Rare coding variants in 35 genes associate with circulating lipid levels—A multi-ancestry analysis of 170,000 exomes
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Title
Rare coding variants in 35 genes associate with circulating lipid levels—A multi-ancestry analysis of 170,000 exomes
Authors
Keywords
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Journal
AMERICAN JOURNAL OF HUMAN GENETICS
Volume 109, Issue 1, Pages 81-96
Publisher
Elsevier BV
Online
2021-12-20
DOI
10.1016/j.ajhg.2021.11.021
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Related references
Note: Only part of the references are listed.- Advancing human genetics research and drug discovery through exome sequencing of the UK Biobank
- (2021) Joseph D. Szustakowski et al. NATURE GENETICS
- Thousands of missing variants in the UK Biobank are recoverable by genome realignment
- (2020) Tongqiu Jia et al. ANNALS OF HUMAN GENETICS
- The mutational constraint spectrum quantified from variation in 141,456 humans
- (2020) Konrad J. Karczewski et al. NATURE
- Loss-of-Function CREB3L3 Variants in Patients With Severe Hypertriglyceridemia
- (2020) Jacqueline S. Dron et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Exome sequencing and characterization of 49,960 individuals in the UK Biobank
- (2020) Cristopher V. Van Hout et al. NATURE
- Heterozygous ABCG5 Gene Deficiency and Risk of Coronary Artery Disease
- (2020) Akihiro Nomura et al. Circulation-Genomic and Precision Medicine
- Predicting Splicing from Primary Sequence with Deep Learning
- (2019) Kishore Jaganathan et al. CELL
- Impaired LXRα Phosphorylation Attenuates Progression of Fatty Liver Disease
- (2019) Natalia Becares et al. Cell Reports
- Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls
- (2019) Jason Flannick et al. NATURE
- Genetic analyses of diverse populations improves discovery for complex traits
- (2019) Genevieve L. Wojcik et al. NATURE
- Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits
- (2019) Eleonora Porcu et al. Nature Communications
- Rare Protein-Truncating Variants in APOB , Lower Low-Density Lipoprotein Cholesterol, and Protection Against Coronary Heart Disease
- (2019) Gina M. Peloso et al. Circulation-Genomic and Precision Medicine
- Role of Blood Lipids in the Development of Ischemic Stroke and its Subtypes
- (2018) George Hindy et al. STROKE
- Perilipin 1 Mediates Lipid Metabolism Homeostasis and Inhibits Inflammatory Cytokine Synthesis in Bovine Adipocytes
- (2018) Shiqi Zhang et al. Frontiers in Immunology
- Deep-coverage whole genome sequences and blood lipids among 16,324 individuals
- (2018) Pradeep Natarajan et al. Nature Communications
- Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program
- (2018) Derek Klarin et al. NATURE GENETICS
- COSMIC: the Catalogue Of Somatic Mutations In Cancer
- (2018) John G Tate et al. NUCLEIC ACIDS RESEARCH
- Association of Triglyceride-Related Genetic Variants With Mitral Annular Calcification
- (2017) Mehdi Afshar et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Exome-wide association study of plasma lipids in >300,000 individuals
- (2017) Dajiang J Liu et al. NATURE GENETICS
- Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease
- (2017) Marc S. Sabatine et al. NEW ENGLAND JOURNAL OF MEDICINE
- Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease
- (2017) Frederick E. Dewey et al. NEW ENGLAND JOURNAL OF MEDICINE
- DrugBank 5.0: a major update to the DrugBank database for 2018
- (2017) David S Wishart et al. NUCLEIC ACIDS RESEARCH
- Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease
- (2017) Pim van der Harst et al. CIRCULATION RESEARCH
- RVTESTS: an efficient and comprehensive tool for rare variant association analysis using sequence data: Table 1.
- (2016) Xiaowei Zhan et al. BIOINFORMATICS
- dbNSFP v3.0: A One-Stop Database of Functional Predictions and Annotations for Human Nonsynonymous and Splice-Site SNVs
- (2016) Xiaoming Liu et al. HUMAN MUTATION
- Liver-Specific Deletion of SRSF2 Caused Acute Liver Failure and Early Death in Mice
- (2016) Yuanming Cheng et al. MOLECULAR AND CELLULAR BIOLOGY
- Weighting sequence variants based on their annotation increases power of whole-genome association studies
- (2016) Gardar Sveinbjornsson et al. NATURE GENETICS
- Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease
- (2016) Frederick E. Dewey et al. NEW ENGLAND JOURNAL OF MEDICINE
- Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study
- (2016) Frederick E. Dewey et al. SCIENCE
- Novel CREB3L3 Nonsense Mutation in a Family With Dominant HypertriglyceridemiaSignificance
- (2015) Angelo B. Cefalù et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Antisense Inhibition of Apolipoprotein C-III in Patients with Hypertriglyceridemia
- (2015) Daniel Gaudet et al. NEW ENGLAND JOURNAL OF MEDICINE
- Comparison and integration of deleteriousness prediction methods for nonsynonymous SNVs in whole exome sequencing studies
- (2015) C. Dong et al. HUMAN MOLECULAR GENETICS
- Perilipin1 Deficiency in Whole Body or Bone Marrow-Derived Cells Attenuates Lesions in Atherosclerosis-Prone Mice
- (2015) Xiaojing Zhao et al. PLoS One
- Association of Low-Frequency and Rare Coding-Sequence Variants with Blood Lipids and Coronary Heart Disease in 56,000 Whites and Blacks
- (2014) Gina M. Peloso et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Secretory phospholipase A2 enzymes as pharmacological targets for treatment of disease
- (2014) Nhat D. Quach et al. BIOCHEMICAL PHARMACOLOGY
- Association of Low-Density Lipoprotein Cholesterol–Related Genetic Variants With Aortic Valve Calcium and Incident Aortic Stenosis
- (2014) J. Gustav Smith et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction
- (2014) Ron Do et al. NATURE
- Liver X receptors in lipid metabolism: opportunities for drug discovery
- (2014) Cynthia Hong et al. NATURE REVIEWS DRUG DISCOVERY
- Loss-of-Function Mutations in APOC3 and Risk of Ischemic Vascular Disease
- (2014) Anders Berg Jørgensen et al. NEW ENGLAND JOURNAL OF MEDICINE
- Loss-of-Function Mutations in APOC3, Triglycerides, and Coronary Disease
- (2014) NEW ENGLAND JOURNAL OF MEDICINE
- Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes
- (2014) A. R. Majithia et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Congenital analbuminaemia: Molecular defects and biochemical and clinical aspects
- (2013) Lorenzo Minchiotti et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Meta-analysis of gene-level tests for rare variant association
- (2013) Dajiang J Liu et al. NATURE GENETICS
- Common variants associated with plasma triglycerides and risk for coronary artery disease
- (2013) Ron Do et al. NATURE GENETICS
- Discovery and refinement of loci associated with lipid levels
- (2013) Cristen J Willer et al. NATURE GENETICS
- Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci
- (2012) Folkert W. Asselbergs et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
- (2012) Benjamin F Voight et al. LANCET
- Rare-Variant Association Testing for Sequencing Data with the Sequence Kernel Association Test
- (2011) Michael C. Wu et al. AMERICAN JOURNAL OF HUMAN GENETICS
- The transcription factor cyclic AMP–responsive element–binding protein H regulates triglyceride metabolism
- (2011) Jung Hoon Lee et al. NATURE MEDICINE
- Perilipin Deficiency and Autosomal Dominant Partial Lipodystrophy
- (2011) Sheetal Gandotra et al. NEW ENGLAND JOURNAL OF MEDICINE
- Role of liver sinusoidal endothelial cells and stabilins in elimination of oxidized low-density lipoproteins
- (2010) Ruomei Li et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Biological, clinical and population relevance of 95 loci for blood lipids
- (2010) Tanya M. Teslovich et al. NATURE
- Exome Sequencing,ANGPTL3Mutations, and Familial Combined Hypolipidemia
- (2010) Kiran Musunuru et al. NEW ENGLAND JOURNAL OF MEDICINE
- Major Lipids, Apolipoproteins, and Risk of Vascular Disease
- (2009) The Emerging Risk Factors Collaboration* JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Liver X receptor in cholesterol metabolism
- (2009) Chunyan Zhao et al. JOURNAL OF ENDOCRINOLOGY
- Perilipin A and the control of triacylglycerol metabolism
- (2009) Dawn L. Brasaemle et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency
- (2009) Kathy Jaworski et al. NATURE MEDICINE
- Forty-Three Loci Associated with Plasma Lipoprotein Size, Concentration, and Cholesterol Content in Genome-Wide Analysis
- (2009) Daniel I. Chasman et al. PLoS Genetics
- Does the association of the triglyceride to high-density lipoprotein cholesterol ratio with fasting serum insulin differ by race/ethnicity?
- (2008) Chaoyang Li et al. Cardiovascular Diabetology
- APCSK9Missense Variant Associated with a Reduced Risk of Early-Onset Myocardial Infarction
- (2008) Sekar Kathiresan NEW ENGLAND JOURNAL OF MEDICINE
- A Null Mutation in Human APOC3 Confers a Favorable Plasma Lipid Profile and Apparent Cardioprotection
- (2008) T. I. Pollin et al. SCIENCE
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