Article
Engineering, Biomedical
Ngoc Ton, Una Goncin, Arash Panahifar, Dean Chapman, Sheldon Wiebe, Steven Machtaler
Summary: The study aimed to evaluate the feasibility of ultrasound microbubbles as a contrast agent for X-ray phase contrast imaging. Results suggest that lipid-MBs larger than 4 µm may be candidates for PCI, and a concentration of 5 x 10(6) MBs/ml could be the lowest suitable concentration for generating visible phase contrast in vivo.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ferdinand Roski, Johannes Hammel, Kai Mei, Bernhard Haller, Thomas Baum, Jan S. Kirschke, Daniela Pfeiffer, Klaus Woertler, Franz Pfeiffer, Peter B. Noel, Alexandra S. Gersing, Benedikt J. Schwaiger
Summary: The study assessed the diagnostic accuracy of iodine-corrected vertebral BMD measurements derived from non-dedicated contrast-enhanced phantomless dual-layer spectral CT examinations. Converted BMD values adjusted for individual vessel iodine concentrations showed a high agreement with non-enhanced DLCT-BMD, suggesting that opportunistic BMD measurements are feasible even in non-dedicated contrast-enhanced DLCT examinations.
EUROPEAN RADIOLOGY
(2021)
Article
Computer Science, Interdisciplinary Applications
A. Aminzadeh, B. D. Arhatari, A. Maksimenko, C. J. Hall, D. Hausermann, A. G. Peele, J. Fox, B. Kumar, Z. Prodanovic, M. Dimmock, D. Lockie, K. M. Pavlov, Y. Nesterets, D. Thompson, S. C. Mayo, D. M. Paganin, S. T. Taba, S. Lewis, P. C. Brennan, H. M. Quiney, T. E. Gureyev
Summary: In this study, a method to improve the detection of microcalcifications in breast tissues using propagation-based phase-contrast X-ray computed tomography was proposed. The results showed that the visibility of microcalcifications in the dark-field images was more than two times higher compared to the bright-field images, and the dark-field images provided more accurate information about the size and shape of the microcalcifications.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2022)
Article
Nanoscience & Nanotechnology
Mohamed F. Attia, Roman Akasov, Nancy M. Elbaz, Tyler C. Owens, Evan C. Curtis, Soham Panda, Ralph Santos-Oliveira, Frank Alexis, Forrest M. Kievit, Daniel C. Whitehead
Summary: We report the synthesis of hybrid iodinated silica-lipid nanoemulsions for ultrasound and X-ray imaging. The nanoemulsions showed excellent biocompatibility and significant contrast-enhancing properties, suggesting their potential as dual-modality clinical agents.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Multidisciplinary Sciences
Hongchang Wang, Kawal Sawhney
Summary: Researchers have successfully generated omnidirectional differential phase images using X-ray differential phase contrast imaging, providing more information for studying complex samples and enabling simultaneous extraction of omnidirectional dark-field images to study ordered scattering structures.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Hongchang Wang, Kawal Sawhney
Summary: This article introduces a method for generating omnidirectional differential phase images by scanning a randomly structured modulator, which provides more information than traditional imaging methods and allows the simultaneous extraction of omnidirectional dark-field images for studying strongly ordered scattering structures.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Todd C. Soesbe, Yin Xi, Khaled Nasr, John R. Leyendecker, Robert E. Lenkinski, Matthew A. Lewis
Summary: The study aimed to develop a dual-energy CT method for differentiating and quantifying high-Z contrast elements, evaluating the limitations based on element concentration and atomic number. Results showed that dual-energy CT can effectively differentiate and quantify high-Z elements with high accuracy. Differentiation between elements was proportional to the isoattenuating HU values.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yukichi Tanahashi, Shinichi Shoda, Hiroshi Kawada, Tomohiro Ando, Shoma Nagata, Masaki Takasu, Fuminori Hyodo, Satoshi Goshima, Takashi Mori, Masayuki Matsuo
Summary: This study evaluated the feasibility and image quality of intranodal dynamic contrast-enhanced CT lymphangiography (DCCTL) and dynamic contrast-enhanced MR lymphangiography (DCMRL) in microminipigs. The results showed that both DCCTL and DCMRL enabled excellent visualization of central lymphatic ducts and lymphatic leakage, indicating the research and clinical potential of both modalities.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jesse Tanguay, Fateen Basharat
Summary: Xenon-enhanced dual-energy tomosynthesis (XeDET) is a new method for functional imaging of respiratory disease, which is low-cost and low-dose compared to MRI and CT. Experimental results showed good imaging quality for the XeDET method in a phantom study, demonstrating its potential as an alternative to MRI-based and CT-based approaches.
Article
Radiology, Nuclear Medicine & Medical Imaging
Josua A. A. Decker, Jim O'Doherty, U. Joseph Schoepf, Thomas M. M. Todoran, Gilberto J. J. Aquino, Verena Brandt, Dhiraj Baruah, Nicola Fink, Emese Zsarnoczay, Thomas Flohr, Bernhard Schmidt, Thomas Allmendinger, Franka Risch, Akos Varga-Szemes, Tilman Emrich
Summary: This study assessed the impact of scan modes and reconstruction kernels using a novel dual-source photon-counting detector CT (PCD-CT) on the lumen visibility and sharpness of different stent sizes. The results showed that the UHR acquisition mode and sharp reconstruction kernels significantly improved the in-stent lumen visibility and sharpness, especially for smaller stent sizes.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Thomas Winther Buus, Finn Rasmussen, Hanne Marie Nellemann, Vibeke Logager, Anders Bonde Jensen, Katrine Rye Hauerslev, Peer Christiansen, Erik Morre Pedersen
Summary: The study compared the diagnostic accuracy of contrast-enhanced CT, dual-layer detector spectral CT (DL-CT), and whole-body MRI (WB-MRI) for detecting metastatic breast cancer. Results showed that DL-CT had significantly higher diagnostic performance and sensitivity per lesion compared to CT and WB-MRI, while on a per-patient basis, DL-CT and WB-MRI had superior diagnostic performance to CT.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Takehito Nota, Ken Kageyama, Akira Yamamoto, Anna Kakehashi, Hiroki Yonezawa, Atsushi Jogo, Etsuji Sohgawa, Kazuki Murai, Satoyuki Ogawa, Yukio Miki
Summary: The safety and feasibility of using a nanoparticulate contrast agent, ExiTron nano 12000, in contrast-enhanced computed tomography (CECT) was evaluated in a rat liver tumor model. The study found that CECT with ExiTron nano 12000 enhanced liver contrast and was well tolerated. Therefore, CECT can be a safe and effective method for measuring liver tumors in rats.
ACADEMIC RADIOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Xieming Xu, Yiheng Wu, Yi Zhang, Xiaohui Li, Fang Wang, Xiaoming Jiang, Shaofan Wu, Shuaihua Wang
Summary: This study reports a 2D (C4H9NH3)(2)PbBr4 single crystal with outstanding sensitivity and stability towards X-ray radiation, providing an ultra-wide detectable X-ray range between 8.20 nGy(air) s(-1) (50 keV) and 15.24 mGy(air) s(-1) (9 MeV). The (C4H9NH3)(2)PbBr4 single crystal detector is used for high-performance X-ray imaging, delivering a good spatial resolution of 4.3 lp mm(-1) in a plane-scan imaging system.
ENERGY & ENVIRONMENTAL MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Ammar Alhasan, Hairul Anuar Tajuddin, S. F. Abdul Sani, Tammar Hussein Ali, Shameer Hisham, Muhammad Haniff Mokti, Ngie Min Ung, Min Phin Ng, Kae Shin Sim
Summary: In this study, silica-Ag:Mn3O4 hybrid nanoparticles were synthesized and conjugated with a commercial iodine contrast agent (Iohexol) for CT contrast enhancement. The results showed that the absorption intensity of the nanoparticles drastically increased, with higher Hounsfield unit (HU) values compared to Iohexol, indicating the efficiency of the hybrid nanoparticles in CT contrast enhancement.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Engineering, Biomedical
Fateen Basharat, Jesse Tanguay
Summary: In this study, the feasibility of two-dimensional xenon-enhanced dual-energy (XeDE) radiography for imaging of lung function was experimentally investigated. The optimized technique showed the potential of detecting functional abnormalities associated with early-stage chronic obstructive pulmonary disease (COPD). This low-cost alternative to MRI-based approaches and low-dose alternative to CT-based approaches may play an important role in COPD diagnosis and management.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Elizabeth M. Higbee-Dempsey, Ahmad Amirshaghaghi, Matthew J. Case, Mathilde Bouche, Johoon Kim, David P. Cormode, Andrew Tsourkas
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Computer Science, Interdisciplinary Applications
Trevor Lewis Vent, Raymond Joseph Acciavatti, Andrew D. A. Maidment
Summary: The FSD metric measures the spatial resolution properties of digital tomosynthesis by evaluating modulation in the frequency domain, providing information on optimal image reconstruction parameters and reducing aliasing artifacts.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2021)
Article
Multidisciplinary Sciences
Yulong Wei, Lesan Yan, Lijun Luo, Tao Gui, Biang Jang, Ahmad Amirshaghaghi, Tianyan You, Andrew Tsourkas, Ling Qin, Zhiliang Cheng
Summary: The study found that the enzyme sPLA(2) increases in OA cartilage tissues, and inhibiting its activity could be an effective treatment strategy. By incorporating an sPLA(2) inhibitor into micelles, it improved drug delivery within the joints and showed promising potential as a therapeutic agent for OA.
Article
Oncology
Abdalla Ibrahim, Turkey Refaee, Sergey Primakov, Bruno Barufaldi, Raymond J. Acciavatti, Renee W. Y. Granzier, Roland Hustinx, Felix M. Mottaghy, Henry C. Woodruff, Joachim E. Wildberger, Philippe Lambin, Andrew D. A. Maidment
Summary: Handcrafted radiomic features (HRFs) are quantitative features extracted from medical images, used for associations with different clinical endpoints. Variations in in-plane resolution and image resampling methods significantly affect the reproducibility of HRFs. Most HRFs are sensitive to differences in in-plane resolution, with image resampling methods showing higher reproducibility compared to ComBat harmonization.
Article
Biochemical Research Methods
Wendy Yu, Kevin P. Gillespie, Bonirath Chhay, Anne-Sophie Svensson, Per-Ake Nygren, Ian A. Blair, Feifan Yu, Andrew Tsourkas
Summary: ADCs have great therapeutic potential, but the heterogeneous nature of conventional drug conjugation strategies can impact their safety, efficacy, and stability. Site-specific conjugation methods can address these issues without the need for genetic modification or glycan modification.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Aimilia Gastounioti, Lauren Pantalone, Christopher G. Scott, Eric A. Cohen, Fang F. Wu, Stacey J. Winham, Matthew R. Jensen, Andrew D. A. Maidment, Celine M. Vachon, Emily F. Conant, Despina Kontos
Summary: This study compared the associations of digital breast tomosynthesis (DBT) and digital mammography (DM) with breast cancer, and found that density estimates from DBT were more strongly associated with breast cancer risk.
Article
Biochemical Research Methods
Linghan Mei, Fabiana Zappala, Andrew Tsourkas
Summary: Bispecific antibodies are capable of binding two antigens simultaneously, leading to unique biological effects. Two methods are introduced for rapid assembly of Bispecific antibodies from any two off-the-shelf IgG antibodies, allowing for low-cost, high-throughput production and validation.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Computer Science, Interdisciplinary Applications
Bruno Barufaldi, Craig K. Abbey, Miguel A. Lago, Trevor L. Vent, Raymond J. Acciavatti, Predrag R. Bakic, Andrew D. A. Maidment
Summary: This study proposed a technique using Perlin noise method to simulate the structure of breast tissue, which can be used in virtual clinical trials for breast imaging. The images simulated using this method showed similar power-law spectra compared to clinical mammograms, and were able to better simulate breast anatomical noise.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2021)
Article
Engineering, Biomedical
Tao Gui, Lijun Luo, Bonirath Chhay, Leilei Zhong, Yulong Wei, Lutian Yao, Wei Yu, Jun Li, Charles L. Nelson, Andrew Tsourkas, Ling Qin, Zhiliang Cheng
Summary: Oxidative stress and reactive oxygen species play important roles in the development and progression of osteoarthritis (OA). This study utilized SOD-loaded nanoparticles to deliver antioxidant enzymes to mouse knee joints, demonstrating the accumulation of nanoparticles in the synovium and reduction of oxidative damage. Intra-articular injections of the nanoparticles were effective in attenuating OA initiation and progression, via reduction of reactive oxygen species production and catabolic protease synthesis.
Article
Medicine, Research & Experimental
Alexander Chan, Hejia Henry Wang, Rebecca M. Haley, Cindy Song, David Gonzalez-Martinez, Lukasz Bugaj, Michael J. Mitchell, Andrew Tsourkas
Summary: This study demonstrates the feasibility of using small protein scaffolds with anionic polypeptides to interact with positively charged nonviral lipid-based delivery systems, enabling efficient intracellular delivery. This method can be used to inhibit intracellular proteins that are currently not amenable to small molecule drugs and biologics.
MOLECULAR PHARMACEUTICS
(2022)
Article
Multidisciplinary Sciences
Fabiana Zappala, Elizabeth Higbee-Dempsey, Bian Jang, Joann Miller, Lesan Yan, Nicholas G. Minutolo, Gabriela T. Rosado Gonzalez, Andrew Tsourkas, Burcin Altun Ozdemir
Summary: Researchers have developed a simple method to attach a T cell-redirecting domain to off-the-shelf human immunoglobulin G (IgG) or native IgG, allowing the generation of T cell-redirecting autoantibodies (TRAAbs) without the need for antibody engineering, cloning, or knowledge of the antibody sequence. These TRAAbs preferentially bind tumor tissue over healthy tissue, indicating a previously unexplored therapeutic window. This approach represents a new paradigm in personalized medicine.
Article
Endocrinology & Metabolism
Tao Gui, Yulong Wei, Lijun Luo, Jun Li, Leilei Zhong, Lutian Yao, Frank Beier, Charles L. Nelson, Andrew Tsourkas, X. Sherry Liu, Motomi Enomoto-Iwamoto, Feifan Yu, Zhiliang Cheng, Ling Qin
Summary: This study demonstrates the importance of EGFR signaling in maintaining articular cartilage during PTOA development and explores the development of novel nanomedicines for PTOA treatment.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Nanoscience & Nanotechnology
Rebecca M. Haley, Alexander Chan, Margaret M. Billingsley, Ningqiang Gong, Marshall S. Padilla, Emily H. Kim, Hejia Wang, Dingzi Yin, Kirk J. Wangensteen, Andrew Tsourkas, Michael J. Mitchell
Summary: This study demonstrates the successful delivery of DARPin protein K27-D30 to the cytosol of liver cancer cells using a lipid nanoparticle platform, inhibiting RAS-driven tumor growth and highlighting the potential of K27 as a new cancer therapeutic.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Ahmad Amirshaghaghi, Wen-Chi Chang, Bonirath Chhay, Ariane R. Bartolomeu, Margie L. Clapper, Zhiliang Cheng, Andrew Tsourkas
Summary: The current standard of care for colon cancer surveillance, white light endoscopy, often misses dysplastic lesions that are not visible to the naked eye. Dye-based chromoendoscopy shows promise but lacks accuracy in differentiating tumor tissues from healthy tissues. This study aimed to improve tumor tissue visualization using various phthalocyanine (PC) dye-loaded micelles administered intravenously. Zinc PC (tetra-tert-butyl)-loaded micelles were identified as the optimal formulation, turning tumors dark blue for easy identification. These micelles were also effective in turning colorectal adenomas in mice a dark blue color, aiding in their detection and removal.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Chemistry, Multidisciplinary
Lenitza M. Nieves, Katherine Mossburg, Jessica C. Hsu, Andrew D. A. Maidment, David P. Cormode
Summary: Silver chalcogenide nanoparticles have attracted significant attention for their excellent performance in both electronics and biomedical applications. Recent advancements have shown their potential in various biomedical fields such as bio-imaging and theranostics. The development of different synthetic approaches has further expanded the applications of silver chalcogenide nanoparticles in biomedicine.