The utility of animal models to evaluate novel anti-obesity agents

Combination therapy for obesity and metabolic disease

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Brown fat as a therapy for obesity and diabetes

(2011) Aaron M Cypess et al.   Current Opinion in Endocrinology Diabetes and Obesity

Overfeeding-Induced Obesity in Spontaneously Hypertensive Rats: An Animal Model of the Human Metabolic Syndrome

(2010) Anja Miesel et al.   ANNALS OF NUTRITION AND METABOLISM

Prophylactic use of anti-emetic medications reduced nausea and vomiting associated with exenatide treatment: a retrospective analysis of an open-label, parallel-group, single-dose study in healthy subjects

(2010) C. Ellero et al.   DIABETIC MEDICINE

Mouse models of the metabolic syndrome

(2010) A. J. Kennedy et al.   Disease Models & Mechanisms

The novel triple monoamine reuptake inhibitor tesofensine induces sustained weight loss and improves glycemic control in the diet-induced obese rat: Comparison to sibutramine and rimonabant

(2010) Henrik H. Hansen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Long-term characterization of the diet-induced obese and diet-resistant rat model: a polygenetic rat model mimicking the human obesity syndrome

(2010) Andreas Nygaard Madsen et al.   JOURNAL OF ENDOCRINOLOGY

Involvement of adipokines in rimonabant-mediated insulin sensitivity inob/obmice

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Pharmacological management of appetite expression in obesity

(2010) Jason C. G. Halford et al.   Nature Reviews Endocrinology

Depression-like phenotype following chronic CB1 receptor antagonism

(2010) Chad E. Beyer et al.   NEUROBIOLOGY OF DISEASE

Multicenter, Placebo-Controlled Trial of Lorcaserin for Weight Management

(2010) Steven R. Smith et al.   NEW ENGLAND JOURNAL OF MEDICINE

Diabetes and Obesity: Thrifty Mutants?

(2010) D. L. Coleman   NUTRITION REVIEWS

New approaches to the pharmacological treatment of obesity: Can they break through the efficacy barrier?

(2010) G.A. Kennett et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Behavioural satiety sequence (BSS): Separating wheat from chaff in the behavioural pharmacology of appetite

(2010) R.J. Rodgers et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Quantitative in vitro and in vivo pharmacological profile of CE-178253, a potent and selective cannabinoid type 1 (CB1) Receptor Antagonist

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Leptin: a pivotal regulator of human energy homeostasis

(2009) I Sadaf Farooqi et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Estimating the changes in energy flux that characterize the rise in obesity prevalence

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Regulatory challenges for new drugs to treat obesity and comorbid metabolic disorders

(2009) David J. Heal et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Davalintide (AC2307), a novel amylin-mimetic peptide: enhanced pharmacological properties over native amylin to reduce food intake and body weight

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Enhanced Weight Loss With Pramlintide/Metreleptin: An Integrated Neurohormonal Approach to Obesity Pharmacotherapy

(2009) Eric Ravussin et al.   Obesity

Hypertension and disrupted blood pressure circadian rhythm in Type 2 diabetic db/db mice

(2008) Wen Su et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Sibutramine-induced anorexia: Potent, dose-dependent and behaviourally-selective profile in male rats

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Amylin-Mediated Restoration of Leptin Responsiveness in Diet-Induced Obesity: Magnitude and Mechanisms

(2008) James L. Trevaskis et al.   ENDOCRINOLOGY

Sleep Modulates Hypertension in Leptin-Deficient Obese Mice

(2008) Alessandro Silvani et al.   HYPERTENSION

Lorcaserin, a Novel Selective Human 5-Hydroxytryptamine2C Agonist: in Vitro and in Vivo Pharmacological Characterization

(2008) W. J. Thomsen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Assessment of Diet-induced Obese Rats as an Obesity Model by Comparative Functional Genomics

(2008) Shuyu Li et al.   Obesity

Rational Design of a Combination Medication for the Treatment of Obesity

(2008) Frank L. Greenway et al.   Obesity

Leptin responsiveness restored by amylin agonism in diet-induced obesity: Evidence from nonclinical and clinical studies

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Review Paper: Current Strategies in the Development of Anti-obesity Drugs and Their Safety Concerns

(2008) C. S. Elangbam   VETERINARY PATHOLOGY

Mutations in ligands and receptors of the leptin–melanocortin pathway that lead to obesity

(2008) I Sadaf Farooqi et al.   Nature clinical practice. Endocrinology & metabolism

Discovery and Structure−Activity Relationship of (1R)-8-Chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a Selective Serotonin 5-HT2CReceptor Agonist for the Treatment of Obesity

(2007) Brian M. Smith et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selective 5-HT6 receptor ligands: Progress in the development of a novel pharmacological approach to the treatment of obesity and related metabolic disorders

(2007) D.J. Heal et al.   PHARMACOLOGY & THERAPEUTICS

Chronic 5-HT6 receptor modulation by E-6837 induces hypophagia and sustained weight loss in diet-induced obese rats

(2006) Angels Fisas et al.   BRITISH JOURNAL OF PHARMACOLOGY