Urinary kidney biomarkers for early detection of nephrotoxicity in clinical drug development

Acute Kidney Injury During Therapy With an Antisense Oligonucleotide Directed Against PCSK9

(2013) Eveline P. van Poelgeest et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

A New Equation to Estimate Glomerular Filtration Rate

(2013) Andrew S. Levey et al.   ANNALS OF INTERNAL MEDICINE

Evaluation and Management of Chronic Kidney Disease: Synopsis of the Kidney Disease: Improving Global Outcomes 2012 Clinical Practice Guideline

(2013) Paul E. Stevens   ANNALS OF INTERNAL MEDICINE

Mesenchymal stem cell-conditioned medium accelerates regeneration of human renal proximal tubule epithelial cells after gentamicin toxicity

(2012) Reza Moghadasali et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Detection and management of nephrotoxicity during drug development

(2012) Dr Mahmoud Loghman-Adham et al.   Expert Opinion On Drug Safety

UrinaryN-acetyl-β-d-Glucosaminidase Levels are Positively Correlated With 2-Hr Plasma Glucose Levels During Oral Glucose Tolerance Testing in Prediabetes

(2012) Motoshi Ouchi et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Signaling through the interleukin-18 receptor α attenuates inflammation in cisplatin-induced acute kidney injury

(2012) Yuji Nozaki et al.   KIDNEY INTERNATIONAL

Tissue Kim-1 and Urinary Clusterin as Early Indicators of Cisplatin-Induced Acute Kidney Injury in Rats

(2012) Petra Vinken et al.   TOXICOLOGIC PATHOLOGY

Trefoil Factor 3 Predicts Incident Chronic Kidney Disease: A Case-Control Study Nested within the Atherosclerosis Risk in Communities (ARIC) Study

(2011) Brad C. Astor et al.   AMERICAN JOURNAL OF NEPHROLOGY

Comparison of the course of biomarker changes and kidney injury in a rat model of drug-induced acute kidney injury

(2011) Daisuke Sasaki et al.   BIOMARKERS

The Clinician and Estimation of Glomerular Filtration Rate by Creatinine-based Formulas: Current Limitations and Quo Vadis

(2011) R. Botev et al.   Clinical Journal of the American Society of Nephrology

Mesures de la performance rénale en clinique : principes et limites

(2011) A. Prigent   JOURNAL DE RADIOLOGIE

Nephrotoxicity of hexachloro-1:3-butadiene in the male Hanover Wistar rat; correlation of minimal histopathological changes with biomarkers of renal injury

(2011) Aubrey Swain et al.   JOURNAL OF APPLIED TOXICOLOGY

Cystatin C: influence of perfusion and myocardial injury on early (

(2011) Antony Vassalos et al.   PEDIATRIC ANESTHESIA

Biological Qualification of Biomarkers of Chemical-Induced Renal Toxicity in Two Strains of Male Rat

(2011) Ernie Harpur et al.   TOXICOLOGICAL SCIENCES

Association of Urinary Biomarkers With Disease Severity in Patients With Autosomal Dominant Polycystic Kidney Disease: A Cross-sectional Analysis

(2010) Esther Meijer et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Biomarkers of Acute Kidney Injury

(2010) David R. McIlroy et al.   ANESTHESIOLOGY

Early biomarkers of cadmium exposure and nephrotoxicity

(2010) Walter C. Prozialeck et al.   BIOMETALS

Comparative profile of commercially available urinary biomarkers in preclinical drug-induced kidney injury and recovery in rats

(2010) Rodney L. Rouse et al.   KIDNEY INTERNATIONAL

Urinary biomarkers trefoil factor 3 and albumin enable early detection of kidney tubular injury

(2010) Yan Yu et al.   NATURE BIOTECHNOLOGY

Urinary clusterin, cystatin C, β2-microglobulin and total protein as markers to detect drug-induced kidney injury

(2010) Frank Dieterle et al.   NATURE BIOTECHNOLOGY

A panel of urinary biomarkers to monitor reversibility of renal injury and a serum marker with improved potential to assess renal function

(2010) Josef S Ozer et al.   NATURE BIOTECHNOLOGY

Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies

(2010) Vishal S Vaidya et al.   NATURE BIOTECHNOLOGY

Kidney Injury Molecule-1 Expression in Rat Proximal Tubule after Treatment with Segment-Specific Nephrotoxicants

(2010) Arianna Chiusolo et al.   TOXICOLOGIC PATHOLOGY

Evaluation of the usefulness of urinary biomarkers for nephrotoxicity in rats

(2010) Yutaka Tonomura et al.   TOXICOLOGY

Evaluation of a urinary kidney biomarker panel in rat models of acute and subchronic nephrotoxicity

(2010) Dana Hoffmann et al.   TOXICOLOGY

Novel conditionally immortalized human proximal tubule cell line expressing functional influx and efflux transporters

(2009) Martijn J. Wilmer et al.   CELL AND TISSUE RESEARCH

Glomerular filtration rate measurement and prediction equations

(2009) Ariana Aguiar Soares et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Measured GFR as a Confirmatory Test for Estimated GFR

(2009) L. A. Stevens et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

IL-18 neutralization ameliorates obstruction-induced epithelial–mesenchymal transition and renal fibrosis

(2009) Ahmad H. Bani-Hani et al.   KIDNEY INTERNATIONAL

Early prediction of urinary tract infection with urinary neutrophil gelatinase associated lipocalin

(2009) Alev Yilmaz et al.   PEDIATRIC NEPHROLOGY

Comparative Analysis of Novel Noninvasive Renal Biomarkers and Metabonomic Changes in a Rat Model of Gentamicin Nephrotoxicity

(2009) Max Sieber et al.   TOXICOLOGICAL SCIENCES

Urinary Biomarkers for Sensitive and Specific Detection of Acute Kidney Injury in Humans

(2008) Vishal S. Vaidya et al.   CTS-Clinical and Translational Science