Targeting cannabinoid receptor CB2 in cardiovascular disorders: promises and controversies

Cannabinoid receptor CB2 protects against balloon-induced neointima formation

(2012) Filippo Molica et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Activation of Cannabinoid Receptor 2 Attenuates Leukocyte-Endothelial Cell Interactions and Blood-Brain Barrier Dysfunction under Inflammatory Conditions

(2012) S. H. Ramirez et al.   JOURNAL OF NEUROSCIENCE

Cannabinoid receptor 2 undergoes Rab5-mediated internalization and recycles via a Rab11-dependent pathway

(2011) Natasha L. Grimsey et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A new cannabinoid CB2 receptor agonist HU-910 attenuates oxidative stress, inflammation and cell death associated with hepatic ischaemia/reperfusion injury

(2011) Bėla Horváth et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mechanisms of Osteoclastogenesis Inhibition by a Novel Class of Biphenyl-Type Cannabinoid CB2 Receptor Inverse Agonists

(2011) Wolfgang Schuehly et al.   CHEMISTRY & BIOLOGY

Protective Role of Cannabinoid Receptor Type 2 in a Mouse Model of Diabetic Nephropathy

(2011) F. Barutta et al.   DIABETES

The activation of the cannabinoid receptor type 2 reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques

(2011) Fabrizio Montecucco et al.   EUROPEAN HEART JOURNAL

N-Arachidonoyl-l-Serine is Neuroprotective after Traumatic Brain Injury by Reducing Apoptosis

(2011) Ayelet Cohen-Yeshurun et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Endocannabinoid content in fetal bovine sera — Unexpected effects on mononuclear cells and osteoclastogenesis

(2011) Janine Marazzi et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Atheroprotection via cannabinoid receptor-2 is mediated by circulating and vascular cells in vivo

(2011) Friedrich Felix Hoyer et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Progress and challenges in translating the biology of atherosclerosis

(2011) Peter Libby et al.   NATURE

Cannabinoid Receptor 2 Signaling Does Not Modulate Atherogenesis in Mice

(2011) Florian Willecke et al.   PLoS One

Is lipid signaling through cannabinoid 2 receptors part of a protective system?

(2011) P. Pacher et al.   PROGRESS IN LIPID RESEARCH

Cannabinoid Type 2 Receptor Activation Downregulates Stroke-Induced Classic and Alternative Brain Macrophage/Microglial Activation Concomitant to Neuroprotection

(2011) Juan G. Zarruk et al.   STROKE

Cannabinoid receptor type 2 (CB2) deficiency alters atherosclerotic lesion formation in hyperlipidemic Ldlr-null mice

(2010) Courtney D. Netherland et al.   ATHEROSCLEROSIS

Functionally selective cannabinoid receptor signalling: Therapeutic implications and opportunities

(2010) Barbara Bosier et al.   BIOCHEMICAL PHARMACOLOGY

Cannabinoid CB1 receptor-interacting proteins: novel targets for central nervous system drug discovery?

(2010) Tricia H Smith et al.   BRITISH JOURNAL OF PHARMACOLOGY

WIN55212-2 ameliorates atherosclerosis associated with suppression of pro-inflammatory responses in ApoE-knockout mice

(2010) Yan Zhao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Activation of Cannabinoid CB2 Receptor Ameliorates Atherosclerosis Associated With Suppression of Adhesion Molecules

(2010) Yan Zhao et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

CB1 cannabinoid receptors promote oxidative stress and cell death in murine models of doxorubicin-induced cardiomyopathy and in human cardiomyocytes

(2009) Partha Mukhopadhyay et al.   CARDIOVASCULAR RESEARCH

The cannabinoid receptor type 2 promotes cardiac myocyte and fibroblast survival and protects against ischemia/reperfusion-induced cardiomyopathy

(2009) Nicole Defer et al.   FASEB JOURNAL

Activation of cannabinoid 2 receptors protects against cerebral ischemia by inhibiting neutrophil recruitment

(2009) Sasidhar Murikinati et al.   FASEB JOURNAL

Cannabinoid-2 receptor limits inflammation, oxidative/nitrosative stress, and cell death in nephropathy

(2009) Partha Mukhopadhyay et al.   FREE RADICAL BIOLOGY AND MEDICINE

CB2 cannabinoid receptor activation is cardioprotective in a mouse model of ischemia/reperfusion

(2009) Fabrizio Montecucco et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Substantially altered expression pattern of cannabinoid receptor 2 and activated endocannabinoid system in patients with severe heart failure

(2009) Florian Weis et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Fine-tuning of GPCR activity by receptor-interacting proteins

(2009) Stefanie L. Ritter et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CB2 cannabinoid receptor agonist JWH-015 modulates human monocyte migration through defined intracellular signaling pathways

(2008) Fabrizio Montecucco et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Role of Smooth Muscle Cells in the Initiation and Early Progression of Atherosclerosis

(2008) Amanda C. Doran et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cannabinoid CB 1 Receptor Antagonists for Atherosclerosis and Cardiometabolic Disorders

(2008) Pál Pacher   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Myocardial repair/remodelling following infarction: roles of local factors

(2008) Y. Sun   CARDIOVASCULAR RESEARCH

Role of activated endocannabinoid system in regulation of cellular cholesterol metabolism in macrophages

(2008) L.-s. Jiang et al.   CARDIOVASCULAR RESEARCH

MAPK signalling in cardiovascular health and disease: molecular mechanisms and therapeutic targets

(2008) Anthony J. Muslin   CLINICAL SCIENCE

Cannabinoid (CB2) receptor deficiency reduces the susceptibility of macrophages to oxidized LDL/oxysterol-induced apoptosis

(2008) Natalie E. Freeman-Anderson et al.   JOURNAL OF LIPID RESEARCH

Modulation of the balance between cannabinoid CB1 and CB2 receptor activation during cerebral ischemic/reperfusion injury

(2008) M. Zhang et al.   NEUROSCIENCE

CB2cannabinoid receptor agonists attenuate TNF-α-induced human vascular smooth muscle cell proliferation and migration

(2007) M Rajesh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Endocannabinoids and cannabinoid receptors in ischaemia-reperfusion injury and preconditioning

(2007) P Pacher et al.   BRITISH JOURNAL OF PHARMACOLOGY

CB2receptor-mediated migration of immune cells: it can go either way

(2007) A M Miller et al.   BRITISH JOURNAL OF PHARMACOLOGY

Endogenous cannabinoids contribute to remote ischemic preconditioning via cannabinoid CB2 receptors in the rat heart

(2007) Amir Reza Hajrasouliha et al.   EUROPEAN JOURNAL OF PHARMACOLOGY