Neuropeptide receptors as potential drug targets in the treatment of inflammatory conditions

Ghrelin Protects against Experimental Sepsis by Inhibiting High-Mobility Group Box 1 Release and by Killing Bacteria

(2014) A. Chorny et al.   JOURNAL OF IMMUNOLOGY

Neurogenic airway microvascular leakage induced by toluene inhalation in rats

(2012) Tatsuo Sakamoto et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Hemokinins modulate endothelium function and promote angiogenesis through neurokinin-1 receptor

(2012) Hongjin Song et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Protective Effects of Saizen in Combination With Stilamin on Intestinal Mucosa of a Rabbit Model of Severe Acute Pancreatitis

(2012) Yan Lu et al.   PANCREAS

Rolapitant (SCH 619734): A potent, selective and orally active neurokinin NK1 receptor antagonist with centrally-mediated antiemetic effects in ferrets

(2012) Ruth A. Duffy et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Galanin Transgenic Mice with Elevated Circulating Galanin Levels Alleviate Demyelination in a Cuprizone-Induced MS Mouse Model

(2012) Lin Zhang et al.   PLoS One

Involvement of Tachykinins and NK1 Receptor in the Joint Inflammation with Collagen Type II-Specific Monoclonal Antibody-Induced Arthritis in Mice

(2012) Akira Makino et al.   JOURNAL OF NIPPON MEDICAL SCHOOL

Randomised clinical trial: the clinical effects of a novel neurokinin receptor antagonist, DNK333, in women with diarrhoea-predominant irritable bowel syndrome

(2011) S. Zakko et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

The Melanocortin Agonist AP214 Exerts Anti-Inflammatory and Proresolving Properties

(2011) Trinidad Montero-Melendez et al.   AMERICAN JOURNAL OF PATHOLOGY

Urocortin 1 modulates immunosignaling in a rat model of colitis via corticotropin-releasing factor receptor 2

(2011) Jen Chang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Casopitant and Ondansetron for Postoperative Nausea and Vomiting Prevention in Women at High Risk for Emesis

(2011) ron Altorjay   ARCHIVES OF SURGERY

Differential antiinflammatory and antinociceptive effects of the somatostatin analogs octreotide and pasireotide in a mouse model of immune-mediated arthritis

(2011) Anne-Katja Imhof et al.   ARTHRITIS AND RHEUMATISM

Adrenomedullin22-52combats inflammation and prevents systemic bone loss in murine collagen-induced arthritis

(2011) Marie-Dominique Ah Kioon et al.   ARTHRITIS AND RHEUMATISM

Central substance P NK1 receptors are involved in fever induced by LPS but not by IL-1β and CCL3/MIP-1α in rats

(2011) R.C. Reis et al.   BRAIN RESEARCH

Guide to Receptors and Channels (GRAC), 5th edition

(2011) SPH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Somatostatin and Octreotide on the Treatment of Acute Pancreatitis - Basic and Clinical Studies for Three Decades

(2011) Jing Li et al.   CURRENT PHARMACEUTICAL DESIGN

New Agents for Acute Treatment of Migraine: CGRP Receptor Antagonists, iNOS Inhibitors

(2011) Jan Hoffmann et al.   Current Treatment Options in Neurology

Intra-articular administration of tachykinin NK1 receptor antagonists reduces hyperalgesia and cartilage destruction in the inflammatory joint in rats with adjuvant-induced arthritis

(2011) Takuya Uematsu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Impact of adrenomedullin on dextran sulfate sodium-induced inflammatory colitis in mice: insights from in vitro and in vivo experimental studies

(2011) Yoshiaki Hayashi et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Mapping the CRF-urocortins system in human osteoarthritic and rheumatoid synovial fibroblasts: Effect of vasoactive intestinal peptide

(2011) Selene Pérez-García et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Results From 2 Randomized, Double-Blind, Placebo-Controlled Studies of the Novel NK1 Receptor Antagonist Casopitant in Patients With Major Depressive Disorder

(2011) Emiliangelo Ratti et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Comparison of the Anti-inflammatory and Anti-nociceptive Effects of Cortistatin-14 and Somatostatin-14 in Distinct In Vitro and In Vivo Model Systems

(2011) Adrienn Markovics et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Immunosuppressive activity of a novel peptide analog of alpha-melanocyte stimulating hormone (α-MSH) in experimental autoimmune uveitis

(2011) Andrea E. Edling et al.   JOURNAL OF NEUROIMMUNOLOGY

Pituitary adenylate cyclase-activating polypeptide plays a key role in nitroglycerol-induced trigeminovascular activation in mice

(2011) Adrienn Markovics et al.   NEUROBIOLOGY OF DISEASE

Galanin receptor 3 - a potential target for acute pancreatitis therapy

(2011) S. G. Barreto et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Galanin Receptor Antagonist M35 but Not M40 or C7 Ameliorates Cerulein-Induced Acute Pancreatitis in Mice

(2011) M. Bhandari et al.   PANCREATOLOGY

The Melanocortin System in Control of Inflammation

(2011) Anna Catania et al.   TheScientificWorldJOURNAL

Tachykinin receptors antagonism for asthma: a systematic review

(2011) Renata Ramalho et al.   BMC Pulmonary Medicine

Substance P and glutamate receptor antagonists improve the anti-arthritic actions of dexamethasone in rats

(2010) Francis FY Lam et al.   BRITISH JOURNAL OF PHARMACOLOGY

Regulatory effect of vasoactive intestinal peptide on the balance of Treg and Th17 in collagen-induced arthritis

(2010) Shaohua Deng et al.   CELLULAR IMMUNOLOGY

The melanocortin receptor agonist NDP-MSH impairs the allostimulatory function of dendritic cells

(2010) La’Verne P. Rennalls et al.   IMMUNOLOGY

Adrenomedullin Inhibits IL-1β-Induced Rheumatoid Synovial Fibroblast Proliferation and MMPs, COX-2 and PGE2 Production

(2010) Eun-Gyeong Lee et al.   INFLAMMATION

The First Clinical Pilot Study of Intravenous Adrenomedullin Administration in Patients With Acute Myocardial Infarction

(2010) Yu Kataoka et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Cutaneous nociception and neurogenic inflammation evoked by PACAP38 and VIP

(2010) Henrik Winther Schytz et al.   JOURNAL OF HEADACHE AND PAIN

Cerulein-Induced Acute Pancreatitis in PACAP Knockout Mice

(2010) Yusuke Sakurai et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Galanin Mediates the Pathogenesis of Cerulein-Induced Acute Pancreatitis in the Mouse

(2010) Mayank Bhandari et al.   PANCREAS

Subcutaneous injection of endokinin C/D attenuates carrageenan-induced inflammation

(2010) Rumi Naono-Nakayama et al.   PEPTIDES

Human adrenomedullin and its binding protein ameliorate sepsis-induced organ injury and mortality in jaundiced rats

(2010) Juntao Yang et al.   PEPTIDES

Vasoactive intestinal peptide loss leads to impaired CNS parenchymal T-cell infiltration and resistance to experimental autoimmune encephalomyelitis

(2010) C. Abad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurokinin-1 receptor antagonists in the prevention of postoperative nausea and vomiting

(2009) P. Diemunsch et al.   BRITISH JOURNAL OF ANAESTHESIA

Tachykinin Receptors as Therapeutic Targets in Stress-Related Disorders

(2009) Karl Ebner et al.   CURRENT PHARMACEUTICAL DESIGN

Aprepitant

(2009) Monique P. Curran et al.   DRUGS

Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the Discovery

(2009) D. Vaudry et al.   PHARMACOLOGICAL REVIEWS

Pituitary adenylyl cyclase-activating polypeptide is an intrinsic regulator of Treg abundance and protects against experimental autoimmune encephalomyelitis

(2009) Yossan-Var Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The effect of the tachykinin NK2 receptor antagonist MEN11420 (nepadutant) on neurokinin A-induced bronchoconstriction in asthmatics

(2009) Venessa Schelfhout et al.   Therapeutic Advances in Respiratory Disease

Neuropeptides Rescue Mice from Lethal Sepsis by Down-regulating Secretion of the Late-Acting Inflammatory Mediator High Mobility Group Box 1

(2008) Alejo Chorny et al.   AMERICAN JOURNAL OF PATHOLOGY

Antiinflammatory role of endomorphins in osteoarthritis, rheumatoid arthritis, and adjuvant-induced polyarthritis

(2008) Rainer H. Straub et al.   ARTHRITIS AND RHEUMATISM

Protection from DNBS-induced colitis by the tachykinin NK1 receptor antagonist SR140333 in rats

(2008) Maria Grazia Ursino et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Anti-inflammatory action of alpha-melanocyte stimulating hormone (α-MSH) in anti-CD3/CD28-mediated spleen and CD4+CD25− T cells and a partial participation of IL-10

(2008) Sung Ho Chang et al.   IMMUNOLOGY LETTERS

AP214, an analogue of α-melanocyte-stimulating hormone, ameliorates sepsis-induced acute kidney injury and mortality

(2008) K. Doi et al.   KIDNEY INTERNATIONAL

SOMATOSTATIN INFUSION INCREASES INTESTINAL ISCHEMIA AND DOES NOT IMPROVE VASOCONSTRICTOR RESPONSE TO NOREPINEPHRINE IN OVINE ENDOTOXEMIA

(2008) Stefan Lauer et al.   SHOCK

Inhibitory effects of synthetic somatostatin receptor subtype 4 agonists on acute and chronic airway inflammation and hyperreactivity in the mouse

(2007) Krisztián Elekes et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease

(2007) Klaus Kannengiesser et al.   INFLAMMATORY BOWEL DISEASES

Emergence of cortistatin as a new immunomodulatory factor with therapeutic potential in immune disorders

(2007) Elena Gonzalez-Rey et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY