Review
Cell Biology
Yaoyao Zhu, Xia Li
Summary: Colorectal cancer is a common and deadly cancer worldwide, with a close association to genetic mutations, chronic inflammatory disorders, and poor dietary habits. The Wnt signaling pathway plays a crucial role in various physiological processes of colorectal cancer. This review summarizes the recent advances in understanding the mechanisms and potential regulators of the three branches of the Wnt signaling pathway in colorectal cancer.
Article
Medicine, Research & Experimental
Chang Xu, Yu-han Ding, Kun Wang, Mengdi Hao, Huimin Li, Lei Ding
Summary: The study demonstrates that Cldn7 deficiency in CRC promotes stemness properties through Sox9-mediated Wnt/beta -catenin signaling. This finding elucidates the inhibitory role of Cldn7 in CRC and reveals a potential molecular mechanism, contributing to further research on Cldn7 and cancer stem cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Mathieu J. F. Crupi, Zaid Taha, Thijs J. A. Janssen, Julia Petryk, Stephen Boulton, Nouf Alluqmani, Anna Jirovec, Omar Kassas, Sarwat T. Khan, Sydney Vallati, Emily Lee, Ben Zhen Huang, Michael Huh, Larissa Pikor, Xiaohong He, Ricardo Marius, Bradley Austin, Jessie Duong, Adrian Pelin, Serge Neault, Taha Azad, Caroline J. Breitbach, David F. Stojdl, Michael F. Burgess, Scott McComb, Rebecca Auer, Jean-Simon Diallo, Carolina S. Ilkow, John Cameron Bell
Summary: This study proposes a novel combination strategy for the treatment of colorectal cancers using oncolytic vaccinia virus to enhance immune-payload delivery and boost T cell responses within tumors. TCEs targeting CEACAM5 and CD3 stimulate robust activation of CD4 and CD8-positive T cells in in vitro co-culture models with colorectal cancer cells, and lead to regression of colorectal tumors in syngeneic and xenograft mouse models.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Guanlin Wu, Weidong Weng, Pengfei Xia, Shixian Yan, Cheng Zhong, Lei Xie, Yu Xie, Gang Fan
Summary: This review aims to summarize previous studies related to bladder cancer and the Wnt signaling pathway, with a focus on exploring the participating substances and their mechanisms in the regulation of the Wnt signaling pathway to better determine how to promote new chemotherapeutic drugs, potential therapeutic targets, and diagnostic biomarkers.
CELLULAR SIGNALLING
(2021)
Article
Oncology
Jie Yu, Qi Sun, Yi Hui, Jinping Xu, Pancheng Shi, Yu Chen, Yunzhao Chen
Summary: This study investigated the protective role of vitamin D receptor (VDR) in colorectal cancer (CRC) progression by inhibiting Wnt/beta-catenin signaling to control cancer cell invasion and apoptosis. The results showed that VDR overexpression inhibited invasion and promoted apoptosis in CRC cells, and it interacted with beta-catenin to prevent its nuclear accumulation. VDR also regulated the expression of beta-catenin, cyclin D1, and LEF-1, and directly activated LEF-1 transcription. These findings provide new evidence to explore VDR biomarkers or agonists for CRC patient diagnosis and treatment.
Review
Oncology
Gabriela Goncalves Roliano, Juliana Hofstatter Azambuja, Veronica Toniazzo Brunetto, Hannah Elizabeth Butterfield, Antonio Nochi Kalil, Elizandra Braganhol
Summary: Colorectal cancer is a major cause of cancer-related death. In this study, we explored how cancer evades immune cells by altering purine levels. We reviewed literature that identified specific enzymes and receptors involved in this process and found that targeting these enzymes and receptors could activate immune response and halt cancer progression in colorectal cancer.
Article
Pharmacology & Pharmacy
Ester Pagano, Barbara Romano, Donatella Cicia, Fabio A. Iannotti, Tommaso Venneri, Giuseppe Lucariello, Maria Francesca Nani, Fabio Cattaneo, Paola De Cicco, Maria D'Armiento, Marcello De Luca, Ruggiero Lionetti, Stefania Lama, Paola Stiuso, Pietro Zoppoli, Geppino Falco, Silvia Marchiano, Stefano Fiorucci, Raffaele Capasso, Vincenzo Di Marzo, Francesca Borrelli, Angelo A. Izzo
Summary: TRPM8 is overexpressed in colorectal cancer and its high expression is associated with lower survival rate of patients and hyperactivation of related signaling pathways. TRPM8 may serve as a prognostic marker and potential drug target for colorectal cancer.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Cell Biology
Hyun-Yi Kim, Shujin Li, Dong-Joon Lee, Jin Hoo Park, Takashi Muramatsu, Hidemitsu Harada, Young-Soo Jung, Han-Sung Jung
Summary: A potential cancer stem cell population was identified in ameloblastoma cells, and the activation of Wnt signaling pathway was found to be a promising therapeutic approach to decrease this population.
CELL PROLIFERATION
(2021)
Article
Biochemistry & Molecular Biology
Roland Kotolloshi, Mieczyslaw Gajda, Marc-Oliver Grimm, Daniel Steinbach
Summary: The study revealed that BCL9L and Wnt/beta-catenin signaling play an oncogenic role in bladder cancer cells, and may be associated with the progression of bladder cancer. Mutations in UTRs of BCL9L can affect its activity, thereby influencing cell proliferation, migration, and invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Nathalie Sphyris, Michael C. Hodder, Owen J. Sansom
Summary: The intestinal epithelium performs diverse functions, constantly renewing cells to maintain its barrier against toxins. Stem cells play a crucial role in this process under the guidance of the niche signals. Dysfunction of intestinal stem cells may contribute to the development of colorectal cancer.
Review
Biochemistry & Molecular Biology
Cyrollah Disoma, Yuzheng Zhou, Shanni Li, Jian Peng, Zanxian Xia
Summary: The Wnt/β-catenin signaling pathway plays a crucial role in colorectal carcinogenesis, but no clinically approved therapies targeting this pathway currently exist. New modulators of the pathway are involved not only in cancer initiation but also in chemoresistance, epithelial-mesenchymal transition, and cancer stem cell renewal. CDX2 shows potential as a promising molecular target for colorectal cancer therapeutics, although further studies are needed to determine its significance. Overall, the regulation of the Wnt/β-catenin signaling pathway remains complex and not fully understood, posing a major barrier to the development of targeted chemotherapeutic agents.
Article
Genetics & Heredity
Carli M. King, Olivia M. Marx, Wei Ding, Walter A. Koltun, Gregory S. Yochum
Summary: Mutations in Wnt/beta-catenin signaling pathway components drive colorectal cancer by deregulating gene expression controlled by TCF family transcription factors. TCF7L1 plays a significant role in this process by repressing LGR5 expression through binding to a novel WRE at the LGR5 gene locus. This modulation governs spheroid formation potential of CRC cells.
Article
Oncology
Yue-Ju Li, Cheng-Ning Yang, Mark Yen-Ping Kuo, Wei-Ting Lai, Tai-Sheng Wu, Been-Ren Lin
Summary: ATMIN plays a crucial role in regulating invasion abilities and tumor progression in MSS tumors, affecting cell motility. Through co-immunoprecipitation analyses, it was found that ATMIN acts on the Wnt signaling pathway via PARP1.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Yanhui Si, Lei Li, Weiwei Zhang, Qiling Liu, Baochi Liu
Summary: The study found that GANT61 effectively eliminates cancer cells and CSCs in colorectal cancer by blocking the Wnt/beta-catenin and Notch signaling pathways.
Article
Oncology
Esther Strating, Emma Wassenaar, Mathijs Verhagen, Paulien Rauwerdink, Susanne van Schelven, Ignace de Hingh, Inne Borel Rinkes, Djamila Boerma, Arjen Witkamp, Miangela Lacle, Riccardo Fodde, Richard Volckmann, Jan Koster, Kris Stedingk, Frederik Giesel, Remmert de Roos, Alex Poot, Guus Bol, Marnix Lam, Sjoerd Elias, Onno Kranenburg
Summary: In colorectal cancer, the consensus molecular subtype 4 (CMS4) is associated with therapy resistance and poor prognosis. This study found that fibroblast activation protein (FAP) mRNA can accurately identify CMS4 and is associated with shorter relapse-free survival. The heterogeneity of FAP expression among and within tumor lesions correlates with CMS4 heterogeneity.
BRITISH JOURNAL OF CANCER
(2022)
Review
Neurosciences
Phillippa J. Carling, Heather Mortiboys, Claire Green, Simeon Mihaylov, Cynthia Sandor, Aurelie Schwartzentruber, Rosie Taylor, Wenbin Wei, Chris Hastings, Siew Wong, Christine Lo, Samuel Evetts, Hannah Clemmens, Matthew Wyles, Sam Willcox, Thomas Payne, Rachel Hughes, Laura Ferraiuolo, Caleb Webber, Winston Hide, Richard Wade-Martins, Kevin Talbot, Michele T. Hu, Oliver Bandmann
PROGRESS IN NEUROBIOLOGY
(2020)
Article
Multidisciplinary Sciences
Taha Elmetwali, Asmaa Salman, Wenbin Wei, Syed A. Hussain, Lawrence S. Young, Daniel H. Palmer
SCIENTIFIC REPORTS
(2020)
Article
Oncology
Massimo Granai, Lucia Mundo, Ayse U. Akarca, Maria Chiara Siciliano, Hasan Rizvi, Virginia Mancini, Noel Onyango, Joshua Nyagol, Nicholas Othieno Abinya, Ibrahim Maha, Sandra Margielewska, Wenbin Wi, Michele Bibas, Pier Paolo Piccaluga, Leticia Quintanilla-Martinez, Falko Fend, Stefano Lazzi, Lorenzo Leoncini, Teresa Marafioti
INFECTIOUS AGENTS AND CANCER
(2020)
Article
Psychiatry
Michail S. Kukharsky, Natalia N. Ninkina, Haiyan An, Vsevolod Telezhkin, Wenbin Wei, Camille Rabesahala de Meritens, Johnathan Cooper-Knock, Shinichi Nakagawa, Tetsuro Hirose, Vladimir L. Buchman, Tatyana A. Shelkovnikova
TRANSLATIONAL PSYCHIATRY
(2020)
Article
Cell Biology
Ying-Wooi Wan, Rami Al-Ouran, Carl G. Mangleburg, Thanneer M. Perumal, Tom Lee, Katherine Allison, Vivek Swarup, Cory C. Funk, Chris Gaiteri, Mariet Allen, Minghui Wang, Sarah M. Neuner, Catherine C. Kaczorowski, Vivek M. Philip, Gareth R. Howell, Heidi Martini-Stoica, Hui Zheng, Hongkang Mei, Xiaoyan Zhong, Jungwoo Wren Kim, Valina L. Dawson, Ted M. Dawson, Ping-Chieh Pao, Li-Huei Tsai, Jean-Vianney Haure-Mirande, Michelle E. Ehrlich, Paramita Chakrabarty, Yona Levites, Xue Wang, Eric B. Dammer, Gyan Srivastava, Sumit Mukherjee, Solveig K. Sieberts, Larsson Omberg, Kristen D. Dang, James A. Eddy, Phil Snyder, Yooree Chae, Sandeep Amberkar, Wenbin Wei, Winston Hide, Christoph Preuss, Ayla Ergun, Phillip J. Ebert, David C. Airey, Sara Mostafavi, Lei Yu, Hans-Ulrich Klein, Gregory W. Carter, David A. Collier, Todd E. Golde, Allan Levey, David A. Bennett, Karol Estrada, T. Matthew Townsend, Bin Zhang, Eric Schadt, Philip L. De Jager, Nathan D. Price, Nilufer Ertekin-Taner, Zhandong Liu, Joshua M. Shulman, Lara M. Mangravite, Benjamin A. Logsdon
Article
Chemistry, Medicinal
John G. M. Mina, Rebecca L. Charlton, Edubiel Alpizar-Sosa, Douglas O. Escrivani, Christopher Brown, Amjed Alqaisi, Maria Paula G. Borsodi, Claudia P. Figueiredo, Emanuelle de Lima, Emily A. Dickie, Wenbin Wei, Robson Coutinho-Silva, Andy Merritt, Terry K. Smith, Michael P. Barrett, Bartira Rossi-Bergmann, Paul W. Denny, Patrick G. Steel
Summary: This study successfully identified an over-the-counter antihistamine, clemastine fumarate, as a potential candidate for the treatment of leishmaniasis. Through multiple screenings and experiments, the drug showed promising activity and effectiveness, suggesting it could be repurposed for the treatment of this disease.
ACS INFECTIOUS DISEASES
(2021)
Article
Neurosciences
Hannah Larbalestier, Marcus Keatinge, Lisa Watson, Emma White, Siri Gowda, Wenbin Wei, Katjusa Koler, Svetlana A. Semenova, Adam M. Elkin, Neal Rimmer, Sean T. Sweeney, Julie Mazzolini, Dirk Sieger, Winston Hide, Jonathan McDearmid, Pertti Panula, Ryan B. MacDonald, Oliver Bandmann
Summary: In this study, a loss of function zebrafish gch1(-/-) mutant was generated using CRISPR/Cas technology to investigate the mechanisms by which GCH1 deficiency may contribute to PD. The results suggest that GCH1 deficiency may indirectly contribute to neuronal cell death via immune-mediated mechanisms. The study highlights the importance of functional validation for GWAS risk factors and emphasizes the role of inflammation in the pathogenesis of PD.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Haiyan An, Gioana Litscher, Naruaki Watanabe, Wenbin Wei, Tadafumi Hashimoto, Takeshi Iwatsubo, Vladimir L. Buchman, Tatyana A. Shelkovnikova
Summary: This study reveals that SG-like structures formed by mutant FUS are structurally distinct from SGs, unlikely to functionally replace SGs, and affect a spectrum of cellular pathways.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Agronomy
Abdulkarim Lakmes, Abdullah Jhar, R. Varma Penmetsa, Wenbin Wei, Adrian C. Brennan, Abdullah Kahriman
Summary: This study used genetic mapping to identify quantitative trait loci (QTLs) for days to first flowering and flower color in chickpea, demonstrating the quantitative inheritance and potential of wild relatives as a source of novel alleles for chickpea breeding.
Article
Infectious Diseases
Edubiel A. Alpizar-Sosa, Nur Raihana Binti Ithnin, Wenbin Wei, Andrew W. Pountain, Stefan K. Weidt, Anne M. Donachie, Ryan Ritchie, Emily A. Dickie, Richard J. S. Burchmore, Paul W. Denny, Michael P. Barrett
Summary: Amphotericin B resistance in Leishmania is associated with changes in sterol composition, which are caused by gene mutations. The sensitivity of the cells to the drug also varies depending on the growth medium. Some resistant lines show reduced virulence, but still retain their resistance phenotype.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Immunology
Edubiel A. Alpizar-Sosa, Yasmine Kumordzi, Wenbin Wei, Phillip D. Whitfield, Michael P. Barrett, Paul W. Denny
Summary: With the global spread of the neglected tropical disease leishmaniasis, the validation of new drug targets in the causative insect vector is crucial. Using CRISPR Cas9 technology, a study reveals the essentiality of a gene and the possibility of simultaneous deletion of two genes, providing insights into the physiological process of the parasite.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Agronomy
Abdulkarim Lakmes, Abdullah Jhar, R. Varma Penmetsa, Wenbin Wei, Adrian C. Brennan, Abdullah Kahriman
Summary: This study aims to investigate the inheritance of seed weight and plant growth habit in chickpea and identifies the associated quantitative trait loci (QTL). The findings provide important insights for chickpea breeding.
Article
Cell Biology
Benjamin Allcock, Wenbin Wei, Kirsty Goncalves, Henry Hoyle, Alisha Robert, Rebecca Quelch-Cliffe, Adam Hayward, Jim Cooper, Stefan Przyborski
Summary: Cells respond to their microenvironment, and this has implications for cell culture practices. In this study, the cellular processes that occur when a cell is cultured on 2D or 3D surfaces for a short period of time were examined. The study found that this priming process improved the cell's functionality and drug toxicity profiles. The findings have broad significance in the field of cell biology, demonstrating the fundamental impact of mechanotransduction in bioengineering and cell biology.
Article
Microbiology
Karunakaran Kalesh, Wenbin Wei, Brian S. Mantilla, Theodoros Roumeliotis, Jyoti Choudhary, Paul W. Denny
Summary: This study identified RNA-binding proteins in Leishmania, including proteins that interact with non-adenylated RNAs. The study also revealed the involvement of RNA-protein interactions in various biological processes in Leishmania, such as gene regulation and protein synthesis. Additionally, the study showed the impact of heat shock protein 90 inhibition on RNA-protein interactions in Leishmania.
MICROBIOLOGY SPECTRUM
(2022)
Article
Evolutionary Biology
Xiaoyan Gu, Adrian Brennan, Wenbin Wei, Guangqin Guo, Keith Lindsey
EVOLUTIONARY BIOINFORMATICS
(2020)