Review
Biochemistry & Molecular Biology
Rosa Maria Vitale, Fabio Arturo Iannotti, Pietro Amodeo
Summary: CBD, as a major nonpsychoactive constituent of Cannabis, has been proposed for the treatment of various neurological and neuropsychiatric disorders. Efforts have been devoted to shed light on its complex pharmacological profile and molecular basis, with an increasing number of molecular targets identified for the therapeutic effects of CBD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Eric S. White, Matthew Thomas, Susanne Stowasser, Kay Tetzlaff
Summary: Pulmonary fibrosis is a pathologic process associated with scarring of the lung interstitium. Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic interstitial lung disease (ILD) characterized by respiratory failure and death. The development of pirfenidone and nintedanib has been a major breakthrough in the treatment of IPF, but there is still no cure for pulmonary fibrosis. Future treatment of pulmonary fibrosis may require more precision in targeting specific cell populations and exploring novel measures of efficacy.
FRONTIERS IN PHARMACOLOGY
(2022)
Editorial Material
Respiratory System
Ruth E. Barker, Samantha S. C. Kon, Stuart F. Clarke, Jenni Wenneberg, Claire M. Nolan, Suhani Patel, Jessica A. Walsh, Oliver Polgar, Matthew Maddocks, Morag Farquhar, Nicholas S. Hopkinson, Derek Bell, Jadwiga A. Wedzicha, William D-C. Man
Summary: Pulmonary rehabilitation following hospitalisation for AECOPD is beneficial for patients' exercise capacity and quality of life. This study suggests that COPD discharge bundles delivered by PR practitioners can significantly increase the referral and uptake of post-hospitalisation PR. Closer integration between hospital and PR services may help improve the rates of post-hospitalisation PR referral and uptake.
Article
Multidisciplinary Sciences
Danyang Zhang, Remigijus Lape, Saher A. Shaikh, Bianka K. Kohegyi, Jake F. Watson, Ondrej Cais, Terunaga Nakagawa, Ingo H. Greger
Summary: In this study, the authors provide cryo-EM structures of receptors bound to three selective drugs and reveal the bifunctionality of one ligand.
NATURE COMMUNICATIONS
(2023)
Article
Health Care Sciences & Services
Paula Irina Barata, Alexandru Florian Crisan, Adelina Maritescu, Rodica Anamaria Negrean, Ovidiu Rosca, Felix Bratosin, Cosmin Citu, Cristian Oancea
Summary: Chronic obstructive pulmonary disease (COPD) is a common and burdensome disease. This study compared traditional inpatient pulmonary rehabilitation with online rehabilitation, and found that the online method performed as well as or better than the traditional method in several measurements.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Chemistry, Medicinal
Maria Ferraro, Serena Di Vincenzo, Claudia Sangiorgi, Stefania Leto Barone, Sebastiano Gangemi, Luigi Lanata, Elisabetta Pace
Summary: This study assessed the effects of carbocysteine on patients with Chronic Obstructive Pulmonary Disease (COPD) during acute exacerbation. The results showed that carbocysteine improved symptoms, reduced levels of inflammatory markers, and helped manage mild AECOPD.
Review
Biochemistry & Molecular Biology
Mariarita Laforgia, Carmelo Laface, Concetta Calabro, Simona Ferraiuolo, Valentina Ungaro, Domenico Tricarico, Cosmo Damiano Gadaleta, Patrizia Nardulli, Girolamo Ranieri
Summary: Peripheral neurologic complications are common during cancer treatment, often resulting in dose reduction, treatment delays, and decreased quality of life. Recognizing symptoms and collaboration between health professionals are crucial for managing this issue effectively.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemical Research Methods
Siqin Zhang, Kuo Yang, Zhenhong Liu, Xinxing Lai, Zhen Yang, Jianyang Zeng, Shao Li
Summary: Understanding the mechanisms of candidate drugs is crucial in drug discovery. Deep learning methods have been used to predict activating/inhibiting mechanisms between drugs and targets, but due to the complexity and scarcity of data, accurate predictions remain challenging. In this study, a multi-view deep learning model called DrugAI is proposed, which combines different modules to accurately predict DT activating/inhibiting mechanisms. Computational experiments and bioassay validation demonstrate the reliability and superior performance of DrugAI.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Biochemical Research Methods
Siqin Zhang, Kuo Yang, Zhenhong Liu, Xinxing Lai, Zhen Yang, Jianyang Michael Zeng, Shao Li
Summary: Understanding the mechanisms of candidate drugs is crucial in drug discovery, particularly the activating/inhibiting mechanisms between drugs and targets. Due to the complexity of drug-target (DT) mechanisms and limited data, accurately predicting DT activating/inhibiting mechanisms using deep learning methods remains a challenge. In this study, a multi-view deep learning model called DrugAl is proposed, which combines various modules to predict activating/inhibiting mechanisms. Experimental results demonstrate that DrugAl outperforms existing methods and exhibits good robustness and generalization. Bioassay experiments and external validation support the reliability of DrugAl's predictions. Overall, DrugAl provides a powerful framework for predicting DT activating/inhibiting mechanisms.
BRIEFINGS IN BIOINFORMATICS
(2023)
Article
Respiratory System
Sara Souto-Miranda, Isabel Saraiva, Martijn A. Spruit, Alda Marques
Summary: A core outcome set (COS) for pulmonary rehabilitation (PR) of people with chronic obstructive pulmonary disease (COPD) has been developed, consisting of nine crucial outcomes. This COS can enhance consistency and comparability of studies, benchmark PR, and improve the quality of care provided.
Review
Microbiology
Yehudis Rosenwasser, Irene Berger, Zvi G. Loewy
Summary: This article discusses the pharmacotherapeutic approaches for COPD exacerbation, including antimicrobials, bronchodilators, and anti-inflammatory drugs, as well as the connection between the oral cavity and the lungs.
Review
Multidisciplinary Sciences
Hamidreza Shaye, Benjamin Stauch, Cornelius Gati, Vadim Cherezov
Summary: GABA(B) receptors play a crucial role in inhibitory neurotransmission in the brain, modulating neuronal signaling and being linked to various neurological disorders. Recent cryo-EM studies have provided detailed insights into the activation mechanism of GABA(B) receptors, offering potential for the discovery of new therapeutic drugs and neuromodulators. The structures of the receptor in different conformational states and bound to various ligands contribute to a comprehensive understanding of the receptor's activation process.
Article
Chemistry, Medicinal
Yuanyuan Zhong, Bin Wang, Wenjing Chen, Hongying Zhang, Jing Sun, Jingcheng Dong
Summary: This study investigated the effectiveness and mechanisms of action of modified Bu-Shen-Yi-Qi decoction (MBSYQ) in the treatment of osteoporosis associated with chronic obstructive pulmonary disease (COPD). The results showed that MBSYQ improved lung pathology and bone loss, and activated the MAPK and PI3K/AKT pathways while improving oxygen metabolism. This suggests that MBSYQ has potential for prevention and treatment of COPD-related osteoporosis.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Review
Pharmacology & Pharmacy
Hongbo Ma, Xuyi Wu, Yi Li, Yong Xia
Summary: Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with various factors contributing to its development, including cell dysregulation, genetic mutations, environmental factors, and epigenetics. Recent clinical trials have led to the discovery of novel therapeutic targets and drugs for IPF.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Vahideh Ghorani, Mohammad Reza Khazdair, Majid Mirsadraee, Omid Rajabi, Mohammad Hossein Boskabady
Summary: The study suggests that Zataria multiflora may have therapeutic effects on chronic obstructive pulmonary disease (COPD) patients by reducing inflammatory cytokines, improving pulmonary function test values, and alleviating respiratory symptoms.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
D. Blakeley, D. A. Sykes, P. Ensor, E. Bertran, P. J. Aston, S. J. Charlton
BRITISH JOURNAL OF PHARMACOLOGY
(2015)
Article
Pharmacology & Pharmacy
Georges Vauquelin, David Hall, Steven J. Charlton
BRITISH JOURNAL OF PHARMACOLOGY
(2015)
Article
Pharmacology & Pharmacy
Alexandre Trifilieff, Brian T. Ethell, David A. Sykes, Kenny J. Watson, Steve Collingwood, Steven J. Charlton, Toby C. Kent
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2015)
Article
Chemistry, Medicinal
Callum J. Dickson, Viktor Hornak, Camilo Velez-Vega, Daniel J. J. McKay, John Reilly, David A. Sandham, Duncan Shaw, Robin A. Fairhurs, Steven J. Charlton, David A. Sykes, Robert A. Pearlstein, Jose S. Duca
JOURNAL OF MEDICINAL CHEMISTRY
(2016)
Article
Multidisciplinary Sciences
Carmen Klein Herenbrink, David A. Sykes, Prashant Donthamsetti, Meritxell Canals, Thomas Coudrat, Jeremy Shonberg, Peter J. Scammells, Ben Capuano, Patrick M. Sexton, Steven J. Charlton, Jonathan A. Javitch, Arthur Christopoulos, J. Robert Lane
NATURE COMMUNICATIONS
(2016)
Article
Chemistry, Medicinal
David A. Sandham, Lucy Barker, Lyndon Brown, Zarin Brown, David Budd, Steven J. Charlton, Devnandan Chatterjee, Brian Cox, Gerald Dubois, Nicholas Duggan, Edward Hall, Julia Hatto, Janet Maas, Jodie Manini, Rachael Profit, Darren Riddy, Catherine Ritchie, Bindi Sohal, Duncan Shaw, Rowan Stringer, David A. Sykes, Matthew Thomas, Katharine L. Turner, Simon J. Watson, Ryan West, Elisabeth Willard, Gareth Williams, Jennifer Willis
ACS MEDICINAL CHEMISTRY LETTERS
(2017)
Article
Multidisciplinary Sciences
David A. Sykes, Holly Moore, Lisa Stott, Nicholas Holliday, Jonathan A. Javitch, J. Robert Lane, Steven J. Charlton
NATURE COMMUNICATIONS
(2017)
Article
Multidisciplinary Sciences
Karolina Gherbi, Stephen J. Briddon, Steven J. Charlton
SCIENTIFIC REPORTS
(2018)
Letter
Multidisciplinary Sciences
David A. Sykes, J. Robert Lane, Monika Szabo, Ben Capuano, Jonathan A. Javitch, Steven J. Charlton
NATURE COMMUNICATIONS
(2018)
Article
Biochemistry & Molecular Biology
Srgjan Civciristov, Andrew M. Ellisdon, Ryan Suderman, Cindy K. Pon, Bronwyn A. Evans, Oded Kleifeld, Steven J. Charlton, William S. Hlavacek, Meritxell Canals, Michelle L. Halls
Article
Chemistry, Multidisciplinary
Hsin-Yung Yen, Idlir Liko, Wanling Song, Parth Kapoor, Fernando Almeida, Joanna Toporowska, Karolina Gherbi, Jonathan T. S. Hopper, Steven J. Charlton, Argyris Politis, Mark S. P. Sansom, Ali Jazayeri, Carol Robinson
Summary: This study presents a mass spectrometry-based approach to investigate the biased signaling and allosteric modulation of the beta(1)-adrenergic receptor in response to different ligands. The researchers discovered that isoprenaline can act as a biased agonist and that endogenous zinc ions enhance the binding between the receptor and G(s) proteins.
Article
Chemistry, Medicinal
Bianca Maria Casella, James P. P. Farmer, Desislava N. N. Nesheva, Huw E. L. Williams, Steven J. J. Charlton, Nicholas D. D. Holliday, Charles A. A. Laughton, Shailesh N. N. Mistry
Summary: Inhibition of CXCR2 is a potential strategy for the treatment of pulmonary diseases and cancers. This study reports the design and synthesis of fluorescent NAMs that selectively bind to CXCR2, enabling the measurement and evaluation of their pharmacological properties. These NAMs can be used as alternative compounds for targeting these receptors.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
David A. Sykes, Michelle E. Bradley, Darren M. Riddy, Elizabeth Willard, John Reilly, Asadh Miah, Carsten Bauer, Simon J. Watson, David A. Sandham, Gerald Dubois, Steven J. Charlton
MOLECULAR PHARMACOLOGY
(2016)
Article
Biochemical Research Methods
Christian Bergsdorf, Cedric Fiez-Vandal, David A. Sykes, Pascal Bernet, Sonia Aussenac, Steven J. Charlton, Ulrich Schopfer, Johannes Ottl, Myriam Duckely
JOURNAL OF BIOMOLECULAR SCREENING
(2016)
Article
Pharmacology & Pharmacy
M. E. Bradley, B. Dombrecht, J. Manini, J. Willis, D. Vlerick, S. De Taeye, K. Van den Heede, A. Roobrouck, E. Grot, T. C. Kent, T. Laeremans, S. Steffensen, G. Van Heeke, Z. Brown, S. J. Charlton, K. D. Cromie
MOLECULAR PHARMACOLOGY
(2015)