The potential contribution of circulating and locally produced leptin to cardiac hypertrophy and failure

Role of Leptin Signaling in the Pathogenesis of Angiotensin II–Mediated Atrial Fibrosis and Fibrillation

(2013) Akira Fukui et al.   Circulation-Arrhythmia and Electrophysiology

Identification of Fat Mass and Obesity Associated (FTO) Protein Expression in Cardiomyocytes: Regulation by Leptin and Its Contribution to Leptin-Induced Hypertrophy

(2013) Xiaohong Tracey Gan et al.   PLoS One

Pressure mediated hypertrophy and mechanical stretch up-regulate expression of the long form of leptin receptor (ob-Rb) in rat cardiac myocytes

(2012) Hiroki Matsui et al.   BMC CELL BIOLOGY

Adipokines and the cardiovascular system: mechanisms mediating health and disease

(2012) Josette M. Northcott et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Leptin-induced Cardiomyocyte Hypertrophy Reveals both Calcium-dependent and Calcium-independent/RhoA-dependent Calcineurin Activation and NFAT Nuclear Translocation

(2012) Venkatesh Rajapurohitam et al.   CELLULAR SIGNALLING

Intestinal microbiota determine severity of myocardial infarction in rats

(2012) Vy Lam et al.   FASEB JOURNAL

Role of NF-κB and p38 MAPK activation in mediating angiotensin II and endothelin-1-induced stimulation in leptin production and cardiomyocyte hypertrophy

(2012) Venkatesh Rajapurohitam et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The Obesity-Related Peptide Leptin Sensitizes Cardiac Mitochondria to Calcium-Induced Permeability Transition Pore Opening and Apoptosis

(2012) Eduardo Martinez-Abundis et al.   PLoS One

From GWAS to biology: lessons from FTO

(2011) Yi-Chun Loraine Tung et al.   Annals of the New York Academy of Sciences

Leptin’s regulation of obesity-induced cardiac extracellular matrix remodeling

(2011) Sherma Zibadi et al.   Cardiovascular Toxicology

Leptin, leptin gene and leptin receptor gene polymorphism in heart failure with preserved ejection fraction

(2011) Tarek A. Abd El-Aziz et al.   HEART AND VESSELS

Dynamics in Insulin Resistance and Plasma Levels of Adipokines in Patients With Acute Decompensated and Chronic Stable Heart Failure

(2011) P. Christian Schulze et al.   JOURNAL OF CARDIAC FAILURE

Ginseng (Panax quinquefolius) Attenuates Leptin-Induced Cardiac Hypertrophy through Inhibition of p115Rho Guanine Nucleotide Exchange Factor-RhoA/Rho-Associated, Coiled-Coil Containing Protein Kinase-Dependent Mitogen-Activated Protein Kinase Pathway Activation

(2011) M. Moey et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Obesity and Risk of Incident Heart Failure in Older Men With and Without Pre-Existing Coronary Heart Disease

(2011) S. Goya Wannamethee et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Obesity, Leptin, and Incident Heart Failure⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.

(2011) Anita Deswal   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

mTOR mediates RhoA-dependent leptin-induced cardiomyocyte hypertrophy

(2011) Asad Zeidan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Direct evidence for leptin-induced lipid oxidation independent of long-form leptin receptor

(2010) Yunike Akasaka et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Cardiac-specific leptin receptor deletion exacerbates ischaemic heart failure in mice

(2010) Kenneth R. McGaffin et al.   CARDIOVASCULAR RESEARCH

Inhibition of cardiac leptin expression after infarction reduces subsequent dysfunction

(2010) C. Moro et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Where to go with FTO?

(2010) Rachel Larder et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Leptin receptor signaling and the regulation of mammalian physiology

(2009) E C Villanueva et al.   INTERNATIONAL JOURNAL OF OBESITY

Inactivation of the Fto gene protects from obesity

(2009) Julia Fischer et al.   NATURE

Molecular targets and regulators of cardiac hypertrophy

(2009) Agrawal Rohini et al.   PHARMACOLOGICAL RESEARCH

Newer Biomarkers in Heart Failure

(2009) Sachin Gupta et al.   Heart Failure Clinics

A neutralizing leptin receptor antibody mitigates hypertrophy and hemodynamic dysfunction in the postinfarcted rat heart

(2008) Daniel M. Purdham et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Signalling mechanisms underlying the metabolic and other effects of adipokines on the heart

(2008) M. Karmazyn et al.   CARDIOVASCULAR RESEARCH

Plasma Leptin Levels and Incidence of Heart Failure, Cardiovascular Disease, and Total Mortality in Elderly Individuals

(2008) W. Lieb et al.   DIABETES CARE

The Obesity Gene, FTO, Is of Ancient Origin, Up-Regulated during Food Deprivation and Expressed in Neurons of Feeding-Related Nuclei of the Brain

(2008) Robert Fredriksson et al.   ENDOCRINOLOGY

Adiponectin is released from the heart in patients with heart failure

(2008) Hajime Takano et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Increased expression and cell surface localization of MT1-MMP plays a role in stimulation of MMP-2 activity by leptin in neonatal rat cardiac myofibroblasts

(2008) Kristin Schram et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY