The Crisis of Reproducibility, the Denominator Problem and the Scientific Role of Multi-scale Modeling

Opinion: Is science really facing a reproducibility crisis, and do we need it to?

(2018) Daniele Fanelli   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Examining the controllability of sepsis using genetic algorithms on an agent-based model of systemic inflammation

(2018) Robert Chase Cockrell et al.   PLoS Computational Biology

Estimation of The Percentage of US Patients With Cancer Who Benefit From Genome-Driven Oncology

(2018) John Marquart et al.   JAMA Oncology

Sepsis reconsidered: Identifying novel metrics for behavioral landscape characterization with a high-performance computing implementation of an agent-based model

(2017) Chase Cockrell et al.   JOURNAL OF THEORETICAL BIOLOGY

Systematic heterogenization for better reproducibility in animal experimentation

(2017) S Helene Richter   LAB ANIMAL

Never Waste a Good Crisis: Confronting Reproducibility in Translational Research

(2016) Daniel J. Drucker   Cell Metabolism

Precision Medicine for Critical Illness and Injury

(2016) Timothy G. Buchman et al.   CRITICAL CARE MEDICINE

1,500 scientists lift the lid on reproducibility

(2016) Monya Baker   NATURE

Irreproducibility in Preclinical Biomedical Research: Perceptions, Uncertainties, and Knowledge Gaps

(2016) Michael F. Jarvis et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Tackling reproducibility in academic preclinical drug discovery

(2015) Stephen V. Frye et al.   NATURE REVIEWS DRUG DISCOVERY

A New Initiative on Precision Medicine

(2015) Francis S. Collins et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Economics of Reproducibility in Preclinical Research

(2015) Leonard P. Freedman et al.   PLOS BIOLOGY

Refinement of Experimental Design and Conduct in Laboratory Animal Research

(2014) J. D. Bailoo et al.   ILAR JOURNAL

Power failure: why small sample size undermines the reliability of neuroscience

(2013) Katherine S. Button et al.   NATURE REVIEWS NEUROSCIENCE

Raise standards for preclinical cancer research

(2012) C. Glenn Begley et al.   NATURE

Believe it or not: how much can we rely on published data on potential drug targets?

(2011) Florian Prinz et al.   NATURE REVIEWS DRUG DISCOVERY

Architecture, constraints, and behavior

(2011) J. C. Doyle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Environmental standardization: cure or cause of poor reproducibility in animal experiments?

(2009) S Helene Richter et al.   NATURE METHODS

Translational research: Crossing the valley of death

(2008) Declan Butler   NATURE