Article
Clinical Neurology
Catherine Kulick-Soper, Russell T. Shinohara, Colin A. Ellis, Taneeta M. Ganguly, Ramya Raghupathi, Jay S. Pathmanathan, Erin C. Conrad
Summary: This study aimed to determine the effectiveness of pharmacologic paralysis and quantitative artifact reduction in improving the detection of epileptiform discharges. The results showed that paralysis significantly improved the detection rate, while artifact reduction was effective in cases with high EMG artifact but not with myoclonus artifact.
CLINICAL NEUROPHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Maged Kharouba, Dimple D. Patel, Rami H. Jaber, Sherif Hanafy Mahmoud
Summary: Metabolomics is the study of metabolites in biological matrices using high-throughput profiling. It has been traditionally used to identify biomarkers for disease diagnosis and pathophysiology. However, current evidence suggests limited utility due to inconsistencies and a lack of reproducible data. Future research should focus on addressing these gaps and reproducing data on the use of specific metabolite panels.
Article
Critical Care Medicine
Ryan L. DeSanti, Binod Balakrishnan, Tom B. Rice, Jose A. Pineda, Peter A. Ferrazzano
Summary: This study aimed to define the prevalence of neurologic diagnoses and evaluate the utilization of critical care resources among children in the PICU. The findings showed that a diagnosis of acute neurologic disease was associated with greater use of resources and was linked to a decline in functional status and an increase in mortality.
PEDIATRIC CRITICAL CARE MEDICINE
(2022)
Article
Critical Care Medicine
Rianne G. F. Dolmans, Faith C. Robertson, Marleen Eijkholt, Peter van Vliet, Marike L. D. Broekman
Summary: Traumatic brain injury (TBI) is a major cause of death and disability globally, and many TBI patients require intensive care unit (ICU) management. However, the palliative care approach is often underutilized in the ICU, especially for neurosurgical patients. This article highlights the importance of palliative care for TBI patients and the challenges associated with implementing it in the ICU, focusing on young adult patients and their family members.
NEUROCRITICAL CARE
(2023)
Article
Clinical Neurology
Anetta Lasek-Bal, Milena Dewerenda-Sikora, Lukasz Binek, Sebastian Student, Beata Labuz-Roszak, Ewa Krzystanek, Aleksandra Kaczmarczyk, Aleksandra Krzan, Amadeusz Zak, Aleksandra Cieslik, Magdalena Bosak
Summary: This study aimed to determine the prevalence and significance of EEG abnormalities in stroke patients. The results showed that about 40% of stroke patients had abnormal EEG, and these abnormalities were associated with neurological and functional status after stroke.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
G. Narula, M. Haeberlin, J. Balsiger, C. Strassle, L. L. Imbach, E. Keller
Summary: The study introduces a novel unsupervised learning algorithm for detecting bursts in EEG and generating burst estimates for monitoring sedation levels in the ICU. Results show competitive performance compared to neural networks learned through supervised learning, with a small mean absolute error in bursts per minute.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Tseun Han James Kong, Mohammad Abdul Azeem, Ayesha Naeem, Shawn Allen, Jennifer Ahjin Kim, Aaron F. Struck
Summary: This study found that Epileptiform Activity, suspected seizures, and particularly the 2HELPS2B/S score in the acute phase are risk factors for the development of epilepsy after nontraumatic intraparenchymal and subarachnoid hemorrhage.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Review
Critical Care Medicine
Sira M. Baumann, Natalie J. Kruse, Paulina S. C. Kliem, Simon A. Amacher, Sabina Hunziker, Tolga D. Dittrich, Fabienne Renetseder, Pascale Grzonka, Raoul Sutter
Summary: This review examines the challenges and obstacles in implementing and translating patients' advance directives (ADs) in intensive care units (ICUs). The study reveals variations in the prevalence of ADs across different regions and significant effects of ADs on intensive care provision, do-not-resuscitate orders, and treatment costs. However, insufficient knowledge, lack of awareness, communication issues, and ethical/legal concerns hinder the implementation of ADs.
JOURNAL OF INTENSIVE CARE
(2023)
Article
Pharmacology & Pharmacy
Micheal Strein, John P. Holton-Burke, Spiro Stilianoudakis, Carley Moses, Sulaiman Almohaish, Gretchen M. Brophy
Summary: The objective of this study was to determine the incidence of levetiracetam-associated BAEs in NCC patients. A retrospective cohort analysis of patient charts revealed that 46% of patients experienced BAEs, mostly hyperactive in nature. Therefore, monitoring and evaluation of patients experiencing BAEs is recommended.
Article
Clinical Neurology
Christian Sandoe Musaeus, Troels Wesenberg Kjaer, Melita Cacic Hribljan, Birgitte Bo Andersen, Peter Hogh, Preben Kidmose, Martin Fabricius, Martin Christian Hemmsen, Mike Lind Rank, Gunhild Waldemar, Kristian Steen Frederiksen
Summary: Patients with DLB have a higher occurrence of interictal epileptiform discharges (IED) compared to healthy controls. These findings suggest that IED may be a consequence of neurodegeneration in patients with DLB.
MOVEMENT DISORDERS
(2023)
Article
Pediatrics
Jennifer C. Erklauer, Ajay X. Thomas, Sue J. Hong, Brian L. Appavu, Jessica L. Carpenter, Nicolas R. Chiriboga-Salazar, Peter A. Ferrazzano, Zachary Goldstein, Jennifer L. Griffith, Kristin P. Guilliams, Matthew P. Kirschen, Karen Lidsky, Marlina E. Lovett, Brandon McLaughlin, Jennifer C. Munoz Pareja, Sarah Murphy, Wendy O'Donnell, James J. Riviello, Michelle E. Schober, Alexis A. Topjian, Mark S. Wainwright, Dennis W. Simon
Summary: Pediatric neurocritical care is a rapidly growing field, and during the COVID-19 pandemic, virtual education has provided creative solutions to the challenges faced by medical trainees in accessing educational opportunities involving direct patient care.
Article
Neurosciences
Alexandru Calin, Andrei S. Ilie, Colin J. Akerman
Summary: In this study, it was found that depolarization block in PV interneurons plays a significant role during the loss of inhibitory restraint, and that depolarization block in feedforward inhibitory synaptic mechanisms is a point of weakness.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Critical Care Medicine
Sira M. Baumann, Pia De Stefano, Paulina S. C. Kliem, Pascale Grzonka, Caroline E. Gebhard, Oana E. Sarbu, Gian Marco De Marchis, Sabina Hunziker, Stephan Ruegg, Andreas Kleinschmidt, Jerome Pugin, Herve Quintard, Stephan Marsch, Margitta Seeck, Raoul Sutter
Summary: This study aimed to investigate sex-related disparities in adult patients with status epilepticus (SE), focusing on treatment, disease course, and outcome. The study found sex-related differences in clinical features, treatment modalities, and outcome, with women being at a disadvantage. Therefore, sex-based factors should be considered when managing SE and forecasting outcomes.
Article
Critical Care Medicine
Andrea Loggini, Ali Mansour, Faten El Ammar, Christos Lazaridis, Christopher L. Kramer, Zachary Bulwa, Faddi Saleh Velez, Cedric McCoy, Fernando D. Goldenberg
Summary: The study focused on patients with spontaneous intracerebral hemorrhage admitted to the neurocritical care unit through the Emergency Department, aiming to identify clinical variables associated with prolonged length of stay. A decision tree model revealed that intubation status, neurosurgical intervention, and components of the ICH score were reliable predictors of prolonged length of stay.
NEUROCRITICAL CARE
(2021)
Article
Nutrition & Dietetics
Ruiqi Xiong, Hua Huang, Yongming Wu, Shengnan Wang, Dongmei Wang, Zhong Ji, Zhenzhou Lin, Nailiang Zang, Suyue Pan, Kaibin Huang
Summary: The study found that RFS is not uncommon in neurocritically ill patients and is more likely to occur in patients with higher nutritional risk and more severe conditions. RFS not only leads to longer NCU stay, higher mortality rates, and poorer functional outcomes, but is also identified as an independent risk factor for 6-month mortality in neurocritically ill patients.
CLINICAL NUTRITION
(2021)
Review
Clinical Neurology
Churl-Su Kwon, Ryan G. Wagner, Arturo Carpio, Nathalie Jette, Charles R. Newton, David J. Thurman
Summary: This article systematically reviews worldwide studies of the epilepsy treatment gap (ETG) and provides recommendations for an updated International League Against Epilepsy (ILAE) definition of ETG. The study found that the definitions and reported ETGs varied widely, highlighting the need for a standardized definition to compare levels of unmet epilepsy care across different countries and regions.
Review
Clinical Neurology
Churl-Su Kwon, Ann Jacoby, Amza Ali, Joan Austin, Gretchen L. Birbeck, Patricia Braga, J. Helen Cross, Hanneke de Boer, Tarun Dua, Paula T. Fernandes, Kirsten M. Fiest, Jonathan Goldstein, Sheryl Haut, Diane Lorenzetti, Janet Mifsud, Solomon Moshe, Karen L. Parko, Manjari Tripathi, Samuel Wiebe, Nathalie Jette
Summary: This study reviewed the evidence of stigma and attitudes toward persons living with epilepsy, and identified factors associated with enacted stigma. The study found that stigma frequency varied widely between regions, and factors such as low level of knowledge about epilepsy and lower socioeconomic status were associated with enacted stigma. Persons with epilepsy often internalized negative stereotypes, leading to felt stigma and increased risk of psychological difficulties and impaired quality of life. The study also highlighted the potential contribution of epilepsy terminology to stigma production. Negative attitudes toward those with epilepsy were common across different population groups, and better attitudes were generally observed in younger individuals or those with higher educational status.
Article
Clinical Neurology
Gabriela Tantillo, Hernan Nicolas Lemus, Nathalie Jette, Saadi Ghatan, Fedor Panov, Dina Bolden, Madeline C. Fields
Summary: Longstanding epilepsy can lead to modulation of cortical networks over time and unexpected seizure onset zones. Frontal lobe seizures, in particular, can have diverse semiologies and evolution patterns. This case demonstrates the complexity of broad seizure networks that develop over time, leading to remote seizure spread.
EPILEPTIC DISORDERS
(2022)
Article
Clinical Neurology
Emily M. Schorr, Daniel Kurz, Kyle C. Rossi, Margaret Zhang, Anusha K. Yeshokumar, Nathalie Jette, Mandip S. Dhamoon
Summary: The study found that patients with multiple sclerosis (MS) had a higher incidence of depression before hospital admission, as well as a higher risk of depression readmission after admission, especially when comorbid with psychiatric disease or substance abuse.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Clinical Neurology
Rory M. C. Abrams, David M. Simpson, Allison Navis, Nathalie Jette, Lan Zhou, Susan C. Shin
Summary: Small fiber neuropathy may be associated with symptoms following COVID-19, presenting as pain, paresthesia, and numbness in affected patients. Skin biopsy can confirm SFN, which may underlie the long-haul post-COVID-19 symptoms experienced by some individuals.
Article
Clinical Neurology
Benjamin R. Kummer, Parul Agarwal, Chloe Sweetnam, Jessica Robinson-Papp, Leah J. Blank, Ilana Katz Sand, Georges Naasan, Christina A. Palmese, Joohi Jimenez-Shahed, Jihan Grant, Shanna Patterson, Alison Navis, Laura K. Stein, Nathalie Jette
Summary: This study aimed to investigate the utilization of video teleneurology during the COVID-19 pandemic and found that certain sociodemographic characteristics were associated with the utilization rate, but not necessarily with loss to follow-up.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Aaron M. Spring, Daniel J. Pittman, Arsalan Rizwan, Yahya Aghakhani, Jeffrey Jirsch, Mary Connolly, Samuel Wiebe, Juan Pablo Appendino, Anita Datta, Trevor Steve, Neelan Pillay, Manouchehr Javidan, Morris Scantlebury, Chantelle Hrazdil, Colin Bruce Josephson, Cyrus Boelman, Donald Gross, Shaily Singh, Luis Bello-Espinosa, Linda Huh, Nathalie Jette, Paolo Federico
Summary: This study examines the impact of a Delphi-style intervention on the evaluation of high frequency oscillations (HFOs). The results show that the intervention significantly reduces the variability between evaluators, improves consistency, and increases generalizability. This has important implications for the standardization and implementation of HFO evaluations in clinical care.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Gabriela B. Tantillo, Nathalie Jette, Kapil Gururangan, Parul Agarwal, Lara Marcuse, Anuradha Singh, Jonathan Goldstein, Churl-Su Kwon, Mandip S. Dhamoon, Allison Navis, Girish N. Nadkarni, Alexander W. Charney, James J. Young, Leah J. Blank, Madeline Fields, Ji Yeoun Yoo
Summary: The study characterized continuous video electroencephalogram (VEEG) findings of hospitalized COVID-19 patients. Most patients had severe COVID-19 and acute cerebral injury, while seizures were uncommon. VEEG findings were nonspecific.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Clinical Neurology
Laura K. Stein, Naomi Mayman, Nathalie Jette, Stanley Tuhrim, Mandip S. Dhamoon
Summary: This study assessed the risk and determinants of new-onset depression in acute ischemic stroke (AIS) patients and examined the treatment patterns of post-stroke depression (PSD) with pharmacotherapy. The findings revealed a persistent increase in the cumulative risk of PSD within 1.5 years following AIS, and sertraline was the most commonly prescribed antidepressant for PSD patients.
Article
Clinical Neurology
Nafisa Husein, Timothe Langlois-Therien, Bastien Rioux, Colin B. B. Josephson, Nathalie Jette, Mark R. R. Keezer
Summary: This study investigated physician opinion and practice regarding the treatment of epilepsy in older adults aged 65 years or older. The findings showed heterogeneity in therapeutic decisions and misalignment with available clinical evidence among different physician groups, indicating the need for clinical guidelines dedicated to this population.
Article
Clinical Neurology
Dustin Kee, Nathalie Jette, Leah J. Blank, Benjamin R. Kummer, Madhu Mazumdar, Parul Agarwal
Summary: The objective of this study was to determine the proportions of uptake and factors associated with electronic health (eHealth) behaviors among adults with epilepsy. The findings showed that 65.87% of adults with epilepsy had at least one eHealth behavior in the prior year. Factors such as female sex, frequent computer usage, and internet usage were associated with eHealth behaviors.
Review
Psychology, Clinical
Yin Wu, Brooke Levis, Federico M. Daray, John P. A. Ioannidis, Scott B. Patten, Pim Cuijpers, Roy C. Ziegelstein, Simon Gilbody, Felix H. Fischer, Suiqiong Fan, Ying Sun, Chen He, Ankur Krishnan, Dipika Neupane, Parash Mani Bhandari, Zelalem Negeri, Kira E. Riehm, Danielle B. Rice, Marleine Azar, Xin Wei Yan, Mahrukh Imran, Matthew J. Chiovitti, Jill T. Boruff, Dean McMillan, Lorie A. Kloda, Sarah Markham, Melissa Henry, Zahinoor Ismail, Carmen G. Loiselle, Nicholas D. Mitchell, Samir Al-Adawi, Kevin R. Beck, Anna Beraldi, Charles N. Bernstein, Birgitte Boye, Natalie Buel-Drabe, Adomas Bunevicius, Ceyhun Can, Gregory Carter, Chih-Ken Chen, Gary Cheung, Kerrie Clover, Ronan M. Conroy, Gema Costa-Requena, Daniel Cukor, Eli Dabscheck, Jennifer De Souza, Marina Downing, Anthony Feinstein, Panagiotis P. Ferentinos, Alastair J. Flint, Pamela Gallagher, Milena Gandy, Luigi Grassi, Martin Haerter, Asuncion Hernando, Melinda L. Jackson, Josef Jenewein, Nathalie Jette, Miguel Juliao, Marie Kjaergaard, Sebastian Kohler, Hans-Helmut Konig, Lalit K. R. Krishna, Yu Lee, Margrit Loebner, Wim L. Loosman, Anthony W. Love, Bernd Loewe, Ulrik F. Malt, Ruth Ann Marrie, Loreto Massardo, Yutaka Matsuoka, Anja Mehnert, Ioannis Michopoulos, Laurent Misery, Christian J. Nelson, Chong Guan Ng, Meaghan L. O'Donnell, Suzanne J. O'Rourke, Ahmet Ozturk, Alexander Pabst, Julie A. Pasco, Jurate Peceliuniene, Luis Pintor, Jennie L. Ponsford, Federico Pulido, Terence J. Quinn, Silje E. Reme, Katrin Reuter, Steffi G. Riedel-Heller, Alasdair G. Rooney, Roberto Sanchez-Gonzalez, Rebecca M. Saracino, Melanie P. J. Schellekens, Martin Scherer, Marcelo L. Schwarzbold, Vesile Senturk Cankorur, Louise Sharpe, Michael Sharpe, Sebastien Simard, Susanne Singer, Lesley Stafford, Jon Stone, Natalie A. Strobe, Serge Sultan, Antonio L. Teixeira, Istvan Tiringer, Alyna Turner, Jane Walker, Mark Walterfang, Liang-Jen Wang, Siegfried B. Weyerer, Jennifer White, Birgitt Wiese, Lana J. Williams, Lai-Yi Wong, Andrea Benedetti, Brett D. Thombsi
Summary: This study compared the screening accuracy of HADS-D and HADS-T for major depression and found no significant difference in diagnostic accuracy between the two. The shorter HADS-D would be preferred in most clinical and research settings as it not only reduces patient burden but also has equivalent diagnostic accuracy to HADS-T.
PSYCHOLOGICAL ASSESSMENT
(2023)
Article
Neuroimaging
Laura K. Stein, Luke Maillie, John Erdman, Emma Loebel, Naomi Mayman, Akarsh Sharma, Sophia Wolmer, Stanley Tuhrim, Johanna T. Fifi, Nathalie Jette, J. Mocco, Mandip S. Dhamoon
Summary: This study examined regional variation in the treatment of acute ischemic stroke (AIS) and found significant differences in the utilization of revascularization therapy and stroke center certification among different regions.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Multidisciplinary Sciences
Lily McCarthy, Oleksandr Khegai, Jonathan Goldstein, Puneet Belani, Puneet Pawha, Shingo Kihira, Brian Mathew, Kapil Gururangan, Qing Hao, Anuradha Singh, Allison Navis, Bradley N. Delman, Nathalie Jette, Priti Balchandani
Summary: This retrospective observational study aims to evaluate the neuroimaging findings in hospitalized COVID-19 patients with neurological manifestations. The study found an association between COVID-19 and neurological manifestations, but no significant differences between patients with and without cancer.
Article
Medicine, Research & Experimental
Mark J. Kupersmith, Nathalie Jette
Summary: There are multiple reasons for the failure or limited applicability of clinical trials, including restrictive entry criteria, short duration studies, unrecognized adverse drug effects, and reporting bias. To improve the conduct and applicability of clinical trials, two approaches are suggested: utilizing animal models that more accurately simulate human disease to determine dosing and outcomes, and using big data to identify and manage known and potential risk factors and confounding issues.