor through PET/CT imaging and biopsy. The tumor was found to be receptor-positive.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Margherita Lorusso, Giuseppe Angelico, Michela Quirino, Valentina Scolozzi, Maria Lucia Calcagni
Summary: A 58-year-old man with a mesenteric nodule detected during CT for abdominal pain was later diagnosed with high-grade leiomyosarcoma through multiple PET/CT and MRI evaluations.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Endocrinology & Metabolism
R. S. Jallad, I Shimon, M. Fraenkel, V Medvedovsky, A. Akirov, F. H. Duarte, M. D. Bronstein
CLINICAL ENDOCRINOLOGY
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Oussama ElMokh, Vincent Taelman, Piotr Radojewski, Matthias A. Roelli, Amandine Stoss, Rebecca A. Dumont, Matthias S. Dettmer, Wayne A. Phillips, Martin A. Walter, Roch-Philippe Charles
JOURNAL OF NUCLEAR MEDICINE
(2019)
Article
Oncology
Esben Andreas Carlsen, Nicola Fazio, Dan Granberg, Simona Grozinsky-Glasberg, Hojjat Ahmadzadehfar, Chiara Maria Grana, Wouter T. Zandee, Jaroslaw Cwikla, Martin A. Walter, Peter Sandor Oturai, Anja Rinke, Andrew Weaver, Andrea Frilling, Sara Gritti, Anne Kirstine Arveschoug, Amichay Meirovitz, Ulrich Knigge, Halfdan Sorbye
ENDOCRINE-RELATED CANCER
(2019)
Review
Oncology
Reto M. Kaderli, Marko Spanjol, Attila Kollar, Lukas Butikofer, Viktoria Gloy, Rebecca A. Dumont, Christian A. Seiler, Emanuel R. Christ, Piotr Radojewski, Matthias Briel, Martin A. Walter
Article
Surgery
Dominik A. Jakob, Philipp Riss, Christian Scheuba, Michael Hermann, Corina Kim-Fuchs, Christian A. Seiler, Martin A. Walter, Reto M. Kaderli
WORLD JOURNAL OF SURGERY
(2019)
Review
Surgery
Olivier Rager, Piotr Radojewski, Rebecca A. Dumont, Giorgio Treglia, Luca Giovanella, Martin A. Walter
Article
Radiology, Nuclear Medicine & Medical Imaging
O. Maas, F. Forrer, M. Maas, C. M. Panje, J. Blautzik, M. Bruhlmeier, I. Engel-Bicik, L. Giovanella, A. Haldemann, M. E. Kamel, S. Kneifel, C. Rottenburger, N. Schaefer, M. A. Walter, S. Weidner, P. M. Putora
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2020)
Article
Oncology
Merav Fraenkel, Victor Novack, Yuval Mizrakli, Michael Koretz, Ethel Siris, Larry Norton, Tali Shafat, David B. Geffen
Summary: Women newly diagnosed with breast cancer tend to have higher bone mineral density (BMD) compared to women without breast cancer, suggesting that BMD may be a biomarker for breast cancer risk.
Article
Otorhinolaryngology
Shoham Rigbi, Ben-Zion Joshua, Lior Baraf, Uri Yoel, Merav Fraenkel
Summary: Preoperative serum thyroglobulin alone is insufficient to differentiate between malignant and benign thyroid nodular disease.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Engineering, Biomedical
Lotem Gotnayer, Dina Aranovich, Merav Fraenkel, Uri Yoel, Netta Vidavsky
Summary: Thyroid nodules are common findings in neck ultrasonography, but only a small percentage of them are malignant. Fine needle aspiration for cytology is indicated when ultrasound characteristics suggest TN malignancy. However, indeterminate results are common, requiring further evaluation through repeated FNAC or expensive molecular testing. This study suggests that the presence of zinc in microscopic calcifications may serve as a biomarker for TN malignancy.
ACTA BIOMATERIALIA
(2023)
Biographical-Item
Endocrinology & Metabolism
John P. Bilezikian, Merav Fraenkel, Liana Tripto-Shkolnik, Rene Rizzoli, Ethel Siris
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Tamar Eshkoli, Merav Fraenkel, Dana Zaid, Dayana Cohen, Uri Yoel, Gloria Tsvetov, Alexander Gorshtein, Adi Goldbart, Yona Greenman, Ilan Shimon
Summary: DA-resistant prolactinomas usually require a multi-modal treatment strategy, and a combination of surgery, radiotherapy, and medication can achieve better treatment outcomes.
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
O. C. Maas, M. Maas, P. M. Putora, C. M. Panje, J. Blautzik, M. Bruhlmeier, I. Engel-Bizik, L. Giovanella, A. Haldemann, M. E. Kamel, S. Kneifel, C. Rottenburger, N. Schafer, M. A. Walter, S. Weidner, F. Forrer
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2019)
Meeting Abstract
Surgery
R. Kaderli, M. Spanjol, A. Kollar, L. Butikofer, V. Gloy, C. A. Seiler, E. R. Christ, P. Radojewski, M. Briel, M. A. Walter
BRITISH JOURNAL OF SURGERY
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
C. Boy, T. Poeppel, J. Kotzerke, B. J. Krause, H. Amthauer, R. P. Baum, I. Buchmann, S. Ezziddin, D. Fuehrer, M. Gabriel, T. Kuwert, H. Lahner, T. Lauenstein, H. R. Maecke, J. Nagarajah, F. Roesch, K. Scheidhauer, M. Schmidt, M. A. Walter, A. Bockisch
NUKLEARMEDIZIN-NUCLEAR MEDICINE
(2018)