Article
Medicine, General & Internal
Juanying Zhen, Shuyun Liu, Ryan Yan Lam Kam, Guoru Zhao, Hao Peng, Jianguo Liang, Aimin Xu, Chao Li, Lijie Ren, Jun Wu, Bernard Man Yung Cheung
Summary: We aimed to investigate the relationship of B2M, cystatin C, and LCN-2 with stroke risk in a general Chinese population. Elevated levels of serum B2M, cystatin C, and LCN-2 were significantly associated with stroke risk. These biomarkers may serve as useful tools for clinicians to assess stroke risk.
ANNALS OF MEDICINE
(2023)
Article
Veterinary Sciences
Kenan Cagri Tumer, Pelin Fatos Polat Dincer, Sumeyye Babacan, Zeynep Yerlikaya
Summary: Schizont-infected nucleated cells and anemia-induced hypoxia may lead to acute kidney injury (AKI) in cattle with tropical theileriosis. Urine biomarkers such as neutrophil gelatinase-associated lipocalin (NGAL), Cystatin C (CysC), and Clusterin (Clu) have shown better performance than serum creatinine (sCr) in detecting AKI in various animal species, but their effectiveness in cattle for AKI detection has not been studied. This study examined AKI in cattle with tropical theileriosis using serum and urinary NGAL, CysC, and Clu, and compared them to standard renal function markers such as sCr, urine protein to creatinine (uPC) ratio, and urine-specific gravity (USG). The results indicated that cattle with tropical theileriosis had acute tubular injury.
PAKISTAN VETERINARY JOURNAL
(2023)
Article
Urology & Nephrology
Lara Staechele, Daniel J. Stekhoven, Jan A. Birzele, Martin Risch, Raeto T. Strebel
Summary: The purpose of this preliminary study was to assess the changes in concentration of biomarkers indicating renal injury after RIRS. The results showed a significant increase in certain biomarkers after RIRS, but this increase was temporary and normalized within 14 days. Further studies are needed to determine the clinical value of these markers in assessing the long-term impact of intrarenal pressure elevation during RIRS.
WORLD JOURNAL OF UROLOGY
(2022)
Article
Chemistry, Multidisciplinary
Olusola Bolaji Adewale, Scholastica Onyebuchi Anadozie, Regina T. Okpiri, Kikelomo Folake Jaiyesimi, Olutunmise Owolabi, Oluwatobiloba Akinlade, Tajudeen Olabisi Obafemi, Olukemi Adetutu Osukoya, Amos Onasanya
Summary: This study investigated the protective effects of C. rubens-gold nanoparticles against Cd-induced kidney damage in rats by inhibiting oxidative stress and down-regulating the expression of kidney injury markers. The results suggest that C. rubens-AuNPs have the potential to ameliorate Cd-induced kidney damage.
DRUG AND CHEMICAL TOXICOLOGY
(2023)
Article
Immunology
Bin Zhang, Yanyan Song, Qian Ma, Jian Yang, Lei Bai
Summary: This study aimed to investigate the changes and significance of perioperative expression levels of kidney injury molecule-1 (KIM-1), neutrophil gelatinase-related lipocalin (NGAL), and heme oxygenase-1 (HO-1) in patients with acute kidney injury (AKI) after cardiac valve replacement under cardiopulmonary bypass. The results showed that the expression levels of KIM-1, NGAL, and HO-1 can serve as early warning indicators of postoperative AKI.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Endocrinology & Metabolism
Peng Zhou, Chao Yang, Shan Zhang, Zun-Xiang Ke, Dian-Xi Chen, Yi-Qing Li, Qin Li
Summary: The importance of early diagnosis and treatment of diabetes and its cutaneous complications is increasingly recognized. High glucose affects collagen gene expression in human dermal fibroblasts, leading to an imbalance of matrix metalloproteinases and tissue inhibitors of metalloproteinases. Inhibiting MMP-2 and MMP-9 can alleviate collagen deposition disorder in the skin of diabetic mice.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Anamika Gupta, Abaher O. Al-Tamimi, Rabih Halwani, Hend Alsaidi, Meganathan Kannan, Firdos Ahmad
Summary: This study investigates the role of inflammatory markers (LNC2, S100A8/A9, CST3) in cardiovascular complications and severity of COVID-19. The results show an upregulation of plasma LNC2 in moderate COVID-19 patients and a profound induction of S100A8/A9 and CST3 in severe patients. Myoglobin levels were unchanged in moderate patients but significantly elevated in critically ill COVID-19 patients. These findings suggest that LNC2 may play a role in advancing the severity of COVID-19, while S100A8/A9 and CST3 may serve as predictive biomarkers for thromboembolism and tissue injury.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Article
Urology & Nephrology
Guangming Chen, Xiaoyun Shan, Huabin Wang
Summary: The study compared urinary alpha-1-microglobulin with NGAL as biomarkers for renal insufficiency in type-2 diabetes patients. The traditional marker A1MCR showed stronger association with renal dysfunction and higher diagnostic efficiency compared to NGAL.
Article
Immunology
Shan Cao, Anne Schnelzer, Nicole Hannemann, Georg Schett, Didier Soulat, Aline Bozec
Summary: The study suggests that the AP-1 transcription factor FRA-1 may play a role in myeloid cell tolerance responses during sepsis by regulating NGAL expression, thus contributing to the resolution of inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Yasmina M. Abd-Elhakim, Wafaa A. M. Mohamed, Khlood M. El Bohi, Haytham A. Ali, Fagr A. Mahmoud, Taghred M. Saber
Summary: This study demonstrated that the ethanolic extract of Moringa oleifera has significant prophylactic and therapeutic effects against melamine-induced hepatorenal damage by modulating oxidative stress, apoptosis, and inflammation.
Article
Medicine, General & Internal
Eryk Latoch, Katarzyna Kononczuk, Katarzyna Muszynska-Roslan, Katarzyna Taranta-Janusz, Anna Wasilewska, Edyta Szymczak, Justyna Trochim, Maryna Krawczuk-Rybak
Summary: The study indicates that urine KIM-1 and NGAL levels increase many years after completion of childhood solid tumors treatment, positively correlating with cumulative doses of ifosfamide and cisplatin. Unilateral nephrectomy may also influence the concentration of the studied biomarkers.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Kevin Pilarczyk, Bernd Panholzer, Katharina Huenges, Mohamed Salem, Toni Jacob, Jochen Cremer, Assad Haneya
Summary: This study investigates the role of new biomarkers in predicting acute kidney injury (AKI) after thoracic aortic surgery (TAS) with moderate hypothermic circulatory arrest (MHCA). The results show that Cystatin C is a highly sensitive and specific biomarker for predicting AKI even before surgery, while the predictive capacity of [TIMP-2]*[IGFBP7] is only moderate and inferior to that of serum creatinine.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Sandra Georgy Chafik, Haidy E. Michel, Ebtehal El-Demerdash
Summary: This study aimed to investigate the potential protective effects of a selective CB2 receptor agonist, 1-phenylisatin, on acute nephrotoxicity induced by cisplatin. The results showed that 1-phenylisatin significantly mitigated the damage to the kidneys caused by cisplatin through its anti-apoptotic, anti-inflammatory, and antioxidant effects. These effects were mainly mediated through the CB2 receptor.
Article
Peripheral Vascular Disease
Shangyan Liang, Qingling Li, Qianwei Lai, Ying Zhou, Hui Zhang, Xueyan Chen, Bin Yao, Wen Xu, Xubin Yang
Summary: This study aimed to investigate the association between serum beta-2-microglobulin (B2M) or cystatin C (CysC) and asymptomatic carotid atherosclerosis in patients with primary aldosteronism (PA). The results showed a positive correlation between B2M and carotid intima-media thickness (cIMT), suggesting that B2M could be an independent risk factor for asymptomatic carotid atherosclerosis.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2022)
Article
Immunology
Guantong Hu, Zhong-Su Xia, Xuan Guo
Summary: The study aimed to analyze the correlation and differential expression of GBP-28, TIMP-1, and NBP-Cyc 3 in HDP, finding their association with lipid and glucose metabolism abnormalities. These factors play crucial roles in the diagnosis and prognosis of HDP.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Mycology
Nicole Lorenz, Sven Daenicke, Lutz Edler, Christoph Gottschalk, Eva Lassek, Doris Marko, Michael Rychlik, Angela Mally
MYCOTOXIN RESEARCH
(2019)
Article
Agriculture, Multidisciplinary
Michael Hellwig, Hans-Ulrich Humpf, Jan Hengstler, Angela Mally, Stefan Vieths, Thomas Henle
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2019)
Review
Toxicology
Sabine Guth, Stephanie Hueser, Angelika Roth, Gisela Degen, Patrick Diel, Karolina Edlund, Gerhard Eisenbrand, Karl-Heinz Engel, Bernd Epe, Tilman Grune, Volker Heinz, Thomas Henle, Hans-Ulrich Humpf, Henry Jaeger, Hans-Georg Joost, Sabine E. Kulling, Alfonso Lampen, Angela Mally, Rosemarie Marchan, Doris Marko, Eva Muehle, Michael A. Nitsche, Elke Roehrdanz, Richard Stadler, Christoph van Thriel, Stefan Vieths, Rudi F. Vogel, Edmund Wascher, Carsten Watzl, Ute Noethlings, Jan G. Hengstler
ARCHIVES OF TOXICOLOGY
(2020)
Article
Food Science & Technology
Dieter Schrenk, Laurent Bodin, James Kevin Chipman, Jesus del Mazo, Bettina Grasl-Kraupp, Christer Hogstrand, Laurentius (Ron) Hoogenboom, Jean-Charles Leblanc, Carlo Stefano Nebbia, Elsa Nielsen, Evangelia Ntzani, Annette Petersen, Salomon Sand, Tanja Schwerdtle, Christiane Vleminckx, Heather Wallace, Jan Alexander, Chiara Dall'Asta, Angela Mally, Manfred Metzler, Marco Binaglia, Zsuzsanna Horvath, Hans Steinkellner, Margherita Bignami
Article
Food Science & Technology
D. Karlstetter, A. Mally
FOOD AND CHEMICAL TOXICOLOGY
(2020)
Article
Food Science & Technology
Sabine Guth, Angelika Roth, Barbara Engeli, Dirk W. Lachenmeier, Alexander T. Cartus, Stephanie Hueser, Matthias Baum, Patrick Diel, Gerhard Eisenbrand, Jan G. Hengstler, Hans-Ulrich Humpf, Hans-Georg Joost, Alfonso Lampen, Marcel Leist, Doris Marko, Pablo Steinberg, Angela Mally, Juerg A. Zarn
FOOD AND CHEMICAL TOXICOLOGY
(2020)
Editorial Material
Toxicology
Sabine Guth, Stephanie Hueser, Angelika Roth, Gisela Degen, Patrick Diel, Karolina Edlund, Gerhard Eisenbrand, Karl-Heinz Engel, Bernd Epe, Tilman Grune, Volker Heinz, Thomas Henle, Hans-Ulrich Humpf, Henry Jaeger, Hans-Georg Joost, Sabine E. Kulling, Alfonso Lampen, Angela Mally, Rosemarie Marchan, Doris Marko, Eva Muehle, Michael A. Nitsche, Elke Roehrdanz, Richard Stadler, Christoph van Thriel, Stefan Vieths, Rudi F. Vogel, Edmund Wascher, Carsten Watzl, Ute Noethlings, Jan G. Hengstler
Summary: Since the 1940s, there have been ongoing discussions about the benefits and risks of adding fluoride to drinking water. A recent review focused on assessing the risk of current exposure levels in Europe to human health. Despite inconsistent data, the evidence does not support the idea that fluoride should be considered a human developmental neurotoxicant at current exposure levels in European countries.
ARCHIVES OF TOXICOLOGY
(2021)
Letter
Toxicology
Frank A. Barile, Colin Berry, Bas Blaauboer, Alan Boobis, Herrmann M. Bolt, Christopher Borgert, Wolfgang Dekant, Daniel Dietrich, Jose L. Domingo, Corrado L. Galli, Gio Batta Gori, Helmut Greim, Jan G. Hengstler, Pat Heslop-Harrison, Sam Kacew, Hans Marquardt, Angela Mally, Olavi Pelkonen, Kai Savolainen, Emanuela Testai, Aristides Tsatsakis, Nico P. Vermeulen
Summary: The EU chemicals strategy for sustainability emphasizes the need for further regulation due to threats to human health and the environment. Concerns were raised by the German BfR regarding the scientific justification for this strategy. Any initiatives to improve consumer protection must be based on scientific knowledge and avoid confounding risk with other factors in policy-making.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Toxicology
Benedikt Bauer, Daniel Liedtke, Sebastian Jarzina, Emilia Stammler, Katrin Kreisel, Viola Lalomia, Markus Diefenbacher, Eva Klopocki, Angela Mally
Summary: Zebrafish larvae are considered a promising alternative whole-animal model for assessing systemic toxicity. Exposure of zebrafish larvae to various nephrotoxins resulted in kidney injury and impaired function. Gene expression analysis showed the most prominent changes in larvae treated with gentamicin compared to other nephrotoxins.
TOXICOLOGY LETTERS
(2021)
Article
Food Science & Technology
Raphael Dekant, Michael Langer, Maria Lupp, Cynthia Adaku Chilaka, Angela Mally
Summary: The study found that OTA-derived glucuronides in urine are suitable biomarkers for monitoring, but there is insufficient evidence to support the use of OTA-derived mercapturic acids as biomarkers. There is a linear relationship between urinary glucuronide excretion and OTA exposure, but more data is needed to establish this relationship between metabolites in urine and external dose.
Review
Biochemistry & Molecular Biology
Benedikt Bauer, Angela Mally, Daniel Liedtke
Summary: Before conducting experiments involving living animals in biological laboratories, it is important to consider the necessity, ethics, and potential harm. The development of the 3R principle has become a key standard in animal experimentation worldwide, leading to the exploration of alternative methods in species like zebrafish to reduce experiments on mammals. Zebrafish, with their favorable biological properties, have shown promise in toxicological testing, particularly in cardio-, neuro, hepato- and nephrotoxicity studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Toxicology
Nataly Bittner, Andy Boon, Evert H. Delbanco, Christof Walter, Angela Mally
Summary: Recent analyses conducted by German official food control reported the detection of aromatic amides in cold water extracts from certain food contact materials made from paper or cardboard. The experiments using in vitro digestion models showed that these aromatic amides could be cleaved to potentially genotoxic aromatic amines during the simulated passage through the gastrointestinal tract. However, the rate of cleavage was found to be very low, suggesting that the health risks associated with the presence of aromatic amides in food contact materials might be overestimated.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Toxicology
R. Dekant, R. Bertermann, J. Serban, S. Sharma, M. Shinohara, Y. Morizawa, H. Okamoto, W. Brock, W. Dekant, A. Mally
Summary: Inhalation exposure to HFO-1123 resulted in severe toxicity in minipigs and rabbits, but not in rats. This study aimed to evaluate species differences in the metabolism of HFO-1123 and found that minipigs had higher beta-lyase activity, which led to the formation of a highly toxic compound compared to humans. This suggests that humans may be less susceptible to HFO-1123 toxicity compared to minipigs.
ARCHIVES OF TOXICOLOGY
(2023)
Review
Food Science & Technology
Cynthia Adaku Chilaka, Angela Mally
Article
Toxicology
Elisabeth Limbeck, Jens T. Vanselow, Julian Hofmann, Andreas Schlosser, Angela Mally
ARCHIVES OF TOXICOLOGY
(2018)