Article
Biochemistry & Molecular Biology
Hao Cui, Xiaowen Cheng, Tahira Batool, Xiao Zhang, Jin-Ping Li
Summary: The study suggests that a defect in the key enzyme glucuronyl C5-epimerase (Hsepi) involved in heparan sulfate biosynthesis may lead to lung developmental failure in mice. Despite no significant morphological differences before E16.5, mutant animals show abnormal lung structure at E17.5-18.5, with impaired AT1 cell differentiation possibly associated with reduced lung vascularization.
Article
Biochemistry & Molecular Biology
Hao Cui, Zhaoguang Wang, Tianji Zhang, Jin-ping Li, Jianping Fang
Summary: The translation explores the role of Heparan sulfate (HS) in protein recognition and interaction, highlighting the importance of specific sulfation and epimerization patterns modulated by Golgi-localized enzymes. The study investigates the effects of restoring Hsepi in mutant MEF cells, showing increased IdoA residues and rescued cell signaling, although Hsepi knockout did not influence cellular transport or enzymatic activity of 2OST. These findings suggest potential differences in regulatory mechanisms for 2OST and Hsepi.
Article
Gastroenterology & Hepatology
Fei He, Haowen Jiang, Chang Peng, Tingting Wang, Rongrong Xiao, Meilin Chen, Nixue Song, Zhenyun Du, Hanlin Wang, Xiaoyu Ding, Yikai Shao, Jianping Fang, Yi Zang, Rong Hua, Jia Li, Kan Ding
Summary: This study investigated the role of hepatic glucuronyl C5-epimerase (Glce) in obesity development. It found that hepatic Glce deficiency facilitates obesity progression and reduces secretion of growth differentiation factor 15 (GDF15), disrupting lipid homeostasis.
JOURNAL OF HEPATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Anthony J. Hayes, James Melrose
Summary: The recent discovery of nuclear and perinuclear perlecan in annulus fibrosus and nucleus pulposus cells and its potential roles in stabilizing the nucleus through interactions with nuclear envelope components raises the possibility of regulating gene expression. The presence of perlecan in tumor cell nuclei suggests its involvement in disease progression, while this review aims to explore its roles in both normal and malignant cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Ana A. Jones, Elvira Diamantopoulou, Sarah Baxendale, Tanya T. Whitfield
Summary: Epithelial morphogenesis of the zebrafish inner ear depends on the production and localization of glycosaminoglycans, particularly hyaluronan and proteoglycans, which play critical roles in epithelial projection outgrowth and otolith development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Tayler F. L. Wishart, Frank J. Lovicu
Summary: Heparan sulphate proteoglycans (HSPGs) are composed of a core protein and sulphated HS-glycosaminoglycan (GAG) chains. These HS-GAG chains bind to and regulate the activity of HS-binding proteins, including growth factors, playing a crucial role in cellular processes during lens development. The different localisation of HSPG core proteins suggests their specialized roles in lens induction and morphogenesis.
Correction
Biochemistry & Molecular Biology
Wan Li, Qingxia Wang, Xiaoyu Qi, Hongmei Lu, Yuheng Chen, Jiale Shi, Fei Wang, Ziyu Wang, Yao Lu, Zhongmou Lu, Qin Yan, Cong Wang, Shou-Jiang Gao, Chun Lu
Summary: A revised version of this paper has been published and is accessible through a link at the top of the paper.
CELL DEATH AND DIFFERENTIATION
(2021)
Review
Biochemistry & Molecular Biology
Jessica Oyie Sousa Onyeisi, Carla Cristina Lopes, Martin Goette
Summary: Syndecan-4 plays crucial roles in cell behavior and interactions with growth factors, extracellular matrix molecules, and signaling proteins in various cancers. The expression level of syndecan-4 is important for understanding malignant transformation and it emerges as a target for cancer therapy and diagnosis.
Review
Biochemistry & Molecular Biology
Shashank Kumar, Kumari Sunita Prajapati, Sanjay Gupta
Summary: Signal peptide, CUB, and EGF-like domain-containing proteins (SCUBE) are secretory cell surface glycoproteins that play key roles in the developmental process. SCUBE proteins participate in the progression of several diseases, including cancer, and are recognized for their oncogenic and tumor suppressor functions depending on the cellular context. SCUBE proteins promote cancer cell proliferation, angiogenesis, invasion, or metastasis, stemness or self-renewal, and drug resistance. SCUBE proteins have potential prognostic and diagnostic value for breast cancer, renal cell carcinoma, endometrial carcinoma, and nasopharyngeal carcinoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Bin Sun, Weidan Ji, Chunying Liu, Xuejing Lin, Lei Chen, Haihua Qian, Changqing Su
Summary: miR-2392 is significantly down-regulated in HCC and functions as a tumor suppressor by targeting JAG2 to inhibit proliferation, clonogenicity, mobility, spheroid formation, and maintenance of CSC-like characteristics in HCC cells. CTCs from HCC patients with lower serum miR-2392 levels exhibit stronger spheroid formation ability, and a negative correlation between miR-2392 levels in serum and the number of CTC spheroids has been observed. JAG2 is highly expressed in HCC and is associated with poor prognosis and patient survival.
LIVER INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Seung-hwan Jeong, Myung Jin Yang, Seunghyeok Choi, JungMo Kim, Gou Young Koh
Summary: STING agonists have been shown to induce early apoptosis of endothelial cells in subcutaneous xenografts models, while additional inhibition of AKT is required for efficient induction of apoptosis in primary tumors. This study proposes a more advanced avenue for treating primary tumors that are refractory to single STING agonist therapy.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Rama Rao Malla, Gugalavath Shailender, Mohammad Amjad Kamal
Summary: Tumour microenvironment (TME) is a complex network of cells that plays a crucial role in cancer progression and metastasis. TME-derived exosomes are recognized as important communicators in reprogramming TME cells, and have applications in precision medicine. This review highlights the role of TME-derived exosomes in modulating stroma and outlines potential precision strategies for targeted therapeutic intervention.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Cell Biology
Elham Shakiba, Ali Bazi, Hamed Ghasemi, Reza Eshaghi Gorji, Seyyed Alireza Mehdipour, Banafsheh Nikfar, Mohsen Rashidi, Sepideh Mirzaei
Summary: This study evaluated the therapeutic potential of hesperidin in mice with 4T1 breast cancer tumors. The results showed that combination treatment with hesperidin and doxorubicin significantly improved survival rates and reduced the expression of tumor-related biomarkers compared to hesperidin or doxorubicin alone. Additionally, this combination treatment had a significant impact on the pathological response of tumor tissues. This suggests that hesperidin may be a potentially suitable anti-cancer agent for breast cancer and can synergize with other chemotherapeutics.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Christopher D'Arcy, Clarissa Constanze Zimmermann, Nancy Adriana Espinoza-Sanchez, Burkhard Greve, Annika Schmidt, Ludwig Kiesel, Marie-Kristin von Wahlde, Martin Goette
Summary: This study found that diminished Sdc-1 expression plays a role in the progression of DCIS to IBC through deregulation of proteolytic factors and a partial EMT.
Article
Mathematics, Applied
Jose M. Sanz Nogales, S. Zazo
Summary: The proposed tumour growth model is based on public goods games, where cells interact and compete by releasing and absorbing diffusible factors. This model extends the replicator equation to consider the dynamics of cell populations with different phenotypes. It covers various tumour characteristics, metastasis mechanisms, and conditions for specific phenotype proliferation and patient recovery, with results reported on targeted therapies using reversible inhibitors.
COMMUNICATIONS IN NONLINEAR SCIENCE AND NUMERICAL SIMULATION
(2021)
Article
Cell Biology
Anastasia V. Suhovskih, Vladimir I. Kashuba, George Klein, Elvira V. Grigorieva
CELL ADHESION & MIGRATION
(2017)
Article
Genetics & Heredity
Valentina A. Belyayskaya, Tatiana Y. Prudnikova, Natalya V. Domanitskaya, Nikolay V. Litviakov, Vladimir N. Maksimov, Nadezhda V. Cherdyntseva, Elvira V. Grigorieva
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Biochemistry & Molecular Biology
Victor S. Ushakov, Alexandra Y. Tsidulko, Gabin de La Bourdonnaye, Galina M. Kazanskaya, Alexander M. Volkov, Roman S. Kiselev, Vyacheslav V. Kobozev, Diana V. Kostromskaya, Alexey S. Gaytan, Alexei L. Krivoshapkin, Svetlana V. Aidagulova, Elvira V. Grigorieva
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Cell Biology
Galina M. Kazanskaya, Alexandra Y. Tsidulko, Alexander M. Volkov, Roman S. Kiselev, Anastasia V. Suhovskih, Vyacheslav V. Kobozev, Alexei S. Gaytan, Svetlana V. Aidagulova, Alexei L. Krivoshapkin, Elvira V. Grigorieva
HISTOCHEMISTRY AND CELL BIOLOGY
(2018)
Article
Multidisciplinary Sciences
Muhammad Mushtaq, Lasse Jensen, Sabina Davidsson, Oleksandr Grygoruk, Ove Andren, Vladimir Kashuba, Elena Kashuba
SCIENTIFIC REPORTS
(2018)
Article
Pharmacology & Pharmacy
Alexandra Y. Tsidulko, Cynthia Bezier, Gabin de la Bourdonnaye, Anastasia V. Suhovskih, Tatiana M. Pankova, Galina M. Kazanskaya, Svetlana V. Aidagulova, Elvira V. Grigorieva
FRONTIERS IN PHARMACOLOGY
(2018)
Review
Pharmacology & Pharmacy
Oksana Maksymchuk, Vladimir Kashuba
PHARMACOLOGICAL REPORTS
(2019)
Article
Cell Biology
Anastasia V. Suhovskih, Galina M. Kazanskaya, Alexander M. Volkov, Alexandra Y. Tsidulko, Svetlana V. Aidagulova, Elvira V. Grigorieva
HISTOCHEMISTRY AND CELL BIOLOGY
(2019)
Article
Cell Biology
Alexandra Y. Tsidulko, Galina M. Kazanskaya, Alexander M. Volkov, Anastasia V. Suhovskih, Roman S. Kiselev, Vyacheslav V. Kobozev, Alexei S. Gaytan, Alexei L. Krivoshapkin, Svetlana V. Aidagulova, Elvira V. Grigorieva
CELL AND TISSUE RESEARCH
(2020)
Article
Oncology
Kostyantyn A. Nekrasov, Mark V. Vikarchuk, Evgeniya E. Rudenko, Igor V. Ivanitskiy, Viacheslav M. Grygorenko, Rostyslav O. Danylets, Alexander G. Kondratov, Liubov A. Stoliar, Bizhan R. Sharopov, Volodymyr I. Kashuba
Article
Biochemistry & Molecular Biology
Anastasia Suhovskih, Galina M. Kazanskaya, Alexander M. Volkov, Alexandra Y. Tsidulko, Svetlana Aidagulova, Elvira Grigorieva
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
A. A. Dmitriev, A. D. Beniaminov, N. V. Melnikova, E. N. Pushkova, G. V. Gerashchenko, A. V. Kudryavtseva, V. I. Kashuba
Review
Pharmacology & Pharmacy
Oksana V. Maksymchuk, Vladimir I. Kashuba
PHARMACOLOGICAL REPORTS
(2020)
Article
Chemistry, Medicinal
Nataliia Melnichuk, Vladimir Kashuba, Svitlana Rybalko, Zenoviy Tkachuk