Review
Neurosciences
Osama A. Abulseoud, Fawaz Alasmari, Abdelaziz M. Hussein, Youssef Sari
Summary: This review explores the translational potential of CEF in neuropsychiatric disorders based on preclinical efficacy, highlighting its possible clinical effectiveness in selected cases of acute and transient hyperglutamatergic states such as early drug withdrawal conditions.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Hong-Ju Yang, Briana J. Hempel, Guo-Hua Bi, Yi He, Hai-Ying Zhang, Eliot L. Gardner, Zheng-Xiong Xi
Summary: Glutamate negatively regulates the rewarding effects of cocaine in the nucleus accumbens, but excess glutamate in multiple brain regions can trigger reinstatement of drug-seeking behavior.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Environmental Sciences
Woonyen Wong, Youssef Sari
Summary: Exposure to hydrocodone may lead to downregulation of glutamate transporter 1 (GLT-1), cystine/glutamate antiporter (xCT), and upregulation of metabotropic glutamate receptors (mGluR5). Treatment with ceftriaxone may reverse these changes and attenuate the downregulation of signaling pathways, suggesting its therapeutic potential.
Article
Immunology
Asmaa M. Mohamed, Dina A. Ali, Eman Kolieb, Eman Z. Abdelaziz
Summary: Epilepsy is a serious neurological disorder that causes cognitive-psychosocial damage through recurrent seizures. Drug resistance is common among patients, so new drugs are needed to improve seizure management and quality of life. This study investigated the therapeutic effects of ceftriaxone and selenium against epilepsy in rats. The results showed that the combined treatment of selenium and ceftriaxone improved epilepsy symptoms by reducing oxidative stress and inflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Duriye Nur Dagdelen, Aysenur Akkulak, Gizem Donmez Yalcin
Summary: This study investigated the regulation of glutamate metabolism by the GLT-1 degradation pathway in glioblastoma and glial cell lines. The results showed increased expression of GLT-1 in glioblastoma cells, with decreased levels of PKC protein and total ubiquitin. Glutamate accumulation in glioblastoma cells was also found to be reduced compared to glial cells. Exciting opportunities for drug and treatment development may arise from further research focusing on GLT-1 degradation or activation pathway in glioblastoma.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Karima A. Hamed, Saima A. El-Fiky, Azza Gawish, Hanan Mohamed, Wagdy K. B. Khalil, Xue Huang, Murtaza Hasan, Ayesha Zafar, Giovanni Caprioli
Summary: This study investigated the potential protective effects of fenugreek saponin and nanofenugreek saponin against nicotine-induced toxicity in male rats. The results showed that administration of fenugreek saponin or nanofenugreek saponin reduced DNA damage and histopathological alterations caused by nicotine.
Article
Neurosciences
Eva Perez-Jimenez, Rosa Viana, Carmen Munoz-Ballester, Carlos Vendrell-Tornero, Raquel Moll-Diaz, Maria Adelaida Garcia-Gimeno, Pascual Sanz
Summary: Lafora disease is a fatal rare form of progressive myoclonus epilepsy caused by mutations in the EPM2A or EPM2B genes, resulting in early adolescent onset. Dysfunction of the laforin/malin complex may lead to alterations in the ubiquitination of GLT-1, potentially contributing to the epilepsy associated with LD.
Article
Neurosciences
Allison R. Peterson, Terese A. Garcia, Kyle Cullion, Seema K. Tiwari-Woodruff, Ernest Pedapati, Devin K. Binder
Summary: Astrocytic glutamate transporters play a crucial role in maintaining glutamate homeostasis in the brain, and targeting glutamate uptake may be a promising therapeutic strategy for epilepsy. Upregulation of GLT-1 in astrocytes has shown to be neuroprotective, reducing seizure frequency and eliminating large behavioral seizures in epilepsy models.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Medicine, Research & Experimental
Longze Sha, Guanjun Li, Xiuneng Zhang, Yarong Lin, Yunjie Qiu, Yu Deng, Wanwan Zhu, Qi Xu
Summary: The dysregulation of EAAT2 is involved in the development of TLE. The E3 ubiquitin ligase AMFR interacts with EAAT2 and increases its oligomeric level. Acetaminophen (APAP) induces the transcriptional activation of AMFR via SP1, leading to reduced occurrence of epileptic seizures. APAP treatment enhances the antiepileptic effects of the Hsp90 inhibitor 17AAG.
Article
Neurosciences
ShuJuan Fan, Li Li, LiRong Liu, He Li, XiaoHui Xian, WenBin Li
Summary: This study investigated the improving effect of ceftriaxone (Cef) on recognition memory deficits and the involvement of Group II mGluRs in the process using the APP/PS1 AD mouse model. The results showed that Cef treatment significantly improved the recognition memory deficits of the AD mice by suppressing the upregulation of Group II mGluRs expression and restoring the downregulation in the downstream molecules of Group II mGluRs activation.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Simone A. A. Romariz, Bevan S. Main, Alex C. Harvey, Beatriz M. Longo, Mark P. Burns
Summary: The pathophysiological changes after traumatic brain injury (TBI) can lead to post-traumatic epilepsy, and the etiology of it remains unknown. This study investigated the effects of brain injury on chemically-induced seizures in mice and whether enhancing glutamate transporters can reduce post-traumatic seizures. The results showed that mice with controlled cortical impact (CCI) had delayed susceptibility to seizures and exhibited increased seizure frequency and duration. Administration of ceftriaxone, a glutamate transporter enhancer, prevented seizures in CCI mice.
Article
Multidisciplinary Sciences
Takafumi Kato, Tsukasa Kusakizako, Chunhuan Jin, Xinyu Zhou, Ryuichi Ohgaki, LiLi Quan, Minhui Xu, Suguru Okuda, Kan Kobayashi, Keitaro Yamashita, Tomohiro Nishizawa, Yoshikatsu Kanai, Osamu Nureki
Summary: EAAT2 plays crucial roles in glutamate homeostasis in the brain and therapy resistance of cancer cells. This study presents the cryo-EM structures of EAAT2 and the inhibitory mechanisms of selective inhibitor WAY213613. The structures reveal the binding sites and disruption of EAAT2 by WAY213613, providing insights for structure-based drug design targeting EAAT2.
NATURE COMMUNICATIONS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andreia Rocha, Bruna Bellaver, Debora G. Souza, Guilherme Schu, Igor C. Fontana, Gianina T. Venturin, Samuel Greggio, Fernanda U. Fontella, Manoela L. Schiavenin, Luiza S. Machado, Diogo Miron, Jaderson C. da Costa, Pedro Rosa-Neto, Diogo O. Souza, Luc Pellerin, Eduardo R. Zimmer
Summary: This study used FDG-PET imaging to investigate the impact of the antipsychotic drug clozapine on brain glucose metabolism in rats, and found that downregulation of GLT-1 resulted in astrocyte-dependent cortical hypometabolism, resembling the hypometabolic signature observed in people developing dementia.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Infectious Diseases
Clemence Lacroix, Annie-Pierre Bera-Jonville, Francois Montastruc, Lionel Velly, Joelle Micallef, Romain Guilhaumou
Summary: The study analyzed the largest case series of serious CNS adverse drug reactions induced by ceftriaxone, identifying common symptoms including convulsions, myoclonia, and confusion, mainly in elderly female patients. It suggests caution in the use of ceftriaxone, particularly in older patients or those with renal impairment.
Review
Behavioral Sciences
Fawaz Alasmari, Deen B. Sari, Hasan Alhaddad, Salim S. Al-Rejaie, Youssef Sari
Summary: This review explores the interactive role of acid-sensing ion channels (ASICs) and ionotropic glutamate receptors (iGluRs) in opioid dependence. The dysregulation of ASICs and iGluRs may play a crucial role in drug abuse and addiction.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Behavioral Sciences
Harshini Neelakantan, Ronald J. Tallarida, Zachary W. Reichenbach, Ronald F. Tuma, Sara J. Ward, Ellen A. Walker
BEHAVIOURAL PHARMACOLOGY
(2015)
Article
Substance Abuse
Christopher S. Tallarida, Ronald J. Tallarida, Scott M. Rawls
DRUG AND ALCOHOL DEPENDENCE
(2015)
Article
Substance Abuse
Christopher S. Tallarida, Kristopher Bires, Jacob Avershal, Ronald J. Tallarida, Stephanie Seo, Scott M. Rawls
Article
Substance Abuse
Neil S. Lamarre, Robert B. Raffa, Ronald J. Tallarida
DRUG AND ALCOHOL DEPENDENCE
(2013)
Article
Anesthesiology
A. Cowan, R. B. Raffa, C. S. Tallarida, R. J. Tallarida, T. Christoph, W. Schroeder, T. M. Tzschentke
EUROPEAN JOURNAL OF PAIN
(2014)
Review
Pharmacology & Pharmacy
Robert B. Raffa, Ronald J. Tallarida, Robert Taylor, Joseph V. Pergolizzi
EXPERT OPINION ON PHARMACOTHERAPY
(2012)
Article
Pharmacology & Pharmacy
R. J. Tallarida, U. Midic, N. S. Lamarre, Z. Obradovic
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
(2013)
Article
Neurosciences
Christopher S. Tallarida, Erin Egan, Gissel D. Alejo, Robert Raffa, Ronald J. Tallarida, Scott M. Rawls
Article
Neurosciences
L. Ramoz, S. Lodi, P. Bhatt, A. B. Reitz, C. Tallarida, R. J. Tallarida, R. B. Raffa, S. M. Rawls
Article
Chemistry, Multidisciplinary
Ronald J. Tallarida, Neil Lamarre, Robert B. Raffa
PHARMACEUTICAL RESEARCH
(2012)
Article
Medicine, General & Internal
Howard S. Smith, Robert B. Raffa, Joseph V. Pergolizzi, Robert Taylor, Ronald J. Tallarida
POSTGRADUATE MEDICINE
(2014)
Article
Neurosciences
Jonathan M. Slezak, George A. Ricaurte, Ronald J. Tallarida, Jonathan L. Katz
PSYCHOPHARMACOLOGY
(2014)
Review
Anesthesiology
Joseph V. Pergolizzi, Robert B. Raffa, Ronald Tallarida, Robert Taylor, Sumedha A. Labhsetwar
Article
Pharmacology & Pharmacy
Thomas Christoph, Wolfgang Schroeder, Ronald J. Tallarida, Jean De Vry, Thomas M. Tzschentke
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2013)
Article
Pharmacology & Pharmacy
Ronald J. Tallarida
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2012)