Article
Multidisciplinary Sciences
Beatriz Valle-Argos, Giorgia Chiodin, Dean J. Bryant, Joe Taylor, Elizabeth Lemm, Patrick J. Duriez, Philip J. Rock, Jonathan C. Strefford, Francesco Forconi, Richard W. Burack, Graham Packham, Freda K. Stevenson
Summary: In follicular lymphoma, lectin DC-SIGN modulates the function of sIg by binding to acquired mannoses, triggering cell signaling pathways similar to anti-IgM, activating pathways associated with B-cell survival, proliferation and cell-cell communication. This alternative engagement of the B-cell receptor provides lymphoma cells with activation of signaling responses and protection from exogenous antigens.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Cristina Correia, Matthew J. J. Maurer, Samantha J. J. McDonough, Paula A. A. Schneider, Paige E. E. Ross, Anne J. J. Novak, Andrew L. L. Feldman, James R. R. Cerhan, Susan L. L. Slager, Thomas E. E. Witzig, Bruce W. W. Eckloff, Hu Li, Grzegorz S. S. Nowakowski, Scott H. H. Kaufmann
Summary: The identification of follicular lymphoma (FL) patients with low disease burden but high risk for early progression is unclear. In a study on newly diagnosed FLs, BCL2 mutations with high variant allele frequency (VAF) were found to be associated with increased transformation risk and shorter event-free survival. However, other sequenced genes did not contribute significantly to the prognostic value of the panel. Nonsynonymous BCL2 mutations with VAF = 20% were consistently associated with decreased event-free survival and overall survival.
BLOOD CANCER JOURNAL
(2023)
Article
Cell Biology
Yuichiro Hamamoto, Yoji Kukita, Masanori Kitamura, Masako Kurashige, Hiroaki Masaie, Shigeo Fuji, Jun Ishikawa, Keiichiro Honma, Tomoko Wakasa, Hitoshi Hanamoto, Mitsuyoshi Hirokawa, Ayana Suzuki, Eiichi Morii, Shin-ichi Nakatsuka
Summary: The study revealed that different genetic and epigenetic abnormalities may be involved in the oncogenesis of Bcl-2(-)/IGH-BCL2(-) tFLs compared to Bcl-2(+)/IGH-BCL2(+) tFLs and other FLs.
Article
Oncology
Michael Mentz, William Keay, Carolin Dorothea Strobl, Martina Antoniolli, Louisa Adolph, Michael Heide, Axel Lechner, Sarah Haebe, Elisa Osterode, Robert Kridel, Christoph Ziegenhain, Lucas Esteban Wange, Johannes Adrian Hildebrand, Tanaya Shree, Elisabeth Silkenstedt, Annette M. Staiger, German Ott, Heike Horn, Monika Szczepanowski, Julia Richter, Ronald Levy, Andreas Rosenwald, Wolfgang Enard, Ursula Zimber-Strobl, Michael Von Bergwelt-Baildon, Wolfgang Hiddemann, Wolfram Klapper, Marc Schmidt-Supprian, Martina Rudelius, Deepak Bararia, Verena Passerini, Oliver Weigert
Summary: The clinical course of follicular lymphoma (FL) is influenced by the molecular heterogeneity of tumor cells and interactions within the tumor microenvironment (TME). In this study, we found STAT6 mutations in 13% of FL cases, which enhanced the response of FL cells to IL-4 and were associated with increased expression of target genes and nuclear accumulation of pSTAT6. We identified PARP14 as a potential therapeutic target in STAT6-mutated FL cells, as its expression was upregulated and it played a role in the regulatory circuit.
Article
Oncology
Rachel Dobson, Andrew Wotherspoon, Shizhang Alexander Liu, Francesco Cucco, Zi Chen, Yuan Tang, Ming-Qing Du
Summary: The study found widespread distribution of ISFN in lymph nodes with follicular lymphoma and revealed FL-associated mutations in early lesions. The results indicate the dynamic nature of ISFN lesions, with neoplastic cells undergoing active trafficking and clonal evolution.
JOURNAL OF PATHOLOGY
(2022)
Article
Oncology
Adrian Mosquera Orgueira, Miguel Cid Lopez, Andres Peleteiro Raindo, Aitor Abuin Blanco, Jose Angel Diaz Arias, Marta Sonia Gonzalez Perez, Beatriz Antelo Rodriguez, Laura Bao Perez, Roi Ferreiro Ferro, Carlos Aliste Santos, Manuel Mateo Perez Encinas, Maximo Francisco Fraga Rodriguez, Claudio Cerchione, Pablo Mozas, Jose Luis Bello Lopez
Summary: This study utilized machine learning tools to analyze gene expression data and successfully created a model that can provide individualized predictions of overall survival in follicular lymphoma patients. The integration of this model with m7-FLIPI and age achieved high prediction accuracies and a simplified approach identified distinct groups with significantly different survival outcomes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Evelina Rogges, Sabrina Pelliccia, Gianluca Lopez, Sabina Barresi, Agostino Tafuri, Rita Alaggio, Arianna Di Napoli
Summary: In this study, we reported a case of AITL with coexisting SARS-CoV-2 infection and exuberant CD30-positive FDC proliferation. Genetic analysis identified mutations commonly involved in AITL but not in FDC sarcoma, supporting the reactive nature of the CD30-positive FDC expansion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Sarah Haebe, William Keay, Stefan Alig, Anne-Wiebe Mohr, Larissa K. Martin, Michael Heide, Ramona Secci, Stefan Krebs, Helmut Blum, Andreas Moosmann, Abner Louissaint, David M. Weinstock, Silvia Thoene, Michael von Bergwelt-Baildon, Juergen Ruland, Deepak Bararia, Oliver Weigert
Summary: This study found that in relapsed follicular lymphoma, the BCL2/IGH translocation may precede CPC-defining mutations, and cells with BCL2/IGH translocation can persist in clinical remission.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Oncology
Luiza Handschuh, Pawel Wojciechowski, Maciej Kazmierczak, Krzysztof Lewandowski
Summary: The dysregulated expression of BCL2 family genes in acute myeloid leukemia (AML) is characterized by an upregulation of anti-apoptotic genes and a downregulation of pro-apoptotic genes. High expression of BCL2L1 was observed in patients resistant to chemotherapy. BCL2L1 is identified as a key player in apoptosis regulation in different types of tumors.
Article
Oncology
Ryutaro Takada, Tomohiro Watanabe, Ikue Sekai, Keisuke Yoshikawa, Akane Hara, Yasuo Otsuka, Tomoe Yoshikawa, Ken Kamata, Kosuke Minaga, Yoriaki Komeda, Takaaki Chikugo, Yasuyuki Arai, Kohei Yamashita, Masatoshi Kudo
Summary: This case report describes a 64-year-old female diagnosed with abdominal double expressor lymphoma transformed from jejunal follicular lymphoma. Immunohistochemical and FISH analyses confirmed the concurrent occurrence of FL and DEL, suggesting a transformation from primary FL of the jejunum into abdominal aggressive DEL.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jin Roh, Hyo-Kyung Pak, Seongfeel Jeong, Sewon Hwang, Do Eon Kim, Hwal-Seok Choi, So-Jeong Kim, Hyunji Kim, Hyungwoo Cho, Joon Seong Park, Seong Hyun Jeong, Yoon Seok Choi, Jae Ho Han, Dok Hyun Yoon, Chan-Sik Park
Summary: DLBCL is a prevalent and aggressive non-Hodgkin's lymphoma. Increasing the expression levels of BCL2 family members may contribute to the development of new treatment strategies.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Pathology
Ji Yuan, Hui Liu, Shimin Hu, Roberto N. Miranda, Xinjie Xu, Michael G. Bayerl, Cody J. Artymiuk, Holly Berg, Rebecca L. King, Min Shi, Rong He, David Viswanatha, L. Jeffrey Medeiros, Ellen D. Mcphail
Summary: This study reports 5 adult patients with FL and FL/DLBCL with concurrent BCL2 and IRF4 rearrangements. The clinicopathologic and mutational features of these patients are more akin to FL and DLBCL, and should not be characterized as large B-cell lymphoma with IRF4 rearrangement.
Article
Oncology
Sabrina Kalmbach, Michael Grau, Myroslav Zapukhlyak, Ellen Leich, Vindi Jurinovic, Eva M. Hoster, Annette S. Staiger, Katrin Kurz, Oliver Weigert, Erik Gaitzsch, Verena Passerini, Marianne Engelhard, Klaus Herfarth, Klaus Beiske, Francesca Micci, Peter Moeller, Heinz-Wolfram C. Bernd, Alfred Feller, Wolfram Klapper, Harald Stein, Martin-Leo Hansmann, Sylvia Hartmann, Martin Dreyling, Harald Holte, Georg Lenz, Andreas Rosenwald, German Ott, Heike Horn, German Lymphoma Alliance GLA
Summary: Comprehensive analysis of localized follicular lymphoma (lFL) and systemic follicular lymphoma (sFL) revealed overlapping genetic and chromosomal abnormalities. However, significant differences were found in the frequency of chromosomal alterations, specifically in 18q gains. Rare gains in 18q21 were associated with inferior progression-free survival in lFL. ARID1A mutations were more frequently detected in sFL compared to lFL. This study provides novel insights and identifies 18q21 gains as a prognostic marker in lFL.
Article
Hematology
Fenghua Gao, Hengqi Liu, Xiangrui Meng, Jing Liu, Jiesong Wang, Jingwei Yu, Xia Liu, Xianming Liu, Lanfang Li, Lihua Qiu, Zhengzi Qian, Shiyong Zhou, Wenchen Gong, Bin Meng, Xiubao Ren, Zahra Golchehre, Zahra Chavoshzadeh, Jin He, Huilai Zhang, Xianhuo Wang
Summary: In this study, the clinical and genetic features of 415 FL patients were analyzed to identify variables associated with disease progression within 24 months of first-line therapy (POD24). Factors such as B symptoms, elevated lactate dehydrogenase and beta 2-microglobulin levels, unfavourable baseline haemoglobin levels, advanced stage, and high-risk FLIPI scores were found to increase the risk of POD24, with FLIPI being the most important factor. Specific genetic alterations and gene expression related to disease diagnosis and early progression were highlighted.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Hematology
Sarah Haebe, Tanaya Shree, Anuja Sathe, Grady Day, Debra K. Czerwinski, Susan M. Grimes, HoJoon Lee, Michael S. Binkley, Steven R. Long, Brock Martin, Hanlee P. Ji, Ronald Levy
Summary: The study found that B-cell receptor subclones were shared between the two tumor sites in some patients with follicular lymphoma, while in many patients, the disease had evolved separately with limited tumor cell migration between the sites. Differences in tumor gene expression and cell surface protein profiles were observed in patients with divergent BCR evolution. Additionally, a specific correlation was detected between site-to-site tumor heterogeneity and T follicular helper (Tfh) cell abundance.
Article
Hematology
Oliver C. Cohen, Maximillian H. Brodermann, Aoife Dervin, Neel Raja, Teresa Marafioti, Sofia Otero, Tim Beale, Susan Jawad, Alan Ramsay, Sabine Pomplun, Kirit M. Ardeshna, Ian Proctor, William Townsend, Simon Morley
Summary: Core biopsy is a reliable and well-tolerated method for diagnosing lymphoma and confirming relapse, with multiple cores yielding sufficient material in the majority of cases. The study found no significant differences in diagnostic outcomes based on indication or other factors, indicating the effectiveness of core biopsy as a primary diagnostic method.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2021)
Review
Oncology
Lukas Kalinke, Ricky Thakrar, Sam M. Janes
Summary: Survival rates for lung cancer are poor despite advances in targeted therapies and immunotherapies, but there is hope with improvements in early detection tools such as low-dose CT screening and biomarker research. However, challenges remain with LDCT screening primarily targeting high-risk individuals, suggesting a need for a synergistic, multimodal approach in the future for early lung cancer diagnosis.
MOLECULAR ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Matt Lechner, Volker H. Schartinger, Christopher D. Steele, Wen Long Nei, Marc Lucas Ooft, Liesa-Marie Schreiber, Christodoulos P. Pipinikas, Grace Tin-Yun Chung, Yuk Yu Chan, Feng Wu, Ka-Fai To, Chi Man Tsang, Wayne Pearce, Daniele Morelli, Martin Philpott, Liam Masterson, Reshma Nibhani, Graham Wells, Christopher G. Bell, Julia Koller, Susanne Delecluse, Yim Ling Yip, Jacklyn Liu, Cillian T. Forde, Martin D. Forster, Amrita Jay, Jozsef Dudas, Annika Krapp, Simon Wan, Christian Uprimny, Susanne Sprung, Johannes Haybaeck, Tim R. Fenton, Kerry Chester, Christina Thirlwell, Gary Royle, Teresa Marafioti, Rajeev Gupta, Sagung Rai Indrasari, Camelia Herdini, Mohd Afiq Mohd Slim, I. Indrawati, Liam Sutton, Renske Fles, Bing Tan, Joe Yeong, Amit Jain, Shuting Han, Haitao Wang, Kelvin S. H. Loke, Wan He, Ruilian Xu, Hongtao Jin, Zhiqiang Cheng, David Howard, Peter H. Hwang, Quynh-Thu Le, Joshua K. Tay, Robert B. West, Sai Wah Tsao, Tim Meyer, Herbert Riechelmann, Udo Oppermann, Henri-Jacques Delecluse, Stefan M. Willems, Melvin L. K. Chua, Pierre Busson, Kwok Wai Lo, Guido Wollmann, Nischalan Pillay, Bart Vanhaesebroeck, Valerie J. Lund
Summary: This study reveals that somatostatin receptor 2 is induced by the Epstein-Barr virus in nasopharyngeal carcinoma and plays a key role in the diagnosis, imaging, targeted therapies, and prognosis of the disease.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Marina Natoli, John Gallon, Haonan Lu, Ala Amgheib, David J. Pinato, Francesco A. Mauri, Teresa Marafioti, Ayse U. Akarca, Ines Ullmo, Jacey Ip, Eric O. Aboagye, Robert Brown, Anastasios Karadimitris, Sadaf Ghaem-Maghami
Summary: Baseline ERV expression in EOC can define clinically relevant subsets of patients and predict patient prognosis. High ERV score is associated with better survival and correlated with infiltration of CD8+PD1+T cells. Manipulation of ERV expression threshold can affect antitumor immunity.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Cell Biology
Massimo Granai, Stefano Lazzi, Virginia Mancini, Ayse Akarca, Raffaella Santi, Federica Vergoni, Ester Sorrentino, Raffaella Guazzo, Lucia Mundo, Gabriele Cevenini, Claudio Tripodo, Gioia Di Stefano, Benedetta Puccini, Maurilio Ponzoni, Elena Sabattini, Claudio Agostinelli, Nuray Bassullu, Tulay Tecimer, Ahu Senem Demiroz, Leah Mnango, Stephan Dirnhofer, Leticia Quintanilla-Martinez, Teresa Marafioti, Falko Fend, Lorenzo Leoncini
Summary: This study provides insights into the immune cell subsets involved in the early phase of Burkitt lymphoma, which may help in maintaining the tumor in a self-limited state or inducing its regression. These findings may open up new potential therapeutic avenues for EBV-positive BL patients in the era of cellular immunotherapy.
Article
Oncology
Fangtian Wu, Natsuko Watanabe, Maria-Myrsini Tzioni, Ayse Akarca, Chunye Zhang, Yan Li, Zi Chen, Francesco Cucco, Natasha Carmell, Jaeduk Yoshimura Noh, Koichi Ito, Rachel Dobson, Sarah Moody, Wenqing Yao, Wenyan Zhang, Weiping Liu, Hongxiang Liu, Jessica Okosun, Andreas Chott, Yingwen Bi, Shih-Sung Chuang, Markus Raderer, Jian-Yong Li, Teresa Marafioti, Ming-Qing Du
Summary: The study found that genetic changes in CD274 and TNFRSF14 in thyroid MALT lymphoma are significantly associated with Hashimoto's thyroiditis. Inactivation of CD274/TNFRSF14 may disrupt the interaction between malignant B cells and T cells, promoting co-stimulations and impairing peripheral tolerance.
Article
Radiology, Nuclear Medicine & Medical Imaging
Besma Musaddaq, Adam Brown, Sam Dluzewski, Teresa Marafioti, Anmol Malhotra
Summary: COVID-19 vaccines can cause reactive axillary lymphadenopathy, which should be taken into consideration when evaluating breast screening patients. A case study demonstrated biopsy-proven unilateral reactive axillary lymphadenopathy in a high-risk BRCA carrier following Astra Zeneca vaccine administration.
Article
Oncology
Lewis Au, Emine Hatipoglu, Marc Robert de Massy, Kevin Litchfield, Gordon Beattie, Andrew Rowan, Desiree Schnidrig, Rachael Thompson, Fiona Byrne, Stuart Horswell, Nicos Fotiadis, Steve Hazell, David Nicol, Scott T. C. Shepherd, Annika Fendler, Robert Mason, Lyra Del Rosario, Kim Edmonds, Karla Lingard, Sarah Sarker, Mary Mangwende, Eleanor Carlyle, Jan Attig, Kroopa Joshi, Imran Uddin, Pablo D. Becker, Mariana Werner Sunderland, Ayse Akarca, Ignazio Puccio, William W. Yang, Tom Lund, Kim Dhillon, Marcos Duran Vasquez, Ehsan Ghorani, Hang Xu, Charlotte Spencer, Jose Lopez, Anna Green, Ula Mahadeva, Elaine Borg, Miriam Mitchison, David A. Moore, Ian Proctor, Mary Falzon, Lisa Pickering, Andrew J. S. Furness, James L. Reading, Roberto Salgado, Teresa Marafioti, Mariam Jamal-Hanjani, George Kassiotis, Benny Chain, James Larkin, Charles Swanton, Sergio A. Quezada, Samra Turajlic
Summary: The ADAPTeR study aimed to investigate the mechanism of therapeutic response to nivolumab in metastatic clear cell renal cell carcinoma, with genomic analysis showing no correlation between tumor molecular features and response. Pre-existing immunity may play a key role in predicting clinical response.
Article
Cell Biology
Julia P. Gerber, Jenny Russ, Vijay Chandrasekar, Nina Offermann, Hang-Mao Lee, Sarah Spear, Nicola Guzzi, Simona Maida, Sundararaghavan Pattabiraman, Ruoyu Zhang, Amir H. Kayvanjoo, Preeta Datta, Jagath Kasturiarachchi, Teresa Sposito, Natalia Izotova, Kristian Haendler, Peter D. Adams, Teresa Marafioti, Tariq Enver, Jorg Wenzel, Marc Beyer, Elvira Mass, Cristian Bellodi, Joachim L. Schultze, Melania Capasso, Rachael Nimmo, Paolo Salomoni
Summary: The study reveals that the H3.3 chaperone Daxx acts as an epigenetic barrier to control haematopoietic progenitor plasticity and protect against PU.1-mediated inflammation by repressing endogenous retroviral and retrotransposable elements. Defective silencing of these elements has been linked to inflammageing, cancer, and autoimmune diseases, implicating a potential role for Daxx in protection from inflammatory diseases.
NATURE CELL BIOLOGY
(2021)
Correction
Cell Biology
Julia P. Gerber, Jenny Russ, Vijay Chandrasekar, Nina Offermann, Hang-Mao Lee, Sarah Spear, Nicola Guzzi, Simona Maida, Sundararaghavan Pattabiraman, Ruoyu Zhang, Amir H. Kayvanjoo, Preeta Datta, Jagath Kasturiarachchi, Teresa Sposito, Natalia Izotova, Kristian Handler, Peter D. Adams, Teresa Marafioti, Tariq Enver, Jorg Wenzel, Marc Beyer, Elvira Mass, Cristian Bellodi, Joachim L. Schultze, Melania Capasso, Rachael Nimmo, Paolo Salomoni
NATURE CELL BIOLOGY
(2022)
Article
Oncology
Yeman B. Hagos, Ayse U. Akarca, Alan Ramsay, Riccardo L. Rossi, Sabine Pomplun, Victoria Ngai, Alessia Moioli, Andrea Gianatti, Christopher Mcnamara, Alessandro Rambaldi, Sergio A. Quezada, David Linch, Giuseppe Gritti, Yinyin Yuan, Teresa Marafioti
Summary: This study investigated the spatial interplay of immune cells in follicular lymphoma using immunofluorescence images. The results showed that low density of CD8+FOXP3+ cells and their co-localization with CD4+CD8+ cells in the inter-follicular region were significantly associated with relapse and shorter time to progression after treatment.
HEMATOLOGICAL ONCOLOGY
(2022)
Article
Respiratory System
Theresia A. Mikolasch, Eunice Oballa, Mitra Vahdati-Bolouri, Emily Jarvis, Yi Cui, Anthony Cahn, Rebecca L. Terry, Jagdeep Sahota, Ricky Thakrar, Peter Marshall, Joanna C. Porter
Summary: Using mass spectrometry and histopathology, researchers have demonstrated for the first time that an inhaled drug can effectively reach the distal fibrotic lung parenchyma in patients with Interstitial Lung Disease. This discovery suggests that inhaled drugs could potentially be used to treat pulmonary fibrosis.
RESPIRATORY RESEARCH
(2022)
Meeting Abstract
Gastroenterology & Hepatology
David J. Pinato, Alessio Cortellini, Cristina Balcells, Saskia Killmer, Thomas Talbot, Robert Thomas, Anwar A. Sayed, Elias Allara, Paul Tait, Paul Ross, Anna Mary Young, Tom Cole, Robert D. Goldin, Caroline Ward, Ayse Akarca, Jesus Miguens Blanco, Teresa Marafioti, Hector Keun, Alexandros Siskos, Julian Marchesi, Bertram Bengsch, Rohini Sharma
JOURNAL OF HEPATOLOGY
(2021)
Meeting Abstract
Gastroenterology & Hepatology
Sam Murray, Alejandro Forner, Takahiro Kaneko, Petros Fessas, Pierluigi Toniutto, Beatriz Minguez, Valentina Cacciato, Claudio Avellini, Alba Diaz, Rosemary J. Boyton, Daniel M. Altmann, Robert D. Goldin, Ayse U. Akarca, Teresa Marafioti, Francesco A. Mauri, Edoardo Casagrande, Federica Grillo, Edoardo G. Giannini, Sherrie Bhoori, Vincenzo Mazzaferro, David J. Pinato
JOURNAL OF HEPATOLOGY
(2021)
Article
Pathology
Hebah Ali, Ignazio Puccio, Ayse U. Akarca, Roshanak Bob, Sabine Pomplun, Wai Keong Wong, Rajeev Gupta, Mallika Sekhar, Jonathan Lambert, Hytham Al-Masri, Harald Stein, Teresa Marafioti
Summary: Testing for the CALR mutation is now included in the updated WHO criteria for ET and PMF. The CAL2 antibody showed a high positivity rate in MPN and MDS/MPN, suggesting the possible presence of CALR gene abnormalities in stem cells.
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
(2021)