CGRP in the trigeminovascular system: a role for CGRP, adrenomedullin and amylin receptors?

Suppression of adrenomedullin contributes to vascular leakage and altered epithelial repair during asthma

(2012) S. Hagner et al.   ALLERGY

Calcitonin gene-related peptide (CGRP) and its receptor components in human and rat spinal trigeminal nucleus and spinal cord at C1-level

(2012) Sajedeh Eftekhari et al.   BMC NEUROSCIENCE

Targeting a family B GPCR/RAMP receptor complex: CGRP receptor antagonists and migraine

(2012) Eric L Moore et al.   BRITISH JOURNAL OF PHARMACOLOGY

Receptor activity-modifying protein-dependent impairment of calcitonin receptor splice variant Δ(1-47)hCT(a)function

(2012) T Qi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Isolated dorsal root ganglion neurones inhibit receptor-dependent adenylyl cyclase activity in associated glial cells

(2012) KY Ng et al.   BRITISH JOURNAL OF PHARMACOLOGY

Primary trigeminal afferents are the main source for stimulus-induced CGRP release into jugular vein blood and CSF

(2012) Jan Hoffmann et al.   CEPHALALGIA

The expression of calcitonin receptor detected in malignant cells of the brain tumour glioblastoma multiforme and functional properties in the cell line A172

(2012) Peter J Wookey et al.   HISTOPATHOLOGY

Discovery of (5S,6S,9R)-5-Amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate (BMS-927711): An Oral Calcitonin Gene-Related Peptide (CGRP) Antagonist in Clinical Trials for Treating Migraine

(2012) Guanglin Luo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Peripheral Mechanisms of Dental Pain: The Role of Substance P

(2012) Paola Sacerdote et al.   MEDIATORS OF INFLAMMATION

G-protein βγ subunits in vasorelaxing and anti-endothelinergic effects of calcitonin gene-related peptide

(2011) MJPMT Meens et al.   BRITISH JOURNAL OF PHARMACOLOGY

Possible site of action of CGRP antagonists in migraine

(2011) Peer Tfelt-Hansen et al.   CEPHALALGIA

Randomized controlled trial of the CGRP receptor antagonist MK-3207 in the acute treatment of migraine

(2011) David J Hewitt et al.   CEPHALALGIA

Calcitonin gene-related peptide in migraine: intersection of peripheral inflammation and central modulation

(2011) Ann C. Raddant et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Trigeminal satellite cells express functional calcitonin gene-related peptide receptors, whose activation enhances interleukin-1β pro-inflammatory effects

(2011) Alice De Corato et al.   JOURNAL OF NEUROIMMUNOLOGY

Calcitonin Gene-Related Peptide-Mediated Enhancement of Purinergic Neuron/Glia Communication by the Algogenic Factor Bradykinin in Mouse Trigeminal Ganglia from Wild-Type and R192Q Cav2.1 Knock-In Mice: Implications for Basic Mechanisms of Migraine Pain

(2011) S. Ceruti et al.   JOURNAL OF NEUROSCIENCE

Calcitonin Gene-Related Peptide Promotes Cellular Changes in Trigeminal Neurons and Glia Implicated in Peripheral and Central Sensitization

(2011) Ryan J Cady et al.   Molecular Pain

Increased limbic and brainstem activity during migraine attacks following olfactory stimulation

(2011) A. Stankewitz et al.   NEUROLOGY

Emerging migraine treatments and drug targets

(2011) Jes Olesen et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Effect of the calcitonin gene-related peptide (CGRP) receptor antagonist telcagepant in human cranial arteries

(2010) Lars Edvinsson et al.   CEPHALALGIA

Organ culture of the trigeminal ganglion induces enhanced expression of calcitonin gene-related peptide via activation of extracellular signal-regulated protein kinase 1/2

(2010) János Tajti et al.   CEPHALALGIA

BI 44370 TA, an oral CGRP antagonist for the treatment of acute migraine attacks: Results from a phase II study

(2010) Hans-Christoph Diener et al.   CEPHALALGIA

Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with aura

(2010) Jakob Møller Hansen et al.   CEPHALALGIA

Adrenomedullin and calcitonin gene-related peptide receptors in endocrine-related cancers: opportunities and challenges

(2010) D. L. Hay et al.   ENDOCRINE-RELATED CANCER

Lack of Adrenomedullin in the Central Nervous System Results in Apparently Paradoxical Alterations on Pain Sensitivity

(2010) Ana P. Fernández et al.   ENDOCRINOLOGY

Excellent Tolerability But Relatively Low Initial Clinical Efficacy of Telcagepant in Migraine

(2010) Peer Tfelt-Hansen   HEADACHE

β-Arrestin–dependent activation of Ca2+/calmodulin kinase II after β1–adrenergic receptor stimulation

(2010) Supachoke Mangmool et al.   JOURNAL OF CELL BIOLOGY

Pharmacological Properties of MK-3207, a Potent and Orally Active Calcitonin Gene-Related Peptide Receptor Antagonist

(2010) C. A. Salvatore et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

New acute treatments for headache

(2010) Alan M. Rapoport   NEUROLOGICAL SCIENCES

Differential distribution of calcitonin gene-related peptide and its receptor components in the human trigeminal ganglion

(2010) S. Eftekhari et al.   NEUROSCIENCE

Crystal Structure of the Ectodomain Complex of the CGRP Receptor, a Class-B GPCR, Reveals the Site of Drug Antagonism

(2010) Ernst ter Haar et al.   STRUCTURE

Regulation of signal transduction by calcitonin gene-related peptide receptors

(2010) Christopher S Walker et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Possible sites of action of the new calcitonin gene-related peptide receptor antagonists

(2010) Sajedeh Eftekhari et al.   Therapeutic Advances in Neurological Disorders

Non-peptidic antagonists of the CGRP receptor, BIBN4096BS and MK-0974, interact with the calcitonin receptor-like receptor via methionine-42 and RAMP1 via tryptophan-74

(2009) Philip S. Miller et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Calcitonin gene-related peptide receptor antagonist olcegepant acts in the spinal trigeminal nucleus

(2009) Marie-Luise Sixt et al.   BRAIN

ATP-sensitive potassium channels control glioma cells proliferation by regulating ERK activity

(2009) Lianyan Huang et al.   CARCINOGENESIS

Elevated Saliva Calcitonin Gene-Related Peptide Levels During Acute Migraine Predict Therapeutic Response to Rizatriptan

(2009) Roger K. Cady et al.   HEADACHE

Emerging Peripheral Receptor Targets for Deep-tissue Craniofacial Pain Therapies

(2009) R. Ambalavanar et al.   JOURNAL OF DENTAL RESEARCH

CGRP stimulation of iNOS and NO release from trigeminal ganglion glial cells involves mitogen-activated protein kinase pathways

(2009) C. V. Vause et al.   JOURNAL OF NEUROCHEMISTRY

Calcitonin gene-related peptide stimulation of nitric oxide synthesis and release from trigeminal ganglion glial cells

(2008) Jing Li et al.   BRAIN RESEARCH

Calcitonin Gene-Related Peptide Receptor Inhibition Reduces Neuronal Activity Induced by Prolonged Increase in Nitric Oxide in the Rat Spinal Trigeminal Nucleus

(2008) S Kulchitsky et al.   CEPHALALGIA

Mechanisms Mediating the Enhanced Gene Transcription of P2X3Receptor by Calcitonin Gene-related Peptide in Trigeminal Sensory Neurons

(2008) Manuela Simonetti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcitonin receptor-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1), and calcitonin gene-related peptide (CGRP) immunoreactivity in the rat trigeminovascular system: Differences between peripheral and central CGRP receptor distribution

(2008) Jochen K. Lennerz et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Discovery of (R)-4-(8-Fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-carboxamide (BMS-694153): A Potent Antagonist of the Human Calcitonin Gene-Related Peptide Receptor for Migraine with Rapid and Efficient Intranasal Exposure

(2008) Andrew P. Degnan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trial

(2008) Tony W Ho et al.   LANCET

Location, location, location…site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling

(2008) Andrew B. Tobin et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Inhibitory effect of BIBN4096BS, CGRP8-37, a CGRP antibody and an RNA-Spiegelmer on CGRP induced vasodilatation in the perfused and non-perfused rat middle cerebral artery

(2007) L Edvinsson et al.   BRITISH JOURNAL OF PHARMACOLOGY

The GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity

(2007) Yuka Ichikawa-Shindo et al.   JOURNAL OF CLINICAL INVESTIGATION

The effects of C-terminal truncation of receptor activity modifying proteins on the induction of amylin receptor phenotype from human CTb receptors

(2007) Madhara Udawela et al.   REGULATORY PEPTIDES