Review
Immunology
Zhimin Zou, Li Li, Nadine Schafer, Qiaobing Huang, Marc Maegele, Zhengtao Gu
Summary: TBI, a leading cause of death and disability worldwide, has been associated with damage to the endothelial glycocalyx which plays a crucial role in maintaining the balance between blood coagulation and anticoagulation. Recent advances in analytical techniques have made it possible to conduct biochemical, visual, and computational investigations on this vascular component.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Neurosciences
Wenxing Cui, Xun Wu, Dayun Feng, Jianing Luo, Yingwu Shi, Wei Guo, Haixiao Liu, Qiang Wang, Liang Wang, Shunnan Ge, Yan Qu
Summary: This study reveals a significant causal role of acrolein in TBI-induced coagulopathy and vascular leakage, partly through activating the autophagy pathway and affecting endothelial cell integrity by disrupting the blood-brain barrier. Acrolein, as a potential therapeutic target, may contribute to early hypercoagulability after TBI by regulating VWF secretion.
NEUROSCIENCE BULLETIN
(2021)
Review
Medicine, General & Internal
Fabian Kockelmann, Marc Maegele
Summary: Due to the aging population, the number of low falls in elderly people with pre-existing anticoagulation is increasing, leading to traumatic brain injury (TBI) with a social and economic burden. Hemostatic disorders and imbalances seem to play a significant role in bleeding progression. The interrelationships between anticoagulation medication, coagulopathy, and bleeding progression show promise for therapy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Emergency Medicine
Gaku Fujiwara, Yohei Okada, Wataru Ishii, Ryoji Iizuka, Mamoru Murakami, Takehiko Sakakibara, Tarumi Yamaki, Naoya Hashimoto
Summary: The study found that skull fracture is associated with in-hospital mortality among patients with severe traumatic brain injury, and patients with both skull base and skull vault fractures have a higher mortality rate.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Medicine, General & Internal
Yuhui Chen, Jun Tian, Bin Chi, Shangming Zhang, Liangfeng Wei, Shousen Wang
Summary: The incidence of coagulopathy after open traumatic brain injury (TBI) is high. Patients with a low GCS score, high NLR, low PLR, and hyperglycemia at admission are at greater risk of coagulopathy and poor prognosis. The efficacy of TXA in open TBI patients with coagulopathy is unclear. PLR may be a novel indicator for predicting coagulopathy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Critical Care Medicine
Rohan Mathur, Jose I. Suarez
Summary: Traumatic Brain Injury (TBI) is associated with altered hemostasis and coagulopathy. Isolated Traumatic Brain Injury (iTBI) is also associated with systemic coagulopathy and derangements in hemostasis.
NEUROCRITICAL CARE
(2023)
Article
Clinical Neurology
Tao Chang, Xigang Yan, Chao Zhao, Yufu Zhang, Bao Wang, Li Gao
Summary: This study aimed to explore the effect of coagulopathy in patients with TBI during the early postoperative period, and found that factors such as GCS on admission, ISS on admission, pupil mydriasis, intraoperative factors, and crystalloid resuscitation were independent risk factors for developing coagulopathy. Patients with coagulopathy had worse outcomes in terms of mortality and neurological function after surgery.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Review
Clinical Neurology
Marc Maegele
Summary: TBI can lead to hemorrhagic progression and coagulopathy, affecting morbidity and mortality, with potential associations with preinjury use of antithrombotic agents and changes in coagulation function. Further research suggests the presence of both hyper- and hypocoagulable states after TBI, requiring more comprehensive hemostatic analysis.
Article
Clinical Neurology
Jiang Fang, Qiang Yuan, Zhuoying Du, Chaobo Liu, Hao Xu, Weijian Yang, Long Chen, Jianlan Zhao, Rong Xie, Jin Hu, Xing Wu
Summary: This study found that genotypes of -323P0/P10, R353Q, and -401G/T were associated with FVIIa levels. The -323P0/P10 genotype was independently associated with traumatic coagulopathy and PHI in isolated TBI patients, but not with the 6-month GOS.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Article
Critical Care Medicine
Kelly A. Fair, David H. Farrell, Belinda H. McCully, Elizabeth A. Rick, Elizabeth N. Dewey, Cole Hilliard, Rondi Dean, Amber Lin, Holly Hinson, Ronald Barbosa, Martin A. Schreiber, Susan E. Rowell
Summary: Traumatic intracranial hemorrhage is a significant cause of secondary brain injury in patients with traumatic brain injury. The severity of injury and D-dimer levels significantly differ between patients with and without PICH.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Pharmacology & Pharmacy
Chongjie Cheng, Xiaoshu Wang, Yinghua Jiang, Yadan Li, Zhengbu Liao, Wenlu Li, Zhanyang Yu, Michael J. Whalen, Josephine Lok, Aaron S. Dumont, Ning Liu, Xiaoying Wang
Summary: Microvascular failure is crucial in the pathological evolution after TBI. Annexin A2 has shown potential in protecting against cerebral permeability and angiogenesis impairment, suggesting it as a candidate for cerebrovascular therapy. In experiments, rA2 treatment improved BBB integrity, enhanced mRNA levels of pro-angiogenic factors, activated cellular signaling pathways, induced angiogenesis, and improved long-term neurological function after TBI.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biology
Antonio Gatto, Lavinia Capossela, Giorgio Conti, Gemma Eftimiadi, Serena Ferretti, Luigi Manni, Antonietta Curatola, Benedetta Graglia, Lorenzo Di Sarno, Maria Lucia Calcagni, Daniela Di Giuda, Stefano Cecere, Domenico Marco Romeo, Marzia Soligo, Enzo Picconi, Marco Piastra, Giacomo Della Marca, Susanna Staccioli, Antonio Ruggiero, Fabrizio Cocciolillo, Silvia Pulitano, Antonio Chiaretti
Summary: Severe traumatic brain injury in pediatric patients is a critical condition with limited treatment options. A study suggests that intranasal administration of hr-NGF may improve neurological function and clinical outcomes in these patients.
Article
Surgery
Emily Breeding, Margaret Trainor, Ishraq Kabir, Michael Martyak
Summary: A retrospective chart review found that thromboelastography (TEG) is not reliable in assessing NOAC-related coagulopathy in traumatic brain injury (TBI) patients. Caution should be exercised when interpreting TEG data to determine reversal strategies in TBI patients on NOACs.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Hematology
Taylor N. Anderson, David H. Farrell, Susan E. Rowell
Summary: Posttraumatic coagulopathy is caused by disruption of the coagulation and fibrinolytic pathways due to tissue damage, hypotension, and inflammatory upregulation. Early hyperfibrinolysis in TBI patients can lead to uncontrolled bleeding and higher mortality. Fibrinolytic assays are not routinely performed, while viscoelastic tests offer rapid evaluation of coagulation function and tranexamic acid may improve clinical outcomes.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2021)
Article
Clinical Neurology
Kirill Shumilov, Sophia Xiao, Allen Ni, Marta Celorrio, Stuart H. Friess
Summary: Traumatic brain injury (TBI) can cause damage to the white matter through axonal loss and demyelination. The proliferation of oligodendrocyte progenitor cells (OPCs) plays a crucial role in the process of remyelination. However, current treatments for TBI are unable to effectively stimulate OPC proliferation. This study demonstrates the potential of recombinant human erythropoietin (rhEPO) in promoting myelination by increasing the proliferation of oligodendrocyte lineage cells after TBI.
Correction
Pathology
Queenie Hoi-Wing Wong, Kay Ka-Wai Li, Wei-Wei Wang, Tathiane M. Malta, Houtan Noushmehr, Yura Grabovska, Chris Jones, Aden Ka-Yin Chan, Johnny Sheung-Him Kwan, Queenie Jun-Qi Huang, Gabriel Chun-Hei Wong, Wen-Cai Li, Xian-Zhi Liu, Hong Chen, Danny Tat-Ming Chan, Ying Mao, Zhen-Yu Zhang, Zhi-Feng Shi, Ho-Keung Ng
Summary: A correction to this paper has been published.
Article
Neurosciences
Pengmin Qin, Xuehai Wu, Changwei Wu, Hang Wu, Jun Zhang, Zirui Huang, Xuchu Weng, Di Zang, Zengxin Qi, Weijun Tang, Tanikawa Hiromi, Jiaxing Tan, Sean Tanabe, Stuart Fogel, Anthony G. Hudetz, Yihong Yang, Emmanuel A. Stamatakis, Ying Mao, Georg Northoff
Summary: The study aimed to identify critical nodes within the brain's global functional network that support consciousness. Using graph-theoretical measure of degree centrality and ROI-based functional connectivity, the researchers found higher-order sensory and motor regions as well as a sensorimotor circuit to be important hubs whose degree centrality was significantly reduced when consciousness was reduced or absent. This suggests potential mechanism-guided treatment targets for disorders of consciousness.
Article
Chemistry, Multidisciplinary
Zijing Wang, Zhipeng Yang, Jianjuan Jiang, Zhifeng Shi, Ying Mao, Nan Qin, Tiger H. Tao
Summary: A silk fibroin microneedle (SMN) patch designed for glioblastoma (GBM) can bypass the blood-brain barrier and release multiple drugs directly to the tumor site, providing an effective treatment strategy for brain tumors. The biocompatible and biodegradable patch allows for slow drug release over time and can be triggered remotely for rapid drug delivery. In animal models, the patch resulted in decreased tumor volume and increased survival rate, showing potential for clinical treatment of brain tumors.
ADVANCED MATERIALS
(2022)
Review
Developmental Biology
Lijuan Zhang, Yue Cao, Xin Zhang, Xinyang Gu, Ying Mao, Bo Peng
Summary: Microglia, as important immune cells in the central nervous system, play crucial roles in neurodevelopment, acute injury, and neuropsychiatric disorders. They undergo birth, death, and regeneration during their lifetime. Modulating the development of microglia may provide new therapeutic opportunities for preventing inflammation-related effects and controlling excessive inflammation in brain diseases.
DEVELOPMENTAL NEUROBIOLOGY
(2022)
Article
Neurosciences
Yanxia Rao, Siling Du, Baozhi Yang, Yuqing Wang, Yuxin Li, Ruofan Li, Tian Zhou, Xiangjuan Du, Yang He, Yafei Wang, Xin Zhou, Ti-Fei Yuan, Ying Mao, Bo Peng
Summary: This study found that NeuroD1 cannot convert microglia to neurons, instead inducing microglial cell death, hence unable to achieve cross-lineage reprogramming. Lineage tracing revealed virus leakage, confounding the results of glia-to-neuron conversion.
Article
Chemistry, Multidisciplinary
Ziyi Jin, Qi Yue, Wenjia Duan, An Sui, Botao Zhao, Yinhui Deng, Yuting Zhai, Yuwen Zhang, Tao Sun, Guang-Ping Zhang, Limei Han, Ying Mao, Jinhua Yu, Xiao-Yong Zhang, Cong Li
Summary: This article reports an intelligent surface-enhanced Raman scattering navigation system that can delineate the acidic margins of gliomas without using exogenous probes. The system uses a homemade deep learning model to process Raman spectra and quickly delineate the pH map of the tumor resection bed. Experimental results demonstrate a significant improvement in overall survival rate of animal models after surgery guided by this system.
Review
Neurosciences
Rui-Zhe Zheng, Zeng-Xin Qi, Zhe Wang, Ze-Yu Xu, Xue-Hai Wu, Ying Mao
Summary: Significant progress has been made in identifying and managing disorders of consciousness in patients with acquired brain injury. Advanced technology and tools have improved diagnostic accuracy, but there are still challenges in clinical treatment and a lack of effective management protocols.
NEUROSCIENCE BULLETIN
(2023)
Review
Neurosciences
Qiyuan Zhuang, Hui Yang, Ying Mao
Summary: Glioma, the most common and lethal primary brain tumor, is highly heterogeneous and its cell state, including glioma stem cells, microglia, neurons, and immune cells, play crucial roles in tumor initiation, progression, and response to therapy.
NEUROSCIENCE BULLETIN
(2023)
Article
Biochemistry & Molecular Biology
Yifan Yuan, Yang Yu, Yu Guo, Yinghua Chu, Jun Chang, Yicheng Hsu, Patrick Alexander Liebig, Ji Xiong, Wenwen Yu, Danyang Feng, Baofeng Yang, Liang Chen, He Wang, Qi Yue, Ying Mao
Summary: In this study, the diagnostic accuracy of combined CEST and MRS in predicting glioma infiltration was evaluated. The results showed that CEST and MRS were correlated with FET-PET, but the correlation between CEST and MRS was weaker. The combination of CEST/MRS predicted tumor infiltration more accurately than using CEST or MRS alone.
Review
Neurosciences
Lijuan Zhang, Yafei Wang, Taohui Liu, Ying Mao, Bo Peng
Summary: Microglia, as immune cells in the central nervous system, play a crucial role in monitoring the environment and protecting neurons to maintain brain homeostasis. In diseased brains, microglia are important mediators of neuroinflammation and have been extensively studied for their involvement in neurodegeneration. This review summarizes the multifunctional contributions of microglia to homeostasis and their potential as therapeutic targets in neurodegenerative diseases, with a particular focus on microglial replacement therapy.
NEUROSCIENCE BULLETIN
(2023)
Article
Computer Science, Information Systems
Renping Yu, Han Zhang, Xuehai Wu, Xuan Fei, Qing Yang, Zhiwei Ma, Zengxin Qi, Di Zang, Weijun Tang, Ying Mao, Dinggang Shen
Summary: This study aims to predict the outcome of unconscious acquired brain injury patients and differentiate consciousness levels using brain functional imaging and machine learning techniques. The researchers construct functional networks based on resting-state fMRI and use connection strengths as features for outcome prediction and consciousness level differentiation. The study achieves improved classification accuracy for consciousness levels (84.78%) and recovery outcome prediction (89.74%) compared to other methods, and identifies contributive connections across the entire brain. These findings provide potential biomarkers for understanding consciousness and developing diagnostic, prognostic, and therapeutic guidelines for ABI patients.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2023)
Article
Multidisciplinary Sciences
Fushun Wang, Wei Wang, Simeng Gu, Dan Qi, Nathan A. Smith, Weiguo Peng, Wei Dong, Jiajin Yuan, Binbin Zhao, Ying Mao, Peng Cao, Qing Richard Lu, Lee A. Shapiro, S. Stephen Yi, Erxi Wu, Jason H. Huang
Summary: The researchers discovered two distinct astrocytic Ca2+ signals in the mouse barrel cortex, which play different roles in modulating sensory transmission during sleep and arousal states.
NATURE COMMUNICATIONS
(2023)
Correction
Neurosciences
Lijuan Zhang, Yafei Wang, Taohui Liu, Ying Mao, Bo Peng
NEUROSCIENCE BULLETIN
(2023)
Article
Physics, Multidisciplinary
Andrea Buccellato, Yasir Catal, Patrizia Bisiacchi, Di Zang, Federico Zilio, Zhe Wang, Zengxin Qi, Ruizhe Zheng, Zeyu Xu, Xuehai Wu, Alessandra Del Felice, Ying Mao, Georg Northoff
Summary: In this study, the use of permutation entropy (PE) is proposed to estimate time delays from neural time series, which is a more robust alternative to autocorrelation window (ACW). The validity of this approach is demonstrated on synthetic neural data and hd-EEG human data, suggesting its potential use for characterizing conscious states.
Article
Acoustics
Shaoyuan Yan, Jiajun Shou, Junjin Yu, Jianping Song, Ying Mao, Kailiang Xu
Summary: The study developed an ultrafast ultrasound vector Doppler (ultrafast UVD) method for small vasculature hemodynamic imaging by combining multiangle vector Doppler strategy and ultrafast sequencing. The validity of the technique was demonstrated through experiments on a rotational phantom, rat brain, human brain, and human spinal cord. Compared with the widely accepted accurate flow velocimetry technique ultrasound localization microscopy (ULM), the rat brain experiment showed that the average relative error (ARE) of the velocity magnitude estimated by ultrafast UVD was approximately 16.2%, with a root-mean-square error (RMSE) of the velocity direction of 26.7°. The results demonstrated that ultrafast UVD is a promising tool for accurate blood flow velocity measurement, especially for organs with vasculature typically exhibiting tendential alignment of vascular trees, such as the brain and spinal cord.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2023)
Article
Critical Care Medicine
Christina Boncyk, Kimberly Rengel, Joanna Stollings, Matt Marshall, Xiaoke Feng, Matthew Shotwell, Pratik P. Pandharipande, Christopher G. Hughes
Summary: This study describes the incidence and factors associated with recurrent delirium in the intensive care unit (ICU). The researchers found that over 10% of delirious ICU patients experienced recurrent symptoms, and factors such as age, duration of mechanical ventilation, and medication exposure were associated with recurrence.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Thomas C. Rollinson, Luke A. McDonald, Joleen Rose, Glenn Eastwood, Rahul Costa-Pinto, Lucy Modra, Akinori Maeda, Zoe Bacolas, James Anstey, Samantha Bates, Scott Bradley, Jodi Dumbrell, Craig French, Angaj Ghosh, Kimberley Haines, Tim Haydon, Carol L. Hodgson, Jennifer Holmes, Nina Leggett, Forbes McGain, Cara Moore, Kathleen Nelson, Jeffrey Presneill, Hannah Rotherham, Simone Said, Meredith Young, Peinan Zhao, Andrew Udy, Ary Serpa Neto, Anis Chaba, Rinaldo Bellomo
Summary: Neuromuscular blockers (NMBs) used during prone positioning in COVID-19 ARDS patients can improve oxygenation and have a sustained effect upon returning to supine position.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Kyung Hun Nam, Jason Phua, Bin Du, Shinichiro Ohshimo, Hwa Jung Kim, Chae-Man Lim, Sheila Nainan Myatra, Nik Azman Bin Nik Adib, Yaseen M. Arabi, Ming-Cheng Chan, Mohammad Omar Faruq, Ike Sri Redjeki, Do Ngoc Son, Khalid Mahmood Khan Nafees, Dilshan Priyankara, Boonsong Patjanasoontorn, Jose Emmanuel Palo, Aidos Konkayev, Gentle Sunder Shrestha, Younsuck Koh
Summary: This study investigated the current practices of mechanical ventilation in Asian intensive care units. The results showed that low tidal volume ventilation and sufficient PEEP were underused in patients with ARDS, while intermediate tidal volumes were commonly used in patients without ARDS. Country income, age, and severity of illness were associated with mortality.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Rudolf Likar, Ilia Aroyo, Katrin Bangert, Bjorn Degen, Rainer Dziewas, Oliver Galvan, Michaela Trapl Grundschober, Markus Kostenberger, Paul Muhle, Joerg C. Schefold, Patrick Zuercher
Summary: This article presents expert opinions on the diagnosis and management of dysphagia in ICU patients. The panel suggests adopting clinical algorithms to promote standardized and high-quality care, and proposes two clinical management algorithms to improve early detection and effective treatment of dysphagia in ICU patients.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Pawel Pasieka, Anna Surowka, Jakub Fronczek, Evan Skwara, Miroslaw Czuczwar, Michal Borys, Pawel Krawczyk, Miroslaw Zietkiewicz, Lukasz R. Nowak, Maciej Zukowski, Katarzyna Kotfis, Katarzyna Cwyl, Jacek Skowronek, Joanna Solek-Pastuszka, Jowita Biernawska, Pawel Grudzien, Pawel Nasilowski, Natalia Popek, Waldemar Cyrankiewicz, Katarzyna Sierakowska, Wojciech Mudyna, Szymon Bialka, Dorota Studzinska, Szymon Bernas, Mariusz Piechota, Waldemar Machala, Lukasz Sadowski, Jan Stefaniak, Radoslaw Owczuk, Malgorzata Szymkowiak, Ryszard Gawda, Natalia Kozera, Barbara Adamik, Waldemar Gozdzik, Agnieszka Wieczorek, Jaroslaw Janc, Anna Kluzik, Janusz Trzebicki, Pawel Zatorski, Wojciech Gola, Hubert Hymczak, Lukasz J. Krzych, Szymon Czajka, Urszula Kosciuczuk, Bartosz Kudlinski, Hans Flaatten, Wojciech Szczeklik
Summary: The study aims to evaluate whether there is an increased propensity to limit life-sustaining treatment (LST) among elderly patients in Poland from 2018-2019 compared to 2016-2017. The results show that clinicians in Poland have become more proactive in limiting LST in critically ill patients aged 80 and above during the studied period, although the prevalence of LST limitations in Poland remains low.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Jihad Mallat, Malcolm Lemyze, Marc-Olivier Fischer
Summary: In mechanically ventilated patients with acute circulatory failure, changes in PVI induced by PLR accurately predict fluid responsiveness.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Jingyuan Xu, Yanjie Zhang, Jie Jiang, Yi Yang, Fengmei Guo
Summary: This meta-analysis examined the effect of milrinone on prognosis in adult critically ill patients and found a significant decrease in the incidence of ventricular arrhythmia in patients with cardiac surgery. However, there was no significant reduction in all-cause mortality or the incidence of myocardial infarction. More research is needed to determine the reliable and conclusive evidence for the effects of milrinone.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Zhi-Tao Li, Da-Bing Huang, Jian-Feng Zhao, Hui Li, Shui-Qiao Fu, Wei Wang
Summary: Venous congestion is associated with AKI after cardiac surgery, but not necessarily with CRRT. Among the markers tested, IRVF exhibits the strongest correlation with AKI.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Sarah E. Nelson, Spyridoula Tsetsou, John Liang
Summary: This article discusses a range of issues associated with tracking CLABSI and CAUTI metrics, including lack of evidence, moral distress, and definition problems. It recommends forming a task force consisting of key stakeholders to improve the use of these metrics.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Ross Prager, Eric Walser, Kaan Y. Balta, Anton Nikouline, William R. Leeper, Kelly Vogt, Neil Parry, Robert Arntfield
Summary: Resuscitative TEE has been shown to be a valuable diagnostic tool in trauma care, with the potential to impact treatment strategies and diagnostic approaches for patients in the trauma bay.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Jaeyun Sung, Sanu S. Rajendraprasad, Kemuel L. Philbrick, Brent A. Bauer, Ognjen Gajic, Aditya Shah, Krzysztof Laudanski, Johan S. Bakken, Joseph Skalski, Lioudmila V. Karnatovskaia
Summary: With a large number of cells and genes, the human gut microbiome is crucial for health and disease. Modern living disrupts the balance between the host and its microbiome, leading to adverse impacts on critical illness and patient outcomes. Restoring the gut microbiome shows promise for preventing and treating critical illnesses.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Claire Chaignat, Laurent Lagrost, Karena Moretto, Jean-Paul Pais de Barros, Hadrien Winiszewski, Jacques Grober, Philippe Saas, Gael Piton
Summary: The aim of this study was to investigate the correlation between plasma citrulline levels and plasma lipopolysaccharide (LPS) concentration, as well as the impact of sepsis on gut function in critically ill patients. The results showed no correlation between plasma citrulline concentration and plasma LPS concentration or activity. However, septic patients had significantly lower plasma citrulline levels. Additionally, abdominal sepsis was associated with higher plasma LPS activity compared to extra-abdominal sepsis.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Pyoung Jik Lee, Thomas Hampton
Summary: This study found that smartphone applications with low-cost external microphones can reliably measure average noise levels in both laboratory and field settings, but show significant differences compared to professional equipment when measuring maximum noise levels.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Greg Roberts, James S. Krinsley, Jean-Charles Preiser, Stephen Quinn, Peter R. Rule, Michael Brownlee, Guillermo E. Umpierrez, Irl B. Hirsch
Summary: Relative hypoglycemia was commonly seen in patients with HbA1c ≥ 8% and was independently associated with mortality. Absolute hypoglycemia was associated with mortality regardless of HbA1c.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Katsura Hayakawa, Shigehiko Uchino, Hideki Endo, Kazuki Hasegawa, Kazuya Kiyota
Summary: This study assessed the performance of the APACHE III and JROD models under different conditions of missing variables and found that a higher number of missing physiological variables led to underestimated predicted mortality rates and higher standardized mortality ratios.
JOURNAL OF CRITICAL CARE
(2024)