Article
Chemistry, Multidisciplinary
He Wang, Yi-sha Du, Wen-shuo Xu, Chang-jian Li, Hong Sun, Kang-rui Hu, Yuan-zhuo Hu, Teng-jie Yu, Hui-min Guo, Lin Xie, Guang-ji Wang, Yan Liang
Summary: The study demonstrates that exogenous GSH exerts a therapeutic effect on ischemic stroke by increasing intrastriatal DA levels in rats. The accumulated DA enhances the exposure of GSH and its related substances, thereby promoting the therapeutic effect of GSH.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Medicine, Research & Experimental
I Erkizia-Santamaria, R. Alles-Pascual, I Horrillo, J. J. Meana, J. E. Ortega
Summary: The study found that psilocin showed similar affinities for 5HT2AR, 5HT2CR, and 5HT1AR in both human and mice brain. Psilocybin induced a dose-dependent head-twitch response (HTR) and affected body temperature, which were both mediated by 5HT2AR, 5HT2CR, and 5HT1AR. These findings provide key insights into the mechanism of action of psilocybin and its therapeutic effects.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Behavioral Sciences
Tomohisa Mori, Naoki Uzawa, Daiki Masukawa, Shigeto Hirayama, Yoshiyuki Iwase, Mayuna Hokazono, Yuya Udagawa, Tsutomu Suzuki
Summary: Orexinergic system is involved in regulating the rewarding effects of psychostimulants, but there is a risk of establishing these effects even under orexin deficiency. Conversely, deficiencies in orexin may enhance the abuse liability of MDMA by changing a postsynaptic signal transduction accompanied by changes in discriminative stimulus effects themselves.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Environmental Sciences
Li-Xia Liang, Jingjing Liang, Qing-Qing Li, Mohammed Zeeshan, Zheqing Zhang, Nanxiang Jin, Li-Zi Lin, Lu-Yin Wu, Ming-Kun Sun, Wei-Hong Tan, Yang Zhou, Chu Chu, Li-Wen Hu, Ru-Qing Liu, Xiao-Wen Zeng, Yunjiang Yu, Guang-Hui Dong
Summary: This study found that early exposure to F-53B may have adverse effects on neurobehavior in developing children and weaning mice, which may be modulated by dopamine-dependent synaptic plasticity.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Medicine, Research & Experimental
Elias B. Nascimento Jr., R. L. Romero, Marcela M. G. B. Dutra, Bernd L. Fiebich, Igor D. G. Duarte, Marcio M. Coelho
Summary: The activation of 5-HT1D and 5-HT7 receptors plays a role in mechanical allodynia induced by 5-HT in mice, while peripheral 5-HT3 receptors have an inhibitory role in the nociceptive response induced by 5-HT or carrageenan.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Environmental Sciences
Yudong Xu, Huihui Hong, Xiqin Lin, Tong Tong, Jingjing Zhang, Haotian He, Lingling Yang, Gaofeng Mao, Rongrong Hao, Ping Deng, Zhengping Yu, Huifeng Pi, Yong Cheng, Zhou Zhou
Summary: This study revealed that perturbed sphingomyelin lipid metabolism is related to the pathogenesis of Parkinsonism and Cd neurotoxicity, partially compensated for the deficiency in particular metabolic biomarkers for Parkinsonism in relation to Cd exposure, and emphasized the necessity of reducing Cd exposure at the population level.
ENVIRONMENTAL POLLUTION
(2023)
Article
Biochemistry & Molecular Biology
Sarah Thomas Broome, Alessandro Castorina
Summary: Systemic administration of rotenone in mice replicates various pathogenic and behavioral features of Parkinson's disease, and leads to neurochemical alterations at multiple levels of the central nervous system. This study demonstrates the suitability of this pre-clinical model for studying extra-nigral defects in Parkinson's disease.
Article
Pharmacology & Pharmacy
Yi Jiang, Jie Zhou, Bai-Lin Song, Yan Wang, Dong-Lin Zhang, Zheng-Tian Zhang, Lai-Fu Li, Ying-Juan Liu
Summary: Social animals self-organize into dominance hierarchies, influenced by the serotonin system in the amygdala. This study explores the role of different 5-HT receptor subtypes in social rank determination and reveals their involvement in the formation and modulation of social hierarchy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Immunology
Junxing Ma, Ran Wang, Yaoxing Chen, Zixu Wang, Yulan Dong
Summary: This study found that chronic unforeseeable mild stress has a more pronounced effect on the cognitive function, learning, and memory of female mice. Compared to female CUMS mice, TPH2 KO CUMS mice had significantly reduced extracellular serotonin levels and worsened cognitive dysfunction. Additionally, increased hippocampal autophagy levels, decreased neurotransmitter levels, reduced oxidative stress damage, increased neuroinflammatory responses, and disrupted gut flora were observed. Furthermore, L. lactis E001-B-8 showed significant improvement in the cognitive behavior of mice.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Medicine, Research & Experimental
Kate Beecher, Joshua Wang, Fatemeh Chehrehasa, Ronan Depoortere, Mark A. Varney, Adrian Newman-Tancredi, Selena E. Bartlett, Arnauld Belmer
Summary: The consumption of high-sugar food has been linked to the increase in obesity prevalence. A recent study found that chronic sucrose consumption can alter the serotonergic neuroplasticity in the neural circuits involved in feeding control. Specifically, the 5-HT1A receptor subtype plays a role in the regulation of mood, anxiety, and appetite, and may be involved in reversing addiction to substances of abuse. Targeting the 5-HT1A autoreceptors could be an effective therapeutic strategy to combat obesity resulting from overconsumption of high-sugar diet.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Hirohito Esaki, Yuki Sasaki, Naoya Nishitani, Hikari Kamada, Satoko Mukai, Yoshitaka Ohshima, Sao Nakada, Xiyan Ni, Satoshi Deyama, Katsuyuki Kaneda
Summary: This study examined whether the prosocial effects induced by MDMA are mediated by 5-HT neurotransmission in the medial prefrontal cortex (mPFC) and the basolateral nucleus of amygdala (BLA). The results showed that selective inhibition of 5-HT transporters before MDMA administration did not suppress the prosocial effects. However, the 5-HT1A receptor antagonist WAY100635 significantly suppressed the prosocial effects of MDMA. Furthermore, local administration of WAY100635 into the BLA, but not the mPFC, suppressed the MDMA-induced prosocial effects. These findings suggest that MDMA induces prosocial effects through the stimulation of 5-HT1A receptors in the BLA.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Benjamin Butler, Hannah Garver, Stephanie W. Watts, Gregory D. Fink
Summary: The infusion of 5-hydroxytryptamine (5-HT, serotonin) reduces blood pressure by decreasing total peripheral resistance in rats. Contrary to the hypothesis, an increase in blood flow within the skin was not necessary for the observed fall in blood pressure. Instead, a decrease in cutaneous vascular resistance played a role in the reduction of total peripheral resistance.
Article
Biochemistry & Molecular Biology
Yukiko Ochiai, Masayo Fujita, Yoko Hagino, Kazuto Kobayashi, Ryoichi Okiyama, Kazushi Takahashi, Kazutaka Ikeda
Summary: Some diseases associated with dopamine deficiency, like Parkinson's disease, are accompanied by psychiatric symptoms. However, the mechanism behind this is not clear. Previous studies have shown that dopamine-deficient mice display hyperactivity in new environments, which can be improved by certain medications. In this study, the researchers aimed to identify the pharmacological mechanism of psychiatric symptoms associated with dopamine deficiency in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Edward Ofori, Edem K. Onyameh, Uma M. Gonela, Chandrashekhar Voshavar, Barbara Bricker, Tracy L. Swanson, Amy J. Eshleman, Jennifer L. Schmachtenberg, Shelley H. Bloom, Aaron J. Janowsky, Seth Y. Ablordeppey
Summary: We have conducted a study to explore the potential of dual 5-HT1AR and 5-HT7R ligands, resulting in the identification of a new compound with high affinity for these receptors. This compound, designated as 21, shows promising functional characteristics as a potential antidepressant agent.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Psychiatry
Ling Chen, Wan-Kun Gong, Cui-ping Yang, Chan-Chan Shao, Ning-Ning Song, Jia-Yin Chen, Li-Qiang Zhou, Kun-Shan Zhang, Siguang Li, Zhili Huang, Gal Richter-Levin, Lin Xu, Yu-Qiang Ding
Summary: The study suggests that PTEN may serve as an alternative approach for regulating 5-HT neuron activity in the brain and depressive behaviors, compared to selective serotonin reuptake inhibitors (SSRIs) commonly used in depression treatment. Elevated levels of PTEN in 5-HT neurons can induce depressive behaviors in mice, while selective deletion of Pten leads to structural plasticity in these neurons.
TRANSLATIONAL PSYCHIATRY
(2021)
Review
Pharmacology & Pharmacy
Nuria Morales-Puerto, Pablo Gimenez-Gomez, Mercedes Perez-Hernandez, Cristina Abuin-Martinez, Leticia Gil de Biedma-Elduayen, Rebeca Vidal, Maria Dolores Gutierrez-Lopez, Esther O'Shea, Maria Isabel Colado
Summary: Drug use poses a serious threat to health systems worldwide, with the kynurenine pathway being of interest in relation to addictive behavior. Recent studies suggest that modulation of certain stages of this pathway can reduce, prevent, or abolish drug seeking-like behaviors.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Neurosciences
C. Abuin-Martinez, R. Vidal, M. D. Gutierrez-Lopez, M. Perez-Hernandez, P. Gimenez-Gomez, N. Morales-Puerto, E. O'Shea, M. I. Colado
Summary: The study revealed that MDMA induces serotonergic neurotoxicity by activating the KYN pathway and AhR in rats. Modulation of these pathways could serve as potential therapeutic strategies to limit the negative effects of MDMA-induced brain damage.
Article
Pharmacology & Pharmacy
Leticia Gil de Biedma-Elduayen, Pablo Gimenez-Gomez, Nuria Morales-Puerto, Rebeca Vidal, Carlos Nunez-de la Calle, Maria Dolores Gutierrez-Lopez, Esther O'Shea, Maria Isabel Colado
Summary: Inhibition of kynurenine 3-monooxygenase reduces ethanol consumption and preference in male and female mice, which is mediated by alpha 7nAChR. Moreover, this effect can be prolonged by blocking the efflux of peripheral kynurenine to the brain, providing an effective strategy for the treatment of ethanol dependence.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Chemistry, Analytical
Alex Gomez-Gomez, Eulalia Olesti, Blanca Montero-San-Martin, Angie Soldevila, Tessa Deschamps, Nieves Pizarro, Rafael de la Torre, Oscar J. Pozo
Summary: A LC-MS/MS method for the quantification of 20 endogenous R-COOH in different pathways was developed and optimized. The method was applied in various matrices and proved suitable for studying R-COOH status in health and disease through targeted metabolomics. Adequate accuracy and precision were achieved, making this methodology a valuable tool for biochemical research.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Biochemistry & Molecular Biology
Marta Moya, Leticia Lopez-Valencia, Borja Garcia-Bueno, Laura Orio
Summary: Wernicke-Korsakoff syndrome is caused by thiamine deficiency and alcohol consumption, mainly affecting frontal cortex function. This study using a rat model confirms the significant impact of the interaction between alcohol and TD on neuronal damage.
Article
Medicine, Research & Experimental
Francisco Madrid-Gambin, Alex Gomez-Gomez, Arnau Busquets-Garcia, Noemi Haro, Santiago Marco, Natasha L. Mason, Johannes T. Reckweg, Pablo Mallaroni, Lilian Kloft, Kim van Oorsouw, Stefan W. Toennes, Rafael de la Torre, Johannes G. Ramaekers, Kin Van Oorsouw, Stefan W. Toennes, Rafael De la Torre, Johannes G. Ramaekers, Oscar J. Pozo
Summary: This study investigates the human metabolomics signature after consuming the psychedelic ayahuasca and its connection to subjective effects and plasma concentrations of ayahuasca alkaloids. The results suggest a crosstalk between circulating large-neutral amino acids and subjective effects, independent of alkaloid concentrations. Dysregulation in neurotransmission pathways such as serotonin and dopamine synthesis is also observed.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Teresa Oliveras, Iolanda Lazaro, Ferran Rueda, German Cediel, Deepak L. Bhatt, Montserrat Fito, Francisco Madrid-Gambin, Oscar J. Pozo, William S. Harris, Cosme Garcia-Garcia, Aleix Sala-Vila, Antoni Bayes-Genis
Summary: This study found that levels of linoleic acid (LA) in serum phospholipids are associated with susceptibility to primary ventricular fibrillation (PVF). PVF patients had lower levels of LA. Each one standard deviation increase in the proportion of LA was associated with a 42% lower prevalence of PVF.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Maria Flores-Lopez, Nuria Garcia-Marchena, Pedro Araos, Nerea Requena-Ocana, Oscar Porras-Perales, Sandra Torres-Galvan, Juan Suarez, Nieves Pizarro, Rafael de la Torre, Gabriel Rubio, Juan Jesus Ruiz-Ruiz, Fernando Rodriguez de Fonseca, Antonia Serrano, Francisco Javier Pavon-Moron
Summary: The study investigated the concentrations of LPA in patients with substance use disorder, finding that women had higher LPA concentrations than men and SUD patients had lower LPA concentrations. LPA species could potentially serve as biomarkers for SUD in both women and men.
Letter
Clinical Neurology
Laura Orio, Francisco Arias, Berta Escudero
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2022)
Article
Medicine, General & Internal
Giulia Testa, Lucia Camacho-Barcia, Carlos Gomez-Martinez, Bernat Mora-Maltas, Rafael de la Torre, Xavier Pinto, Dolores Corella, Roser Granero, Aida Cuenca-Royo, Susana Jimenez-Murcia, Nancy Babio, Rebeca Fernandez-Carrion, Virginia Esteve-Luque, Laura Forcano, Jiaqi Ni, Mireia Malcampo, Sara De las Heras-Delgado, Montse Fito, Jordi Salas-Salvado, Fernando Fernandez-Aranda
Summary: The study found that impulsivity traits in individuals with T2D seem to affect long-term weight control, but not glycemic control.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Miguel A. A. Olivencia, Leticia Gil de Biedma-Elduayen, Pablo Gimenez-Gomez, Bianca Barreira, Argentina Fernandez, Javier Angulo, Maria Isabel Colado, Esther O'Shea, Francisco Perez-Vizcaino
Summary: This study investigates the relationship between alcohol abuse and erectile dysfunction (ED), finding that alterations in soluble guanylyl cyclase (sGC) may contribute to ED caused by alcoholism. The results show that alcohol abuse reduces the relaxant response of the corpora cavernosa (CC) but enhances the response to sGC activators, while also increasing reactive oxygen species and protein expression of CYP2E1 and NOX2. These findings suggest that sGC activators may be effective in treating ED associated with alcoholism.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Clinical Neurology
Berta Escudero, Marta Moya, Leticia Lopez-Valencia, Francisco Arias, Laura Orio
Summary: This study investigated the expression of APOE4 and reelin, as well as cognitive function, in patients with alcohol use disorder (AUD) and controls. The results showed that APOE4 expression levels were similar between patients and controls, but levels of clusterin and reelin were higher in patients with AUD. Multivariate logistic regression analysis identified reelin as a good indicator of cognitive impairment in early abstinence. During a 6-month abstinence period, reelin levels decreased in patients with AUD and cognitive function improved.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Alba Garcia-Baos, Antoni Pastor, Ines Gallego-Landin, Rafael de la Torre, Ferran Sanz, Olga Valverde
Summary: Patients with Fetal Alcohol Spectrum Disorder (FASD) exhibit long-lasting cognitive disabilities, including memory deficits, but the underlying neurobiological mechanisms are not clear. By studying alcohol-exposed mice, researchers found that prenatal and lactation alcohol exposure induces FASD-like memory impairments through the reduction of N-acylethanolamines (NAEs) and peroxisome proliferator-activated receptor gamma (PPAR-gamma) in the hippocampus during a childhood-like period. Pharmacological interventions targeting NAEs and PPAR-gamma were able to improve memory deficits, and overexpression of PPAR-gamma in hippocampal astrocytes mitigated memory impairments induced by alcohol exposure.
MOLECULAR PSYCHIATRY
(2023)
Review
Biochemistry & Molecular Biology
Anna Boronat, Gabriele Serreli, Jose Rodriguez-Morato, Monica Deiana, Rafael de la Torre
Summary: Epidemiological studies suggest that consuming olive oil rich in phenolic bioactive compounds may lower the risk of neurodegenerative diseases and improve cognitive performance in the elderly. Preclinical evidence indicates that olive oil phenolic compounds can counteract oxidative stress and neuroinflammation, key processes in neurodegeneration. Clinical evidence suggests that high consumption of olive oil phenolic compounds is associated with better cognitive preservation, independent of dietary patterns. Further research is needed to understand the mechanisms and potential clinical applications.
Article
Clinical Neurology
Bjoern Schurad, Cornelius Koch, Barbara Schug, Adelaida Morte, Anna Vaque, Rafael De la Torre, Marc Iniesta
Summary: This study assessed the bioequivalence of a multi-day rivastigmine transdermal patch (RID-TDS) compared to a once-daily Exelon (R) transdermal patch. Both patches had a release rate of 9.5 mg/24 h. The results showed that RID-TDS and Exelon (R) were bioequivalent, with satisfactory adhesion demonstrated for RID-TDS. The findings suggest that the multi-day patch may offer greater convenience for patients' therapeutic management.
CURRENT ALZHEIMER RESEARCH
(2022)