Review
Infectious Diseases
Kylen E. Ridyard, Joerg Overhage
Summary: LL-37 shows promise as an alternative to conventional antibiotics due to its broad spectrum antibacterial and immunomodulatory properties, but faces limitations such as high cost and toxicity to human cells.
Article
Chemistry, Multidisciplinary
Xin Jiang, Chenguang Yang, Jie Qiu, Dongfei Ma, Cheng Xu, Shuxin Hu, Weijing Han, Bing Yuan, Ying Lu
Summary: LL-37 is able to induce specific permeability of a phosphoethanolamine-rich mitochondrial membrane in a protein-independent manner, offering an alternative pathway for LL-37-triggered mitochondrial membrane permeabilization and apoptosis.
Review
Biology
Zahra Chinipardaz, Jessica M. Zhong, Shuying Yang
Summary: The goal of regenerative therapy is to restore the structure and function of lost tissues in medicine and dentistry. Challenges such as oxygen and nutrition delivery and infection risk exist. LL-37, a peptide found only in humans, has been shown to play an essential role in neovascularization, stem cell migration and differentiation, and host immune response modulation. It also possesses functions in wound healing, angiogenesis, cell differentiation, and apoptosis modulation.
Article
Chemistry, Multidisciplinary
Johnson John, Navatha Shree Sharma, Guosheng Tang, Zeyu Luo, Yajuan Su, Shelbie Weihs, S. M. Shatil Shahriar, Guangshun Wang, Alec McCarthy, Justin Dyke, Yu Shrike Zhang, Ali Khademhosseini, Jingwei Xie
Summary: This study introduces a strategy to use nanofiber aerogels combined with the LL-37-mimic peptide W379 for accelerated healing of diabetic wounds, showing great potential for clinical applications.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Xue Chen, Suixin Deng, Wenchao Wang, Stefania Castiglione, Zilei Duan, Lei Luo, Francesca Cianci, Xiaoxue Zhang, Jianglei Xu, Hao Li, Jizong Zhao, Peter Muiruri Kamau, Zhiye Zhang, James Mwangi, Jiali Li, Yousheng Shu, Xintian Hu, Michele Mazzanti, Ren Lai
Summary: This study reveals that the antimicrobial peptide LL-37 promotes the membrane translocation and integration of CLIC1, leading to microglial hyperactivation and neuroinflammation in Alzheimer's disease. The findings suggest that LL-37 may act as an endogenous agonist of CLIC1, driving the progression of AD.
MOLECULAR PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Jiantong Wei, Xuepeng Cao, Jun Qian, Zhixia Liu, Xulong Wang, Qinliuye Su, Yongpin Wang, Ruimin Xie, Xiang Li
Summary: The antimicrobial peptide LL-37, belonging to the cathelicidin family, has potent antistaphylococcal activity. It shows strong antibacterial effects on S. aureus in vitro with a minimum inhibitory concentration of about 0.62 mu M, and significantly inhibits the adhesion of S. aureus and disrupts biofilm formation on titanium alloy surfaces at certain concentrations. This study highlights the potential of LL-37 as a novel approach for refractory S. aureus infections in titanium alloy prosthesis infections.
Article
Biology
Piotr Kolesinski, Kuei-Chen Wang, Yujiro Hirose, Victor Nizet, Partho Ghosh
Summary: This study revealed the specific binding mechanism between the Streptococcus pyogenes M protein and the human antimicrobial peptide LL-37, providing important insights into the drug resistance of streptococcus.
Article
Medicine, Research & Experimental
Chih-Chin Shih, Wei-Chieh Liao, Hung-Yen Ke, Chia-Wen Kuo, Cheng-Ming Tsao, Wen-Chiuan Tsai, Yi-Lin Chiu, Hsieh-Chou Huang, Chin-Chen Wu
Summary: Global warming increases the incidence of heat stroke, which leads to intestinal barrier disruption, microbial translocation, systemic inflammation, and multiple organ failure. Cathelicidin LL-37 has protective effects on the intestine and could prevent heat stress-induced intestinal damage and heat-related illnesses.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Nikhil N. Kulkarni, Alan M. O'Neill, Tatsuya Dokoshi, Elizabeth W. C. Luo, Gerard C. L. Wong, Richard L. Gallo
Summary: Cathelicidins like LL-37 have dual functions in killing microbes and triggering inflammation by recognizing endogenous nucleic acids. Variants of LL-34 showed different antimicrobial and interferon expression capabilities. LL-34 and U1 RNA form supramolecular structures, activating Toll-like receptor 3.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Pediatrics
Shaojie Zhao, Yixiu He, Menglan Pan, Bingzhang Chen, Siqi Zhang, Yufeng Zhang, Yafei Zhu
Summary: Vitamin D deficiency is associated with the occurrence and severity of bacterial pneumonia in infants. The level of LL-37 is increased in infants with bacterial pneumonia but decreases with disease progression.
FRONTIERS IN PEDIATRICS
(2022)
Article
Biochemistry & Molecular Biology
Paulina Piller, Heimo Wolinski, Robert A. Cordfunke, Jan Wouter Drijfhout, Sandro Keller, Karl Lohner, Nermina Malanovic
Summary: The development of antimicrobial agents against multidrug-resistant bacteria is crucial in the medical field. This study found that SAAP-148, an antimicrobial peptide, showed higher efficiency in killing bacteria and had stronger effects on membranes at both cellular and molecular levels compared to OP-145.
Article
Biochemistry & Molecular Biology
Francisco Javier Sanchez-Pena, Maria de los Angeles Romero-Tlalolini, Honorio Torres-Aguilar, Diego Sait Cruz-Hernandez, Rafael Baltierrez-Hoyos, Sarai Remedios Sanchez-Aparicio, Alba Soledad Aquino-Dominguez, Sergio Roberto Aguilar-Ruiz
Summary: Research has shown that the antimicrobial peptide LL-37 activates the antimicrobial function of human platelets by increasing receptor expression and secreted antimicrobial molecules. It also enhances the binding of platelets to E. coli, S. aureus, and C. albicans, and inhibits the growth of these microorganisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Kornelius Zeth, Enea Sancho-Vaello
Summary: The human cathelicidin LL-37 is a versatile peptide with antimicrobial activity, playing a crucial role in targeting microorganisms. Recent structural studies have revealed the diversity and adaptability of LL-37 in interacting with lipid-like molecules. Complexes of LL-37 with detergents provide insights into mimicking lipids and inducing oligomerization and fibrillation, opening avenues for designing LL-37-derived peptides with enhanced antibiotic properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Takeshi Mori, Miyako Yoshida, Mai Hazekawa, Daisuke Ishibashi, Yoshiro Hatanaka, Toshihiro Nagao, Rie Kakehashi, Honami Kojima, Rio Uno, Minoru Ozeki, Ikuo Kawasaki, Taku Yamashita, Junichi Nishikawa, Takahiro Uchida
Summary: The conjugation of antimicrobial peptide fragments with polymers can enhance their antibacterial and antifungal activities while reducing cytotoxicity. Studies have shown that CKR12-PLGA exhibited higher antibacterial activity against S. aureus and E. coli, as well as higher antifungal activity against Candida albicans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Virology
Niloofar Khairkhah, Azam Bolhassani, Farzad Rajaei, Reza Najafipour
Summary: Human papillomavirus (HPV) type 16 is the most common sexually transmitted virus associated with cervical cancer. In this study, optimal gRNA sequences targeting HPV16 E5, E6, E7, and p97 promoter for CRISPR/Cas9-mediated genome editing were designed. The E6 + E7-treated group showed the best treatment efficacy, with a high percentage of cleaved caspase-3 positive cells (45.75%) and a low mitotic index of 2-3. Additionally, the potential of LL-37 peptide to overcome the CRISPR/Cas9 delivery challenge was demonstrated for the first time. Overall, the study suggests that CRISPR/Cas9-mediated gene editing is an effective, specific, and nontoxic treatment for pre-existing tumors, and the future of precise gene therapy in cancer patients is very promising.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Letter
Dermatology
Yu Seong Chu, Solam Lee, Sang Gyun Lee, Kee Yang Chung, Mi Ryung Roh, Sejung Yang, Byungho Oh
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Oncology
Sun-Ae Park, Lee Kyung Kim, Hye Min Park, Hee Jung Kim, Tae-Hwe Heo
Summary: The combination therapy of bazedoxifene and paclitaxel can suppress cell viability, migration, and invasion in ovarian cancer cells, increase apoptosis, reduce STAT3 phosphorylation, and suppress gene expression and EMT.
Review
Oncology
Nour Kibbi, Joshua L. Owen, Brandon Worley, Jake X. Wang, Vishnu Harikumar, Malia B. Downing, Sumaira Z. Aasi, Phyu P. Aung, Christopher A. Barker, Diana Bolotin, Jeremy S. Bordeaux, Todd Cartee, Sunandana Chandra, Nancy L. Cho, Jennifer N. Choi, Kee Yang Chung, William A. Cliby, Oliver Dorigo, Daniel B. Eisen, Yasuhiro Fujisawa, Nicholas Golda, Thorvardur R. Halfdanarson, Christos Iavazzo, Shang I. Brian Jiang, Jean Kanitakis, Ashraf Khan, John Y. S. Kim, Timothy M. Kuzel, Naomi Lawrence, Mario M. Leitao, Allan B. MacLean, Ian A. Maher, Bharat B. Mittal, Kishwer S. Nehal, David M. Ozog, Curtis A. Pettaway, Jeffrey S. Ross, Anthony M. Rossi, Sabah Servaes, Michael J. Solomon, Valencia D. Thomas, Maria Tolia, Bryan B. Voelzke, Abigail Waldman, Michael K. Wong, Youwen Zhou, Nobuo Arai, Alexandria Brackett, Sarah A. Ibrahim, Bianca Y. Kang, Emily Poon, Murad Alam
Summary: Extramammary Paget disease is a frequently recurring malignant neoplasm that requires multiple skin biopsies for diagnosis, with surgical resection preferred for intraepidermal and invasive disease. Non-surgical treatments like radiotherapy and medications are options for unresectable cases, with a recommendation for close follow-up for at least 5 years.
Article
Dermatology
Mi Yeon Cho, Ahreum Song, Kee Yang Chung, Mi Ryung Roh
Summary: This study demonstrates the superiority of the tunneling method over the conventional method in terms of therapeutic effect and side effect occurrence in the treatment of keloids.
DERMATOLOGIC SURGERY
(2022)
Article
Oncology
Taiqin Chen, Ki-Yeol Kim, Yeongjoo Oh, Hei Cheul Jeung, Kee Yang Chung, Mi Ryung Roh, Xianglan Zhang
Summary: The present study reveals that COPB2 may play a crucial role in the pathogenesis of cSCC and can serve as a novel predictive prognostic biomarker and immunotherapeutic target. The findings have significant implications for a better understanding of the molecular mechanisms underlying cSCC and the development of personalized treatment strategies.
Article
Oncology
Z. H. E. N. L. O. N. G. Zheng, D. A. E. SAN Yoo, S. H. A. N. S. H. A. N. LI, M. E. I. L. I. N. G. Pei, Sang Gyun Lee, Ji Young Kim, Kee Yang Chung, Mi Ryung Roh
Summary: This study investigates the clinicopathological significance of cancer-associated fibroblasts (CAFs) in Merkel cell carcinoma (MCC) and their association with tumor-infiltrating lymphocytes (TILs). The results suggest that IL6+CAFs may influence the tumor immune microenvironment of MCC by modulating distinct T-cell populations and functions, providing a potential therapeutic target to overcome resistance to immune therapies in MCC.
ANTICANCER RESEARCH
(2022)
Article
Oncology
Yeongjoo Oh, Zhenlong Zheng, Ki-Yeol Kim, Xiangshu Xu, Meiling Pei, Byungho Oh, Sang Kyem Kim, Kee Yang Chung, Mi Ryung Roh
Summary: A powerful risk prediction model for cSCC recurrence was constructed by combining clinical factors and biomarkers into a nomogram.
Article
Dermatology
Chang Gon Kim, Miso Kim, Jieon Hwang, Seung Tae Kim, Minkyu Jung, Kyoo Hyun Kim, Kyung Hwan Kim, Jee Suk Chang, Woong Sub Koom, Mi Ryung Roh, Kee Yang Chung, Tae Min Kim, Sang Kyum Kim, Jeeyun Lee, Sang Joon Shin
Summary: This study compared the outcomes of first-line pembrolizumab and dabrafenib/trametinib treatment for patients with advanced melanoma with BRAF mutations. The results showed that first-line pembrolizumab treatment resulted in longer overall survival, suggesting it may be a better treatment option.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Dermatology
Byung Ho Oh, Solam Lee, Jung Won Park, Ju Yeong Lee, Mi Ryung Roh, Kyoung Ae Nam, Kee Yang Chung
Summary: This study retrospectively reviewed patients with Minimally invasive nail unit melanoma (NUM) and identified risk factors for recurrence. Male sex, greater Breslow thickness, amelanotic color, ulcers, and nodules were associated with higher risk of recurrence or distant disease. A Breslow thickness of 0.8 mm was determined to be the optimal cut-off point for predicting recurrence risk after surgery.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sun-Ae Park, Young Ju Seo, Lee Kyung Kim, Hee Jung Kim, Kee Dong Yoon, Tae-Hwe Heo
Summary: The study found that Butea monosperma, a traditional Indian medicine, has potent anti-IL-6 activity and can be used for the treatment of ovarian cancer. It inhibits IL-6 signaling pathway, suppresses cell proliferation, migration, and invasion, induces cell cycle arrest and apoptosis, and significantly inhibits the growth of ovarian cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Lee Kyung Kim, Sun-Ae Park, Eun Ji Nam, Young Tae Kim, Tae-Hwe Heo, Hee Jung Kim
Summary: In this study, it was confirmed that the upregulation of long non-coding RNA (lncRNA) SNHG4 is associated with lower survival rates in endometrial cancer patients. Knock-down of SNHG4 reduced cell proliferation, colonization, migration, invasion, and tumor growth of endometrial cancer. Moreover, the role of SNHG4 was mediated by the transcription factor SP-1. These findings suggest that SNHG4/SP-1 may serve as a potential therapeutic and prognostic biomarker for endometrial cancer.
Article
Dermatology
Sujin Park, Yeongjoo Oh, Jong Won Lee, Sooyie Choi, Kyoung Ae Nam, Mi Ryung Roh, Kee Yang Chung
Summary: This study retrospectively reviewed patients who underwent purse-string sutures between January 2015 and December 2019. The results showed that multilayered purse-string suture had the shortest repair duration and effectively minimized the scar size. The average Vancouver scar scale measured at least 6 months postoperatively was 1.62, with a risk of hypertrophic scarring of 8.6%. There was no significant difference in scar assessment and risk of hypertrophic scarring between different surgical method groups.
ANNALS OF DERMATOLOGY
(2023)
Letter
Dermatology
Hyo Jin Park, Kyung Ho Lee, Chul Jong Park
ANNALS OF DERMATOLOGY
(2022)
Article
Dermatology
Hyun Jeong Ju, Hyo Jin Park, In Hye Choi, Kyung Ho Lee, Mi Yeon Kwon, Chul Jong Park
Summary: This study found that the levels of Th1 and Th17 cytokines in tissues were increased in psoriasis patients compared to healthy controls. The increase in IFN-gamma mRNA levels in acute guttate psoriasis and the increase in IL-12 and IL-17A protein levels in chronic plaque psoriasis suggest that an imbalance between Th1 and Th17 cytokines may play a role in the phenotypic transition of psoriasis.
ANNALS OF DERMATOLOGY
(2022)
Article
Dermatology
Kyungduck Park, Jung Min Bae, Kee Yang Chung, Sook Jung Yun, Soo Hong Seo, Hyo Hyun Ahn, Dong-Youn Lee, Heesu Kim, Uri Sohn, Byung Cheol Park
Summary: The incidence and prevalence rates of various tumors in South Korea, especially premalignant actinic keratosis and nonmelanoma skin cancer, have been increasing, which is of significant importance in the development of preventive and therapeutic strategies.
ANNALS OF DERMATOLOGY
(2022)