Article
Oncology
Malay Bajpai, S. Pooja, Mayurika Tyagi, Abhishek Pathre
Summary: Mucinous tubular and spindle cell carcinoma of the kidney (MTSCC-K) is a rare subtype of renal cell cancer, predominantly occurring in females and associated with a favorable prognosis. We report a case of MTSCC-K involving the kidney. The patient responded well after surgery. Accurate diagnosis is crucial for prognostication and understanding the biology of this rare tumor.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2022)
Article
Oncology
Xi Zheng, Felix Wezel, Anca Azoitei, Sabine Meessen, Wenya Wang, Gregoire Najjar, Xue Wang, Johann M. Kraus, Hans A. Kestler, Axel John, Friedemann Zengerling, Christian Bolenz, Cagatay Guenes
Summary: The telomere shortening in BC and RCC patients was significantly shorter compared to patients without malignant disease. The relative telomere length in PBL cells was associated with the survival of BC and RCC patients, making it a potential prognostic marker for these cancers.
Article
Biochemistry & Molecular Biology
Kathleen M. McClain, Joshua N. Sampson, Jessica L. Petrick, Kaitlyn M. Mazzilli, Robert E. Gerszten, Clary B. Clish, Mark P. Purdue, Loren Lipworth, Steven C. Moore
Summary: This study found that six serum metabolites were associated with the risk of kidney cancer, and three of these metabolites had independent associations in the mutually adjusted model. These metabolites may point to new biological pathways relevant to kidney malignancy.
Review
Oncology
Yu-Wei Chen, Brian Rini, Kathryn E. Beckermann
Summary: This review summarizes ongoing efforts in drug development in clear cell renal cell carcinoma (ccRCC), focusing on novel targets and treatment methods. While immunotherapy-based combinations have shown significant efficacy improvement in frontline treatment, there is still a need for new therapies to address non-responsive or resistant patients.
Review
Urology & Nephrology
Laura Bukavina, Karim Bensalah, Freddie Bray, Maria Carlo, Ben Challacombe, Jose A. Karam, Wassim Kassouf, Thomas Mitchell, Rodolfo Montironi, Tim O'Brien, Valeria Panebianco, Ghislaine Scelo, Brian Shuch, Hein van Poppel, Christopher D. Blosser, Sarah P. Psutka
Summary: The incidence and mortality rates of kidney cancer vary significantly globally, with variations across time, geography, and sex. Hypertension, obesity, and smoking are the most well-established risk factors. Recent advances in genetic characterization have improved our understanding of the mutations that predispose individuals to kidney cancer.
Article
Biochemistry & Molecular Biology
Samuel Swearson, Aseel O. Rataan, Steven Eliason, Brad A. Amendt, Yousef Zakharia, Aliasger K. Salem, Thai Ho, Youcef M. Rustum
Summary: This study quantitated the expression levels of miR-17, -19a, -34a, -155, and -210 in different types of renal cell carcinoma cell lines and primary kidney tumors. The results showed that miR-17 and -19a were expressed at lower levels, while miR-34a, miR-155, and miR-210 were expressed at higher levels. In ccRCC cell lines with sarcomatoid differentiation, miR-34a was expressed higher than miR-210, -155, -17, and -19a. More samples are needed to confirm the statistical significance of the differences in miR expression levels in tumor biopsies. Previous studies have shown that miR-210, miR-155, and HIFs are druggable targets, and downregulation of these miRs may be a novel strategy for the treatment of advanced ccRCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Aisheng Dong, Qing Yang, Meimian Hua, Chao Cheng, Changjing Zuo
Summary: This study describes the findings of FAPI PET/CT in renal tumors, including a case of lipid-poor renal angiomyolipoma and a case of high-grade clear cell renal cell carcinoma. Both tumors showed intense FAPI uptake, indicating that lipid-poor renal angiomyolipoma should be considered in the differential diagnosis of FAPI-avid renal tumors.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Aron Bartha, Zsuzsanna Darula, Gyoengyi Munkacsy, Eva Klement, Peter Nyirady, Balazs Gyorffy
Summary: This research used a proteotranscriptomic approach to differentiate normal and tumor tissues in clear cell renal cell carcinoma (ccRCC). Top genes over-expressed in ccRCC were identified using transcriptomic data of patients with malignant and normal tissue samples. Protein level analysis and mass spectrometry further validated the differential protein abundance of these genes. A minimal panel of proteins highly specific for ccRCC tissues was identified using transcriptomic and proteomic data.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Evgenia Efthymiou, Georgios Velonakis, Georgios Charalampopoulos, Argyro Mazioti, Elias Brountzos, Nikolaos Kelekis, Dimitrios Filippiadis
Summary: This study evaluates the performance of RENAL and mRENAL scores in predicting oncological outcomes in patients with T1 renal cell carcinomas treated with microwave ablation. The results show that both RENAL and mRENAL scores have significant prognostic ability in predicting progression in renal cancer.
EUROPEAN RADIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ziad M. El-Zaatari, Luan D. Truong
Summary: Renal cell carcinoma (RCC) occurring in the setting of end-stage renal disease (ESRD) shows unique clinicopathological characteristics, with acquired cystic kidney disease-associated renal cell carcinoma (ACKD-RCC) and clear-cell papillary renal cell carcinoma (ccpRCC) being the most frequent types. Other types of RCC also occur in ESRD, albeit with different frequencies from the non-ESRD general population. While the histological features of RCC do not vary in the setting of ESRD vs. non-ESRD, other findings, such as multifocality and multiple tumor types, are more frequent in ESRD. Studies have generated novel and important knowledge of the etiology, epidemiology, diagnosis, treatment, immunophenotype, and molecular characteristics of ESRD-associated RCC.
Article
Medicine, General & Internal
Xiangyu Che, Wenyan Su, Xiaowei Li, Nana Liu, Qifei Wang, Guangzhen Wu
Summary: Angiogenesis, a highly regulated process disrupted in cancer, was explored in various cancers with protective genes identified in kidney renal clear cell carcinoma (KIRC) patients. Patients in Cluster 2, with upregulated expression of angiogenesis-related genes, showed the highest overall survival rates. Furthermore, a personalized treatment plan based on gene expression was generated for KIRC patients using sensitivity analysis of commonly used molecularly targeted drugs.
FRONTIERS IN MEDICINE
(2021)
Article
Oncology
Gennady Bratslavsky, Stephanie Gleicher, Joseph M. Jacob, Thomas H. Sanford, Oleg Shapiro, Dimitra Bourboulia, Laurie M. Gay, Julie Andrea Elvin, Jo-Anne Vergilio, James Suh, Shakti Ramkissoon, Eric Allan Severson, Jonathan Keith Killian, Alexa Betzig Schrock, Jon H. Chung, Vincent A. Miller, Mehdi Mollapour, Jeffrey S. Ross
Summary: The study found that genomic alteration patterns in collecting duct carcinoma (CDC) and renal medullary carcinoma (RMC) differ significantly from clear cell renal cell carcinoma (CCRCC). Targeted therapies for CDC and RMC appear limited, with rare opportunities to target alterations in receptor tyrosine kinase and MTOR pathways. Similarly, the low TMB and absence of MSI-High status in CDC and RMC suggest resistance to immunotherapies.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2021)
Article
Oncology
Luping Li, Lei Shi, Junjie Zhang, Yingzhong Fan, Qi Li
Summary: The study aimed to assess the impact of tumor size on the prognosis of T3a RCC and proposed an alternative tumor stage system combined with T1-2. The results showed that tumor size significantly affected the survival outcome and the new T-staging system demonstrated better predictive accuracy compared to the current system, emphasizing the importance of considering tumor size in prognostic evaluation.
Article
Oncology
Fenfang Zhou, Dexin Shen, Yaoyi Xiong, Songtao Cheng, Huimin Xu, Gang Wang, Kaiyu Qian, Lingao Ju, Xinhua Zhang
Summary: CTHRC1 expression is elevated in KIRP and KIRC, associated with tumor stage, histology, lymph node metastasis, and clinical prognosis in KIRP, as well as tumor grade, stage, nodal metastasis, and survival prognosis; it is also positively related to various tumor-infiltrating immune cells in KIRP and KIRC.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Marta Correia de Sousa, Etienne Delangre, Miranda Turkal, Michelangelo Foti, Monika Gjorgjieva
Summary: The endoplasmic reticulum plays crucial roles in protein production, metabolism homeostasis, and cell signaling. Endoplasmic reticulum stress occurs when cells are damaged and its normal functions are compromised. In renal cancer cells, the activation of endoplasmic reticulum stress pathway is exploited to promote cell survival through rewiring of metabolism, activation of stress responses, autophagy, and inhibition of cell death. However, a certain threshold of endoplasmic reticulum stress activation is required to shift the response from pro-survival to pro-apoptotic outcome. The therapeutic potential of targeting endoplasmic reticulum stress in renal cancer is still poorly understood and further research is needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Marco Dicanio, Matteo Giaccherini, Alyssa Clay-Gilmour, Angelica Macauda, Juan Sainz, Mitchell J. Machiela, Malwina Rybicka-Ramos, Aaron D. Norman, Agata Tyczynska, Stephen J. Chanock, Torben Barington, Shaji K. Kumar, Parveen Bhatti, Wendy Cozen, Elizabeth E. Brown, Anna Suska, Eva K. Haastrup, Robert Z. Orlowski, Marek Dudzinski, Ramon Garcia-Sanz, Marcin Kruszewski, Joaquin Martinez-Lopez, Katia Beider, Elzbieta Iskierka-Jazdzewska, Matteo Pelosini, Sonja Berndt, Malgorzata Razny, Krzysztof Jamroziak, S. Vincent Rajkumar, Artur Jurczyszyn, Annette Juul Vangsted, Pilar Garrido Collado, Ulla Vogel, Jonathan N. Hofmann, Mario Petrini, Aleksandra Butrym, Susan L. Slager, Elad Ziv, Edyta Subocz, Graham G. Giles, Niels Frost Andersen, Grzegorz Mazur, Marzena Watek, Fabienne Lesueur, Michelle A. T. Hildebrandt, Daria Zawirska, Lene Hyldahl Ebbesen, Herlander Marques, Federica Gemignani, Charles Dumontet, Judit Varkonyi, Gabriele Buda, Arnon Nagler, Agnieszka Druzd-Sitek, Xifeng Wu, Katalin Kadar, Nicola J. Camp, Norbert Grzasko, Rosalie G. Waller, Celine Vachon, Federico Canzian, Daniele Campa
Summary: The aim of this study was to identify novel pleiotropic variants involved in multiple myeloma (MM) risk. Through analysis of 28,684 single nucleotide polymorphisms (SNPs), DNAJB4-rs34517439-A was found to be associated with an increased risk of developing MM.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Letter
Oncology
Ixtaccihuatl H. Obregon, Kelvin C. de Andrade, Renee C. Bremer, Payal P. Khincha, Sharon A. Savage
Article
Oncology
Vicky C. Chang, Gabriella Andreotti, Maria Ospina, Christine G. Parks, Danping Liu, Joseph J. Shearer, Nathaniel Rothman, Debra T. Silverman, Dale P. Sandler, Antonia M. Calafat, Laura E. Beane Freeman, Jonathan N. Hofmann
Summary: This study investigated the association between glyphosate exposure and urinary oxidative stress biomarkers in farmers. The results showed that urinary glyphosate concentrations were positively associated with levels of oxidative stress biomarkers, such as 8-OHdG and MDA. The findings support the association between glyphosate exposure and oxidative stress in humans.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Public, Environmental & Occupational Health
Melissa C. Friesen, Laura Beane E. Freeman, Sarah J. Locke, Pabitra R. Josse, Shuai Xie, Susan Marie Viet, Jean-Francois Sauve, Gabriella Andreotti, Peter S. Thorne, Jonathan N. Hofmann
Summary: An algorithm was developed to estimate endotoxin exposure for farmers in the BEEA Study. It combined task intensity estimates with questionnaire responses to calculate cumulative endotoxin exposures for different tasks and time windows. The study provides insight into the variability and sources of endotoxin exposure among farmers and presents exposure estimates for future investigations.
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Melissa C. Friesen, Shuai Xie, Jean-Francois Sauve, Susan Marie Viet, Pabitra R. Josse, Sarah J. Locke, Felicia Hung, Gabriella Andreotti, Peter S. Thorne, Jonathan N. Hofmann, Laura E. Beane Freeman
Summary: This study estimated endotoxin exposure for farmers in the Biomarkers of Exposure and Effect in Agriculture (BEEA) Study using published data. The task-specific endotoxin concentrations were obtained through meta-regression models. Results showed that tasks such as work in poultry and swine confinement facilities, grinding feed, veterinarian services, and cleaning grain bins had higher endotoxin concentrations, while harvesting or hauling grain and other crop-related tasks had lower concentrations.
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
(2023)
Article
Hematology
Hannah A. Raj, Tsung-Po Lai, Marena R. Niewisch, Neelam Giri, Youjin Wang, Stephen R. Spellman, Abraham Aviv, Shahinaz M. Gadalla, Sharon A. Savage
Summary: Individuals with telomere biology disorders (TBDs) have significantly shortened telomeres in blood cells, which is associated with increased risk of bone marrow failure and reduced survival. The mean telomere length is estimated to be 5 kilobases, but it is the shortest telomeres that indicate cellular senescence. By using the Telomere Shortest Length Assay (TeSLA), it was found that TBD patients have much shorter mean telomere length and an increased number of telomeres less than 3 kilobases. In addition, TBD patients with severe bone marrow failure and multiple organ manifestations have even shorter telomeres.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Environmental Sciences
Darrin A. Thompson, Dana W. Kolpin, Michelle L. Hladik, Hans -Joachim Lehmler, Shannon M. Meppelink, Matthew C. Poch, John D. Vargo, Victor A. Soupene, Nafis Md Irfan, Morgan Robinson, Kurunthachalam Kannan, Laura E. Beane Freeman, Jonathan N. Hofmann, David M. Cwiertny, R. William Field
Summary: A pilot study was conducted in eastern Iowa to assess human exposure to neon-icotinoids (NEOs) among farming households. The study found that NEOs were detected in both outdoor and indoor water samples, with clothianidin being the most frequently detected NEO. Human exposure to NEOs was also found in urine samples, with multiple NEOs and metabolites being present. Additionally, the study concluded that while water consumption may contribute to exposure, other factors like diet and occupational exposure may play a bigger role.
Article
Oncology
Qianlai Luo, Jonathan N. Hofmann, Ruth M. Pfeiffer, Cari M. Kitahara, Minkyo Song, Meredith S. Shiels
Summary: Since the mid-1990s, overweight/obesity appears to have significantly contributed to the rising incidence of renal cell carcinoma (RCC) in the United States, while the contribution of non-smoking has declined. Public health interventions aimed at reducing overweight and obesity could play a crucial role in curbing this trend.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Environmental Sciences
Shuai Xie, Jonathan N. Hofmann, Joshua N. Sampson, Pabitra R. Josse, Gabriella Andreotti, Jessica M. Madrigal, Mary H. Ward, Laura Beane E. Freeman, Melissa C. Friesen
Summary: This study examined the relationship between self-reported use of 2,4-D and house dust concentrations, as well as other factors, in farmers' homes. The results showed that homes with recent occupational use of 2,4-D had higher dust concentrations, and this association may be influenced by home/garden use and household characteristics.
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE
(2023)
Article
Environmental Sciences
Paul M. Bradley, Dana W. Kolpin, Darrin A. Thompson, Kristin M. Romanok, Kelly L. Smalling, Sara E. Breitmeyer, Mary C. Cardon, David M. Cwiertny, Nicola Evans, R. William Field, Michael J. Focazio, Laura E. Beane Freeman, Carrie E. Givens, James L. Gray, Gordon L. Hager, Michelle L. Hladik, Jonathan N. Hofmann, Rena R. Jones, Leslie K. Kanagy, Rachael F. Lane, R. Blaine McCleskey, Danielle Medgyesi, Elizabeth K. Medlock-Kakaley, Shannon M. Meppelink, Michael T. Meyer, Diana A. Stavreva, Mary H. Ward
Summary: Contaminant exposure in unregulated private-well tap water is a public health concern in the United States and globally. A study conducted in northeast Iowa farms found high levels of inorganics, organics, and microbial contaminants in private-well tap water. The presence of pesticides and bacteria in the water exceeds safe limits, highlighting the need for residential treatment systems and increased monitoring of rural private-well homes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Public, Environmental & Occupational Health
Daniel E. Russ, Pabitra Josse, Thomas Remen, Jonathan N. Hofmann, Mark P. Purdue, Jack Siemiatycki, Debra T. Silverman, Yawei Zhang, Jerome Lavoue, Melissa C. Friesen
Summary: Computer-assisted coding of job descriptions to standardized occupational classification codes is important in epidemiologic studies. The study evaluated the performance of SOCcer v2, a computerized algorithm for coding free-text job descriptions to US SOC-2010 system, and found that it had a similar agreement with experts compared to previous versions. The algorithm's score can be used to prioritize jobs for expert review.
ANNALS OF WORK EXPOSURES AND HEALTH
(2023)
Article
Environmental Sciences
Jongeun Rhee, Kathryn H. Barry, Wen-Yi Huang, Joshua N. Sampson, Jonathan N. Hofmann, Debra T. Silverman, Antonia M. Calafat, Julianne Cook Botelho, Kayoko Kato, Mark P. Purdue, Sonja I. Berndt
Summary: This study investigated the association between pre-diagnostic serum PFAS concentrations and aggressive prostate cancer risk. The results showed an inverse association between PFOA and aggressive prostate cancer, but this association was no longer significant for cases diagnosed more than 3 years after blood collection.
ENVIRONMENTAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Chiara Pederiva, Davide M. Trevisan, Dimitra Peirasmaki, Shan Chen, Sharon A. Savage, Ola Larsson, Jernej Ule, Laura Baranello, Federico Agostini, Marianne Farnebo
Summary: Posttranscriptional modifications of mRNA, including pseudouridylation, play a crucial role in gene expression regulation. In this study, dyskerin, a pseudouridine synthase, was found to bind to RNA polymerase II and be responsible for pseudouridylation of thousands of mRNAs. Dyskerin-mediated pseudouridylation was shown to interfere with translation and reduction of the modification led to enhanced protein synthesis. Furthermore, dyskeratosis congenita patients with mutations in the dyskerin-encoding gene showed severe reduction in mRNA pseudouridylation.
Review
Geriatrics & Gerontology
Sharon A. Savage
Summary: Telomere length is crucial in genomic stability and cancer risk, with both too short and too long telomeres associated with increased cancer risks.
Article
Environmental Sciences
Cherrel K. Manley, Maya Spaur, Jessica M. Madrigal, Jared A. Fisher, Rena R. Jones, Christine G. Parks, Jonathan N. Hofmann, Dale P. Sandler, Laura Beane Freeman, Mary H. Ward
Summary: This study describes the drinking water sources and water quality for a large agricultural cohort, finding that agricultural communities may be exposed to elevated nitrate levels due to the proximity of their drinking water sources to farms.
ENVIRONMENTAL EPIDEMIOLOGY
(2022)
