Article
Biochemistry & Molecular Biology
Matyas Meggyes, Timoteus Feik, David U. Nagy, Beata Polgar, Laszlo Szereday
Summary: This study investigated the immunological consequences of improper placenta development in early-onset preeclampsia. The results showed that early-onset preeclampsia affects maternal immunotolerance against the fetus and alters the Th1 predominance developed by the mother's immune system. Significant differences were also found in the expression patterns of immune checkpoint receptors and ligands between early-onset preeclamptic and healthy pregnant women.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Waleed Aljabr, Ahod Al-Amari, Basma Abbas, Alaa Karkashan, Saad Alamri, Mohammed Alnamnakani, Athba Al-Qahtani
Summary: This study investigated the immune response during different stages of SARS-CoV-2 infection, finding lymphopenia in moderate and under-medication patients and increased levels of IgM and IgG antibodies. The findings suggest the importance of cellular immunity and humoral-mediated immunity in controlling SARS-CoV-2 infection.
MICROBIOLOGY SPECTRUM
(2022)
Article
Pharmacology & Pharmacy
Keith M. Olson, Andrea L. Devereaux, Payal Chatterjee, Savanah L. Saldana-Shumaker, Amanda Shafer, Adam Plotkin, Ram Kandasamy, Alexander D. MacKerell, John R. Traynor, Christopher W. Cunningham
Summary: This study investigates the structure-activity relationships of benzylideneoxymorphone analogs in order to develop analgesics with reduced tolerance and side effects. One compound, nitro-BOM (NBOM), showed high-efficacy antinociception but also exhibited tolerance and toxicity upon repeated administration. Despite these issues, NBOM provides an important tool for understanding MOPr/DOPr pharmacology.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biology
Wei Wei, Yanjun Su
Summary: In this study, researchers used single cell sequencing technology to investigate T cells in non-small-cell lung cancer patients, identifying specific genes related to immune cell function and inferring the function of three types of T cells. The application of this technology helps to understand the mechanism of lung cancer occurrence and development, discover new diagnostic markers and therapeutic targets, and provide a theoretical reference for precise treatment of lung cancer patients in the future.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Pharmacology & Pharmacy
M. Carmen Ruiz-Cantero, Elsa Cortes-Montero, Aakanksha Jain, Angeles Montilla-Garcia, Inmaculada Bravo-Caparros, Jaehoon Shim, Pilar Sanchez-Blazquez, Clifford J. Woolf, Jose M. Baeyens, Enrique J. Cobos
Summary: The sigma-1 receptor interacts with TRPV1 and the μ-opioid receptor, and antagonizing sigma-1 receptor can reduce PGE2- and NGF-induced hyperalgesia by increasing the activity of the μ-opioid receptor. This mechanism is not effective against GDNF-induced hyperalgesia. The sigma-1 antagonism transfers the sigma-1 receptor from TRPV1 to μ-opioid receptor and harnesses endogenous opioids produced by TRPV1+ neurons to reduce hyperalgesia.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Plant Sciences
Md Jahangir Alam, Mohammad Amjad Hossain, Kiran D. Bhilare, Chang-Won Kang, Jong-Hoon Kim
Summary: In this study, the researchers investigated the potential of KRG treatment to improve immune activity parameters such as cytotoxicity, populations of CD4+ CD8+T cells, CD3-CD172-CD8+ NK cells, CD172+ monocytes, and natural cytotoxicity receptors like Nkp46, Nkp44, Nkp30. The results showed that KRG significantly increased these immune activities, indicating its distinct immune-enhancing effects on T cells and NK cells in pigs.
JOURNAL OF GINSENG RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Valeria Catalani, Michelle Botha, John Martin Corkery, Amira Guirguis, Alessandro Vento, Fabrizio Schifano
Summary: This study used computational studies to evaluate the binding affinity of 101 designer benzodiazepines on opioid receptors. The results suggest that some of the benzodiazepines may have the potential to activate opioid receptors, which could enhance their effects and worsen side effects associated with opioid use.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Review
Biochemistry & Molecular Biology
Tao Che, Bryan L. Roth
Summary: This article explores the molecular basis of opioid receptor signaling, including the binding of opioids to receptors and the molecular determinants of signaling pathways. Additionally, the synergy between computational biology and medicinal chemistry is mentioned as a means to expedite the discovery of more effective and safer opioid compounds.
Article
Agriculture, Dairy & Animal Science
Sangwook Kim, Byeonghwi Lim, Sameer-ul-Salam Mattoo, Eun-Young Oh, Chang-Gi Jeong, Won-Il Kim, Kyung-Tai Lee, Sang-Myeong Lee, Jun-Mo Kim
Summary: This study comprehensively investigated the functional mechanisms of CD8(+/-) porcine gamma delta T cells related to the immune system using RNA-sequencing technology. The upregulated DEGs were enriched in cytokine-cytokine receptor interaction and TCR signaling pathway, while the downregulated DEGs were enriched in B cell receptor signaling pathway, suggesting potential immune regulatory roles for these genes. The identified genes, such as chemokine-related and IFNG, in the pathways may play a crucial role in immune signaling inter-regulation.
Article
Chemistry, Medicinal
Maree T. Smith, Dehui Kong, Andy Kuo, Mohammad Z. Imam, Craig M. Williams
Summary: The opioid crisis has increased the demand for novel opioid analgesics that have superior profiles compared to morphine. This Perspective reviews and discusses the multitargeted opioid ligand strategy for discovering such analgesics. Dual-targeted mu-opioid/delta-opioid (MOP/DOP) ligands with strong DOP antagonist potency and without DOP or kappa-opioid (KOP) agonist activity are promising candidates. Dual-targeted MOP/NOP partial agonists also show potential. The pharmacologic template of cebranopadol, a full agonist at MOP, DOP, and NOP receptors, and a partial agonist at KOP receptor, should be avoided due to its poor therapeutic indices.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Immunology
Livia Silva Araujo Passos, Carolina Cattoni Koh, Luisa Mourao Dias Magalhaes, Maria do Carmo Pereira Nunes, Kenneth John Gollob, Walderez Ornelas Dutra
Summary: DN T cells play a critical role in the cytokine network associated with Chagas heart disease, with IND patients displaying more central memory cells and CARD patients having more effector memory cells. Central memory DN T cells in IND patients show a balanced cytokine profile, while effector memory DN T cells in CARD patients do not. Targeting the activation of effector memory DN T cells may be a potential strategy to control inflammation in Chagas cardiomyopathy and other inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medical Laboratory Technology
Ben-Abdallah Rym, Kalboussi Yasmine, Bellali Hedia, Issaoui Nesrine, Souissi Olfa, Maatoug Rania, Aoun Karim, Bouratbine Aida
Summary: The Toxoplasma ICT IgG-IgM(R) rapid diagnostic test has shown high sensitivity in detecting specific anti-Toxoplasma IgG and IgM, making it a useful first or second-line serological test for pregnant women.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Cell Biology
Zhixin Cyrillus Tan, Anja Lux, Markus Biburger, Prabha Varghese, Stephen Lees, Falk Nimmerjahn, Aaron S. Meyer
Summary: In this study, the binding of mixed Fc immune complexes to receptors was measured and found to match a mechanistic model, providing refined estimates of the affinities of Fc variants. Additionally, the model was shown to predict effector cell-elicited platelet depletion in humanized mice. Overall, this work demonstrates a quantitative framework for modeling mixed IgG Fc-effector cell regulation.
Article
Neurosciences
Josue Jaramillo-Polanco, Cintya Lopez-Lopez, Yang Yu, Emma Neary, Alan Hegron, Meritxell Canals, Nigel W. Bunnett, David E. Reed, Alan E. Lomax, Stephen J. Vanner
Summary: This study found that chronic high-dose opioid exposure leads to opioid-induced hyperalgesia (OIH) in the gastrointestinal tract, which is mediated by DOPr signaling and dependent on receptor endocytosis and protein kinase C signaling.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Immunology
Zhiheng Wu, Yu Zheng, Jin Sheng, Yicheng Han, Yanyan Yang, Hongming Pan, Junlin Yao
Summary: This article comprehensively reviews the origin, distribution, and functions of DN T cells, focusing on their roles in inflammation, immune disorders, and cancer. It also discusses the recent advances in DN T cell-based therapy for cancer treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
