Mechanisms of rapid opioid receptor desensitization, resensitization and tolerance in brain neurons

Agonist-selective patterns of µ-opioid receptor phosphorylation revealed by phosphosite-specific antibodies

(2011) Christian Doll et al.   BRITISH JOURNAL OF PHARMACOLOGY

Analysis of opioid efficacy, tolerance, addiction and dependence from cell culture to human

(2011) Michael M Morgan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cellular Morphine Tolerance Produced by  Arrestin-2-Dependent Impairment of  -Opioid Receptor Resensitization

(2011) V. C. Dang et al.   JOURNAL OF NEUROSCIENCE

Recovery from  -Opioid Receptor Desensitization after Chronic Treatment with Morphine and Methadone

(2011) N. Quillinan et al.   JOURNAL OF NEUROSCIENCE

How to design an opioid drug that causes reduced tolerance and dependence

(2010) Amy Chang Berger et al.   ANNALS OF NEUROLOGY

Agonist-dependent μ-opioid receptor signaling can lead to heterologous desensitization

(2010) Ji Chu et al.   CELLULAR SIGNALLING

Regulation of opioid receptors by endocytic membrane traffic: Mechanisms and translational implications

(2010) Mark von Zastrow   DRUG AND ALCOHOL DEPENDENCE

Morphine-like Opiates Selectively Antagonize Receptor-Arrestin Interactions

(2010) Paola Molinari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tolerance to the Antinociceptive Effect of Morphine in the Absence of Short-Term Presynaptic Desensitization in Rat Periaqueductal Gray Neurons

(2010) L. W. Fyfe et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

 -Opioid Receptors: Correlation of Agonist Efficacy for Signalling with Ability to Activate Internalization

(2010) J. McPherson et al.   MOLECULAR PHARMACOLOGY

Ligand-directed c-Jun N-terminal kinase activation disrupts opioid receptor signaling

(2010) E. J. Melief et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Involvement of PKCα and G-protein-coupled receptor kinase 2 in agonist-selective desensitization of µ-opioid receptors in mature brain neurons

(2009) CP Bailey et al.   BRITISH JOURNAL OF PHARMACOLOGY

Role of protein kinase C and μ-opioid receptor (MOPr) desensitization in tolerance to morphine in rat locus coeruleus neurons

(2009) C. P. Bailey et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Two Distinct Mechanisms Mediate Acute  -Opioid Receptor Desensitization in Native Neurons

(2009) V. C. Dang et al.   JOURNAL OF NEUROSCIENCE

Buprenorphine Is a Weak Partial Agonist That Inhibits Opioid Receptor Desensitization

(2009) M. S. Virk et al.   JOURNAL OF NEUROSCIENCE

Neurokinin 1 Receptors Regulate Morphine-Induced Endocytosis and Desensitization of  -Opioid Receptors in CNS Neurons

(2009) Y. J. Yu et al.   JOURNAL OF NEUROSCIENCE

Methadone: does it really have low efficacy at μ-opioid receptors?

(2009) Ivan Rodriguez-Martin et al.   NEUROREPORT

Dosing protocol and analgesic efficacy determine opioid tolerance in the mouse

(2009) Priyanka A. Madia et al.   PSYCHOPHARMACOLOGY

Cellular neuroadaptations to chronic opioids: tolerance, withdrawal and addiction

(2008) M J Christie   BRITISH JOURNAL OF PHARMACOLOGY

Morphine-Induced Receptor Endocytosis in a Novel Knockin Mouse Reduces Tolerance and Dependence

(2008) Joseph A. Kim et al.   CURRENT BIOLOGY

Alternative Splicing Determines the Post-endocytic Sorting Fate of G-protein-coupled Receptors

(2008) Michael Tanowitz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Agonist-Specific Regulation of  -Opioid Receptor Desensitization and Recovery from Desensitization

(2008) M. S. Virk et al.   MOLECULAR PHARMACOLOGY

Differential Activation and Trafficking of  -Opioid Receptors in Brain Slices

(2008) S. Arttamangkul et al.   MOLECULAR PHARMACOLOGY

Multiple Actions of Spinophilin Regulate Mu Opioid Receptor Function

(2008) Joanna J. Charlton et al.   NEURON

Agonist-selective signaling is determined by the receptor location within the membrane domains

(2008) H. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C-terminal splice variants of the μ-opioid receptor: existence, distribution and functional characteristics

(2007) Sue Oldfield et al.   JOURNAL OF NEUROCHEMISTRY

Role of receptor internalization in opioid tolerance and dependence

(2007) Thomas Koch et al.   PHARMACOLOGY & THERAPEUTICS