Article
Plant Sciences
Jingyu Ni, Zhihao Liu, Miaomiao Jiang, Lan Li, Jie Deng, Xiaodan Wang, Jing Su, Yan Zhu, Feng He, Jingyuan Mao, Xiumei Gao, Guanwei Fan
Summary: This study confirms the protective effect of ginsenoside Rg3 on heart function in TAC-induced heart failure mice and reveals the molecular mechanisms involved in regulating glucose metabolism and improving insulin resistance.
JOURNAL OF GINSENG RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Karen Lambert, Marie Demion, Jean-Christophe Lagace, Marie Hokayem, Mamta Dass, Anne Virsolvy, Bernard Jover, Annick Bourret, Catherine Bisbal
Summary: The study found that exercise and polyphenols can prevent cardiac hypertrophy, but their combination does not bring additional benefits. Rats supplemented with polyphenols showed a shift from pathologic to physiological hypertrophy. Polyphenols supplementation appears to have a better protective effect in sedentary obese insulin-resistant rats compared to exercised rats.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Hui Ye, Yanan He, Chuan Zheng, Fang Wang, Ming Yang, Junzhi Lin, Runchun Xu, Dingkun Zhang
Summary: Type 2 diabetes mellitus (T2DM) and heart failure (HF) are diseases with high morbidity and mortality. Their combination is common in middle-aged and elderly individuals, making treatment challenging. Abnormal insulin signaling pathway, a common pathogenic mechanism, could serve as a specific target for the treatment of T2DM patients with HF.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Xiaodan Wang, Jingyu Ni, Rui Guo, Lan Li, Jing Su, Feng He, Guanwei Fan
Summary: There is a reciprocal relationship between heart failure (HF) and insulin resistance (IR), with SGLT2 inhibitors showing potential in improving cardiac prognosis of patients with type 2 diabetes mellitus. Studies have revealed the important role of cardiac IR in the pathogenesis and progression of HF, with energy metabolism playing a key role in the process.
HEART FAILURE REVIEWS
(2022)
Article
Multidisciplinary Sciences
Sang R. Lee, Jun H. Heo, Seong Lae Jo, Globinna Kim, Su Jung Kim, Hyun Ju Yoo, Kyu-Pil Lee, Hyo-Jung Kwun, Hyun-Jin Shin, In-Jeoung Baek, Eui-Ju Hong
Summary: Pgrmc1 plays a crucial role in the heart, with its absence leading to high levels of fat and reduced mitochondrial DNA copies. Additionally, the lack of Pgrmc1 results in decreased fatty acid oxidation activity in the heart, particularly under high-fat diet conditions, making the heart more susceptible to lipotoxicity.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Di Zhu, Zhen Zhang, Jianli Zhao, Demin Liu, Lu Gan, Wayne Bond Lau, Dina Xie, Zhijun Meng, Peng Yao, Jumpei Tsukuda, Theodore A. Christopher, Bernard L. Lopez, Erhe Gao, Walter J. Koch, Yajing Wang, Xin-Liang Ma
Summary: In heart failure, blocking AdipoR1 phosphorylation and pharmacological APN treatment can reverse post-MI remodeling and mitigate heart failure progression.
CIRCULATION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Anna K. Scheel, Lena Espelage, Alexandra Chadt
Summary: The discovery of functional brown adipose tissue (BAT) in adult humans and the possibility to recruit beige cells with high thermogenic potential within white adipose tissue (WAT) depots opened the field for new strategies to combat obesity and its associated comorbidities. Exercise training, cold exposure, and dietary interventions can activate metabolically-active beige adipocytes and increase BAT activation, leading to increased energy expenditure and potential improvements in metabolic complications of obesity and Type 2 Diabetes Mellitus (T2DM) such as insulin resistance (IR).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Daniela Sorriento, Maria Rosaria Rusciano, Valeria Visco, Antonella Fiordelisi, Federica Andrea Cerasuolo, Paolo Poggio, Michele Ciccarelli, Guido Iaccarino
Summary: Insulin resistance is a pathophysiological condition associated with obesity, glucose intolerance, dyslipidemia, and hypertension, leading to type 2 diabetes and cardiovascular diseases. Studies have identified G Protein Coupled Receptor Kinase type 2 (GRK2) as a potential therapeutic target for insulin resistance and its associated phenotypes.
Article
Cell Biology
Kiyoto Nishi, Akira Yoshii, Lauren Abell, Bo Zhou, Ricardo Frausto, Julia Ritterhoff, Timothy S. McMillen, Ian Sweet, Yibin Wang, Chen Gao, Rong Tian
Summary: It was found that deficiency of Ppm1k leads to reduced metabolism of branched-chain amino acids (BCAAs) and protects against obesity-induced glucose intolerance. Accumulation of branched-chain keto acids (BCKAs) inhibits glucose production in liver cells. It was observed that BCKAs suppress the activity of liver mitochondrial pyruvate carrier (MPC) and pyruvate-supported respiration. Selective suppression of pyruvate-supported gluconeogenesis was seen in Ppm1k-deficient mice and could be restored through pharmacological activation of BCKA catabolism by BT2. Furthermore, liver MPC was found to be most sensitive to circulating BCKA levels, making it a sensor of BCAA metabolism.
Review
Endocrinology & Metabolism
Min Jeong Park, Kyung Mook Choi
Summary: Sarcopenic obesity, caused by the rising older population, has become a global health concern, leading to cardiometabolic morbidity and mortality. Excessive adiposity creates a pro-inflammatory environment, disrupting metabolic homeostasis and impeding muscle tissue regeneration. The interaction between adipokines and myokines plays a crucial role in the pathophysiology of sarcopenia and obesity, but its complexity makes it challenging to understand.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Biochemistry & Molecular Biology
Lukasz Pilarski, Marta Pelczynska, Anna Koperska, Agnieszka Seraszek-Jaros, Monika Szulinska, Pawel Bogdanski
Summary: This study aimed to determine the association between vaspin concentration and metabolic disorders in obese individuals. The results showed that serum vaspin concentrations were significantly higher in the obese group compared to the control group. The findings suggest that vaspin may be a useful diagnostic parameter for obesity-related complications.
Article
Cardiac & Cardiovascular Systems
Parveen K. Garg, Mary L. Biggs, Jorge R. Kizer, Sanjiv J. Shah, Bruce Psaty, Mercedes Carnethon, John S. Gottdiener, David Siscovick, Kenneth J. Mukamal
Summary: This study evaluated the association between glucose dysregulation and subclinical cardiac dysfunction in an older population. The findings suggest that the relationship between glucose dysregulation and cardiac dysfunction is largely attenuated after adjusting for central adiposity.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Endocrinology & Metabolism
Ayoub Saeidi, Mohammad Amin Saei, Behnam Mohammadi, Hamid Reza Akbarzadeh Zarei, Morvarid Vafaei, Amir Shayan Mohammadi, Masoumeh Barati, Mona Montazer, Omid Razi, Maisa Hamed Kiyumi, Ismail Laher, Mandana Gholami, Katja Weiss, Beat Knechtle, Hassane Zouhal
Summary: This study investigated the effects of 12 weeks of high-intensity functional training (HIFT) combined with spinach-derived thylakoid supplementation on adipokines and insulin resistance in males with obesity. The results showed that HIFT supplemented with spinach-derived thylakoid significantly reduced leptin, resistin, vaspin, visfatin, apelin, RBP4, chemrin, semaphorin3c, and insulin resistance levels, while increasing adiponectin and omentin levels in men with obesity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Asmaa A. El Sehmawy, Fatma Elzhraa Ahmed Diab, Donia Ahmed Hassan, Doaa Sayed Mohammed, Mona Gamal El Din Al Anany, Noha A. Eldesoky, Reham Yousri Elamir
Summary: The study found that obese children had higher weight Z scores, waist-to-height ratios, serum cholesterol, LDL, and TG levels, as well as lower HDL levels. Higher levels of serum lipocalin-2 and adipsin and lower IL-10 levels were observed in the obese group. The results suggest that measuring general and central adiposity markers as well as serum lipocalin-2 can predict insulin resistance in obese children.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Frederique Van de Velde, D. Margriet Ouwens, Arsene-Helene Batens, Yves Van Nieuwenhove, Bruno Lapauw
Summary: Systemic improvements in inflammation and insulin resistance are observed after gastric bypass surgery, but changes in adipokine and myokine expression patterns only partially reflect these improvements. Expression of markers of inflammation and insulin/glucose metabolism in other tissues may be inconsistent and divergent.
Article
Peripheral Vascular Disease
Daniel Kretzschmar, Marcus Thieme, Rene Aschenbach, P. Christian Schulze, Sven Moebius-Winkler
Summary: A 45-year-old healthy woman presented with claudication of the right leg. Thrombotic occlusion of a persisting sciatic artery (PSA) was successfully treated using an interventional approach, resulting in a patent vessel and a positive outcome.
INTERNATIONAL JOURNAL OF ANGIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Safoura Mazrouei, Sebastian Friedrich Petry, Fatemeh Sharifpanah, Shaghayegh Haghjooy Javanmard, Roya Kelishadi, P. Christian Schulze, Marcus Franz, Christian Jung
Summary: The increased expression and activity of arginase-1 in ECs is correlated with the development of obesity-related type 2-DM and vascular disease.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2023)
Article
Peripheral Vascular Disease
Pawel Aftanski, Marcus Thieme, Friederike Klein, P. Christian Schulze, Sven Moebius-Winkler, Daniel Kretzschmar
Summary: This single-center, prospective registry provides compelling evidence for the safety and efficacy of intravascular lithotripsy (IVL) in patients with severe peripheral artery disease (PAD) and calcified lesions. Clinical follow-up data showed a sustained improvement in ankle brachial index (ABI) after 6 months.
INTERNATIONAL JOURNAL OF ANGIOLOGY
(2023)
Article
Emergency Medicine
Elly S. Oh, Paul Schulze, Frank Diaz, Kunal Shah, Jose Rios, Michael E. Silverman
Summary: This study compares the clinical and safety outcomes of andexanet alfa and 4-factor prothrombin complex concentrate for the reversal of apixaban or rivaroxaban-induced intracranial hemorrhage. The results show similar achievement of good hemostatic efficacy upon repeat CT scan between the two treatments, indicating that real-world outcomes align with clinical trial results.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Umidakhon Makhmudova, Beasat Samadifar, Aurel Maloku, Pellumb Haxhikadrija, Jens-Arndt Geiling, Robert Roemer, Bernward Lauer, Sven Moebius-Winkler, Sylvia Otto, P. Christian Schulze, Oliver Weingaertner
Summary: This study demonstrated that early combination therapy and progressive escalation of lipid-lowering treatment effectively achieved recommended LDL-C targets in patients with ST-elevation myocardial infarction, with minimal side effects.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Judith Heiss, Katja Grun, Laura Tempel, Mattia Matasci, Andrea Schrepper, Michael Schwarzer, Reinhard Bauer, Martin Forster, Alexander Berndt, Christian Jung, P. Christian Schulze, Dario Neri, Marcus Franz
Summary: This study compared two formats of immunocytokines and identified potential target cells of IL9. The results showed that targeted delivery of IL9 could have beneficial effects in a mouse model of pulmonary hypertension (PH). Furthermore, IL9 treatment increased the number of regulatory T cells (Tregs) and reduced lung tissue damage in PH mice.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Cardiac & Cardiovascular Systems
Julian G. Westphal, Paul Christian Schulze
Summary: Acute heart failure is a clinical syndrome characterized by elevated intracardiac filling pressures and systemic venous congestion. The underlying cardiac pathology and patient population are heterogeneous, leading to decreased perfusion and retrograde congestion. Therapeutic strategies aim to correct the cardiac dysfunction, reduce volume overload, and stabilize hemodynamics. However, empirical data from randomized trials in acute heart failure is less solid compared to chronic heart failure, resulting in a high mortality rate.
Letter
Cardiac & Cardiovascular Systems
P. Christian Schulze, Juergen Bogoviku, Julian Westphal, Pawel Aftanski, Franz Haertel, Sissy Grund, Stephan von Haehling, Ulrike Schumacher, Sven Moebius-Winkler, Martin Busch
Article
Cardiac & Cardiovascular Systems
T. Dung Nguyen, P. Christian Schulze
Summary: Chronic kidney disease is associated with an increased risk of cardiovascular disorders and may cause structural remodeling and impairments in cardiac function. The concept of uremic cardiomyopathy, a specific cardiomyopathic phenotype, has recently been recognized. The metabolism in the myocardium of uremic heart shows overlapping mechanisms with heart failure. Understanding the similarities and differences in cardiac metabolism between heart failure and uremic cardiomyopathy could lead to new targets for research and treatment.
CIRCULATION RESEARCH
(2023)
Editorial Material
Medicine, General & Internal
Robert Roemer, P. Christian Schulze, Oliver Weingaertner
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Wilfried Mullens, Paul Christian Schulze, Julian Westphal, Juergen Bogoviku, Johann Bauersachs
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Benedikt Schrage, Jonas Sundermeyer, Benedikt Norbert Beer, Letizia Bertoldi, Alexander Bernhardt, Stefan Blankenberg, Jeroen Dauw, Zouhir Dindane, Dennis Eckner, Ingo Eitel, Tobias Graf, Patrick Horn, Paulus Kirchhof, Stefan Kluge, Axel Linke, Ulf Landmesser, Peter Luedike, Enzo Luesebrink, Norman Mangner, Octavian Maniuc, Sven Moebius Winkler, Peter Nordbeck, Martin Orban, Federico Pappalardo, Matthias Pauschinger, Michal Pazdernik, Alastair Proudfoot, Matthew Kelham, Tienush Rassaf, Hermann Reichenspurner, Clemens Scherer, Paul Christian Schulze, Robert H. G. Schwinger, Carsten Skurk, Marek Sramko, Guido Tavazzi, Holger Thiele, Luca Villanova, Nuccia Morici, Antonia Wechsler, Ralf Westenfeld, Ephraim Winzer, Dirk Westermann
Summary: This study aimed to evaluate the use of mechanical circulatory support (MCS) for the treatment of non-ischaemic cardiogenic shock (CS). The results showed that the use of MCS was associated with a lower 30-day mortality rate in patients with non-ischaemic CS. However, MCS treatment was also associated with more complications.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Review
Biology
Christina Schenkl, Estelle Heyne, Torsten Doenst, Paul Christian Schulze, Tien Dung Nguyen
Summary: Despite advances in treating cardiac disorders, heart failure (HF) continues to increase globally and poses a medical and economic burden. HF is characterized by metabolic remodeling in the mitochondria, affecting energy homeostasis, calcium handling, oxidative stress, and inflammation. This study focuses on highlighting mitochondrial metabolic alterations and their impact on the pathophysiology of HF, as well as discussing potential metabolic approaches to improve cardiac function.
Article
Hematology
Joshua N. Gustine, Andrew Staron, Lisa Mendelson, Tracy Joshi, Deepa M. Gopal, Omar K. Siddiqi, Frederick L. Ruberg, Vaishali Sanchorawala
Summary: Patients with advanced cardiac AL amyloidosis have a poor prognosis. Early hematologic and cardiac responses can prolong survival. This study identified factors predictive of treatment outcomes and survival.
Article
Respiratory System
Justin K. Lui, Kari R. Gillmeyer, Ruchika A. Sangani, Robert J. Smyth, Deepa M. Gopal, Marcin A. Trojanowski, Andreea M. Bujor, Renda Soylemez Wiener, Michael P. Lavalley, Elizabeth S. Klings
Summary: The study developed a scoring system to predict the risk of pulmonary hypertension (PH) and all-cause mortality in patients with systemic sclerosis (SSc). The scoring system showed that each one-point increase was associated with a 1.19-fold increase in the risk of all-cause mortality.