Article
Pathology
Xing Fang, Wei Huang, Ping Wu, Junfeng Zeng, Xin Li
Summary: The study revealed that circTRAF3 plays a crucial role in metastasis and survival of NPC patients by adsorbing miR-203a-3p to eliminate its inhibitory effect on AKT3, thus acting as an oncogene in NPC. This finding provides a new therapeutic target for metastatic NPC.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Cell Biology
Yajie Zhao, Chao Li, Yan Zhang, Zhanzhan Li
Summary: CircTMTC1 is highly expressed and miR-495 is downregulated in nasopharyngeal carcinoma (NPC), which are associated with poor prognosis. CircTMTC1 promotes NPC progression through targeting miR-495 and activating the MET-eIF4G1 translational regulation axis.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Gang Wang, Fangzheng Zhou, Tong Ou, Haiyan Sun, Zhirui Shan, Yingshen Lu, Gui Chen, Simin Yuan, Xiaowen Zhang, Song Wu
Summary: The dysregulation of miR-182-5p has been identified as potential diagnostic and prognostic biomarkers for some cancers, however, its role in nasopharyngeal carcinoma (NPC) had not been explored. Our study demonstrated that up-regulation of miR-182-5p in NPC is associated with tumor development and poor prognosis, and it facilitates cell proliferation and migration by down-regulating ZFP36L1 expression through a HIF-1 alpha/miR-182-5p/ZFP36L1 axis, suggesting a novel therapeutic target for NPC management.
CANCER CELL INTERNATIONAL
(2021)
Article
Medicine, Research & Experimental
Mei Lin, Xiao-Long Zhang, Xiong Zou, Rui You, Qi Yang, Xiong Zou, Kai Yu, You-Ping Liu, Ru-Hai Zou, Yi-Jun Hua, Pei-Yu Huang, Jin Wang, Qi Zhao, Xiao-Bing Jiang, Jun Tang, Yang-Kui Gu, Tao Yu, Gui-Ping He, Yu-Long Xie, Zhi-Qiang Wang, Ting Liu, Si-Yuan Chen, Zhi-Xiang Zuo, Ming-Yuan Chen
Summary: By sequencing samples from 26 nasopharyngeal carcinoma patients, it was found that NPC has a higher neoantigen load compared to other cancers. Neoantigen depletion was more severe in metastatic sites, with the reduction occurring during metastasis.
Article
Biochemistry & Molecular Biology
Lixiao Xie, Kaiwen Zhang, Bo You, Haimeng Yin, Panpan Zhang, Ying Shan, Zhifeng Gu, Qicheng Zhang
Summary: In nasopharyngeal carcinoma, exosomes released by cells with high levels of miR-455 enhance vascular permeability and promote metastasis by targeting ZO-1, and this process is associated with HIF-1α. The HIF-1α-miR-455-ZO-1 signaling pathway may serve as a potential predictor and therapeutic target for metastatic nasopharyngeal carcinoma.
MOLECULAR CARCINOGENESIS
(2023)
Article
Oncology
Shanqiang Zhan, Baoliang Ni
Summary: This study demonstrated that hsa-miR-9-5p improved the radiosensitivity of nasopharyngeal carcinoma by targeting HK2. It led to decreased cell proliferation, increased apoptosis, and inhibited tumor growth in vivo after radiation therapy.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2021)
Article
Oncology
Cheng Lin, Keyu Lin, Bin Zhang, Ying Su, Qiaojuan Guo, Tianzhu Lu, Yuanji Xu, Shaojun Lin, Jingfeng Zong, Jianji Pan
Summary: Plasma BART8-3p is a promising biomarker for the detection and prognosis of nasopharyngeal carcinoma (NPC), as high levels of BART8-3p are associated with worse overall survival, distant metastasis-free survival, and locoregional relapse-free survival.
Article
Oncology
Qian-Lan Xu, Zan Luo, Bin Zhang, Guan-Jie Qin, Ru-Yun Zhang, Xiang-Yun Kong, Hua-Ying Tang, Wei Jiang
Summary: The study revealed that miR-9-1 is significantly hypermethylated in nasopharyngeal carcinoma, and it inhibited NPC cell growth and glycolytic metabolism by targeting HK2. Additionally, miR-9-1 expression was identified as an independent prognostic factor in NPC.
Article
Cell Biology
Chun Cheng, Jun Yang, Si-Wei Li, Guofu Huang, Chenxi Li, Wei-Ping Min, Yi Sang
Summary: Histone deacetylases (HDACs) are involved in tumor progression, with HDAC4 playing a crucial role in promoting cell proliferation, migration, and invasion in nasopharyngeal carcinoma (NPC). High expression of HDAC4 in NPC tissues is associated with poor overall survival and progression-free survival. Inhibition of HDAC4 may present a potential therapeutic strategy for NPC patients.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Shih-Chi Su, Chung-Han Hsin, Yen-Ting Lu, Chun-Yi Chuang, Yu-Ting Ho, Fang-Ling Yeh, Shun-Fa Yang, Chiao-Wen Lin
Summary: EF-24, an analog of curcumin, has demonstrated enhanced bioavailability and various anti-cancer properties. It inhibits the invasion of nasopharyngeal carcinoma (NPC) by interfering with the nuclear translocation of NF-kappa B and the activation of JNK, leading to the transcriptional suppression of MMP-9 gene. These findings suggest the potential use of curcumin analogs with increased bioavailability in controlling the spread of NPC.
Article
Oncology
Dong-Hua Luo, Jia-Xin Li, Wan-Ping Guo, Chen-Guang Guo, Xiao-Han Meng, Pei-Jun Xie, Jie-Yi Lin, Hao-Yuan Mo, Qun Zhang, Yong Chen, Guo-Ping Shen
Summary: This study compared the metastatic patterns of synchronous bone metastasis (SBM) and metachronous bone metastasis (MBM) in nasopharyngeal carcinoma (NPC). The thoracic vertebra was the most common site of metastasis, and patients with SBM were more likely to have metastasis to the cervical vertebra. Patients with SBM had better overall survival. Age at bone metastasis detection, metastasis to other organs, and more bone metastasis locations were associated with worse prognosis. Attention should be paid to bone metastases during the first 2 years following NPC diagnosis.
Article
Oncology
Guo-Ying Liu, Wei-Xiong Xia, Zhuo-Fei Bi, Nian Lu, Wang-Zhong Li, Wei-Xin Bei, Hu Liang, Jun-Zhi Xie, Yi-Min Liu, He-Rui Yao, Yan-Qun Xiang
Summary: This study investigated whether longitudinal monitoring of EBV-DNA could accurately detect clinical disease progression in bone-only metastatic NPC patients. The results showed that EBV-DNA provided predictive value for the bone-only metastatic NPC patients. These results should be validated in prospective randomized studies.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Xinping Chen, Weihua Xu, Zhichao Ma, Juan Zhu, Junjie Hu, Xiaojuan Li, Shengmiao Fu
Summary: This study revealed that circ_0000215 is overexpressed in NPC and exerts oncogenic effects by regulating the miR-512-5p/PIK3R1 axis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Rentao Hou, Xiong Liu, Huiling Yang, Shuting Deng, Chao Cheng, Jiahao Liu, Yonghao Li, Yewei Zhang, Jingwen Jiang, Zhibo Zhu, Yun Su, Liyang Wu, Yingying Xie, Xiaoning Li, Wenmin Li, Zhen Liu, Weiyi Fang
Summary: In this study, cinobufagin (CB) was found to inhibit metastasis in nasopharyngeal carcinoma (NPC), and its therapeutic effect was enhanced when combined with cisplatin (DDP). CB induced the expression of ENKUR by deregulating the PI3K/AKT pathway and suppressing c-Jun, leading to the inhibition of NPC metastasis. ENKUR acted as a tumor suppressor by reducing MYH9 expression and preventing p53 ubiquitination degradation, thus suppressing epithelial-mesenchymal transition (EMT).
Article
Biochemistry & Molecular Biology
Xiangqi Zhou, Guangjin Yuan, Yangjie Wu, Sijia Yan, Qingshan Jiang, Sanyuan Tang
Summary: This study found that EIF4A3-induced circFIP1L1 inhibits NPC cell proliferation, promotes NPC cell apoptosis, and enhances NPC radiosensitivity through miR-1253.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Zhiqin Deng, Huangcan Li, Shu Chen, Na Wang, Gongyuan Liu, Danjun Liu, Weihui Ou, Feijie Xu, Xiong Wang, Dangyuan Lei, Pui-Chi Lo, Yang Yang Li, Jian Lu, Mengsu Yang, Ming-Liang He, Guangyu Zhu
Summary: This study reports the use of near-infrared-activated small-molecule Pt(IV) photooxidants to directly oxidize intracellular biomolecules. These photooxidants can effectively eliminate cancer stem cells and show low toxicity in the dark. Metal-enhanced photooxidation induced by these Pt(IV) complexes leads to robust photooxidation of survival-related biomolecules, inducing oxidative stress, disrupting intracellular pH (pHi) homeostasis, and initiating nonclassical necrosis.
Article
Neurosciences
Tatyana Veremeyko, Rongcai Jiang, Mingliang He, Eugene D. Ponomarev
Summary: The complement system plays an important role in immune defense and also has important functions in the central nervous system (CNS). Recent studies have shown that complement subunits C1q, C4, and C3 have roles in synapse pruning and neurologic pathologies. C4B deficiency or low expression is related to the development of schizophrenia and autism spectrum disorders through mechanisms not related to synapse elimination. C4B has a role in the regulation of immediate early gene expression and downstream targets during CNS insults such as epileptic seizures.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Haibo Wang, Ligang Hu, Hongyan Li, Yau-Tsz Lai, Xueying Wei, Xiaohan Xu, Zhenkun Cao, Huiming Cao, Qianya Wan, Yuen-Yan Chang, Aimin Xu, Qunfang Zhou, Guibin Jiang, Ming-Liang He, Hongzhe Sun
Summary: In this study, the researchers identified the Cr(III)-proteome in cells and found that ATP synthase plays a crucial role in relieving hyperglycemia stress.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Wen Wen, Long Liao, Wei Dai, Can-Can Zheng, Xiang-Peng Tan, Yan He, Qi-Hua Zhang, Zhi-Hao Huang, Wen-You Chen, Yan-Ru Qin, Kui-Sheng Chen, Ming-Liang He, Simon Law, Maria Li Lung, Qing-Yu He, Bin Li
Summary: Through genome-wide CRISPR/Cas9 screening and gene profiling, the MEST-PURA-SRCIN1/RASAL1-ERK-snail signaling cascade was identified as an important mechanism underlying cancer metastasis in esophageal squamous cell carcinoma. Blocking the interaction between MEST and PURA could be a potential therapeutic approach for managing tumor metastasis.
Review
Pharmacology & Pharmacy
Ya-Xiu Feng, Huan Hu, Yu-Yuen Wong, Xi Yao, Ming-Liang He
Summary: Vaccination is effective in preventing infectious diseases, and microneedles are a promising tool for painless vaccine delivery, with the advantage of avoiding cold chain storage and improving accessibility for special populations.
Article
Environmental Sciences
Lin Wang, Zhi-Hao Zhou, Yun-Xia Xie, Wen-Jing Liu, Rui-Xiang Zhang, Nan Jiang, Ming-Liang He, Jian-Ge Qiu, Bing-Hua Jiang
Summary: This study revealed the mechanism of Cr(VI) in inducing carcinogenesis and angiogenesis. Chronic exposure to Cr(VI) resulted in a significant decrease in miR-199a expression levels, while overexpression of miR-199a inhibited angiogenesis and tumor growth. Additionally, Cr(VI) exposure also resulted in an increase in CXCL8 levels, while overexpression of miR-199a suppressed CXCL8 expression. These results indicate that the miR-199a/IL8 pathway plays an important role in Cr(VI)-induced carcinogenesis and angiogenesis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Biochemistry & Molecular Biology
Xiaolong Shao, Chunyan Yao, Yiqing Ding, Haiyan Hu, Guoliang Qian, Mingliang He, Xin Deng
Summary: In Pseudomonas aeruginosa, transcription factors play a crucial role in the genetic regulation of adaptability and pathogenicity. Several techniques have been used to identify TF binding sites on the P. aeruginosa genome, and an atlas of TF binding patterns has been created. This review summarizes recent literature on TF regulatory networks involved in various processes, including quorum sensing, biofilm formation, pyocyanin synthesis, motility, secretion systems, and oxidative stress responses. Insights from the global regulatory network of transcriptional regulators could inform strategies for preventing clinical infections caused by P. aeruginosa.
Review
Biochemistry & Molecular Biology
Huan Hu, Yaxiu Feng, Ming-Liang He
Summary: Zika virus (ZIKV) infection causes neurological disorders and elicits a wide range of immune response. Type I interferons (IFNs) and its signaling cascade play a crucial role in innate immunity against ZIKV infection, but ZIKV can antagonize them. Toll-like receptors 3 (TLR3), TLR7/8 and RIG-I-like receptor 1 (RIG-1) recognize the ZIKV genome and induce the expression of Type I IFNs and interferon-stimulated genes (ISGs). ISGs exert antiviral activity at different stages of the ZIKV life cycle. The NS proteins of ZIKV directly interact with factors in the pathways to evade innate immunity, while structural proteins and antibody-binding of BDCA2 or inflammasome activation enhance ZIKV replication. In this review, recent findings about the interaction between ZIKV infection and type I IFNs pathways are summarized, and potential strategies for antiviral drug development are suggested.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Cell Biology
Yun-Xia Xie, Zhi-Hao Zhou, Shu-Wen Liu, Ye Zhang, Wen-Jing Liu, Rui-Ke Zhang, Ming-Liang He, Jian-Ge Qiu, Lin Wang, Bing-Hua Jiang
Summary: This study showed that miR-497 is down-regulated in esophageal cancer and overexpression of miR-497 inhibits cell proliferation, tube formation, and migration. It was found that miR-497 directly binds to QKI and suppresses its expression. Overexpression of miR-497 also enhances the effect of chemotherapy and suppresses tumor growth in esophageal cancer in vivo.
Review
Biochemistry & Molecular Biology
Peiran Chen, Mandi Wu, Yaqing He, Binghua Jiang, Ming-Liang He
Summary: The COVID-19 pandemic caused by SARS-CoV-2 has brought enormous burden with high mortality rates. Targeting the interaction between SARS-CoV-2 and host metabolism holds promise for developing therapeutic strategies. This review summarizes recent studies on the role of host metabolism during the life cycle of SARS-CoV-2, with an emphasis on glucose and lipid metabolism, and discusses microbiota and long COVID-19. Repurposed metabolism-modulating drugs for COVID-19 are also discussed, including statins, ASM inhibitors, NSAIDs, Montelukast, omega-3 fatty acids, 2-DG, and metformin.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Huangcan Li, Xiong Wang, Yiran Wang, Yichen Li, Ying Chen, Yin-Ting Wong, Jufang He, Ming-Liang He
Summary: The proteases of SARS-CoV-2 and EV71 upregulate the expression and secretion of LRPAP1, which binds with IFNAR1 to trigger receptor degradation and enhance viral infection. A peptide derived from LRPAP1 can cause IFNAR1 degradation and enhance viral infections, while an LRPAP1 inhibitor stabilizes IFNAR1 and arrests virus infections. This study reveals a novel mechanism used by viruses to evade host immunity and provides a potential strategy for developing pan-antiviral drugs.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Medicine, Research & Experimental
Yaxiu Feng, Ching Han Young, Siu Hin Lau, Ming-Liang He
Summary: Control management of SARS-CoV-2 infections is a major challenge in the 21st century. While the government responded rapidly in the early days of the outbreak and achieved encouraging results, the high infectivity, new variants, and shortcomings in transmission control measures led to an uncontrollable outbreak in 2022. Vulnerable groups such as the elderly and children experienced high hospitalization and mortality rates due to low vaccination rates. This study timely summarizes the challenges, policies, and lessons learned from the SARS-CoV-2 outbreak from 2020 to 2022, providing valuable insights for other cities facing highly infectious SARS-CoV-2 outbreaks.
Article
Biochemistry & Molecular Biology
Zhuoying Feng, Fanghang Zhou, Miaomiao Tan, Tingting Wang, Ying Chen, Wenwen Xu, Bin Li, Xin Wang, Xin Deng, Ming-Liang He
Summary: HSV-1 infection enhances the expression of m6A modification-related genes to facilitate viral replication, while inhibiting m6A modification reduces viral replication and reproduction.
Article
Biochemistry & Molecular Biology
Yichen Li, Qian Zhang, Mandi Wu, Peidong Zhang, Liang Huang, Xiaolin Ai, Zhengnan Yang, Qiuhong Shen, Yiran Wang, Ping Wang, Shengtao Zhou, Ming-Liang He
Summary: A study has found that a LncRNA associated with ovarian cancer metastasis, LncOVM, is highly correlated with poor prognosis and survival. LncOVM interacts with and stabilizes PPIP5K2, promoting the secretion of complement C5 from ovarian cancer cells, which then attracts myeloid-derived suppressor cells (MDSCs) infiltration in the tumor microenvironment (TME) to facilitate metastasis. Targeting the LncOVM-PPIP5K2-complement axis can inhibit MDSC infiltration and restore the suppression of tumorigenesis and metastasis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Cell Biology
Yiran Wang, Mandi Wu, Yichen Li, Ho Him Yuen, Ming-Liang He
Summary: This review updates the current knowledge on how SARS-CoV-2 modulates the host innate immune response for its evasion from host defense and its corresponding pathogenesis caused by cytokine storm. It emphasizes the Type I interferon response and the strategies used by SARS-CoV-2 to evade innate immune defense. The review extensively discusses the cells and their function involved in the innate immune response and inflammatory response, as well as the promises and challenges of drugs targeting excessive inflammation for antiviral treatment. It provides insights into the current challenges and future directions for studying the impact of SARS-CoV-2 infection on innate immunity.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)