Review
Pharmacology & Pharmacy
Waldemar Brola, Maciej Wilski
Summary: COVID-19 infection can lead to various neurological complications, including encephalopathy, meningitis, and stroke. Early symptoms often include olfactory and gustatory disorders, while severe neurological manifestations are relatively rare but increasing in number.
PHARMACOLOGICAL REPORTS
(2022)
Article
Immunology
Silvia Llorens, Eduardo Nava, Monica Munoz-Lopez, Alvaro Sanchez-Larsen, Tomas Segura
Summary: The COVID-19 pandemic caused by SARS-CoV-2 in 2020 has led to global outbreak, with patients experiencing respiratory, digestive, and neurological symptoms, including anosmia suggesting potential neurotropism. Research proposes an alternative pathway from gut infection involving Toll-like receptor 4 (TLR4), protease-activated receptor 2 (PAR2), and zonulin, and suggests investigation into the use of zonulin antagonists to mitigate neurological manifestations caused by SARS-CoV-19 infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Martina Patone, Lahiru Handunnetthi, Defne Saatci, Jiafeng Pan, Srinivasa Vittal Katikireddi, Saif Razvi, David Hunt, Xue W. Mei, Sharon Dixon, Francesco Zaccardi, Kamlesh Khunti, Peter Watkinson, Carol A. C. Coupland, James Doidge, David A. Harrison, Rommel Ravanan, Aziz Sheikh, Chris Robertson, Julia Hippisley-Cox
Summary: Emerging reports of rare neurological complications associated with COVID-19 infection and vaccinations are leading to concerns in regulatory, clinical, and public health sectors. A self-controlled case series study in England showed an increased risk of rare neurological complications following COVID-19 vaccination and infection. The study highlighted a higher risk of Guillain-Barre syndrome after ChAdOx1nCoV-19 vaccination.
Article
Neurosciences
Saikat Dewanjee, Jayalakshmi Vallamkondu, Rajkumar Singh Kalra, Nagaprasad Puvvada, Ramesh Kandimalla, P. Hemachandra Reddy
Summary: The COVID-19 pandemic caused by SARS-CoV-2 has led to a year-long phase of public health adversaries and compromised healthcare globally. Understanding of neurological complications in COVID-19 patients is still limited, and factors such as age, sex, comorbidity, and disease severity play a role in exacerbating neurological manifestations in these patients.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Clinical Neurology
Xiangliang Chen, Sarah Laurent, Oezguer A. Onur, Nina N. Kleineberg, Gereon R. Fink, Finja Schweitzer, Clemens Warnke
Summary: The study aims to examine the frequency of neurological symptoms and complications in COVID-19 patients through a systematic review of literature. The most commonly described neurological symptoms include headache, dizziness, taste and smell dysfunctions, and impaired consciousness. Cerebrovascular events, seizures, meningoencephalitis, and immune-mediated neurological diseases have been reported in smaller studies or single cases, but are not suitable for quantitative analysis.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Nara Miriam Michaelson, Ashwin Malhotra, Zehui Wang, Linda Heier, Kurenai Tanji, Scott Wolfe, Alka Gupta, Daniel MacGowan
Summary: This study investigates the peripheral neurologic complications in patients with COVID-19 and highlights the presence of nerve system damage in some patients. The study found that 14 out of 25 patients had peripheral neurological complications, while the other 11 patients did not have such complications. Peripheral neurological complications often exhibit multiple types concurrently.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Review
Immunology
Yoshitaka Kase, Hideyuki Okano
Summary: Since the outbreak of COVID-19 in 2020, research reports have shown that the virus causes not only respiratory disorders, but also various neural disorders. However, there has been relatively limited research and summaries on COVID-19-related neural disorders compared to other illnesses caused by the virus.
INFLAMMATION AND REGENERATION
(2021)
Review
Clinical Neurology
Biyan Nathanael Harapan, Hyeon Joo Yoo
Summary: The novel coronavirus SARS-CoV-2 causing COVID-19 has become a significant global challenge. In addition to respiratory symptoms, COVID-19 can also lead to neurological symptoms and complications. Further research is needed to understand the impact of neurological symptoms on the disease progression.
JOURNAL OF NEUROLOGY
(2021)
Article
Immunology
Shao Lin, Xinlei Deng, Ian Ryan, Kai Zhang, Wangjian Zhang, Ese Oghaghare, DeeDee Bennett Gayle, Benjamin Shaw
Summary: Age, gender, and race are associated with the risk of COVID-19 death among healthcare workers. Severe clinical indicators and specific symptoms can predict COVID-19-related deaths in healthcare workers.
EMERGING INFECTIOUS DISEASES
(2022)
Review
Cell Biology
Helena T. Hogberg, Ann Lam, Elan Ohayon, Muhammad Ali Shahbaz, Laure-Alix Clerbaux, Anna Bal-Price, Sandra Coecke, Rachel Concha, Francesca De Bernardi, Eizleayne Edrosa, Alan J. Hargreaves, Katja M. Kanninen, Amalia Munoz, Francesca Pistollato, Surat Saravanan, Natalia Garcia-Reyero, Clemens Wittwehr, Magdalini Sachana
Summary: This review organizes available knowledge on the neurobiological mechanisms of COVID-19, identifies four AOPs leading to neurological adverse outcomes, and discusses factors influencing the impact of COVID-19 on neurological AOPs. The use of the AOP framework helps visualize core pathways and shared mechanisms.
Article
Medicine, Research & Experimental
Pi -Ching Hsu, Md. Shahed-Al-Mahmud
Summary: The emergence of SARS-CoV-2 leads to COVID-19 by recognizing ACE2 and TMPRESS2 receptors, causing neurological complications in patients, particularly those with Parkinson's disease and Alzheimer's disease. Immune-mediated cytokines released during SARS-CoV-2 infection damage the central nervous system, resulting in a cytokine storm and CNS damage in COVID-19 patients.
Article
Neurosciences
Gretel Sanabria-Diaz, Manina Maja Etter, Lester Melie-Garcia, Johanna M. M. Lieb, Marios-Nikos Psychogios, Gregor Hutter, Cristina Granziera
Summary: This study assessed the cortical gray matter volume, thickness, and surface area in SARS-CoV-2 infected patients with neurological symptoms. The findings suggest that viral-triggered inflammation leads to neurotoxic damage in certain cortical areas during the acute phase of the infection.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Ettore Beghi, Raimund Helbok, Michael Crean, Sherry Hsiang-Yi Chou, Molly McNett, Elena Moro, Claudio Bassetti
Summary: The COVID-19 pandemic has led to neurological complications in up to one-third of cases, with varying prevalence, incidence, and characteristics. The ENERGY international registry was created to better understand the neurological manifestations and outcomes of COVID-19 infections.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Sofia Portela-Sanchez, Antonio Sanchez-Soblechero, Pedro Jose Melgarejo Otalora, Angela Rodriguez Lopez, Gabriel Velilla Alonso, Michael Armando Palacios-Mendoza, Carlos Catedra Carame, Laura Amaya Pascasio, Miguel Mas Serrano, Andreu Massot-Tarrus, Beatriz De La Casa-Fages, Fernando Diaz-Otero, Irene Catalina, Jose Manuel Garcia Dominguez, Javier Ricardo Perez-Sanchez, Jose Luis Munoz-Blanco, Francisco Grandas
Summary: This study described the spectrum of neurological complications in COVID-19 patients requiring a neurological assessment, with only 2.6% of hospitalized patients experiencing at least one complication. The most common diagnoses were neuromuscular disorders, cerebrovascular diseases, acute encephalopathy, and seizures. Mortality was higher in the cerebrovascular diseases group.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Review
Chemistry, Medicinal
Faezeh Almasi, Wen Dang, Fatemeh Mohammadipanah, Ning Li
Summary: In addition to respiratory symptoms, COVID-19 can also lead to various neurological disorders. Despite the growing research on the neurological aspects of COVID-19, the underlying mechanisms and therapeutic methods are still unclear. However, some natural compounds have shown neuroprotective effects and could be potential drugs for treating neurological complications of SARS-CoV-2.
ARCHIVES OF PHARMACAL RESEARCH
(2022)
Article
Clinical Neurology
Marc J. Casale, Lara Marcuse, James J. Young, Nathalie Jette, Fedor E. Panov, H. Allison Bender, Adam E. Saad, Ravi S. Ghotra, Saadi Ghatan, Anuradha Singh, Ji Yeoun Yoo, Madeline C. Fields
Summary: Scalp EEG is not sensitive for detecting focal aware and subclinical seizures, but highly sensitive for detecting focal impaired aware and focal to bilateral tonic-clonic seizures. Longer duration of seizure and seizures from patients without MRI lesions are more likely to be found on the scalp.
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Clinical Neurology
Aaron M. Spring, Daniel J. Pittman, Arsalan Rizwan, Yahya Aghakhani, Jeffrey Jirsch, Mary Connolly, Samuel Wiebe, Juan Pablo Appendino, Anita Datta, Trevor Steve, Neelan Pillay, Manouchehr Javidan, Morris Scantlebury, Chantelle Hrazdil, Colin Bruce Josephson, Cyrus Boelman, Donald Gross, Shaily Singh, Luis Bello-Espinosa, Linda Huh, Nathalie Jette, Paolo Federico
Summary: This study examines the impact of a Delphi-style intervention on the evaluation of high frequency oscillations (HFOs). The results show that the intervention significantly reduces the variability between evaluators, improves consistency, and increases generalizability. This has important implications for the standardization and implementation of HFO evaluations in clinical care.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Gabriela B. Tantillo, Nathalie Jette, Kapil Gururangan, Parul Agarwal, Lara Marcuse, Anuradha Singh, Jonathan Goldstein, Churl-Su Kwon, Mandip S. Dhamoon, Allison Navis, Girish N. Nadkarni, Alexander W. Charney, James J. Young, Leah J. Blank, Madeline Fields, Ji Yeoun Yoo
Summary: The study characterized continuous video electroencephalogram (VEEG) findings of hospitalized COVID-19 patients. Most patients had severe COVID-19 and acute cerebral injury, while seizures were uncommon. VEEG findings were nonspecific.
CLINICAL NEUROPHYSIOLOGY
(2022)
Review
Clinical Neurology
Lahoud Touma, Benedicte Dansereau, Alvin Y. Chan, Nathalie Jette, Churl-Su Kwon, Kees P. J. Braun, Daniel Friedman, Lara Jehi, John D. Rolston, Sumeet Vadera, Lily C. Wong-Kisiel, Dario J. Englot, Mark R. Keezer
Summary: Neurostimulation modalities are effective in treating drug-resistant epilepsy, with improving outcomes over time and few major complications.
Letter
Clinical Neurology
Rory M. C. Abrams, David M. Simpson, Allison Navis, Nathalie Jette, Lan Zhou, Susan C. Shin
Article
Clinical Neurology
Mackenzie T. Langan, Derek A. Smith, Gaurav Verma, Oleksandr Khegai, Sera Saju, Shams Rashid, Daniel Ranti, Matthew Markowitz, Puneet Belani, Nathalie Jette, Brian Mathew, Jonathan Goldstein, Claudia F. E. Kirsch, Laurel S. Morris, Jacqueline H. Becker, Bradley N. Delman, Priti Balchandani
Summary: COVID-19, in addition to being a respiratory disease, can affect the central nervous system and lead to neuroinflammatory processes. The study found that the count of perivascular spaces (PVS) could be a biomarker for neuroinflammation in COVID-19.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Lara Jehi, Nathalie Jette, Churl-Su Kwon, Colin B. Josephson, Jorge G. Burneo, Fernando Cendes, Michael R. Sperling, Sallie Baxendale, Robyn M. Busch, Chahnez Charfi Triki, J. Helen Cross, Dana Ekstein, Dario J. Englot, Guoming Luan, Andre Palmini, Loreto Rios, Xiongfei Wang, Karl Roessler, Bertil Rydenhag, Georgia Ramantani, Stephan Schuele, Jo M. Wilmshurst, Sarah Wilson, Samuel Wiebe
Summary: Epilepsy surgery is the preferred treatment for patients with drug-resistant seizures. Timely referral for surgical evaluation can be life-saving for suitable candidates, and also improve the care of non-surgical candidates. The International League Against Epilepsy (ILAE) conducted a Delphi consensus process with experts from 28 countries, resulting in three expert consensus recommendations: every drug-resistant epilepsy patient should be offered a surgical evaluation regardless of various factors, a surgical referral should be considered for older patients with drug-resistant epilepsy and patients seizure-free on 1-2 antiseizure medications (ASMs) but with a brain lesion, and surgery should not be offered to patients with active substance abuse who are noncooperative with management.
Article
Clinical Neurology
Laura K. Stein, Naomi Mayman, Nathalie Jette, Stanley Tuhrim, Mandip S. Dhamoon
Summary: This study assessed the risk and determinants of new-onset depression in acute ischemic stroke (AIS) patients and examined the treatment patterns of post-stroke depression (PSD) with pharmacotherapy. The findings revealed a persistent increase in the cumulative risk of PSD within 1.5 years following AIS, and sertraline was the most commonly prescribed antidepressant for PSD patients.
Article
Clinical Neurology
Nafisa Husein, Timothe Langlois-Therien, Bastien Rioux, Colin B. B. Josephson, Nathalie Jette, Mark R. R. Keezer
Summary: This study investigated physician opinion and practice regarding the treatment of epilepsy in older adults aged 65 years or older. The findings showed heterogeneity in therapeutic decisions and misalignment with available clinical evidence among different physician groups, indicating the need for clinical guidelines dedicated to this population.
Article
Clinical Neurology
Dustin Kee, Nathalie Jette, Leah J. Blank, Benjamin R. Kummer, Madhu Mazumdar, Parul Agarwal
Summary: The objective of this study was to determine the proportions of uptake and factors associated with electronic health (eHealth) behaviors among adults with epilepsy. The findings showed that 65.87% of adults with epilepsy had at least one eHealth behavior in the prior year. Factors such as female sex, frequent computer usage, and internet usage were associated with eHealth behaviors.
Review
Psychology, Clinical
Yin Wu, Brooke Levis, Federico M. Daray, John P. A. Ioannidis, Scott B. Patten, Pim Cuijpers, Roy C. Ziegelstein, Simon Gilbody, Felix H. Fischer, Suiqiong Fan, Ying Sun, Chen He, Ankur Krishnan, Dipika Neupane, Parash Mani Bhandari, Zelalem Negeri, Kira E. Riehm, Danielle B. Rice, Marleine Azar, Xin Wei Yan, Mahrukh Imran, Matthew J. Chiovitti, Jill T. Boruff, Dean McMillan, Lorie A. Kloda, Sarah Markham, Melissa Henry, Zahinoor Ismail, Carmen G. Loiselle, Nicholas D. Mitchell, Samir Al-Adawi, Kevin R. Beck, Anna Beraldi, Charles N. Bernstein, Birgitte Boye, Natalie Buel-Drabe, Adomas Bunevicius, Ceyhun Can, Gregory Carter, Chih-Ken Chen, Gary Cheung, Kerrie Clover, Ronan M. Conroy, Gema Costa-Requena, Daniel Cukor, Eli Dabscheck, Jennifer De Souza, Marina Downing, Anthony Feinstein, Panagiotis P. Ferentinos, Alastair J. Flint, Pamela Gallagher, Milena Gandy, Luigi Grassi, Martin Haerter, Asuncion Hernando, Melinda L. Jackson, Josef Jenewein, Nathalie Jette, Miguel Juliao, Marie Kjaergaard, Sebastian Kohler, Hans-Helmut Konig, Lalit K. R. Krishna, Yu Lee, Margrit Loebner, Wim L. Loosman, Anthony W. Love, Bernd Loewe, Ulrik F. Malt, Ruth Ann Marrie, Loreto Massardo, Yutaka Matsuoka, Anja Mehnert, Ioannis Michopoulos, Laurent Misery, Christian J. Nelson, Chong Guan Ng, Meaghan L. O'Donnell, Suzanne J. O'Rourke, Ahmet Ozturk, Alexander Pabst, Julie A. Pasco, Jurate Peceliuniene, Luis Pintor, Jennie L. Ponsford, Federico Pulido, Terence J. Quinn, Silje E. Reme, Katrin Reuter, Steffi G. Riedel-Heller, Alasdair G. Rooney, Roberto Sanchez-Gonzalez, Rebecca M. Saracino, Melanie P. J. Schellekens, Martin Scherer, Marcelo L. Schwarzbold, Vesile Senturk Cankorur, Louise Sharpe, Michael Sharpe, Sebastien Simard, Susanne Singer, Lesley Stafford, Jon Stone, Natalie A. Strobe, Serge Sultan, Antonio L. Teixeira, Istvan Tiringer, Alyna Turner, Jane Walker, Mark Walterfang, Liang-Jen Wang, Siegfried B. Weyerer, Jennifer White, Birgitt Wiese, Lana J. Williams, Lai-Yi Wong, Andrea Benedetti, Brett D. Thombsi
Summary: This study compared the screening accuracy of HADS-D and HADS-T for major depression and found no significant difference in diagnostic accuracy between the two. The shorter HADS-D would be preferred in most clinical and research settings as it not only reduces patient burden but also has equivalent diagnostic accuracy to HADS-T.
PSYCHOLOGICAL ASSESSMENT
(2023)
Article
Neuroimaging
Laura K. Stein, Luke Maillie, John Erdman, Emma Loebel, Naomi Mayman, Akarsh Sharma, Sophia Wolmer, Stanley Tuhrim, Johanna T. Fifi, Nathalie Jette, J. Mocco, Mandip S. Dhamoon
Summary: This study examined regional variation in the treatment of acute ischemic stroke (AIS) and found significant differences in the utilization of revascularization therapy and stroke center certification among different regions.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Multidisciplinary Sciences
Lily McCarthy, Oleksandr Khegai, Jonathan Goldstein, Puneet Belani, Puneet Pawha, Shingo Kihira, Brian Mathew, Kapil Gururangan, Qing Hao, Anuradha Singh, Allison Navis, Bradley N. Delman, Nathalie Jette, Priti Balchandani
Summary: This retrospective observational study aims to evaluate the neuroimaging findings in hospitalized COVID-19 patients with neurological manifestations. The study found an association between COVID-19 and neurological manifestations, but no significant differences between patients with and without cancer.
Article
Medicine, Research & Experimental
Mark J. Kupersmith, Nathalie Jette
Summary: There are multiple reasons for the failure or limited applicability of clinical trials, including restrictive entry criteria, short duration studies, unrecognized adverse drug effects, and reporting bias. To improve the conduct and applicability of clinical trials, two approaches are suggested: utilizing animal models that more accurately simulate human disease to determine dosing and outcomes, and using big data to identify and manage known and potential risk factors and confounding issues.
Meeting Abstract
Oncology
Rita Crooms, Jennie Taylor, Nathalie Jette, Rachelle Morgenstern, Parul Agarwal, Nathan Goldstein, Barbara Vickrey