A predictive biomimetic model of cytokine release induced by TGN1412 and other therapeutic monoclonal antibodies

Endothelial cells co-stimulate peripheral blood mononuclear cell responses to monoclonal antibody TGN1412 in culture

(2011) Lucy Findlay et al.   CYTOKINE

Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells

(2010) D Eastwood et al.   BRITISH JOURNAL OF PHARMACOLOGY

Were monocytes responsible for initiating the cytokine storm in the TGN1412 clinical trial tragedy?

(2010) G. P. Sandilands et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The safety and side effects of monoclonal antibodies

(2010) Trevor T. Hansel et al.   NATURE REVIEWS DRUG DISCOVERY

Monoclonal antibody-induced cytokine-release syndrome

(2009) Peter J Bugelski et al.   Expert Review of Clinical Immunology

Improved in vitro methods to predict the in vivo toxicity in man of therapeutic monoclonal antibodies including TGN1412

(2009) Lucy Findlay et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Monoclonal Antibody First Dose Cytokine Release Syndromes–Mechanisms and Prediction

(2008) Mark Wing   Journal of Immunotoxicology