Article
Microbiology
Jie Wang, Kun-Te Shang, Qiong-Hong Ma, Zhao-Ying Dong, Yi-Hong Chen, Yu-Feng Yao
Summary: This study aimed to determine whether HSV-1 can be transmitted through TNTs and to investigate the effect of inhibiting the Arp2/3 complex on the intercellular transmission of HSV-1. The results showed that HSV-1 can be transmitted through TNTs and that inhibiting the Arp2/3 complex reduces the number of TNTs and the spread of HSV-1. This finding provides new insights into the transmission mode of HSV-1 and suggests a potential new antiviral target.
Article
Immunology
Mette Ratzer Freytag, Sofie Eg Jorgensen, Michelle Molgaard Thomsen, Ali Al-Mousawi, Alon Schneider Hait, David Olagnier, Jakob T. Bay, Marie Helleberg, Trine H. Mogensen
Summary: This study describes a 19-year-old woman with systemic HSV-1 infection and HLH, as well as a fatal course of neonatal herpesvirus infection postpartum. Investigation showed impaired antiviral responses in the mother's cells, potentially caused by variants in CASP8 or other noncoding regions of the genome.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Microbiology
Ye Liu, Qiao You, Fang Zhang, Deyan Chen, Zhenping Huang, Zhiwei Wu
Summary: Harringtonine (HT) significantly inhibited HSV-1 infection and two ACV-resistant strains by mainly targeting HVEM and reducing the early stage of HSV-1 infection. The study demonstrated that HT could be a promising therapeutic candidate for mitigating HSV-1-induced pathogenesis.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Pu Huang, Xu Wang, Mengyue Lei, Ying Ma, Hongli Chen, Jing Sun, Yunzhang Hu, Jiandong Shi
Summary: This study investigates the metabolic interaction between host cells and HSV-1. By analyzing the metabolic profiles in HSV-1-infected lung fibroblasts, the researchers found that HSV-1 induces metabolic reprogramming in host cells to promote or resist viral replication. They confirmed that the addition of the tryptophan metabolite kynurenine promotes viral replication, while the addition of 25-Hydroxycholesterol inhibits replication. Additionally, HSV-1 replication was enhanced in choline metabolic rate-limiting enzyme-deficient mouse macrophages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Elizabeth B. Draganova, Ekaterina E. Heldwein
Summary: Herpesviruses infect a majority of the human population, establishing lifelong latent infections with no cure, and periodic viral reactivation spreads infection while causing disease states that are particularly harmful in the immunocompromised. The viral replication and spread of infection rely on the nuclear egress complex (NEC), which helps translocate viral capsids and mature them into infectious virions. Peptides derived from the UL25 capsid protein have been shown to inhibit the membrane-budding activity of the NEC, providing a potential new avenue for developing inhibitors against herpesvirus replication.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Ines Ripa, Sabina Andreu, Jose Antonio Lopez-Guerrero, Raquel Bello-Morales
Summary: The article discusses the role of the HSV-1 viral protein ICP34.5 in controlling cellular antiviral responses and debates its controversial functions such as autophagy inhibition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Domenica Donatella Li Puma, Maria Elena Marcocci, Giacomo Lazzarino, Giovanna De Chiara, Barbara Tavazzi, Anna Teresa Palamara, Roberto Piacentini, Claudio Grassi
Summary: Astrocytes release extracellular ATP upon HSV-1 infection, activating P2 receptors on neurons and astrocytes through a GSK-3-dependent pathway, facilitating viral entry and replication. Inhibition of astrocyte metabolism or blockade of P2 receptors or GSK-3 activation can reduce HSV-1 infection in both neurons and astrocytes, highlighting the critical role of astrocytes in regulating neuronal response to microbial stimuli.
Article
Biochemistry & Molecular Biology
Giorgia Napoletani, Virginia Protto, Maria Elena Marcocci, Lucia Nencioni, Anna Teresa Palamara, Giovanna De Chiara
Summary: This study investigated the impact of recurrent HSV-1 infection on neuronal aging, revealing a significant increase in H4K16ac, Sin3, and HDAC1 levels, which are related to aging markers. There was a significant decrease in H3K56ac specifically linked to viral reactivation, and a complex modulation of HIRA expression and localization in HSV-1 infected mouse brains, suggesting a specific role of this protein in viral latency and reactivation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Kevin Danastas, Gerry Guo, Jessica Merjane, Nathan Hong, Ava Larsen, Monica Miranda-Saksena, Anthony L. Cunningham
Summary: This study explores the effects of interferons (IFNs) on herpes simplex virus-1 (HSV-1) and reveals that IFNs have the potential to block virus release from nerve endings, thereby preventing transmission into the skin. The study also highlights the potential wider antiviral effects of IFN-γ in neurons, suggesting its role in HSV-1 reactivation. These findings identify new targets for the development of immunotherapies to impede HSV-1 spread from nerves to the skin.
Review
Biochemistry & Molecular Biology
Matylda Barbara Mielcarska, Katarzyna Skowronska, Zbigniew Wyzewski, Felix Ngosa Toka
Summary: Current data strongly indicate that herpes simplex virus type 1 (HSV-1) infection is a contributing factor to Alzheimer's disease (AD). HSV-1 infection causes damage to neurons and glial cells, as well as modifications in their environment, leading to impaired signal transmission and homeostatic and immune functions. This review discusses the pathological alterations in central nervous system (CNS) cells following HSV-1 infection, including inflammatory responses, oxidative damage, and cellular dysfunctions associated with AD development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Virology
Marianne Graninger, Hannes Vietzen, Elisabeth Puchhammer-Stoeckl
Summary: Herpes simplex virus encephalitis (HSE) is a rare complication of herpes simplex virus type 1 (HSV-1) infection or reactivation. Certain genetic variants associated with the host NK cell response, such as HLA-E*0101 and rs9916629C, are significantly associated with HSE. These genetic variations could potentially be used as clinical markers to predict HSE prognosis and guide personalized treatment.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Gabrielle Pageau, Marianne Levasseur, Teresa Paniconi, Eric Jubinville, Valerie Goulet-Beaulieu, Guy Boivin, Julie Jean
Summary: This study investigated the persistence of HSV-1 on surfaces and in food, suggesting that sharing food with infected carriers may pose certain risks.
JOURNAL OF APPLIED MICROBIOLOGY
(2023)
Article
Immunology
S. M. Shamsul Islam, Hye-Myung Ryu, Hasan M. Sayeed, Seonghyang Sohn
Summary: This study investigated the effects of stress and environmental factors on the induction of Behcet's disease using an HSV-1 infected mouse model. The results showed that environment and stress significantly influenced the incidence of BD, with different stressors affecting immune mechanisms and gut microbiota compositions. The findings suggest that microbial diversity due to environmental differences may explain regional variations in BD incidence.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Noemie Berry, Rodolphe Suspene, Vincent Caval, Pierre Khalfi, Guillaume Beauclair, Stephane Rigaud, Herve Blanc, Marco Vignuzzi, Simon Wain-Hobson, Jean-Pierre Vartanian
Summary: HSV-1 impairs the mitochondrial network and releases mtDNA, leading to the upregulation of type I interferon and APOBEC3A expression. The RNA polymerase III/RIG-I pathway is crucial for interferon production. Released mtDNA causes mutations induced by APOBEC3A, resulting in DNA catabolism.
Review
Infectious Diseases
Noora Kazanji, Andrew Benvenuto, Daniel Rizk
Summary: The goal of this study was to understand the frequency and trend of Herpes Simplex Virus Encephalitis (HSVE) after neurosurgery, with a focus on comparing HSV-1 and HSV-2. Through data collection, it was found that HSVE has a relatively low incidence rate after neurosurgery but is often overlooked, emphasizing the importance of timely diagnosis and treatment.
SURGICAL INFECTIONS
(2023)