Herpes Simplex Virus Type 1 Infection Disturbs the Mitochondrial Network, Leading to Type I Interferon Production through the RNA Polymerase III/RIG-I Pathway

Genotoxic stress increases cytoplasmic mitochondrial DNA editing by human APOBEC3 mutator enzymes at a single cell level

(2019) Bianka Mussil et al.   Scientific Reports

Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis

(2019) Mia Petljak et al.   CELL

A Conserved Mechanism of APOBEC3 Relocalization by Herpesviral Ribonucleotide Reductase Large Subunits

(2019) Adam Z. Cheng et al.   JOURNAL OF VIROLOGY

Human Herpes Simplex Virus-1 depletes APOBEC3A from nuclei

(2019) Jessica A. Stewart et al.   VIROLOGY

Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses

(2019) Miyu Moriyama et al.   Nature Communications

Human herpesvirus type 1 and type 2 disrupt mitochondrial dynamics in human keratinocytes

(2018) Marcin Chodkowski et al.   ARCHIVES OF VIROLOGY

Structure of the Human cGAS–DNA Complex Reveals Enhanced Control of Immune Surveillance

(2018) Wen Zhou et al.   CELL

Substrate sequence selectivity of APOBEC3A implicates intra-DNA interactions

(2018) Tania V. Silvas et al.   Scientific Reports

Mitochondrial DNA depletion induces innate immune dysfunction rescued by IFN-γ

(2017) John D. Widdrington et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Inborn errors in RNA polymerase III underlie severe varicella zoster virus infections

(2017) Benson Ogunjimi et al.   JOURNAL OF CLINICAL INVESTIGATION

Self-cytoplasmic DNA upregulates the mutator enzyme APOBEC3A leading to chromosomal DNA damage

(2017) Rodolphe Suspène et al.   NUCLEIC ACIDS RESEARCH

Dengue Virus Perturbs Mitochondrial Morphodynamics to Dampen Innate Immune Responses

(2016) Laurent Chatel-Chaix et al.   Cell Host & Microbe

APOBEC3DE Antagonizes Hepatitis B Virus Restriction Factors APOBEC3F and APOBEC3G

(2016) Mohamed S. Bouzidi et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B

(2016) Ke Shi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B

(2016) Ke Shi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mitochondrial dynamics and viral infections: A close nexus

(2015) Mohsin Khan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers

(2015) Kin Chan et al.   NATURE GENETICS

Molecular basis of the attenuated phenotype of human APOBEC3B DNA mutator enzyme

(2015) Vincent Caval et al.   NUCLEIC ACIDS RESEARCH

APOBEC3A cytidine deaminase induces RNA editing in monocytes and macrophages

(2015) Shraddha Sharma et al.   Nature Communications

A prevalent cancer susceptibility APOBEC3A hybrid allele bearing APOBEC3B 3′UTR enhances chromosomal DNA damage

(2014) Vincent Caval et al.   Nature Communications

Mitochondrial Nucleases ENDOG and EXOG Participate in Mitochondrial DNA Depletion Initiated by Herpes Simplex Virus 1 UL12.5

(2013) B. A. Duguay et al.   JOURNAL OF VIROLOGY

Elimination of Mitochondrial DNA Is Not Required for Herpes Simplex Virus 1 Replication

(2013) B. A. Duguay et al.   JOURNAL OF VIROLOGY

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers

(2013) Steven A Roberts et al.   NATURE GENETICS

Directional Spread of Alphaherpesviruses in the Nervous System

(2013) Tal Kramer et al.   Viruses-Basel

Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer

(2012) Jalees Rehman et al.   FASEB JOURNAL

Human Tribbles 3 Protects Nuclear DNA from Cytidine Deamination by APOBEC3A

(2012) Marie-Ming Aynaud et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The landscape of cancer genes and mutational processes in breast cancer

(2012) Philip J. Stephens et al.   NATURE

Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein

(2012) M. H. Orzalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

APOBEC3A can activate the DNA damage response and cause cell-cycle arrest

(2011) Sébastien Landry et al.   EMBO REPORTS

Somatic hypermutation of human mitochondrial and nuclear DNA by APOBEC3 cytidine deaminases, a pathway for DNA catabolism

(2011) R. Suspene et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatitis C virus E2 protein induce reactive oxygen species (ROS)-related fibrogenesis in the HSC-T6 hepatic stellate cell line

(2010) Hsieh Ming-Ju et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

APOBEC3 proteins mediate the clearance of foreign DNA from human cells

(2010) Mark D Stenglein et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway

(2009) Yu-Hsin Chiu et al.   CELL

Herpes Simplex Virus UL12.5 Targets Mitochondria through a Mitochondrial Localization Sequence Proximal to the N Terminus

(2009) J. A. Corcoran et al.   JOURNAL OF VIROLOGY

Defining APOBEC3 Expression Patterns in Human Tissues and Hematopoietic Cell Subsets

(2009) F. A. Koning et al.   JOURNAL OF VIROLOGY

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

Mitofusin 2 Inhibits Mitochondrial Antiviral Signaling

(2009) K. Yasukawa et al.   Science Signaling

Database indexing for production MegaBLAST searches

(2008) Aleksandr Morgulis et al.   BIOINFORMATICS