Journal
PULMONARY PHARMACOLOGY & THERAPEUTICS
Volume 26, Issue 1, Pages 121-131Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pupt.2012.06.005
Keywords
Calcium; Ca2+-mobilization; Ca2+-sensitization; CPI-17; Palmitoylation; ROCK
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Contractile G-protein-coupled receptors (GPCRs) have emerged as key regulators of smooth muscle contraction, both under healthy and diseased conditions. This brief review will discuss some key topics and novel insights regarding GPCR-mediated airway and vascular smooth muscle contraction as discussed at the 7th International Young Investigators' Symposium on Smooth Muscle (2011, Winnipeg, Manitoba, Canada) and will in particular focus on processes driving Ca2+-mobilization and -sensitization. (C) 2012 Elsevier Ltd. All rights reserved.
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