The Molecular Basis for Load-Induced Skeletal Muscle Hypertrophy

Testosterone deficiency: a historical perspective

(2014) Eberhard Nieschlag et al.   ASIAN JOURNAL OF ANDROLOGY

Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome

(2014) Suchithra Menon et al.   CELL

The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism

(2014) Chen-Song Zhang et al.   Cell Metabolism

Requirement for lysosomal localization of mTOR for its activation differs between leucine and other amino acids

(2014) Julien Averous et al.   CELLULAR SIGNALLING

Editorial overview: Cell regulation: The ins and outs of G protein-coupled receptors

(2014) Jeffrey L Benovic et al.   CURRENT OPINION IN CELL BIOLOGY

Creb coactivators direct anabolic responses and enhance performance of skeletal muscle

(2014) N. E. Bruno et al.   EMBO JOURNAL

Effects of Chronic Administration of Clenbuterol on Contractile Properties and Calcium Homeostasis in Rat Extensor Digitorum Longus Muscle

(2014) Pascal Sirvent et al.   PLoS One

G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy

(2014) J. P. White et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGF-β signaling to chromatin: How Smads regulate transcription during self-renewal and differentiation

(2014) Tessa Gaarenstroom et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Regulation of mTORC1 by amino acids

(2014) Liron Bar-Peled et al.   TRENDS IN CELL BIOLOGY

Muscle hypertrophy is associated with increases in proteasome activity that is independent of MuRF1 and MAFbx expression

(2014) Leslie M. Baehr et al.   Frontiers in Physiology

Maintenance of muscle mass and load-induced growth in Muscle RING Finger 1 null mice with age

(2013) Darren T. Hwee et al.   AGING CELL

Functional selectivity of GPCR signaling in animals

(2013) Lei Zhou et al.   CURRENT OPINION IN CELL BIOLOGY

Disuse-induced muscle wasting

(2013) Sue C. Bodine   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Role of Diacylglycerol Kinase ζ and Phosphatidic Acid in the Mechanical Activation of Mammalian Target of Rapamycin (mTOR) Signaling and Skeletal Muscle Hypertrophy

(2013) Jae-Sung You et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amino Acids Activate Mammalian Target of Rapamycin (mTOR) Complex 1 without Changing Rag GTPase Guanyl Nucleotide Charging

(2013) Noriko Oshiro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass

(2013) Catherine E. Winbanks et al.   JOURNAL OF CELL BIOLOGY

Eccentric contractions increase the phosphorylation of tuberous sclerosis complex-2 (TSC2) and alter the targeting of TSC2 and the mechanistic target of rapamycin to the lysosome

(2013) Brittany L. Jacobs et al.   JOURNAL OF PHYSIOLOGY-LONDON

Timing and distribution of protein ingestion during prolonged recovery from resistance exercise alters myofibrillar protein synthesis

(2013) José L. Areta et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1

(2013) Zhi-Yang Tsun et al.   MOLECULAR CELL

BMP signaling controls muscle mass

(2013) Roberta Sartori et al.   NATURE GENETICS

Inhibition of Myostatin Signaling through Notch Activation following Acute Resistance Exercise

(2013) Matthew G. MacKenzie et al.   PLoS One

A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

(2013) L. Bar-Peled et al.   SCIENCE

Molecular Networks of Human Muscle Adaptation to Exercise and Age

(2013) Bethan E. Phillips et al.   PLoS Genetics

Effects of energy-restricted high-protein, low-fat compared with standard-protein, low-fat diets: a meta-analysis of randomized controlled trials

(2012) Thomas P Wycherley et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

How phosphoinositide 3-phosphate controls growth downstream of amino acids and autophagy downstream of amino acid withdrawal

(2012) Nicholas T. Ktistakis et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

(2012) Liron Bar-Peled et al.   CELL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway

(2012) Jung Min Han et al.   CELL

Calpastatin overexpression in the skeletal muscle of mice prevents clenbuterol-induced muscle hypertrophy and phenotypic shift

(2012) Aymeric Douillard et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Nuclear factor-κB signalling and transcriptional regulation in skeletal muscle atrophy

(2012) Robert W. Jackman et al.   EXPERIMENTAL PHYSIOLOGY

Resistance exercise load does not determine training-mediated hypertrophic gains in young men

(2012) Cameron J. Mitchell et al.   JOURNAL OF APPLIED PHYSIOLOGY

Follistatin-mediated skeletal muscle hypertrophy is regulated by Smad3 and mTOR independently of myostatin

(2012) Catherine E. Winbanks et al.   JOURNAL OF CELL BIOLOGY

Supplementation of a suboptimal protein dose with leucine or essential amino acids: effects on myofibrillar protein synthesis at rest and following resistance exercise in men

(2012) Tyler A. Churchward-Venne et al.   JOURNAL OF PHYSIOLOGY-LONDON

Strength Training Induces Muscle Hypertrophy and Functional Gains in Black Prostate Cancer Patients Despite Androgen Deprivation Therapy

(2012) E. D. Hanson et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1

(2012) Christian C. Dibble et al.   MOLECULAR CELL

Sequenced response of extracellular matrix deadhesion and fibrotic regulators after muscle damage is involved in protection against future injury in human skeletal muscle

(2011) Abigail L. Mackey et al.   FASEB JOURNAL

Skeletal muscle amino acid transporter expression is increased in young and older adults following resistance exercise

(2011) Micah J. Drummond et al.   JOURNAL OF APPLIED PHYSIOLOGY

Mammalian Target of Rapamycin Complex 1 Activation Is Required for the Stimulation of Human Skeletal Muscle Protein Synthesis by Essential Amino Acids

(2011) Jared M. Dickinson et al.   JOURNAL OF NUTRITION

Enhanced Amino Acid Sensitivity of Myofibrillar Protein Synthesis Persists for up to 24 h after Resistance Exercise in Young Men

(2011) Nicholas A. Burd et al.   JOURNAL OF NUTRITION

The role of skeletal muscle mTOR in the regulation of mechanical load-induced growth

(2011) Craig A. Goodman et al.   JOURNAL OF PHYSIOLOGY-LONDON

Wnt7a–Fzd7 signalling directly activates the Akt/mTOR anabolic growth pathway in skeletal muscle

(2011) Julia von Maltzahn et al.   NATURE CELL BIOLOGY

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

G i2 Signaling Promotes Skeletal Muscle Hypertrophy, Myoblast Differentiation, and Muscle Regeneration

(2011) G. C. Minetti et al.   Science Signaling

Strength Training as a Countermeasure to Aging Muscle and Chronic Disease

(2011) Ben F. Hurley et al.   SPORTS MEDICINE

Long-term oxandrolone treatment increases muscle protein net deposition via improving amino acid utilization in pediatric patients 6 months after burn injury

(2011) Demidmaa Tuvdendorj et al.   SURGERY

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

A Phosphatidylinositol 3-Kinase/Protein Kinase B-independent Activation of Mammalian Target of Rapamycin Signaling Is Sufficient to Induce Skeletal Muscle Hypertrophy

(2010) Craig A. Goodman et al.   MOLECULAR BIOLOGY OF THE CELL

Regular Multicomponent Exercise Increases Physical Fitness and Muscle Protein Anabolism in Frail, Obese, Older Adults

(2010) Dennis T. Villareal et al.   Obesity

Low-Load High Volume Resistance Exercise Stimulates Muscle Protein Synthesis More Than High-Load Low Volume Resistance Exercise in Young Men

(2010) Nicholas A. Burd et al.   PLoS One

Acute resistance exercise results in catecholaminergic rather than hypothalamic–pituitary–adrenal axis stimulation during exercise in young men

(2010) Ioannis Fatouros et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size

(2009) Anne Ulrike Trendelenburg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Stimulation of skeletal muscle myofibrillar protein synthesis, p70 S6 kinase phosphorylation, and ribosomal protein S6 phosphorylation by inhibition of myostatin in mature mice

(2009) Stephen Welle et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Sympathetic Actions on the Skeletal Muscle

(2009) Silvestro Roatta et al.   EXERCISE AND SPORT SCIENCES REVIEWS

Ingestion of whey hydrolysate, casein, or soy protein isolate: effects on mixed muscle protein synthesis at rest and following resistance exercise in young men

(2009) Jason E. Tang et al.   JOURNAL OF APPLIED PHYSIOLOGY

Elevations in ostensibly anabolic hormones with resistance exercise enhance neither training-induced muscle hypertrophy nor strength of the elbow flexors

(2009) Daniel W. D. West et al.   JOURNAL OF APPLIED PHYSIOLOGY

Specific Activation of mTORC1 by Rheb G-proteinin VitroInvolves Enhanced Recruitment of Its Substrate Protein

(2009) Tatsuhiro Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis

(2009) Micah J. Drummond et al.   JOURNAL OF PHYSIOLOGY-LONDON

Resistance exercise-induced increases in putative anabolic hormones do not enhance muscle protein synthesis or intracellular signalling in young men

(2009) Daniel W. D. West et al.   JOURNAL OF PHYSIOLOGY-LONDON

From mechanical loading to collagen synthesis, structural changes and function in human tendon

(2009) M. Kjaer et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

Ingested protein dose response of muscle and albumin protein synthesis after resistance exercise in young men

(2008) Daniel R Moore et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Disassociation between the effects of amino acids and insulin on signaling, ubiquitin ligases, and protein turnover in human muscle

(2008) P. L. Greenhaff et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The response of bone to mechanical loading and disuse: Fundamental principles and influences on osteoblast/osteocyte homeostasis

(2008) Tim M. Skerry   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Down-Regulation of Akt/Mammalian Target of Rapamycin Signaling Pathway in Response to Myostatin Overexpression in Skeletal Muscle

(2008) Adel Amirouche et al.   ENDOCRINOLOGY

Decrease in Akt/PKB signalling in human skeletal muscle by resistance exercise

(2008) Louise Deldicque et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Mighty is a novel promyogenic factor in skeletal myogenesis

(2008) Amy Marshall et al.   EXPERIMENTAL CELL RESEARCH

mVps34 is activated following high-resistance contractions

(2008) Matthew G. MacKenzie et al.   JOURNAL OF PHYSIOLOGY-LONDON

Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells

(2008) Morgan E. Carlson et al.   NATURE

Regulation of TORC1 by Rag GTPases in nutrient response

(2008) Eunjung Kim et al.   NATURE CELL BIOLOGY

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE

A functional insulin-like growth factor receptor is not necessary for load-induced skeletal muscle hypertrophy

(2007) Espen E. Spangenburg et al.   JOURNAL OF PHYSIOLOGY-LONDON

Systemic administration of β2-adrenoceptor agonists, formoterol and salmeterol, elicit skeletal muscle hypertrophy in rats at micromolar doses

(2006) James G Ryall et al.   BRITISH JOURNAL OF PHARMACOLOGY