期刊
BRITISH JOURNAL OF CANCER
卷 105, 期 11, 页码 1772-1775出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/bjc.2011.444
关键词
telomere; renal cell carcinoma; kidney cancer
类别
资金
- National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics
- HSPH-NIEHS Center for Environmental Health [ES000002]
BACKGROUND: There are few known risk factors for renal cell carcinoma (RCC). Two small hospital-based case-control studies suggested an association between short blood telomere length (TL) and increased RCC risk. METHODS: We conducted a large population-based case-control study in two metropolitan regions of the United States comparing relative TL in DNA derived from peripheral blood samples from 891 RCC cases and 894 controls. Odds ratios and 95% confidence intervals were estimated using unconditional logistic regression in both unadjusted and adjusted models. RESULTS: Median TL was 0.85 for both cases and controls (P = 0.40), and no differences in RCC risk by quartiles of TL were observed. Results of analyses stratified by age, sex, race, tumour stage, and time from RCC diagnosis to blood collection were similarly null. In multivariate analyses among controls, increasing age and history of hypertension were associated with shorter TL (P<0.001 and P = 0.07, respectively), and African Americans had longer TL than Caucasians (P<0.001). CONCLUSION: These data do not support the hypothesis that blood TL is associated with RCC. This population-based case-control study is, to our knowledge, the largest investigation to date of TL and RCC. British Journal of Cancer (2011) 105, 1772-1775. doi:10.1038/bjc.2011.444 www.bjcancer.com
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据