Article
Biophysics
Bo Wang, Guanghua Lu, Kaihang Song, Aopan Chen, Hu Xing, Jiezhou Wu, Qi Sun, Gen Li, Ming Cai
Summary: In this study, dual bioactive agent-loaded electrospinning nanofibers were successfully prepared for the treatment of infectious wounds. The addition of zinc oxide nanoparticles and vascular endothelial growth factors to the fibers resulted in membranes with suitable physicochemical properties and promising biological activity, as demonstrated through in vitro and in vivo experiments.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Materials Science, Composites
Zhiyong Ma, Qifan Wang, Wenjia Xie, Wenjie Ye, Linna Zhong, Jile Huge, Ying Wang
Summary: In this study, a PCL/PLGA/HA scaffold with good pore structure was prepared by 3D printing method. The composite scaffold showed good mechanical and cell test performance, indicating potential applications in the field of bone tissue engineering.
POLYMER COMPOSITES
(2021)
Article
Chemistry, Multidisciplinary
Jin Zhang, Dongmei Tong, Honghai Song, Renjie Ruan, Yifu Sun, Yandai Lin, Jun Wang, Linxi Hou, Jiayong Dai, Jianxun Ding, Huanghao Yang
Summary: Engineering a biomimetically hierarchical scaffold can improve bone tissue regeneration by facilitating the balance of the immune system and bone metabolism. The scaffold exhibits strong immunomodulatory, intensive angiogenic, weak osteoclastogenic, and superior osteogenic abilities, providing a valuable foundation and inspiration for large-scale bone defect repair.
ADVANCED MATERIALS
(2022)
Article
Engineering, Biomedical
Yuankun Zhai, Kevin Schilling, Tao Wang, Mirna El Khatib, Sergei Vinogradov, Edward B. Brown, Xinping Zhang
Summary: This study demonstrates the importance of spatiotemporal vessel type distribution in bone tissue engineering, providing new insights for devising more effective vascularization strategies. The research highlights the interdependent role of osteogenesis and angiogenesis, and the differential vascular response and vessel type distribution in healing and non-healing defects.
Article
Pharmacology & Pharmacy
Hala Jarrar, Damla Cetin Altindal, Menemse Gumusderelioglu
Summary: The study revealed that combining low doses of BMP-2 with MEL in a dual release system significantly enhanced the osteogenic activity of MC3T3-E1 cells, leading to increased cell number, ECM density, expression of differentiation markers, and mineralization compared to other groups.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Parisa Ghandforoushan, Jalal Hanaee, Zahra Aghazadeh, Mohammad Samiei, Amir Mohammad Navali, Ali Khatibi, Soodabeh Davaran
Summary: A novel nanocomposite hydrogel scaffold composed of natural-based gelatin and synthetic-based triblock copolymer was developed and loaded with TGF-beta 1. The scaffold showed promising effects on promoting adhesion, viability, and chondrogenic differentiation of hDPSCs.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Cell Biology
Peiyi Qi, Yali Niu, Bin Wang
Summary: Bioactive nanofibres incorporating miR-181a/b-1 in PLGA scaffolds enhance osteogenic differentiation of AT-MSCs with improved biocompatibility and osteoinductive capacity, as shown by higher ALP activity and calcium measures.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Nanoscience & Nanotechnology
Matthew McGrath, Karolina Zimkowska, Katelyn J. Genoud, Jack Maughan, Javier Gutierrez Gonzalez, Shane Browne, Fergal J. O'Brien
Summary: A biomimetic, bilayered antimicrobial collagen-based scaffold was developed to deal with the etiology of diabetic foot ulcers (DFUs). The scaffold exhibited high structural stability, successfully inhibited the growth and infiltration of Staphylococcus aureus, and supported the proliferation of epidermal cells and vascularization. These results suggest that the bilayered scaffold is a promising candidate for enhancing diabetic wound healing.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Pharmacology & Pharmacy
Valeria Mastrullo, Daan R. van der Veen, Priyanka Gupta, Rolando S. Matos, Jonathan D. Johnston, John H. McVey, Paolo Madeddu, Eirini G. Velliou, Paola Campagnolo
Summary: Pericytes play a critical role in regulating circadian rhythms in endothelial cells and silencing this system disproportionately affects their pro-angiogenic function. Considering the effect of circadian rhythms is important for the development of mature vascular structures and to obtain the maximal reparative effect in tissue engineering and regenerative medicine.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Changsong Zhou, Shenghui Su, Jiwen Fan, Jiuzao Lin, Xiaoyong Wang
Summary: In this study, PLGA/Si3N4 composite nanofiber scaffolds were successfully prepared and showed promising potential for bone regeneration due to their enhanced mechanical strength and biological activity.
FRONTIERS IN MATERIALS
(2022)
Article
Engineering, Biomedical
Marianna Sofman, Alexander Brown, Linda G. Griffith, Paula T. Hammond
Summary: Three-dimensional micro-physiological in vitro models, such as embedding degradable hydrogel microbeads coated with induced pluripotent stem cell-derived endothelial cells, have the potential to drive angiogenesis and support vascularization of cell-dense tissues with high metabolic demand.
Article
Materials Science, Multidisciplinary
Gaorui Cai, Feiyan Zhu, Wei Liu, Tianfei Zhu, Li Duan, Hui Tan, Jing Pan, Jianyi Xiong, Daping Wang
Summary: In this study, mesoporous silica nanoparticles (MSNs) were introduced into poly(lactic-co-glycolic acid) (PLGA) to prepare a novel three-dimensional porous scaffold by low-temperature deposition manufacturing (LDM). The scaffolds exhibited 3D geometry and desirable big pore structures, while maintaining the bioactivity of the biomaterials. This research demonstrated that the 3D-printed PLGA/MSNs scaffolds have promising potential in cartilage tissue engineering, with enhanced cell proliferation and mechanical properties compared to PLGA scaffolds.
MATERIALS TODAY COMMUNICATIONS
(2021)
Review
Biotechnology & Applied Microbiology
Arezoo Saberi, Maryam Kouhjani, Marzieh Mohammadi, Leticia Hosta-Rigau
Summary: Currently, using bone-mimicking scaffolds to promote osteogenesis and angiogenesis is an effective method to overcome the challenge of treating critical size bone defects. Incorporating bioactive agents like growth factors, genes, and small molecules into these scaffolds has emerged as a promising strategy. Researchers have developed scaffolds incorporating nanoparticles and conducted related studies to maximize the synergistic effects of osteogenesis and angiogenesis.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Medicine, General & Internal
Ping Wu, Lin Shen, Hui-Fan Liu, Xiang-Hui Zou, Juan Zhao, Yu Huang, Yu-Fan Zhu, Zhao-Yu Li, Chao Xu, Li-Hua Luo, Zhi-Qiang Luo, Min-Hao Wu, Lin Cai, Xiao-Kun Li, Zhou-Guang Wang
Summary: In this study, a porous piezoelectric hydrogel bone scaffold was developed by incorporating PDA-modified ceramic hydroxyapatite and PDA-modified barium titanate nanoparticles into a chitosan/gelatin matrix. The resulting hydrogels exhibited cytocompatibility, immunomodulatory, angiogenic, and osteogenic capabilities. In vivo evaluations showed that these hydrogels significantly facilitated new bone formation in a rat cranial injury model, suggesting their potential application in bone tissue engineering.
MILITARY MEDICAL RESEARCH
(2023)
Article
Polymer Science
Arely M. Gonzalez-Gonzalez, Raymundo Cruz, Raul Rosales-Ibanez, Fernando Hernandez-Sanchez, Hugo J. Carrillo-Escalante, Jesus Jiovanni Rodriguez-Martinez, Cristina Velasquillo, Daniel Talamas-Lara, Juan E. Ludert
Summary: Articular cartilage is a specialized tissue that has limited regenerative capacity. Tissue engineering using Dental Follicle Mesenchymal Stem Cells (DFMSCs) and polymer blends like PCL and PLGA has shown promise in repairing and regenerating articular cartilage. The physicochemical properties of the polymer blends were evaluated, DFMSCs demonstrated stemness, and the scaffold showed biocompatibility. The PCL/PLGA scaffold demonstrated better repair capacity than commercial compounds in a chondral defect rat model.
Article
Veterinary Sciences
M. C. Nolff, A. Layer, A. Meyer-Lindenberg
AUSTRALIAN VETERINARY JOURNAL
(2015)
Article
Veterinary Sciences
B. Ullmann, N. Seehaus, S. Hungerbuehler, A. Meyer-Lindenberg
JOURNAL OF SMALL ANIMAL PRACTICE
(2016)
Article
Veterinary Sciences
B. Berger, J. Knebel, S. Steigmeier-Raith, S. Reese, A. Meyer-Lindenberg
TIERAERZTLICHE PRAXIS AUSGABE KLEINTIERE HEIMTIERE
(2015)
Article
Veterinary Sciences
Mirja Christine Nolff, Michael Fehr, Sven Reese, Andrea E. Meyer-Lindenberg
JOURNAL OF FELINE MEDICINE AND SURGERY
(2017)
Article
Veterinary Sciences
M. C. Nolff, S. Reese, M. Fehr, R. Dening, A. Meyer-Lindenberg
JOURNAL OF SMALL ANIMAL PRACTICE
(2016)
Article
Veterinary Sciences
M. C. Nolff, A. Meyer-Lindenberg
TIERAERZTLICHE PRAXIS AUSGABE KLEINTIERE HEIMTIERE
(2016)
Article
Veterinary Sciences
M. C. Nolff, A. Meyer-Lindenberg
JOURNAL OF SMALL ANIMAL PRACTICE
(2015)
Article
Veterinary Sciences
M. C. Nolff, M. Fehr, A. Bolling, R. Dening, S. Kramer, S. Reese, A. Meyer-Lindenberg
VETERINARY AND COMPARATIVE ORTHOPAEDICS AND TRAUMATOLOGY
(2015)
Article
Veterinary Sciences
Lena von Spiessen, Julia Karck, Karl Rohn, Andrea Meyer-Lindenberg
VETERINARY OPHTHALMOLOGY
(2015)
Article
Engineering, Biomedical
Ann-Kathrin Gartzke, Stefan Julmi, Christian Klose, Silke Besdo, Anja-Christina Waselau, Andrea Meyer-Lindenberg, Hans Juergen Maier, Peter Wriggers
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2020)
Article
Anatomy & Morphology
Klara Theresia Besuden, Andrea Meyer-Lindenberg, Andreas Bruehschwein
Summary: This study utilized helical CT images to describe the normal anatomy of canine hindlimb veins, retrospectively reviewing 30 dogs that underwent CT venography with a 64-slice helical CT scanner and generating three-dimensional images.
ANATOMIA HISTOLOGIA EMBRYOLOGIA
(2022)
Article
Agriculture, Dairy & Animal Science
Florian Boehmer, Katharina Erber, Anja Ewringmann, Ruth Klein, Sven Reese, Christine Boehmer, Andrea Meyer-Lindenberg, Beate Walter
Summary: This study aimed to investigate the value of serum AMH concentrations in distinguishing spayed from intact female rabbits and its relationship with pseudopregnancy and ovarian follicle numbers. The results showed that a single determination of serum AMH concentrations was adequate to differentiate spayed from intact female rabbits, and the follicular or luteal phase did not significantly influence the measured serum AMH concentrations.
REPRODUCTION IN DOMESTIC ANIMALS
(2022)
Article
Materials Science, Multidisciplinary
N. Kleer, S. Julmi, A. -K. Gartzke, J. Augustin, F. Feichtner, A. -C. Waselau, C. Klose, H. J. Maier, P. Wriggers, A. Meyer-Lindenberg
Article
Veterinary Sciences
Bjoern Berger, Andreas Bruehschwein, Lina Eddicks, Andrea Meyer-Lindenberg
CANADIAN VETERINARY JOURNAL-REVUE VETERINAIRE CANADIENNE
(2016)