Expansion of a PBPK model to predict disposition in pregnant women of drugs cleared via multiple CYP enzymes, including CYP2B6, CYP2C9 and CYP2C19

Reduced indinavir exposure during pregnancy

(2013) Tim R. Cressey et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

The status of pharmacometrics in pregnancy: highlights from the 3rdAmerican conference on pharmacometrics

(2012) J. G. Coen van Hasselt et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

A pregnancy physiologically based pharmacokinetic (p-PBPK) model for disposition of drugs metabolized by CYP1A2, CYP2D6 and CYP3A4

(2012) Lu Gaohua et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Anatomical, Physiological and Metabolic Changes with Gestational Age during Normal Pregnancy

(2012) Khaled Abduljalil et al.   CLINICAL PHARMACOKINETICS

Pharmacokinetic and Pharmacodynamic Analysis of Efavirenz Dose Reduction Using an In Vitro–In Vivo Extrapolation Model

(2012) M Siccardi et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Pharmacokinetic-Pharmacodynamic Modeling of Mood and Withdrawal Symptoms in Relation to Plasma Concentrations of Methadone in Patients Undergoing Methadone Maintenance Treatment

(2012) Mohammad-Reza Shiran et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Physiologically Based Modeling of Pravastatin Transporter-Mediated Hepatobiliary Disposition and Drug-Drug Interactions

(2012) Manthena V. S. Varma et al.   PHARMACEUTICAL RESEARCH

Physiologically-Based Pharmacokinetics in Drug Development and Regulatory Science

(2011) Malcolm Rowland et al.   Annual Review of Pharmacology and Toxicology

Efavirenz Pharmacokinetics During the Third Trimester of Pregnancy and Postpartum

(2011) Tim R. Cressey et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Breast Cancer Resistance Protein (BCRP)-Mediated Glyburide Transport: Effect of the C421A/Q141K BCRP Single-Nucleotide Polymorphism

(2010) E. K. Pollex et al.   DRUG METABOLISM AND DISPOSITION

Altered drug metabolism during pregnancy: hormonal regulation of drug-metabolizing enzymes

(2010) Hyunyoung Jeong   Expert Opinion on Drug Metabolism & Toxicology

Regulation of CYP2C19 Expression by Estrogen Receptor  : Implications for Estrogen-Dependent Inhibition of Drug Metabolism

(2010) J. Mwinyi et al.   MOLECULAR PHARMACOLOGY

Role of CYP2B6 in Stereoselective Human Methadone Metabolism

(2009) Rheem A. Totah et al.   ANESTHESIOLOGY

Methadone Pharmacokinetics Are Independent of Cytochrome P4503A (CYP3A) Activity and Gastrointestinal Drug Transport

(2009) Evan D. Kharasch et al.   ANESTHESIOLOGY

Identification of the major human hepatic and placental enzymes responsible for the biotransformation of glyburide

(2009) Olga L. Zharikova et al.   BIOCHEMICAL PHARMACOLOGY

Are We Optimizing Gestational Diabetes Treatment With Glyburide? The Pharmacologic Basis for Better Clinical Practice

(2009) MF Hebert et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Towards a Quantitative Framework for the Prediction of DDIs Arising from Cytochrome P450 Induction

(2009) L. Almond et al.   CURRENT DRUG METABOLISM

A Framework for Assessing Inter-individual Variability in Pharmacokinetics Using Virtual Human Populations and Integrating General Knowledge of Physical Chemistry, Biology, Anatomy, Physiology and Genetics: A Tale of ‘Bottom-Up’ vs ‘Top-Down’ Recognition of Covariates

(2009) Masoud Jamei et al.   Drug Metabolism and Pharmacokinetics

Coadministration of Pioglitazone or Glyburide and Alogliptin: Pharmacokinetic Drug Interaction Assessment in Healthy Participants

(2009) Aziz Karim et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Elucidating Rifampin's Inducing and Inhibiting Effects on Glyburide Pharmacokinetics and Blood Glucose in Healthy Volunteers: Unmasking the Differential Effects of Enzyme Induction and Transporter Inhibition for a Drug and Its Primary Metabolite

(2008) HX Zheng et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 670 Drug Compounds

(2008) R. S. Obach et al.   DRUG METABOLISM AND DISPOSITION

Pharmacokinetics and Pharmacodynamics of Methadone Enantiomers After Coadministration with Fosamprenavir-Ritonavir in Opioid-Dependent Subjects

(2008) Ying-Jun Cao et al.   PHARMACOTHERAPY