Article
Nanoscience & Nanotechnology
Seong Uk Son, Eun-Kyung Lim, Soojin Jang, Jaewoo Lim, Seung Beom Seo, Taejoon Kang, Juyeon Jung, Seo Yeong Oh, Sun-Woo Yoon, Dongeun Yong, Jaejong Lee
Summary: The study developed a conductive thread-based immunosensor to easily detect airborne viruses, which is important in preventing the spread of infectious diseases.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Immunology
Min Gu, Kaibiao Chen, Zhichuang Ge, Jun Jiao, Tianyu Cai, Suhan Liu, Xiaoquan Wang, Xinan Jiao, Daxin Peng, Xiufan Liu
Summary: This study investigated the genetic and biologic characteristics of two Eurasian avian-like H1N1 swine influenza viruses from pigs in China. One swine isolate showed high similarity to contemporary human Eurasian avian-like H1N1 isolates, had a preference for binding to human-type receptors, and demonstrated vigorous replication in mice without the need for adaptation.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Microbiology
Suhrobjon Mullo Mirzo, Anand Kumar, Naresh Kumar Sharma, Lin Li, Robert Balshaw, Francis A. Plummer, Ma Luo, Binhua Liang
Summary: Genetic variations in the NF kappa B1 gene could influence clinical outcomes of pandemic H1N1 infections.
Article
Virology
Oksana Zolotarova, Anna Fesenko, Olga Holubka, Larysa Radchenko, Eric Bortz, Iryna Budzanivska, Alla Mironenko
Summary: The 2015/16 influenza epidemic season in Ukraine was characterized by a severe outbreak caused by the A(H1N1)pdm09 viruses, leading to a high incidence of acute respiratory infections and a significant number of fatalities. Genetic analysis revealed a diverse spectrum of mutations in the viral genomes, affecting antigenicity, virulence, and immune evasion mechanisms. The circulation of multiple lineages of A(H1N1)pdm09 viruses in Ukraine, a country with low vaccination coverage, posed challenges for public health measures against influenza.
Article
Immunology
Siran Lin, YuBing Peng, Yuzhen Xu, Wei Zhang, Jing Wu, Wenhong Zhang, Lingyun Shao, Yan Gao
Summary: In this study, a risk score model was built to identify patients at risk of developing severe H1N1 disease based on the analysis of PBMC samples.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Virology
Min Dou, Wenjun Song, Yongping Lin, Qigao Chen, Chang Lu, Zhongmin Liu
Summary: The study analyzed clinical characteristics and viral genes in patients with severe pneumonia due to H1N1 influenza virus in Guangzhou in 2019. Risk factors for severe disease were identified as chronic lung disease and cardiovascular disease, with a significant rate of secondary infections in critically ill patients. Furthermore, serum IL-8 levels were significantly higher in critically ill patients compared to nonsevere patients and healthy controls.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Immunology
Jose Alberto Choreno-Parra, Luis Armando Jimenez-Alvarez, Gustavo Ramirez-Martinez, Montserrat Sandoval-Vega, Citlaltepetl Salinas-Lara, Carlos Sanchez-Garibay, Cesar Luna-Rivero, Erika Mariana Hernandez-Montiel, Luis Alejandro Fernandez-Lopez, Maria Fernanda Cabrera-Cornejo, Eduardo Misael Choreno-Parra, Alfredo Cruz-Lagunas, Andrea Dominguez, Eduardo Marquez-Garcia, Carlos Cabello-Gutierrez, Francina Valezka Bolanos-Morales, Lourdes Mena-Hernandez, Diego Delgado-Zaldivar, Daniel Rebolledo-Garcia, Parmenides Guadarrama-Ortiz, Nora E. Regino-Zamarripa, Criselda Mendoza-Milla, Ethel A. Garcia-Latorre, Tatiana Sofia Rodiguez-Reyna, Diana Cervantes-Rosete, Carmen M. Hernandez-Cardenas, Shabaana A. Khader, Albert Zlotnik, Joaquin Zuniga
Summary: The study found that serum levels of CXCL17 were increased only in patients with pandemic influenza A(H1N1), and its expression in lung tissue had specific patterns, while no similar observations were made in COVID-19 and TB patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Vaclav Brazda, Otilia Porubiakova, Alessio Cantara, Natalia Bohalova, Jan Coufal, Martin Bartas, Miroslav Fojta, Jean-Louis Mergny
Summary: The study identified multiple potential G-quadruplex forming sequences in the G4-EA-H1N1 genomes, which could serve as potential therapeutic targets.
Article
Immunology
Jose Alberto Choreno-Parra, Luis Armando Jimenez-Alvarez, Gustavo Ramirez-Martinez, Alfredo Cruz-Lagunas, Mahima Thapa, Luis Alejandro Fernandez-Lopez, Martha Carnalla-Cortes, Eduardo M. Choreno-Parra, Lourdes Mena-Hernandez, Montserrat Sandoval-Vega, Erika Mariana Hernandez-Montiel, Diana Lizzeth Hernandez-Garcia, Jazmin Ariadna Ramirez-Noyola, Cynthia Estefania Reyes-Lopez, Andrea Dominguez-Faure, Guillermo Yamil Zamudio-Lopez, Eduardo Marquez-Garcia, Angelica Moncada-Morales, Criselda Mendoza-Milla, Diana Cervantes-Rosete, Marcela Munoz-Torrico, Cesar Luna-Rivero, Ethel A. Garcia-Latorre, Parmenides Guadarrama-Ortiz, Federico Avila-Moreno, Guillermo Dominguez-Cherit, Tatiana Sofia Rodriguez-Reyna, Philip A. Mudd, Carmen Margarita Hernandez-Cardenas, Shabaana A. Khader, Joaquin Zuniga
Summary: Surfactant protein D (SP-D) may help differentiate severe pandemic influenza from COVID-19, with high serum SP-D levels possibly associated with death and renal failure in severe pandemic influenza cases. However, SP-D levels do not distinguish seasonal influenza from COVID-19 in mild-to-moderate disease.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Tingting Li, Junyu Chen, Qingbing Zheng, Wenhui Xue, Limin Zhang, Rui Rong, Sibo Zhang, Qian Wang, Minqing Hong, Yuyun Zhang, Lingyan Cui, Maozhou He, Zhen Lu, Zhenyong Zhang, Xin Chi, Jinjin Li, Yang Huang, Hong Wang, Jixian Tang, Dong Ying, Lizhi Zhou, Yingbin Wang, Hai Yu, Jun Zhang, Ying Gu, Yixin Chen, Shaowei Li, Ningshao Xia
Summary: Influenza A viruses are a significant global threat, and this study has identified a chimeric monoclonal antibody, C12H5, that offers broad neutralization against H1N1 and H5N1 viruses. The antibody targets a specific epitope on the surface glycoprotein of the virus, leading to control of virus entry and egress. This discovery could have implications for the development of antiviral drugs and broad-protection vaccines against influenza.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Xiao Huang, Feng Lu, Huanhuan Tian, Haoran Hu, Fangyu Ning, Quanmei Shang, Dong Hao, Weiwei Zhu, Guiqing Kong, Xiaohong Ma, Jiali Feng, Tao Wang, Xiaozhi Wang
Summary: Plasma levels of syndecan-1 and hyaluronan are positively correlated with disease severity in patients with influenza A (H1N1). Elevated syndecan-1 levels may have a potential role in systemic organ dysfunction and could serve as an indicator of disease severity and mortality in these patients.
SCIENTIFIC REPORTS
(2022)
Review
Critical Care Medicine
Lida P. Hariri, Crystal M. North, Angela R. Shih, Rebecca A. Israel, Jason H. Maley, Julian A. Villalba, Vladimir Vinarsky, Jonah Rubin, Daniel A. Okin, Alyssa Sclafani, Jehan W. Alladina, Jason W. Griffith, Michael A. Gillette, Yuval Raz, Christopher J. Richards, Alexandra K. Wong, Amy Ly, Yin P. Hung, Raghu R. Chivukula, Camille R. Petri, Tiara F. Calhoun, Laura N. Brenner, Kathryn A. Hibbert, Benjamin D. Medoff, C. Corey Hardin, James R. Stone, Mari Mino-Kenudson
Summary: The histopathologic pattern of COVID-19, H1N1 influenza, and SARS patients predominantly involves acute-phase diffuse alveolar damage (DAD), with more frequent pulmonary microthrombi observed in COVID-19 and SARS patients compared to H1N1 influenza. Further research is needed to validate these findings and explore their clinical implications.
Article
Virology
Denisa Bojkova, Marco Bechtel, Tamara Rothenburger, Joshua D. D. Kandler, Lauren Hayes, Ruth Olmer, Ulrich Martin, Danny Jonigk, Sandra Ciesek, Mark N. N. Wass, Martin Michaelis, Jindrich Cinatl Jr
Summary: Recent findings show that SARS-CoV-2 Omicron BA.1 induces a stronger interferon response compared to Delta. In this study, it was demonstrated that BA.1 and BA.5, but not Delta, induce an antiviral state in air-liquid interface cultures of primary human bronchial epithelial cells and primary human monocytes. Both Omicron subvariants trigger the production of biologically active interferons and protect cells from super-infection with influenza A viruses. These findings highlight the significance of Omicron in the immune response against viral infections.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Editorial Material
Multidisciplinary Sciences
Mireille Farjo, Christopher B. Brooke
Summary: Influenza viruses infecting the same host can hinder each other's replication, leading to spatial structuring of infected cells in tissue and impacting viral evolution.
Article
Immunology
Irina Nudelman, Daniil Kudrin, German Nudelman, Raamesh Deshpande, Boris M. M. Hartmann, Steven H. Kleinstein, Chad L. L. Myers, Stuart C. C. Sealfon, Elena Zaslavsky
Summary: The study examined the activation of functional modules in host cells by influenza viruses of varying pathogenicity, revealing a common core response to infection that is temporally shifted for different viruses. Differentially regulated functional modules highlighted unique elements of host responses to different virus strains, providing mechanistic insight into the differences in host response to influenza strains.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Jean-Louis Vincent, Jacques Creteur
Summary: With increasing life expectancy, more elderly patients are being admitted to ICU, representing a unique subgroup with changes in organ function, reduced daily living activities, decreased mobility, and cognitive decline. Ethical decisions regarding intensive care, life-sustaining interventions, life support withdrawal/withholding, and terminal sedation are more common in elderly patients, and should be personalized to consider individual beliefs and wishes.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Fabio Silvio Taccone, Fuhong Su, Xinrong He, Lorenzo Peluso, Katia Donadello, Sabino Scolletta, Daniel De Backer, Jean-Louis Vincent
Summary: The effects of correcting hypotension with vasopressors in septic shock may improve cerebral oxygenation but do not reverse the alterations in brain microcirculation or cerebral metabolism.
Review
Critical Care Medicine
Daniel De Backer, Nadia Aissaoui, Maurizio Cecconi, Michelle S. Chew, Andre Denault, Ludhmila Hajjar, Glenn Hernandez, Antonio Messina, Sheila Nainan Myatra, Marlies Ostermann, Michael R. Pinsky, Jean-Louis Teboul, Philippe Vignon, Jean-Louis Vincent, Xavier Monnet
Summary: In critically ill patients, evaluating the risks and benefits of fluid infusion is essential for individualized fluid management. Monitoring techniques such as central venous pressure, pulmonary artery catheter, transpulmonary thermodilution, echocardiography, and lung ultrasound help assess volume status, assess the risk of fluid overload, and determine fluid responsiveness. Using specific triggers and critical endpoints, fluid resuscitation should be performed cautiously and the effects should be carefully evaluated.
INTENSIVE CARE MEDICINE
(2022)
Letter
Critical Care Medicine
Daniel De Backer, Xavier Monnet
INTENSIVE CARE MEDICINE
(2022)
Article
Neurosciences
Katia Donadello, Fuhong Su, Filippo Annoni, Sabino Scolletta, Xinrong He, Lorenzo Peluso, Leonardo Gottin, Enrico Polati, Jacques Creteur, Olivier De Witte, Jean-Louis Vincent, Daniel De Backer, Fabio Silvio Taccone
Summary: This study investigated the effects of cooling on cerebral microcirculation, oxygenation and metabolism in a healthy swine model. The results showed that during the cooling phase, cerebral functional capillary density and proportion of small-perfused vessels decreased, while oxygenation increased and metabolism decreased. After rewarming, all variables returned to normal values, except for an increased metabolism in the two groups subjected to hypothermia during the rewarming phase compared to the normothermia group.
Article
Critical Care Medicine
Gustavo A. Ospina-Tascon, Jose L. Aldana, Alberto Garcia F. Marin, Luis E. Calderon-Tapia, Angela Marulanda, Elena P. Escobar, Gustavo Garcia-Gallardo, Nicolas Orozco, Maria I. Velasco, Edwin Rios, Daniel De Backer, Glenn Hernandez, Jan Bakker
Summary: In endotoxic shock, immediate start of norepinephrine significantly improved regional splanchnic and intestinal microcirculatory flows when compared with mandatory fixed-dose fluid loading preceding norepinephrine. Immediate norepinephrine strategy was related with less resuscitation fluids and lower vasopressor doses at the end of the experiment.
CRITICAL CARE MEDICINE
(2023)
Review
Critical Care Medicine
Daniel De Backer, Gustavo A. Ospina-Tascon
Summary: This review discusses various techniques used to assess tissue oxygenation in critically ill patients. Historically, analysis of oxygen consumption/oxygen delivery relationships has provided valuable information, but it is limited for bedside use due to methodological constraints. Surrogates of tissue oxygenation, such as lactate levels and venous oxygen saturation, are commonly used, but they have limitations in certain conditions. Recent studies have shown promise in using measurements of Pv-aCO2 and Pv-aCO2/CavO2 ratio as physiologically sound and responsive indicators of tissue perfusion and dysoxia.
CURRENT OPINION IN CRITICAL CARE
(2023)
Article
Critical Care Medicine
Raphael Romano Bruno, Jakob Wollborn, Karl Fengler, Moritz Flick, Christian Jung, Sebastian Allgaeuer, Holger Thiele, Mara Schemmelmann, Johanna Hornemann, Helene Mathilde Emilie Moecke, Filiz Demirtas, Lina Palici, Marcus Franz, Bernd Saugel, Eduardo Kattan, Daniel De Backer, Jan Bakker, Glenn Hernandez, Malte Kelm, Christian Jung
Summary: This study aimed to determine whether considering sublingual microcirculatory perfusion variables improves the 30-day mortality in shock patients in the ICU. Results showed that although more patients in the intervention group had adjustments in medication or fluids within the next hour, there was no significant difference in microcirculatory values 24 hours later and 30-day mortality. Thus, integrating sublingual microcirculatory perfusion variables in the therapy plan did not improve patient survival.
INTENSIVE CARE MEDICINE
(2023)
Article
Critical Care Medicine
Giacomo Grasselli, Carolyn S. Calfee, Luigi Camporota, Daniele Poole, Marcelo B. P. Amato, Massimo Antonelli, Yaseen M. Arabi, Francesca Baroncelli, Jeremy R. Beitler, Giacomo Bellani, Geoff Bellingan, Bronagh Blackwood, Lieuwe D. J. Bos, Laurent Brochard, Daniel Brodie, Karen E. A. Burns, Alain Combes, Sonia D'Arrigo, Daniel De Backer, Alexandre Demoule, Sharon Einav, Eddy Fan, Niall D. Ferguson, Jean-Pierre Frat, Luciano Gattinoni, Claude Guerin, Margaret S. Herridge, Carol Hodgson, Catherine L. Hough, Samir Jaber, Nicole P. Juffermans, Christian Karagiannidis, Jozef Kesecioglu, Arthur Kwizera, John G. Laffey, Jordi Mancebo, Michael A. Matthay, Daniel F. McAuley, Alain Mercat, Nuala J. Meyer, Marc Moss, Laveena Munshi, Sheila N. Myatra, Michelle Ng Gong, Laurent Papazian, Bhakti K. Patel, Mariangela Pellegrini, Anders Perner, Antonio Pesenti, Lise Piquilloud, Haibo Qiu, Marco Ranieri, Elisabeth Riviello, Arthur S. Slutsky, Renee D. Stapleton, Charlotte Summers, Taylor B. Thompson, Carmen Valente Barbas, Jesus Villar, Lorraine B. Ware, Bjoern Weiss, Fernando G. Zampieri, Elie Azoulay, Maurizio Cecconi
Summary: The aim of these guidelines is to update the 2017 clinical practice guideline (CPG) of the European Society of Intensive Care Medicine (ESICM). The scope of this CPG is limited to adult patients and to non-pharmacological respiratory support strategies across different aspects of acute respiratory distress syndrome (ARDS), including ARDS due to coronavirus disease 2019 (COVID-19). These guidelines were formulated by an international panel of clinical experts, one methodologist and patients' representatives on behalf of the ESICM.
INTENSIVE CARE MEDICINE
(2023)
Article
Medicine, General & Internal
Ludhmila Abrahao Hajjar, Marco B. Ancona, Roberto Kalil Filho, Moreno Tresoldi, Jose Guilherme Caldas, Giacomo Monti, Francisco Cesar Carnevale, Francesco De Cobelli, Andre Moreira de Assis, Fabio Ciceri, Giovanni Landoni, Jouke Dijkstra, Francesco Moroni, Alexandre Antonio Cunha Abizaid, Fernanda Willemann Ungaretti, Maria Jose Carvalho Carmona, Daniel De Backer, Carlos Eduardo Pompilio, Fabio S. de Britto Jr, Carlos M. Campos, Alberto Zangrillo, Matteo Montorfano
Summary: This study aimed to evaluate the diagnostic value of optical coherence tomography (OCT) for pulmonary microvascular thromboinflammatory syndrome in patients with COVID-19 pneumonia. The results showed that OCT assessment of the distal pulmonary arteries in hospitalized COVID-19 patients is safe and accurate, enabling the first in vivo documentation of distal pulmonary arterial thrombosis in patients with elevated thromboinflammatory markers, even when their CT angiogram was negative for pulmonary thrombosis.
FRONTIERS IN MEDICINE
(2023)
Article
Critical Care Medicine
Stephen Huang, Antoine Vieillard-Baron, Bruno Evrard, Gwenael Prat, Michelle Chew, Martin Balik, Fernando Clau-Terre, Daniel De Backer, Armand Mekontso Dessap, Sam Orde, Andrea Morelli, Filippo Sanfilippo, Cyril Charron, Philippe Vignon, ECHO COVID Study Grp
Summary: This study aimed to evaluate the association between different phenotypes of right ventricular (RV) involvement and mortality in the intensive care unit (ICU) in patients with acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19). Post-hoc analysis of longitudinal data from the ECHO-COVID observational study showed that RV involvement is prevalent in patients ventilated for COVID-19 ARDS and different phenotypes of RV involvement may lead to different ICU mortality, with acute cor pulmonale (ACP) having the worst outcome.
INTENSIVE CARE MEDICINE
(2023)
Correction
Critical Care Medicine
Raphael Romano Bruno, Jakob Wollborn, Karl Fengler, Moritz Flick, Christian Wunder, Sebastian Allgaeuer, Holger Thiele, Mara Schemmelmann, Johanna Hornemann, Helene Mathilde Emilie Moecke, Filiz Demirtas, Lina Palici, Marcus Franz, Bernd Saugel, Eduardo Kattan, Daniel De Backer, Jan Bakker, Glenn Hernandez, Malte Kelm, Christian Jung
INTENSIVE CARE MEDICINE
(2023)
Editorial Material
Critical Care Medicine
Daniel De Backer, Marlies Ostermann, Xavier Monnet
INTENSIVE CARE MEDICINE
(2023)
Review
Critical Care Medicine
J. Duranteau, D. De Backer, K. Donadello, N. I. Shapiro, S. D. Hutchings, A. Rovas, M. Legrand, A. Harrois, C. Ince
Summary: The goal of hemodynamic resuscitation is to optimize the microcirculation of organs to meet their oxygen and metabolic needs. Clinicians currently lack the ability to assess and analyze the microcirculation, hindering individualized treatment. The future challenge is to develop noninvasive equipment for reliable assessment and analysis of the microcirculation at the bedside.
Correction
Critical Care Medicine
Alberto Fogagnolo, Fabio Silvio Taccone, Jean Louis Vincent, Giulia Benetto, Elaine Cavalcante, Elisabetta Marangoni, Riccardo Ragazzi, Jacques Creteur, Carlo Alberto Volta, Savino Spadaro