Article
Surgery
Hazel L. Marecki, Eric J. Finnesgard, Sri Nuvvula, Tammy T. Nguyen, Laura T. Boitano, Douglas W. Jones, Andres Schanzer, Jessica P. Simons
Summary: This study investigated the incidence and complexity of type II endoleaks after F/B-EVAR. The results showed that nearly half of the patients experienced endoleaks, with the majority being type II and nearly a fifth associated with sac expansion. Treatment of type II endoleaks often led to increased complexity, with the presence of significant type I or III endoleaks. Further research is needed to determine the treatment goal for complex aneurysm repair and the management of type II endoleaks.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Surgery
Randall R. Demartino, Matthew D. Breite, Dan Neal, Bernardo C. Mendes, Jill J. Colglazier, David H. Stone, Salvatore T. Scali
Summary: Type II endoleaks are common after EVAR and do not have an impact on long-term mortality. Reinterventions for Type II endoleaks do not improve overall survival for patients with these endoleaks.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Medicine, General & Internal
Roy Zuidema, Anna C. M. Geraedts, Willemina van Veldhuizen, Sana Mulay, Jean-Paul P. M. de Vries, Richte C. L. Schuurmann, Ron Balm
Summary: This study investigated the evolution of the shortest apposition length (SAL) post-EVAR and found that a declining SAL during follow-up may be an indicator for the development of late type 1a endoleaks (T1aELs). It is important to include apposition analysis during follow-up as SAL < 10mm is an indicator for T1aEL.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Anna-Leonie Menges, Lorenz Meuli, Philip Dueppers, Kerstin Stoklasa, Reinhard Kopp, Benedikt Reutersberg, Alexander Zimmermann
Summary: This study retrospectively analyzed the significance of type II endoleaks (T2ELs) after endovascular aortic repair (rEVAR). The results showed that T2ELs had a benign course in most cases, but the possibility of persistent bleeding should be considered in the short term. Regular follow-up is necessary to detect late complications after EVAR and prevent secondary rupture and death.
JOURNAL OF ENDOVASCULAR THERAPY
(2023)
Article
Surgery
Toru Ide, Kazuo Shimamura, Takayuki Shijo, Toru Kuratani, Ryoto Sakaniwa, Shigeru Miyagawa
Summary: This study investigated the impact of the number of patent lumbar arteries (LAs) on sac enlargement after endovascular aneurysm repair (EVAR). The results showed that when the inferior mesenteric artery (IMA) was patent pre-operatively, a high number of patent LAs significantly promoted sac enlargement with type II endoleak (T2EL). However, when the IMA was occluded pre-operatively, a high number of patent LAs had limited influence on sac enlargement.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Review
Surgery
Petroula Nana, Konstantinos Spanos, Franziska Heidemann, Giuseppe Panuccio, George Kouvelos, Fiona Rohlffs, Athanasios Giannoukas, Tilo Koelbel
Summary: Transcaval embolization for the treatment of type II endoleak shows high technical success rate and low mortality in the early and mid-term period. The persistence rate of type II endoleak is low during the available 12-month follow-up.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Yoshimasa Seike, Hitoshi Matsuda, Hideyuki Shimizu, Shin Ishimaru, Katsuyuki Hoshina, Nobuaki Michihata, Hideo Yasunaga, Kimihiro Komori
Summary: This study based on the Japanese Committee for Stentgraft Management registry reveals a correlation between persistent type II endoleak (p-T2EL) and late adverse events, including aneurysm sac enlargement, reintervention, rupture, and abdominal aortic aneurysm-related mortality following endovascular aneurysm repair. Apart from p-T2EL, older age, female sex, chronic kidney disease, and dilated proximal neck were associated with sac enlargement.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ge Hu, Ning Ding, Zhiwei Wang, Zhengyu Jin
Summary: This study explores the feasibility of using unenhanced CT images for endoleak detection in AAA after EVAR. The results show that unenhanced CT has high sensitivity and specificity and can help detect endoleaks in AAA. This is of great importance for patients who cannot use contrast media.
EUROPEAN RADIOLOGY
(2023)
Article
Surgery
Aurelien Hostalrich, Thomas Mesnard, Raphael Soler, Paul Girardet, Adrien Kaladji, Elixene Jean Baptiste, Serguei Malikov, Thierry Reix, Jean-Baptiste Ricco, Xavier Chaufour
Summary: The study evaluated the effectiveness of fenestrated/branched EVAR (F/BEVAR) in treating failed EVAR with type Ia endoleak, showing a technical success rate of 94%. However, some patients still required secondary endovascular and open surgical procedures, with a low rate of post-operative complications.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2021)
Article
Surgery
Tanya R. Flohr, Rachael Snow, Faisal Aziz
Summary: Late endoleaks were more common in patients treated with anticoagulation after EVAR. No difference in late endoleak frequency was detected between anticoagulation with warfarin and novel oral anticoagulants. Patients on anticoagulation and those with an index endoleak were at a higher risk of having a late endoleak.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Surgery
Shinichi Iwakoshi, Yukihisa Ogawa, Michael D. Dake, Yusuke Ono, Hiroki Higashihara, Akira Ikoma, Motoki Nakai, Takanori Taniguchi, Takahiro Ogi, Hiroshi Kawada, Akio Tamura, Yoshirou Ieko, Ryoichi Tanaka, Etsuji Sohgawa, Satoru Nagatomi, Reiko Woodhams, Osamu Ikeda, Kensaku Mori, Hiroshi Nishimaki, Jun Koizumi, Terutoshi Senokuchi, Makiyo Hagihara, Masashi Shimohira, Shohei Takasugi, Akira Imaizumi, Wataru Higashiura, Shoji Sakaguchi, Shigeo Ichihashi, Takeshi Inoue, Takashi Inoue, Kimihiko Kichikawa
Summary: This study aimed to investigate the mid-term outcomes of embolization procedures for type II endoleak after endovascular abdominal aortic repair and identify the risk factors for aneurysm enlargement. The results showed that embolization procedures were generally ineffective in preventing further expansion of abdominal aortic aneurysms in patients with type II endoleaks, especially in those with a large abdominal aortic aneurysm and/or a presence of a Moyamoya endoleak.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Surgery
Stefano Gennai, Francesco Andreoli, Nicola Leone, Luigi Alberto Maria Bartolotti, Gianmarco Maleti, Roberto Silingardi
Summary: This study assessed the incidence, outcomes, and risk factors of type III endoleaks (TIIIEL) after endovascular aneurysm repair (EVAR) for abdominal aortic aneurysms (AAAs). TIIIEL had a significant impact on patient survival, and the risk factors included old endografts, non-proprietary extensions, large AAAs, and angulated and calcified necks.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Article
Surgery
Matthew Major, Graham W. Long, Christine L. Eden, Diane M. Studzinski, Rose E. Callahan, O. William Brown
Summary: This study evaluated the incidence and long-term outcomes of postoperative Type 1a endoleak (PT1a) following endovascular aortic aneurysm repair (EVAR). The study found that PT1a incidence was 8.2% with an average onset time of 52 months. Patients who developed PT1a were more likely to be female and had higher mortality rates. Patients with successful intervention for PT1a showed no significant difference in median survival.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Surgery
Xin Li, Pengcheng Guo, Lunchang Wang, Quanming Li, Lei Zhang, Jian Qiu, Hao He, Jiehua Li, Chenzi Yang, Chang Shu
Summary: This study aimed to assess the efficacy of different treatment strategies for endoleak. Data from 30 patients who underwent endovascular abdominal aortic aneurysm repair (EVAR) and developed endoleak were analyzed. The results indicated that endoleak is the most frequent complication that impacts survival and re-intervention rates.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Surgery
Franziska Heidemann, Fiona Rohlffs, Nikolaos Tsilimparis, Kostantinos Spanos, Christian-Alexander Behrendt, Ahmed Eleshra, Giuseppe Panuccio, E. Sebastian Debus, Tilo Kolbel
Summary: The study showed that TCE is a viable treatment option for type II endoleak with aneurysm sac enlargement after EVAR for infrarenal abdominal aortic aneurysms and F/BEVAR for juxtarenal and type IV thoracoabdominal aortic aneurysms.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Genetics & Heredity
George Hindy, Peter Dornbos, Mark D. Chaffin, Dajiang J. Liu, Minxian Wang, Margaret Sunitha Selvaraj, David Zhang, Joseph Park, Carlos A. Aguilar-Salinas, Lucinda Antonacci-Fulton, Diego Ardissino, Donna K. Arnett, Stella Aslibekyan, Gil Atzmon, Christie M. Ballantyne, Francisco Barajas-Olmos, Nir Barzilai, Lewis C. Becker, Lawrence F. Bielak, Joshua C. Bis, John Blangero, Eric Boerwinkle, Lori L. Bonnycastle, Erwin Bottinger, Donald W. Bowden, Matthew J. Bown, Jennifer A. Brody, Jai G. Broome, Noel P. Burtt, Brian E. Cade, Federico Centeno-Cruz, Edmund Chan, Yi-Cheng Chang, Yii-Der I. Chen, Ching-Yu Cheng, Won Jung Choi, Rajiv Chowdhury, Cecilia Contreras-Cubas, Emilio J. Cordova, Adolfo Correa, L. Adrienne Cupples, Joanne E. Curran, John Danesh, Paul S. de Vries, Ralph A. DeFronzo, Harsha Doddapaneni, Ravindranath Duggirala, Susan K. Dutcher, Patrick T. Ellinor, Leslie S. Emery, Jose C. Florez, Myriam Fornage, Barry I. Freedman, Valentin Fuster, Ma. Eugenia Garay-Sevilla, Humberto Garcia-Ortiz, Soren Germer, Richard A. Gibbs, Christian Gieger, Benjamin Glaser, Clicerio Gonzalez, Maria Elena Gonzalez-Villalpando, Mariaelisa Graff, Sarah E. Graham, Niels Grarup, Leif C. Groop, Xiuqing Guo, Namrata Gupta, Sohee Han, Craig L. Hanis, Torben Hansen, Jiang He, Nancy L. Heard-Costa, Yi-Jen Hung, Mi Yeong Hwang, Marguerite R. Irvin, Sergio Islas-Andrade, Gail P. Jarvik, Hyun Min Kang, Sharon L. R. Kardia, Tanika Kelly, Eimear E. Kenny, Alyna T. Khan, Bong-Jo Kim, Ryan W. Kim, Young Jin Kim, Heikki A. Koistinen, Charles Kooperberg, Johanna Kuusisto, Soo Heon Kwak, Markku Laakso, Leslie A. Lange, Jiwon Lee, Juyoung Lee, Seonwook Lee, Donna M. Lehman, Rozenn N. Lemaitre, Allan Linneberg, Jianjun Liu, Ruth J. F. Loos, Steven A. Lubitz, Valeriya Lyssenko, Ronald C. W. Ma, Lisa Warsinger Martin, Angelica Martinez-Hernandez, Rasika A. Mathias, Stephen T. McGarvey, Ruth McPherson, James B. Meigs, Thomas Meitinger, Olle Melander, Elvia Mendoza-Caamal, Ginger A. Metcalf, Xuenan Mi, Karen L. Mohlke, May E. Montasser, Jee-Young Moon, Hortensia Moreno-Macias, Alanna C. Morrison, Donna M. Muzny, Sarah C. Nelson, Peter M. Nilsson, Jeffrey R. O'Connell, Marju Orho-Melander, Lorena Orozco, Colin N. A. Palmer, Nicholette D. Palmer, Cheol Joo Park, Kyong Soo Park, Oluf Pedersen, Juan M. Peralta, Patricia A. Peyser, Wendy S. Post, Michael Preuss, Bruce M. Psatsy, Qibin Qi, D. C. Rao, Susan Redline, Alexander P. Reiner, Cristina Revilla-Monsalve, Stephen S. Rich, Nilesh Samani, Heribert Schunkert, Claudia Schurmann, Daekwan Seo, Jeong-Sun Seo, Xueling Sim, Rob Sladek, Kerrin S. Small, Wing Yee So, Adrienne M. Stilp, E. Shyong Tai, Claudia H. T. Tam, Kent D. Taylor, Yik Ying Teo, Farook Thameem, Brian Tomlinson, Michael Y. Tsai, Tiinamaij Tuomi, Jaakko Tuomilehto, Teresa Tusie-Luna, Miriam S. Udler, Rob M. van Dam, Ramachandran S. Vasan, Karine A. Viaud Martinez, Fei Fei Wang, Xuzhi Wang, Hugh Watkins, Daniel E. Weeks, James G. Wilson, Daniel R. Witte, Tien-Yin Wong, Lisa R. Yanek, Sekar Kathiresan, Daniel J. Rader, Jerome I. Rotter, Michael Boehnke, Mark I. McCarthy, Cristen J. Willer, Pradeep Natarajan, Jason A. Flannick, Amit V. Khera, Gina M. Peloso
Summary: Large-scale gene sequencing studies have the potential to identify causal genes for therapeutic purposes. This study identified gene associations with blood lipid levels using rare coding variants and found new genes not previously associated with lipid levels. The findings suggest the utility of gene-based associations for drug development and indicate that the gene closest to the array-based GWAS index SNP is often the functional gene for blood lipid levels.
AMERICAN JOURNAL OF HUMAN GENETICS
(2022)
Article
Surgery
Lakmini Liyanage, Liam Musto, Charley Budgeon, Guy Rutty, Mike Biggs, Athanasios Saratzis, David A. Vorp, Vasileios Vavourakis, Matthew Bown, Alkiviadis Tsamis
Summary: The study assessed the proportion of collagen and elastin in the arterial wall and evaluated the collagen microstructure. The results showed that the aorta and iliac arteries are structurally non-uniform, with variations in the percentages of collagen and elastin and differences in collagen fiber diameter in different regions.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2022)
Article
Surgery
Dylan R. Morris, Gregory T. Jones, Michael Holmes, Matthew J. Bown, Richard Bulbulia, Tejas P. Singh, Jonathan Golledge
Summary: This study used Mendelian randomisation to investigate the causal association between type II diabetes predisposition and abdominal aortic aneurysm (AAA). The results showed no direct association between the two.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2022)
Review
Genetics & Heredity
Sanna Gudmundsson, Moriel Singer-Berk, Nicholas A. Watts, William Phu, Julia K. Goodrich, Matthew Solomonson, Heidi L. Rehm, Daniel G. MacArthur, Anne O'Donnell-Luria
Summary: Reference population databases are crucial for variant and gene interpretation, aiding in identifying pathogenic variants and discovering new disease-gene relationships. The Genome Aggregation Database is currently the largest and most widely utilized collection of population variation, accessible through the gnomAD browser for rapid and intuitive variant analysis.
Article
Biology
Susan Martin, Jessica Tyrrell, E. Louise Thomas, Matthew J. Bown, Andrew R. Wood, Robin N. Beaumont, Lam C. Tsoi, Philip E. Stuart, James T. Elder, Philip Law, Richard Houlston, Christopher Kabrhel, Nikos Papadimitriou, Marc J. Gunter, Caroline J. Bull, Joshua A. Bell, Emma E. Vincent, Naveed Sattar, Malcolm G. Dunlop, Ian P. M. Tomlinson, Jimmy D. Bell, Timothy M. Frayling, Hanieh Yaghootkar
Summary: This study used Mendelian randomisation (MR) and specific genetic variants to test the causal roles of higher adiposity with and without its adverse metabolic effects on diseases. The results identified diseases where the metabolic effect of higher adiposity is the primary cause, as well as diseases where the non-metabolic effects of excess weight are likely a cause.
Article
Health Care Sciences & Services
Maria Zubair, Matthew J. Bown, Natalie Armstrong
Summary: Cardiovascular diseases have a significant impact on health in the UK, particularly in terms of mortality. Peripheral arterial disease and high blood pressure are markers of high cardiovascular disease risk, but are currently underdiagnosed and undertreated. The National Health Service abdominal aortic aneurysm screening programme offers an opportunity to screen for these conditions with minimal additional effort or cost. However, staff concerns about practicalities and resource availability need to be considered when introducing additional screening.
BMC HEALTH SERVICES RESEARCH
(2022)
Correction
Biology
Susan Martin, Jessica Tyrrell, E. Louise Thomas, Matthew J. Bown, Andrew R. Wood, Robin N. Beaumont, Lam C. Tsoi, Philip E. Stuart, James T. Elder, Philip Law, Richard Houlston, Christopher Kabrhel, Nikos Papadimitriou, Marc Gunter, Caroline Bull, Joshua A. Bell, Emma E. Vincent, Naveed Sattar, Malcolm G. Dunlop, Ian P. M. Tomlinson, Sara Lindstrom, Jimmy D. Bell, Timothy Frayling, Hanieh Yaghootkar
Correction
Health Care Sciences & Services
Maria Zubair, Matthew J. Bown, Natalie Armstrong
BMC HEALTH SERVICES RESEARCH
(2022)
Review
Surgery
Nadia El -Diaz, Abigail Walker-Jacobs, Ahmad Althaher, Zahra Alalwani, Joseph Borucki, Philip W. Stather
Summary: Despite ongoing challenges in managing aortic graft infection, the use of Omniflow II biosynthetic grafts for aortic reconstruction has shown promise with acceptable mortality and low reinfection rates.
JOURNAL OF VASCULAR SURGERY
(2023)
Editorial Material
Surgery
Enrico Mancuso, Philip W. Stather
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Article
Surgery
Roshan Bootun, Mandy Burrows, Mohammed M. Chowdhury, Philip W. Stather, Wissam Al-Jundi
Summary: This study investigates the impact of delaying varicose veins surgery during the COVID-19 pandemic. The results show that the delay causes major and minor harm to patients, as well as a significant detriment to their quality of life.
Article
Surgery
Enrico Mancuso, Roshan Bootun, Philip W. Stather, Michael Crawford, Michael Delbridge, Mohammad Tariq Ali, Wissam Al-Jundi
Summary: The purpose of this study is to identify preoperative and intraoperative predictors of visceral stent failure in fenestrated endovascular aortic repair (FEVAR). Through retrospective analysis of 75 FEVAR surgeries, it was found that smaller diameter and shorter length of the visceral stent are important predictors of failure.
JOURNAL OF ENDOVASCULAR THERAPY
(2023)
Article
Medicine, General & Internal
Pavithira Sivagangan, Amy E. Harwood, Philip W. Stather
Summary: This study aimed to evaluate patient, public, and healthcare professional priorities regarding a dedicated mobile phone application for remote SET delivery. The majority of patients were interested in monitoring their therapy and measuring walking distances, as well as watching exercise videos. Healthcare professionals prioritized a communication platform, recording other forms of physical activity, and using wearable technology. The ability to interact with other users was not prioritized by either group.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Surgery
Ruth A. Benson
Summary: This study documented the recovery of vascular services in Europe following the first peak of the COVID-19 pandemic. The results showed that many vascular services were still affected by the pandemic, such as aneurysm screening and carotid surgery. Some centers implemented protocols to manage COVID-19 risk. Backlogs in cases were reported for all major vascular surgeries.
EJVES VASCULAR FORUM
(2022)
Meeting Abstract
Surgery
S. Kulkarni, P. Stather, M. Chowdhury
BRITISH JOURNAL OF SURGERY
(2022)