Severity of the TGN1412 trial disaster cytokine storm correlated with IL-2 release

Induced CD4+Foxp3+ Regulatory T Cells in Immune Tolerance

(2012) Angelina M. Bilate et al.   Annual Review of Immunology

ICOS-LICOS interaction is critically involved in TGN1412-mediated T-cell activation

(2012) S. Weissmuller et al.   BLOOD

A predictive biomimetic model of cytokine release induced by TGN1412 and other therapeutic monoclonal antibodies

(2012) Vipra Dhir et al.   Journal of Immunotoxicology

Preculture of PBMCs at high cell density increases sensitivity of T-cell responses, revealing cytokine release by CD28 superagonist TGN1412

(2011) P. S. Romer et al.   BLOOD

Endothelial cells co-stimulate peripheral blood mononuclear cell responses to monoclonal antibody TGN1412 in culture

(2011) Lucy Findlay et al.   CYTOKINE

Development of a human whole blood assay for prediction of cytokine release similar to anti-CD28 superagonists using multiplex cytokine and hierarchical cluster analysis

(2011) Mindi R. Walker et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Comparison of novel methods for predicting the risk of pro-inflammatory clinical infusion reactions during monoclonal antibody therapy

(2011) Lucy Findlay et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells

(2010) D Eastwood et al.   BRITISH JOURNAL OF PHARMACOLOGY

Immunotoxicity of monoclonal antibodies

(2010) Jacques Descotes   mAbs

Characterization of Protective Human CD4+CD25+ FOXP3+ Regulatory T Cells Generated with IL-2, TGF-β and Retinoic Acid

(2010) Ling Lu et al.   PLoS One

Guide to Receptors and Channels (GRAC), 4th edition

(2009)   BRITISH JOURNAL OF PHARMACOLOGY

Monoclonal antibody-induced cytokine-release syndrome

(2009) Peter J Bugelski et al.   Expert Review of Clinical Immunology

Improved in vitro methods to predict the in vivo toxicity in man of therapeutic monoclonal antibodies including TGN1412

(2009) Lucy Findlay et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Heterogeneity of human effector CD4+ T cells

(2009) Francesco Annunziato et al.   ARTHRITIS RESEARCH & THERAPY

Specificity and affinity of human Fc  receptors and their polymorphic variants for human IgG subclasses

(2008) P. Bruhns et al.   BLOOD

Managing Premedications and the Risk for Reactions to Infusional Monoclonal Antibody Therapy

(2008) C. H. Chung   ONCOLOGIST