Editorial Material
Plant Sciences
Mar Sobral, Luis Sampedro
Summary: Plant plastic responses to environmental variation at scales smaller than the individual plant size promote phenotypic and epigenetic diversity within genotypes, potentially influencing plant evolutionary dynamics.
TRENDS IN PLANT SCIENCE
(2022)
Review
Biology
Dragan Stajic, Lars E. T. Jansen
Summary: Heritable gene expression can facilitate adaptation by increasing survival in new environments and enlarging beneficial mutational targets. Additionally, epigenetic control of gene expression allows for stochastic switching between different phenotypes in populations, potentially facilitating adaptation in rapidly fluctuating environments.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Editorial Material
Biochemistry & Molecular Biology
Saifeng Cheng, Yoav Mayshar, Yonatan Stelzer
Summary: In this study, Takahashi and colleagues demonstrate that induced DNA methylation at specific genes can lead to stable transgenerational inheritance of epigenetic changes and associated phenotypes in mice.
Review
Geriatrics & Gerontology
Mark T. Mc Auley
Summary: In the last decade, epigenetics has become a central discipline in the field of biogerontology, as age-associated epigenetic changes are linked to various pathologies and epigenetic clocks can correlate biological age with chronological age. Recent empirical observations also suggest that inherited epigenetic effects could influence lifespan/longevity in different organisms. This review critically evaluates these effects from an evolutionary perspective, aiming to integrate the evidence with the main evolutionary theories of ageing.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Biology
Bernett Lee, Samantha Leeanne Cyrill, Wendy Lee, Rossella Melchiotti, Anand Kumar Andiappan, Michael Poidinger, Olaf Rotzschke
Summary: The NCO recombination rates show a strong correlation with the function of the region, with low rates in introns and quiescent intergenic regions and high rates in splice sites, exons, 5' and 3'-UTRs, as well as CpG islands. Epigenetic modifications such as 5hmC marks are associated with elevated NCO rates in functionally relevant regions, potentially allowing for environmental influence on gene loci.
Review
Ecology
Saul Huitzil, Cristian Huepe, Maximino Aldana, Alejandro Frank
Summary: This review explores the role of the microbiome in evolution, emphasizing its importance in addressing evolutionary phenomena and the missing heritability problem. The article advocates for recognizing the microbiome as a source of evolutionary innovation and analyzes the relevant evidence and implications.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2023)
Review
Biochemistry & Molecular Biology
Simeiyun Liu, Upasna Sharma
Summary: There is increasing evidence that the experiences and environment of ancestors can affect the phenotypes of future generations. The parental environment may regulate offspring phenotypes by influencing epigenetic marks in the gametes. This review examines the inheritance of paternal environmental effects and the role of small RNAs in this process. Recent advances in understanding the small RNA payload of sperm and how it is modulated by environmental conditions are discussed, as well as the potential mechanism of paternal environmental effects through small RNA-mediated regulation of early embryonic gene expression and its impact on offspring phenotypes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Corrado Spadafora
Summary: An increasing amount of data show that epigenetics plays key roles in evolutionary processes. This manuscript aims to gather experimental evidence supporting the involvement of epigenetic factors and networks during embryogenesis in inducing variation, which is crucial for evolution as a global process. This process occurs through the flow of RNA-based information carried by somatic cells exposed to environmental stimuli and delivered to oocytes by spermatozoa, as well as the permissive environments provided by zygotes and totipotent early embryos. These environments promote the emergence of evolutionarily significant phenotypic novelties driven by RNA information, making random genomic mutations and natural selection unnecessary.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Gonzalo Sabaris, Maximilian H. H. Fitz-James, Giacomo Cavalli
Summary: Increasing evidence suggests that environmental stress can trigger epigenetic signals that persist over long timeframes, leading to phenotypic changes and potential selection. Epigenetic inheritance plays a crucial role in rapid phenotypic adaptation to fluctuating environments, ensuring short-term survival while maintaining a bet-hedging strategy. These findings call for a reevaluation of the importance of nongenetic information in adaptive evolution and its broader relevance in nature.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Vanesa Izquierdo, Veronica Palomera-Avalos, Merce Pallas, Christian Grinan-Ferre
Summary: Maternal supplementation of resveratrol under a high-fat diet can prevent cognitive decline in adult offspring, reduce triglycerides and leptin plasma levels, modulate the pro-inflammatory profile, and restore the epigenetic landscape as well as synaptic plasticity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Ling Zeng, Mei Wang, Jinzhao Zhou, Xiaofei Wang, Yanwei Zhang, Ping Su
Summary: The interaction between gametic epigenetic marks and retrotransposons plays a crucial role in the transmission of parental acquired traits during early embryonic development.
Article
Multidisciplinary Sciences
Joanna L. Kelley, Michael Tobler, Daniel Beck, Ingrid Sadler-Riggleman, Corey R. Quackenbush, Lenin Arias Rodriguez, Michael K. Skinner
Summary: The study suggests that the adaptation of P. mexicana to sulfidic environments in southern Mexico may be partially promoted through stable, generational inheritance of epigenetic DNA methylation alterations that are independent of the environment. The epigenetic changes were related to sulfur toxicity and metabolic processes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemical Research Methods
Tomas Alarcon, Josep Sardanyes, Antoni Guillamon, Javier A. Menendez
Summary: Tumour cell heterogeneity poses a major obstacle for targeted anti-cancer therapies, with limited strategies available to mitigate its undesirable impact on clinical outcomes. A computational approach has been developed to design combinatorial therapies against chromatin modifiers, with promising results in circumventing therapeutic challenges posed by tumour heterogeneity. Combinatorial strategies involving modulators of histone H3K4 and H3K27 demethylases are predicted to be more effective in managing non-uniform responses of heterogeneous cancer cell populations.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Chun-Min Shan, Yimeng Fang, Songtao Jia
Summary: Post-translational modifications in histones are crucial for regulating chromatin structure and gene expression, and can be inherited as epigenetic memory. The fission yeast has been a valuable model organism for studying histone modifications in heterochromatin assembly and inheritance, highlighting the role of histone turnover in this process.
Review
Pharmacology & Pharmacy
Chenglong Cheng, Yajie Wu, Yurong Huang, Qiuyun Xue, Yuting Wang, Faxue Liao, Xiaomei Wang, Chenggui Miao
Summary: Osteoarthritis is a leading cause of disability and pain worldwide, and abnormal autophagy has been closely associated with this degenerative disease. Drugs targeting autophagy have shown significant potential in hindering the progression of osteoarthritis. The occurrence and development of autophagy in osteoarthritis are regulated by various factors, and it has greatly influenced the pathological mechanism of the disease. However, further research is needed to determine how autophagy affects the pathology of osteoarthritis and its application in treatment and diagnosis.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Siddharth Srivastava, Hartmut Engels, Ina Schanze, Kirsten Cremer, Thomas Wieland, Moritz Menzel, Max Schubach, Saskia Biskup, Martina Kreiss, Sabine Endele, Tim M. Strom, Dagmar Wieczorek, Martin Zenker, Siddharth Gupta, Julie Cohen, Alexander M. Zink, SakkuBai Naidu
EUROPEAN JOURNAL OF HUMAN GENETICS
(2016)
Article
Multidisciplinary Sciences
Simon Ammanuel, Wesley C. Chan, Daniel A. Adler, Balaji M. Lakshamanan, Siddharth S. Gupta, Joshua B. Ewen, Michael V. Johnston, Carole L. Marcus, Sakkubai Naidu, Shilpa D. Kadam
Article
Genetics & Heredity
Siddharth Srivastava, Heather E. Olson, Julie S. Cohen, Cynthia S. Gubbels, Sharyn Lincoln, Brigette Tippin Davis, Layla Shahmirzadi, Siddharth Gupta, Jonathan Picker, Timothy W. Yu, David T. Miller, Janet S. Soul, Andrea Poretti, SakkuBai Naidu
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2016)
Article
Clinical Neurology
Constance L. Smith-Hicks, Siddharth Gupta, Joshua B. Ewen, Manisha Hong, Lisa Kratz, Richard Kelley, Elaine Tierney, Rebecca Vaurio, Genila Bibat, Abanti Sanyal, Gayane Yenokyan, Nga Brereton, Michael V. Johnston, Sakkubai Naidu
Article
Clinical Neurology
Ali Torkamani, Kevin Bersell, Benjamin S. Jorge, Robert L. Bjork, Jennifer R. Friedman, Cinnamon S. Bloss, Julie Cohen, Siddharth Gupta, Sakkubai Naidu, Carlos G. Vanoye, Alfred L. George, Jennifer A. Kearney
ANNALS OF NEUROLOGY
(2014)
Review
Pharmacology & Pharmacy
Ram B. Singh, Siddharth Gupta, Parinita Dherange, Fabien De Meester, Agnieszka Wilczynska, Shaan E. Alam, Daniel Pella, Douglas W. Wilson
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2012)
Article
Genetics & Heredity
Siddharth Gupta, Maria Schwab, Karen Valdez-Gonzalez, Eric Segal
EUROPEAN JOURNAL OF MEDICAL GENETICS
(2020)
Article
Clinical Neurology
Ivo Bach, Pratibha Surathi, Nora Montealegre, Osama Abu-Hadid, Sara Rubenstein, Sviatoslav Redko, Siddharth Gupta, Machteld Hillen, Pratit Patel, Priyank Khandelwal, Adham Kamel
STROKE AND VASCULAR NEUROLOGY
(2020)
Editorial Material
Clinical Neurology
Siddharth Gupta, Shilpa D. Kadam
Summary: A study reveals that interictal epileptiform discharges (IEDs) observed between seizures in epilepsy patients have a fundamental spatiotemporal similarity with ictal discharges. The majority of IEDs propagate in a traveling wave manner along the path of seizure propagation, providing useful information for localizing the seizure focus.
Review
Pediatrics
Kyra Newmaster, Zahra Zhu, Elizabeth Bolt, Ryan J. Chang, Christopher Day, Asmaa Mhanna, Sita Paudel, Osman Farooq, Arun Swaminathan, Prakrati Acharya, Wisit Cheungpasitporn, Siddharth Gupta, Debopam Samanta, Naeem Mahfooz, Gayatra Mainali, Paul R. Carney, Sunil Naik
Summary: Ketogenic diets are effective for treating epilepsy but can have various complications. Common side effects can be managed with careful monitoring. Rare and serious complications may require advanced investigations and discontinuation of the diet.
Review
Pediatrics
Zahra Zhu, Elizabeth Bolt, Kyra Newmaster, Wendy Osei-Bonsu, Stacey Cohen, Vishnu Anand Cuddapah, Siddharth Gupta, Sita Paudel, Debopam Samanta, Louis T. Dang, Paul R. Carney, Sunil Naik
Summary: This study describes a child with a compound heterozygous variant in the SCN1B gene, and the clinical response to anti-seizure medications and the ketogenic diet. SCN1B pathogenic variants cause epilepsy and neurodevelopmental impairment with variable expressivity and incomplete penetrance.
Article
Radiology, Nuclear Medicine & Medical Imaging
Siddharth Gupta, Reena Razdan, Ranjanigandhi Hanumanthu, Luke Tomycz, Nasrin Ghesani, Jayoung Pak, Sridhar S. Kannurpatti
Summary: A new composite ratio parameter is found to be a more accurate predictor of epileptic seizure lateralization, independent of tissue classification variations. MRI predictions using the composite ratio showed higher accuracy compared to predictions using EEG alone. Additionally, combining clinical EEG findings and seizure semiology improved the predictive accuracy of MRI.
MAGNETIC RESONANCE IMAGING
(2022)
Article
Genetics & Heredity
Jane Crosson, Siddharth Srivastava, Genila M. Bibat, Siddharth Gupta, Aditi Kantipuly, Constance Smith-Hicks, Scott M. Myers, Abanti Sanyal, Gayane Yenokyan, Joel Brenner, Sakkubai R. Naidu
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2017)