Review
Biochemistry & Molecular Biology
Julian Bailes, Mikhail Soloviev
Summary: IGF-1, the principal mediator of GH, plays a crucial role in cell growth, differentiation, and apoptosis, with its bioavailability affected by IGFBPs. The varying expression levels of IGF-1 in clinical conditions and its misuse in sports have raised significant concerns.
Article
Biochemistry & Molecular Biology
Carlos Fernandez-Pereira, Maria Aranzazu Penedo, Tania Rivera-Baltanas, Rafael Fernandez-Martinez, Saida Ortolano, Jose Manuel Olivares, Roberto Carlos Agis-Balboa
Summary: This study aimed to evaluate whether the alterations in insulin-like growth factor 2 (IGF-2) and IGF binding protein 7 (IGFBP-7) in schizophrenia patients are related to the psychiatric disorder itself or are a result of antipsychotic treatment. The results showed that drug-naive first episode patients had lower levels of IGF-2 compared to controls, but no significant change in IGFBP-7 levels. However, both IGF-2 and IGFBP-7 significantly increased after atypical antipsychotic treatment in these patients. Chronic patients, on the other hand, had higher levels of both proteins compared to controls.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Andreas Hoeflich, Brit Fitzner, Christina Walz, Michael Hecker, Armin Tuchscherer, Julia Brenmoehl, Uwe Klaus Zettl
Summary: The study investigated the IGF system in MS patients during TCA treatment, finding that IGF-I levels increased in serum while fragmentation of IGFBP-2 and IGFBP-3 decreased in CSF. The reduction in IGFBP fragmentation and lower ratio of IGF-II to intact IGFBPs indicate a regulation of IGF-II bioactivity in CSF during repeated intrathecal TCA administration in MS patients.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Anne Mette Frobert, Malene Brohus, Tinna S. Roesen, Jonas Kindberg, Ole Frobert, Cheryl A. Conover, Michael T. Overgaard
Summary: Brown bears shift from circulating ternary IGF/IGFBP/ALS complexes in the active state to binary IGF/IGFBP complexes during hibernation, indicating increased tissue IGF-bioactivity. Furthermore, brown bears use a splice variant of IGF-2, suggesting increased bone-specific targeting of IGF anabolic signaling.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Peripheral Vascular Disease
Francesca Gaccioli, Ulla Sovio, Sungsam Gong, Emma Cook, D. Stephen Charnock-Jones, Gordon C. S. Smith
Summary: This study aimed to investigate the relationship between protein levels of sFLT1 and PlGF in maternal serum and placental tissue lysates. The findings showed that the sFLT1:PlGF ratio is increased in both preeclampsia and FGR, but in preeclampsia, it is primarily driven by increased placental sFLT1 levels, while in FGR, it is primarily driven by decreased placental PlGF levels.
Review
Biochemistry & Molecular Biology
Shiva Nasr, Athar Nakisa, Setareh Jandaghian, Monireh Kouhi, Erfan Sadeghi, Jaleh Varshosaz
Summary: This systematic review found that flavonoid supplements do not have a significant effect on IGF-1 and IGFBP-3. However, a high soy diet has beneficial effects on components of the IGF system, which may be useful in breast cancer.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Obstetrics & Gynecology
Li Wei, Zhou Liping, Kang Suya
Summary: The expression of IGFBP-3 is elevated in HELLP syndrome and it may promote cell apoptosis and inflammatory reactions through affecting the expression and function of IGF-1, VEGF, and TGF-beta 1. IGFBP-3 plays a crucial role in the pathogenesis of HELLP syndrome.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Review
Endocrinology & Metabolism
Claus Oxvig, Cheryl A. Conover
Summary: PAPP-A and PAPP-A2 are specific proteolytic enzymes involved in IGF signaling regulation by cleaving IGFBPs and increasing IGF bioactivity. This molecular network plays a significant role in the IGF system, but its precise operation needs further investigation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Obstetrics & Gynecology
Elena N. Alekseenkova, V. N. Babakov, S. A. Selkov, G. C. Di Renzo, I. Yu. Kogan, R. V. Kapustin
Summary: This study investigated the relationship between maternal insulin-like growth factor (IGF) levels and fetal macrosomia. The authors found that higher levels of first-trimester IGF-1 and a higher IGF-1/IGFBP-1 ratio were associated with large-for-gestational-age neonates. The IGF-1/IGFBP-1 ratio showed better performance in predicting birth weight over 4000 g.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Medicine, General & Internal
Ya-nan Zhu, Xiao-wen Gan, Fan Pan, Xiao-tian Ni, Leslie Myatt, Wang-sheng Wang, Kang Sun
Summary: The study demonstrates that lifting EZH2-mediated H3K27me3 during syncytialization increases the expression of ADAM12-S, a placenta-derived protease, through the EGF-activated STAT5B signaling pathway. This may lead to elevated levels of ADAM12-S in maternal blood, resulting in increased availability of IGF for stimulating fetoplacental growth in pregnancy. The role of EZH2-mediated H3K27me3 may switch from cell lineage specification in early blastocyst stage to regulation of fetoplacental growth in later gestation.
Review
Endocrinology & Metabolism
Mengyang Li
Summary: The GH/IGF system plays a role in growth regulation in the body. By studying the basal chordate amphioxus, it was discovered that most members of the GH/IGF system are present in amphioxus, providing strong evidence for the origin of this system in amphioxus.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Dali Kang, Henry J. Waldvogel, Ao Wang, Dawei Fan, Richard L. M. Faull, Maurice A. Curtis, Paul R. Shorten, Jian Guan
Summary: The study evaluated the changes of IGFBPs and cGP, and their effects on the bioavailability and function of IGF-1 in human brain of AD cases. The unbound bioavailable IGF-1 was lower whereas the bound cGP and IGFBP-3 were higher in AD than the control cases. Results provide direct evidence for IGF-1 deficiency in AD brain due to lower bioavailable IGF-1, and the increase of bound cGP is an autocrine response to improve the bioavailability and function of IGF-1 in AD brain.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Carlos Fernandez-Pereira, Maria Aranzazu Penedo, Tania Rivera-Baltanas, Tania Perez-Marquez, Marta Alves-Villar, Rafael Fernandez-Martinez, Cesar Veiga, Angel Salgado-Barreira, Jose Maria Prieto-Gonzalez, Saida Ortolano, Jose Manuel Olivares, Roberto Carlos Agis-Balboa
Summary: IGF-2 and IGFBP-7 levels are significantly increased in depressed patients, while levels of IGF-2, IGFBP-3, and IGFBP-5 are significantly decreased after antidepressant treatment, with IGFBP-7 showing a significant increase. This suggests that peripheral changes in the IGF family may reflect alterations at the brain level in depression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Laith M. Haj-Ahmad, Muhannad M. Mahmoud, Nabil W. G. Sweis, Isam Bsisu, Ahmad M. Alghrabli, Alaa M. Ibrahim, Ayman A. Zayed
Summary: The serum IGF-1/IGFBP-3 ratio is a useful marker for the diagnosis of growth hormone deficiency in children. Combining serum IGF-1, IGFBP-3, and the IGF-1/IGFBP-3 ratio can improve the specificity of the diagnosis.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Nutrition & Dietetics
Wojciech Czogala, Wojciech Strojny, Przemyslaw Tomasik, Miroslaw Bik Multanowski, Malgorzata Wojcik, Klaudia Miklusiak, Emil Krzysztofik, Albert Wrobel, Karol Miklusiak, Szymon Skoczen
Summary: This study analyzed the expression of IGF-axis genes and protein concentrations in obese children compared to healthy controls, finding higher expression of IGFBP7 and lower expression of IGF2 and IGFBP1 in obese children. In addition, IGFBP4 concentration was significantly higher in obese children while IGFBP3 showed a rising trend. The study also found correlations between IGFs and IGFBPs with obesity metabolic parameters.
Review
Obstetrics & Gynecology
Tatiana Priputnevich, Lyudmila Lyubasovskaya, Vera Muravieva, Andrey Kondrakhin, Alla Ignateva, Alexey Gordeev, Roman Shmakov, Gennady Sukhikh, Ekaterina Yarotskaya
Summary: Sepsis associated with Eggerthella lenta is rare and poses challenges in treatment, often linked to bacterial inhabitants of the gastrointestinal tract and vagina.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Cell Biology
Andrey Elchaninov, Timur Fatkhudinov, Andrey Makarov, Iva Vorobieva, Anastasia Lokhonina, Natalia Usman, Evgeniya Kananykhina, Polina Vishnyakova, Maria Nikitina, Dmitry Goldshtein, Galina Bolshakova, Valeria Glinkina, Gennady Sukhikh
CELL BIOLOGY INTERNATIONAL
(2020)
Article
Obstetrics & Gynecology
Oleg R. Baev, Dmitriy A. Babich, Andrey M. Prikhodko, Oleg V. Tysyachniy, Gennadiy T. Sukhikh
Summary: The combination of mifepristone and Dilapan-S is more effective in improving cervical ripening and vaginal delivery rate, reducing labor duration, and minimizing the need for oxytocin augmentation as compared to using Dilapan-S alone.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Developmental Biology
M. M. Ziganshina, G. V. Kulikova, N. M. Fayzullina, E. L. Yarotskaya, A. I. Shchegolev, Jacques Le Pendu, Adrien Breiman, N. V. Shilova, N. R. Khasbiullina, N. V. Bovin, N. E. Kan, V. L. Tyutyunnik, Z. S. Khodzhaeva, G. T. Sukhikh
Article
Medicine, Research & Experimental
O. Abramova, E. A. Zubkov, Ya A. Zorkina, A. Yu Morozova, K. A. Pavlov, V. P. Chekhonin
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2020)
Article
Gastroenterology & Hepatology
Vyacheslav Egorov, Roman Petrov, Aleksandr Schegolev, Elena Dubova, Andrey Vankovich, Eugeny Kondratyev, Andrey Dobriakov, Dmitry Kalinin, Natalia Schvetz, Elena Poputchikova
Summary: This study compared the safety, efficacy, and short- and long-term results of pancreatoduodenectomy (PD) and pancreas-preserving duodenal resection (PPDR) in patients with cystic dystrophy of the duodenal wall (CDDW). The results indicated that PPDR has similar safety and better efficacy compared to PD, making it a potentially optimal procedure for this disease. Early detection of CDDW provides an opportunity for pancreas-preserving surgery.
WORLD JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Virology
Gennady Sukhikh, Ulyana Petrova, Andrey Prikhodko, Natalia Starodubtseva, Konstantin Chingin, Huanwen Chen, Anna Bugrova, Alexey Kononikhin, Olga Bourmenskaya, Alexander Brzhozovskiy, Evgeniya Polushkina, Galina Kulikova, Alexander Shchegolev, Dmitry Trofimov, Vladimir Frankevich, Evgeny Nikolaev, Roman G. Shmakov
Summary: This case study illustrates the potential impact of SARS-CoV-2 infection on pregnancy and fetal health, with vertical transmission of the virus from mother to fetus being a major contributing factor to maternal vascular malperfusion.
Article
Endocrinology & Metabolism
Marina M. Ziganshina, Nataliya V. Dolgushina, Galina V. Kulikova, Nafisa M. Fayzullina, Ekaterina L. Yarotskaya, Nailia R. Khasbiullina, Nigora F. Abdurakhmanova, Aleksandra V. Asaturova, Alexander I. Shchegolev, Alina A. Dovgan, Gennady T. Sukhikh
Summary: This study investigated the composition of the glycocalyx of the apical surface of luminal and glandular epithelial cells in thin endometrium of infertile women. Compared to normal endometrium, thin endometrium showed significantly less expression of MECA-79 glycans, which are crucial for implantation. Unique glycans containing LacNAc unit and binding to MECA-79 MAbs were identified as potential markers of endometrium receptivity in thin endometrium.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Anna Morozova, Yana Zorkina, Olga Abramova, Olga Pavlova, Konstantin Pavlov, Kristina Soloveva, Maria Volkova, Polina Alekseeva, Alisa Andryshchenko, Georgiy Kostyuk, Olga Gurina, Vladimir Chekhonin
Summary: This review focuses on the cognitive impairment as a significant component in various psychiatric disorders and its impact on the quality of life. It summarizes the current understanding of the underlying neurobiological mechanisms of cognitive impairment in individuals with schizophrenia, depression, mild cognitive impairment, and dementia (including Alzheimer's disease). The review also provides data on the prevalence of cognitive impairment in individuals with mental illness and the associated biological markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Tatyana V. Sukhacheva, Roman A. Serov, Natalia V. Nizyaeva, Artem A. Burov, Stanislav V. Pavlovich, Yulia L. Podurovskaya, Maria V. Samsonova, Andrey L. Chernyaev, Aleksandr I. Shchegolev, Alexei I. Kim, Leo A. Bockeria, Gennady T. Sukhikh
Summary: Children with tetralogy of Fallot (TF) experience hemodynamic overload and hypoxemia after birth. Comparative analysis showed significant increase in ploidy and morphology of right ventricular cardiomyocytes in these children. Connexin43-containing gap junctions were predominantly distributed diffusely over the cardiomyocytes sarcolemma and redistributed into intercalated discs during cardiomyocyte differentiation. The number of Ki67-positive cardiomyocytes varied greatly and decreased with increased myocytes differentiation. Ultrastructural signs of immaturity and proliferative activity were observed in cardiomyocytes of children with TF. The proportion of interstitial tissue did not differ significantly from the control group. Myocardium in children with TF under six months of age was most sensitive to hypoxemia, resulting in delayed intercalated discs and myofibril assembly, and dystrophic changes in cardiomyocytes. The adaptation to hemodynamic overload and hypoxemia in immature myocardium of TF children involved the acceleration of ontogenetic growth and differentiation of cardiomyocytes, rather than reactivation of their proliferation.
Review
Biochemistry & Molecular Biology
Aleksandra Ochneva, Yana Zorkina, Olga Abramova, Olga Pavlova, Valeriya Ushakova, Anna Morozova, Eugene Zubkov, Konstantin Pavlov, Olga Gurina, Vladimir Chekhonin
Summary: This review discusses the potential contribution of protein illnesses in the development of psychopathologies. It describes the possible mechanisms of disruption to protein folding and aggregation in the cell, as well as the known proteins whose aggregation has been observed in psychiatric disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Olga Abramova, Kristina Soloveva, Yana Zorkina, Dmitry Gryadunov, Anna Ikonnikova, Elena Fedoseeva, Marina Emelyanova, Aleksandra Ochneva, Nika Andriushchenko, Konstantin Pavlov, Olga Pavlova, Valeriya Ushakova, Timur Syunyakov, Alisa Andryushchenko, Olga Karpenko, Victor Savilov, Marat Kurmishev, Denis Andreuyk, Olga Gurina, Vladimir Chekhonin, Georgy Kostyuk, Anna Morozova
Summary: Dementia has significant implications for patients and the healthcare system. This study investigates the potential link between genetic variants associated with suicide risk and the risk of cognitive decline in older adults. The results suggest that certain genetic markers, including APOE epsilon 4 and APOE epsilon 2, are associated with an increased risk of dementia.
Article
Public, Environmental & Occupational Health
Yana Zorkina, Olga Abramova, Valeria Ushakova, Denis Andreyuk, Nika Andriushchenko, Konstantin Pavlov, Victor Savilov, Kristina Soloveva, Marat Kurmishev, Timur Syunyakov, Olga Karpenko, Alisa Andryushchenko, Olga Gurina, Georgiy Kostyuk, Anna Morozova
Summary: The detection of specific markers of dementia and mild cognitive decline (MCI) is crucial for disease prevention and early treatment. Female gender is a major risk factor for dementia. This study compared the concentration of factors related to lipid metabolism and the immune system in MCI and dementia patients. It was found that Apo A1 and HDL levels were significantly decreased in dementia patients, and Apo A1 levels were also decreased in MCI patients. Furthermore, certain markers were elevated in dementia patients compared to controls, while others were decreased in MCI patients and increased in dementia patients compared to controls.
Article
Pharmacology & Pharmacy
Nika Andriushchenko, Kira Nebogina, Yana Zorkina, Olga Abramova, Eugene Zubkov, Aleksandra Ochneva, Valeria Ushakova, Konstantin Pavlov, Olga Gurina, Vladimir Chekhonin, Anna Morozova
Summary: The search for effective antidepressants with minimal side effects is necessary. Neuropeptide Y (NY) showed a protective effect in a model of acute stress, comparable to the antidepressant effect of clomipramine. When chronically administered, NY also demonstrated an antidepressant action, although to a lesser extent than clomipramine. The combination of NY and clomipramine was less effective in the chronic stress paradigm, but just as effective in the acute stress paradigm. There is no convincing evidence for the efficacy of chronic administration of neuropeptide Y.
SCIENTIA PHARMACEUTICA
(2022)
