Molecular mechanism of allosteric modulation at GPCRs: insight from a binding kinetics study at the human A1adenosine receptor

Drug-Target Residence Time-A Case for G Protein-Coupled Receptors

(2014) Dong Guo et al.   MEDICINAL RESEARCH REVIEWS

Development of M1 mAChR Allosteric and Bitopic Ligands: Prospective Therapeutics for the Treatment of Cognitive Deficits

(2013) Briana J. Davie et al.   ACS Chemical Neuroscience

Exploring avidity: understanding the potential gains in functional affinity and target residence time of bivalent and heterobivalent ligands

(2013) Georges Vauquelin et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Simplified models for heterobivalent ligand binding: when are they applicable and which are the factors that affect their target residence time

(2013) Georges Vauquelin   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

(2013) Adam J. Pawson et al.   NUCLEIC ACIDS RESEARCH

Emerging opportunities for allosteric modulation of G-protein coupled receptors

(2012) Ching-I. Anderson Wang et al.   BIOCHEMICAL PHARMACOLOGY

Functional efficacy of adenosine A2A receptor agonists is positively correlated to their receptor residence time

(2012) Dong Guo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Identification and Quantification of a New Family of Peptide Endocannabinoids (Pepcans) Showing Negative Allosteric Modulation at CB1Receptors

(2012) Mark Bauer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Allosteric modulators of rhodopsin-like G protein-coupled receptors: Opportunities in drug development

(2012) Christa E. Müller et al.   PHARMACOLOGY & THERAPEUTICS

Bridging the gap: bitopic ligands of G-protein-coupled receptors

(2012) J. Robert Lane et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Allosteric Modulation of Seven Transmembrane Spanning Receptors: Theory, Practice, and Opportunities for Central Nervous System Drug Discovery

(2011) Bruce J. Melancon et al.   JOURNAL OF MEDICINAL CHEMISTRY

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors--An Update

(2011) B. B. Fredholm et al.   PHARMACOLOGICAL REVIEWS

Allosteric modulation of adenosine receptors

(2010) Anikó Göblyös et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Binding kinetics and mechanism of action: toward the discovery and development of better and best in class drugs

(2010) Rumin Zhang et al.   Expert Opinion on Drug Discovery

Hybrid Ortho/Allosteric Ligands for the Adenosine A1Receptor

(2010) Rajeshwar Narlawar et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Effect of Allosteric Modulators on the Kinetics of Agonist-G Protein-Coupled Receptor Interactions in Single Living Cells

(2010) L. T. May et al.   MOLECULAR PHARMACOLOGY

Allosteric modulation of G protein-coupled receptors: A pharmacological perspective

(2010) Peter Keov et al.   NEUROPHARMACOLOGY

Synthesis and Biological Evaluation of 2-Amino-3-(4-Chlorobenzoyl)-4-[N-(Substituted) Piperazin-1-yl]Thiophenes as Potent Allosteric Enhancers of the A1Adenosine Receptor

(2008) Romeo Romagnoli et al.   JOURNAL OF MEDICINAL CHEMISTRY