Article
Food Science & Technology
Chandra Sekhar Arigela, Giribabu Nelli, Siew Hua Gan, Kuttulebbai Nainamohamed Salam Sirajudeen, Kumarathevan Krishnan, Nurhanan Abdul Rahman, Visweswara Rao Pasupuleti
Summary: Bitter gourd honey (BGH) shows potential anti-oxidative, anti-inflammatory, and anti-apoptotic effects in the treatment of diabetes, reducing liver and kidney damage and increasing levels of antioxidant enzymes.
Article
Biochemistry & Molecular Biology
Hanna Lesiewska, Alina Wozniak, Pawel Reisner, Krzysztof Czosnyka, Joanna Stachura, Grazyna Malukiewicz
Summary: Oxidative stress and depletion of antioxidant defenses may contribute to cataract incidence in patients under 60 years. This study measured antioxidant enzyme activity, vitamin concentrations, and oxidative stress markers in cataract patients and controls. The results showed lower activity of antioxidant enzymes and lower concentrations of vitamins A and E in cataract patients. Additionally, higher levels of lipid peroxidation and protein oxidation were observed, indicating increased oxidative stress in cataract patients. Supplementation with antioxidants could be beneficial for this group of patients.
Article
Chemistry, Physical
Mingyang Jing, Guangye Han, Yuze Li, Wansong Zong, Rutao Liu
Summary: This study investigates the cytotoxicity and oxidative stress induced by naphthalene and its major metabolite (1-naphthol) on earthworm coelomocytes and the interaction mechanism with critical antioxidant enzymes (CAT and SOD). The results demonstrate that 1-naphthol is more toxic to earthworm coelomocytes than naphthalene, and it induces oxidative stress by binding to CAT and SOD. The binding of 1-naphthol leads to conformational changes and activity inhibition of CAT, while it has minimal effects on SOD.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Food Science & Technology
Muhammad Nouman Shaukat, Rosa Palmeri, Cristina Restuccia, Lucia Parafati, Biagio Fallico
Summary: This study investigated the application of a chitosan coating containing glycerol ginger extract (GGE) to preserve walnut quality during storage. Results showed that the GGE-enriched coating significantly reduced lipid oxidation and peroxide values in walnuts stored under high temperature conditions (45°C), compared to uncoated samples and even chitosan-coated walnuts. Additionally, walnuts treated with the GGE-enriched coating exhibited the lowest disease incidence and spore concentration when artificially inoculated with Aspergillus flavus spores. These findings encourage the use of GGE-containing coatings in other lipid-rich matrices that are prone to oxidation or spoilage caused by phytopathogenic fungi.
Article
Chemistry, Medicinal
Aynaz Tajaddini, Neda Roshanravan, Majid Mobasseri, Zahraa Haleem Al-qaim, Amir Hadi, Aydin Aeinehchi, Pouria Sefid-Mooye Azar, Alireza Ostadrahimi
Summary: In this study, the effect of saffron supplementation on glycemic status, lipid profile, atherogenic indices, and oxidative status in patients with type-2 diabetes (T2DM) was investigated. The results showed that saffron intervention for eight weeks significantly reduced fasting blood sugar, improved lipid profile, decreased atherogenic indices and liver enzymes, and enhanced oxidative status. These findings suggest that saffron supplementation may alleviate T2DM by improving glycemic status, lipid profile, liver enzymes, and oxidative status.
PHYTOTHERAPY RESEARCH
(2023)
Article
Environmental Sciences
Dilek Cavusoglu
Summary: The study explored the dose-related effects of citrinin on various physiological, cytogenetic, biochemical, and anatomical parameters using Allium cepa L. bulbs as a test material. It was found that citrinin caused a decrease in physiological parameters, an increase in micronucleus and chromosome aberration frequency, a reduction in mitotic index, and a dose-dependent increase in catalase and superoxide dismutase activities, as well as malondialdehyde and proline contents. Additionally, anatomical changes such as flattened nucleus, cell wall thickening and cell deformation were observed, with the effects reaching their peak at a 10 mg/L dose of citrinin. The Allium test material proved to be a useful bioindicator for monitoring these inhibitory effects.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Endocrinology & Metabolism
Sanober Kafeel, Zehra Hashim, Asher Fawwad, Syeda Nuzhat Nawab
Summary: This study examined the role of GPX1, CAT, and SOD1 gene variants in the pathogenesis of cataract in diabetes patients. The results showed that GPX1 (rs1800668) variant may serve as an antioxidant biomarker for assessing the risk of cataract in type 2 diabetes mellitus, while CAT (rs1001179) variant may have a protective role against cataract development in diabetes.
ACTA DIABETOLOGICA
(2022)
Article
Biochemistry & Molecular Biology
Chandrasekar Palanichamy, Damodar Nayak Ammunje, Parasuraman Pavadai, Sureshbabu Ram Kumar Pandian, Panneerselvam Theivendren, Shanmugampillai Jeyarajaguru Kabilan, Ewa Babkiewicz, Piotr Maszczyk, Selvaraj Kunjiappan
Summary: This study demonstrates the significant effects of Mimosa pudica Linn. extract on the male sexual system of rats with diabetes, including scavenging excessive free radicals and alleviating the deleterious effects of diabetes. The extract improves body weight, reproductive organ weight, sperm characteristics, and testes histocellular arrangement in rats. Additionally, it increases hormone levels and antioxidant enzymes while reducing oxidative stress markers in both serum and testicular homogenates. In silico molecular docking also predicts high potential compounds in the extract that show binding affinities with the PDE5 receptor. Overall, ethanolic extract of M. pudica L. exhibits significant aphrodisiac performance in diabetic rats.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Azza A. A. Attia, Jehan M. M. Sorour, Neama A. A. Mohamed, Tagreed T. T. Mansour, Rasha A. A. Al-Eisa, Nahla S. S. El-Shenawy
Summary: This study aimed to investigate the protective role of vitamin E in improving cardiotoxicity induced by cyclophosphamide in rats. The results showed that vitamin E could attenuate the elevation of cardiac markers, increase in lipid profiles, reduction in antioxidant enzyme activities, and increase in lipid peroxidation. In addition, vitamin E was found to improve the histopathological alterations caused by cyclophosphamide.
Article
Nutrition & Dietetics
Alok K. Paul, Md K. Hossain, Tooba Mahboob, Veeranoot Nissapatorn, Polrat Wilairatana, Rownak Jahan, Khoshnur Jannat, Tohmina A. Bondhon, Anamul Hasan, Maria de Lourdes Pereira, Mohammed Rahmatullah
Summary: This article explains how SARS-CoV-2 causes more significant kidney damage in diabetic patients and discusses the shared inflammatory pathways of disease progression between COVID-19 and diabetes. The use of antioxidants can prevent renal damage-induced death and help protect individuals from COVID-19-related comorbidities.
Review
Biochemistry & Molecular Biology
Jinjoo Lee, Seungjin Noh, Suhyun Lim, Bonglee Kim
Summary: Type 2 diabetes mellitus is a major global public health issue, with plant extracts being a potential therapeutic agent due to their antidiabetic effects and fewer side effects. These extracts regulate blood glucose, possess anti-inflammatory and antioxidant properties, and can alleviate complications caused by insulin resistance through various pathways.
Review
Plant Sciences
Anna Ekner-Grzyb, Anna Duka, Tomasz Grzyb, Isabel Lopes, Jagna Chmielowska-Bak
Summary: Pollution of the environment with plastic is a significant concern in the modern world. Despite recycling methods, a substantial amount of plastic is still deposited in the environment. Nanoplastic, in particular, poses a serious danger as it can be effectively taken up and transported within organisms. It has been found to exert toxic effects on plants, mainly through oxidative response.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Environmental Sciences
Mohamed S. Othman, Azza M. Khaled, Amal H. Al-Bagawi, Mohamed A. Fareid, Reda A. Hameed, Fatama A. Abu Zahra, Ahmed E. Abdel Moneim
Summary: The study aims to identify the active components in Echinops spinosus plant from the Hail area of Saudi Arabia and investigate its anti-diabetic properties. The results showed that both ESTE and ESHFF demonstrated anti-diabetic properties by lowering glucose levels and alleviating diabetic complications in the kidneys and liver.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Megha Murali, T. Shivanandappa
Summary: Endosulfan exposure causes high levels of oxidative stress in the liver and brain, leading to reduced antioxidant enzyme activity and increased ROS and lipid peroxidation. The brain is more susceptible to oxidative stress than the liver, likely due to its lower antioxidant defenses and higher oxygen consumption.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Biochemistry & Molecular Biology
Iuliia Azarova, Alexey Polonikov, Elena Klyosova
Summary: Numerous studies have shown that oxidative stress plays a major role in the development and progression of type 2 diabetes (T2D). This review summarizes the current understanding of the role of abnormal redox homeostasis in the molecular mechanisms of T2D and discusses the genetic studies investigating the contribution of polymorphisms in genes encoding redox state-regulating enzymes to the disease pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Food Science & Technology
Krishnapura Srinivasan
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2017)
Article
Agriculture, Multidisciplinary
Gavirangappa Hithamani, Krishnapura Srinivasan
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2017)
Article
Biology
Gavirangappa Hithamani, Dhanya Kizhakayil, Krishnapura Srinivasan
JOURNAL OF BIOSCIENCES
(2017)
Article
Agriculture, Multidisciplinary
Shamarao Nagashree, Kottangada K. Archana, Pullabhatla Srinivas, Krishnapura Srinivasan, Halagur B. Sowbhagya
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2017)
Article
Biochemistry & Molecular Biology
Susmita Barman, Seetur R. Pradeep, Krishnapura Srinivasan
Article
Food Science & Technology
Gavirangappa Hithamani, Krishnapura Srinivasan
Article
Biochemistry & Molecular Biology
Susmita Barman, Krishnapura Srinivasan
BIOLOGICAL TRACE ELEMENT RESEARCH
(2019)
Article
Medicine, Research & Experimental
Seetur R. Pradeep, Krishnapura Srinivasan
BIOMEDICINE & PHARMACOTHERAPY
(2018)
Article
Biochemistry & Molecular Biology
Susmita Barman, Seetur R. Pradeep, Krishnapura Srinivasan
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Seetur R. Pradeep, Krishnapura Srinivasan
Article
Nutrition & Dietetics
Seetur R. Pradeep, Susmita Barman, Krishnapura Srinivasan
Article
Cardiac & Cardiovascular Systems
Seetur R. Pradeep, Krishnapura Srinivasan
CARDIOVASCULAR TOXICOLOGY
(2018)
Article
Medicine, Research & Experimental
Ravula Venkatesh, Krishnapura Srinivasan, Sridevi Annapurna Singh
BIOMEDICINE & PHARMACOTHERAPY
(2017)
Article
Nutrition & Dietetics
Seetur R. Pradeep, Krishnapura Srinivasan
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2017)
Article
Nutrition & Dietetics
Susmita Barman, Krishnapura Srinivasan
BRITISH JOURNAL OF NUTRITION
(2017)