Article
Biochemical Research Methods
Ayomikun Esan, Frederique Vanholsbeeck, Simon Swift, Cushla M. M. McGoverin
Summary: With the global increase in food exchange, it has become crucial to efficiently separate bacterial cells from debris in order to protect consumers from bacterial contamination. In this study, passive-based inertial microfluidics was used to separate bacterial cells from debris extracted from ground meat and meat swabs, achieving average recovery efficiencies of approximately 80% and 70%, respectively.
Review
Nanoscience & Nanotechnology
Hao Tang, Jiaqi Niu, Han Jin, Shujing Lin, Daxiang Cui
Summary: Passive and label-free microfluidic devices, with their simple design and reliance on geometric structure, have become popular in medical and bioresearch applications. This review discusses the importance of geometric design principles in passive and label-free microfluidics and summarizes the most creative innovations in microfluidic schemes such as deterministic lateral displacement, inertial microfluidics, and viscoelastic microfluidics. The aim of this review is to provide researchers with a guideline for incorporating geometric innovations into passive and label-free microfluidics.
MICROSYSTEMS & NANOENGINEERING
(2022)
Article
Physics, Applied
Xun Liu, Doudou Ma, Yapeng Yuan, Tao Tang, Yoichiroh Hosokawa, Yaxiaer Yalikun
Summary: This study investigates the use of passive pinched flow fractionation to achieve highly accurate separation of droplets with different sizes. Experimental and simulation results show that a suitable sheath flow rate ensures stable droplet separation. These findings serve as a valuable guide for designing passive droplet separation methods for various types of droplet-based cell sorting systems.
APPLIED PHYSICS EXPRESS
(2023)
Article
Biochemical Research Methods
Satoru Nagatoishi, Toshinobu Toyoshima, Kotohiro Furukawa, Kouhei Tsumoto
Summary: This study introduces a new method called Pinched-Flow Fractionation (PFF)-Coulter for the quantitative analysis of submicron-sized particles. The method combines PFF and Coulter techniques to separate and detect particles, allowing for more accurate particle analysis.
ANALYTICAL BIOCHEMISTRY
(2023)
Article
Mechanics
Mohammad Charjouei Moghadam, Armin Eilaghi, Pouya Rezai
Summary: This study used numerical simulation to investigate elasto-inertial focusing of microparticles in a straight microchannel, proposing a new threshold for particle dispersion prediction. An empirical non-dimensional correlation was developed to predict elasto-inertial particle dispersion in straight square cross-sectional microchannels, reducing the predicted dispersion variation from about 15% to less than about 5%.
Article
Chemistry, Analytical
Mohammad Moein Naderi, Ludovica Barilla, Jian Zhou, Ian Papautsky, Zhangli Peng
Summary: The study on elasto-inertial focusing highlighted the interaction between elastic force and shear-gradient lift force leading to different particle focusing patterns. Both experimental and simulation studies were conducted to investigate the effects of flowrate, particle size, and shear-thinning extent on focusing patterns, emphasizing the importance of accurately estimating shear-thinning extent in modeling.
Article
Chemistry, Analytical
Kenta Fukada, Michiko Seyama
Summary: Microfluidic control using reinforced learning with failure-based rewards can maximize training effect and find optimal separating conditions automatically, making it valuable in fields such as automatic synthetic chemistry, biomedical analysis, and microfabrication robotics.
ANALYTICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Amir Shamloo, Amin Naghdloo, Mohsen Besanjideh
Summary: The study focused on isolating rare cancer cells using two centrifugal microfluidic devices. The passive design isolates cells through inertial effects and bifurcation law, while the hybrid design captures magnetically labeled cells using permanent magnets at the end of the microchannel. The hybrid design offers better separation efficiency and purity, while the passive one is simpler and cost-effective without the need for cell labeling.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Analytical
Haidong Feng, Alexander R. Jafek, Bonan Wang, Hayden Brady, Jules J. Magda, Bruce K. Gale
Summary: This paper studies particle focusing in viscoelastic flow and predicts the focusing position by analyzing the force balance. The research finds that particle separation resolution can be improved in viscoelastic flows.
Article
Biochemical Research Methods
Andrew S. Clark, Adriana San-Miguel
Summary: We have developed two microfluidic lobe filters inspired by the filtration mechanism of manta rays to address clogging issues. These filters can efficiently filtrate particles around 10-30 μm with high throughput and precise control, showing increased filtration efficiency with fluid flow rate.
Article
Chemistry, Analytical
Navya Rastogi, Pranjal Seth, Ramray Bhat, Prosenjit Sen
Summary: The novel orthogonal vortex chip enables size-based cell separation at lower velocities to avoid cell damage caused by high flow speeds. The device utilizes shear-gradient lift, centrifugal, and Dean flow drag forces to selectively trap particles of different sizes, showing promising results for gentle isolation of rare cells from blood.
ANALYTICA CHIMICA ACTA
(2021)
Article
Mechanics
I. Banerjee, M. E. Rosti, T. Kumar, L. Brandt, A. Russom
Summary: A unique tunable trend in particle focusing is reported in elasto-inertial flows, where particles can be tuned to different focusing bandwidths. Numerical simulations and experimental observations show that particle focusing is affected by minute amounts of elasticity and flow rates. The study provides a new understanding of particle focusing in weakly elastic and strongly inertial flows, with potential applications in microfluidics-based biological sorting.
Article
Engineering, Electrical & Electronic
Rituraj Bhattacharjee, R. Kumar
Summary: In the process of uncontrolled tumor proliferation, circulating tumor cells (CTCs) serve as an important biomarker for early cancer diagnosis. This simulation study proposes a DLD device model based on an array of micropillars to isolate multiple CTCs from injected blood flow. The design approach improves the separation resolution of DLD devices while restricting the length of the device. The results show that the purity of extracted cells is over 95% for different sizes of CTC microbeads. These findings provide guidance for future DLD designs for multiple bio-particle isolation.
MICROSYSTEM TECHNOLOGIES-MICRO-AND NANOSYSTEMS-INFORMATION STORAGE AND PROCESSING SYSTEMS
(2023)
Article
Chemistry, Analytical
Dezhi Tang, Mu Chen, Yu Han, Nan Xiang, Zhonghua Ni
Summary: The paper utilizes an asymmetric serpentine structure and elasto-inertial focusing methods to manipulate cells' transit position, accurately describe cellular impedance signature, and differentiate and detect tumor cells efficiently.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Physics, Multidisciplinary
Mohammad Khalid, V Shankar, Ganesh Subramanian
Summary: Research has shown that highly concentrated polymer solutions exhibit linear instability in the absence of inertia under high elasticity conditions, which persists up to a Reynolds number of O(1000). This may provide insights into the transition to turbulence in elastic solids.
PHYSICAL REVIEW LETTERS
(2021)
