Journal
DRUG DISCOVERY TODAY
Volume 18, Issue 21-22, Pages 1052-1066Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2013.06.004
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Funding
- Irish National Biophotonics and Imaging Platform
- European Commission Framework Programme 7 AngioTox and AngioPredict initiatives
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Current therapeutic strategies against glioblastoma (GBM) have failed to prevent disease progression and recurrence effectively. The part played by molecular imaging (MI) in the development of novel therapies has gained increasing traction in recent years. For the first time, using expertise from an integrated multidisciplinary group of authors, herein we present a comprehensive evaluation of state-of-the-art GBM imaging and explore how advances facilitate the emergence of new treatment options. We propose a novel next-generation treatment paradigm based on the targeting of multiple hallmarks of cancer evolution that will heavily rely on MI.
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