Article
Biochemistry & Molecular Biology
Conor J. Sugden, Valentina Iorio, Lee D. Troughton, Ke Liu, Mychel R. P. T. Morais, Rachel Lennon, George Bou-Gharios, Kevin J. Hamill
Summary: Transgenic expression of LaNt alpha 31 in mice resulted in defects in tissue morphogenesis, including extravascular bleeding, kidney epithelial detachment, tubular dilation, disruption of the epidermal basal cell layer and hair follicle outer root sheath, as well as reduced cell numbers in the liver.
Review
Biochemistry & Molecular Biology
Luhuai Shi, Xiaoguang Li, Hua Qian
Summary: Anti-LM332-type mucous membrane pemphigoid is a rare autoimmune bullous disease that is difficult to diagnose and treat, and may be correlated with tumors.
Article
Medicine, General & Internal
Katarzyna Skowron-Kandzia, Marcin Tomsia, Halina Koryciak-Komarska, Danuta Plewka, Patrycja Wieczorek, Piotr Czekaj
Summary: The study found that laminin 332 (LN-332) significantly influences the viability and expression characteristics of human amniotic cells (hAC), including increasing the total number of cells, reducing SSEA-4 positive cells, and increasing HLA-ABC positive cells. Additionally, the presence of LN-332 in the culture medium was found to modulate gene expression in hAC, affecting cell proliferation, adhesion, and differentiation.
FRONTIERS IN MEDICINE
(2021)
Article
Cell Biology
Samarpita Banerjee, Wen-Cheng Lo, Payel Majumder, Debleena Roy, Mimosa Ghorai, Nusrat K. Shaikh, Nishi Kant, Mahipal S. Shekhawat, Vijaykumar Shivaji Gadekar, Suchanda Ghosh, Ercan Bursal, Faris Alrumaihi, Navneet Kumar Dubey, Sanjay Kumar, Danish Iqbal, Wael Alturaiki, Vijay Jagdish Upadhye, Niraj Kumar Jha, Abhijit Dey, Rohit Gundamaraju
Summary: Metastasis is a major challenge in cancer therapy, and the epithelial-mesenchymal transition plays a critical role in this process. Collagen, laminin, and integrin are important components involved in tumor cell metastasis and can also serve as biomarkers for metastatic cells. This review summarizes the current knowledge of therapeutics in preclinical or clinical stages.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2022)
Article
Medicine, General & Internal
Eleonora Quattri, Martina Zussino, Wanda Lauro, Emilio Berti, Angelo Valerio Marzano, Giovanni Genovese
Summary: A 74-year-old woman presented with blisters and erosions in the oral cavity, trunk, and left eye conjunctival mucosa, along with weight loss. The diagnosis of anti-laminin 332 mucous membrane pemphigoid was confirmed, and the patient received topical and oral treatments for symptom relief.
FRONTIERS IN MEDICINE
(2022)
Article
Immunology
Stephanie Goletz, Federica Giurdanella, Maike M. Holtsche, Miranda Nijenhuis, Barbara Horvath, Gilles F. H. Diercks, Detlef Zillikens, Takashi Hashimoto, Enno Schmidt, Hendri H. Pas
Summary: This study compared two diagnostic tests for anti-laminin 332 MMP and found that both assays are easy to perform, highly sensitive, and specific, which will further facilitate the diagnosis of the disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Lixiang Feng, Jun Yang, Wei Zhang, Xiong Wang, Lili Li, Min Peng, Pengcheng Luo
Summary: Based on the importance of the basement membrane (BM) in cancer invasion and metastasis, this study constructed a BM-associated lncRNA risk model for bladder cancer (BCa) patients. The model accurately predicted prognosis, tumor invasion, and metastasis, and showed good predictive power for the tumor microenvironment and mutational burden. The study provides new insights into predicting prognosis and understanding the molecular mechanisms of BCa.
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
Hiroyuki Honda, Kosuke Matsuzono, Kota Satoh, Masayoshi Fujisawa, Satoshi O. Suzuki, Chiaki Furuyama, Tetsuyuki Kitamoto, Shigeru Fujimoto, Koji Abe, Toru Iwaki
Summary: Immunohistochemical detection of PrP in cutaneous samples revealed abnormal PrP deposits in patients with GPI-anchorless PrP disease, particularly localized at the basement membrane and colocalized with laminin. This method could be used for definitive diagnosis of the disease.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Oncology
Zijie Wang, Hui Liu, Qing Hu, Lei Shi, Muhan Lu, Mingming Deng, Gang Luo
Summary: The study demonstrated that CAR can inhibit the proliferation, migration, and invasion of esophageal cancer cells and induce apoptosis. Furthermore, CAR promotes apoptosis by inhibiting the PI3K/AKT signaling pathway, showing a strong anticancer effect.
Review
Dermatology
Monique Aumailley
Summary: The basement membrane at the dermal-epidermal junction is composed of four categories of extracellular matrix proteins, which are precisely arranged through specific interactions. Some proteins are provided by both fibroblasts and keratinocytes, while others are exclusively synthesized by one of the cell types. Further research is needed to determine how the components from fibroblasts are targeted to the junction and integrated with keratinocytes' proteins to form the basement membrane.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Oncology
Lorena Carmona-Rodriguez, Diego Martinez-Rey, Paula Martin-Gonzalez, Monica Franch, Lydia Sorokin, Emilia Mira, Santos Manes
Summary: Tumor-infiltrating lymphocytes play a crucial role in cancer prognosis and the response to immunotherapy. This study investigates the effect of SOD3 protein on the expression of laminin-alpha 4 and laminin-alpha 5 in tumor blood vessels. The results show that SOD3 regulates laminin-alpha 4 and laminin-alpha 5 differentially, promoting a balance that allows T cell infiltration into tumors and improves cancer immune surveillance. The study provides insights into the mechanism of immune cell infiltration in tumors and highlights the potential importance of SOD3 in cancer therapy.
Article
Biochemistry & Molecular Biology
Monica S. Schoenenberger, Willi Halfter, Alexia Ferrand, Kathrin Halfter, Alexandar Tzankov, Hendrik P. N. Scholl, Paul Bernhard Henrich, Christophe A. Monnier
Summary: This article examines the compositional and biophysical properties of human basement membranes, revealing them to be stiff yet highly elastic materials. The role of composition, mechanics, and hydration in determining the properties of basement membranes is highlighted.
Article
Biochemistry & Molecular Biology
Anna-Liisa Luik, Melanie-Jane Hannocks, Sophie Loismann, Kishan Kapupara, Manuela Cerina, Miesje van der Stoel, Yaroslav Tsytsyura, Nataliya Glyvuk, Caroline Nordenvall, Jurgen Klingauf, Stephan Huveneers, Sven Meuth, Lars Jakobsson, Lydia Sorokin
Summary: Using high-resolution confocal imaging, we identified novel components of myoendo-thelial junctions (MEJs) in blood vessels, including integrins, vinculin, focal adhesion kinase (FAK), and laminins. The electron microscopy revealed multiple layers of endothelial basement membranes (BMs) in MEJs. The TRPV4 calcium channel, which is shear-responsive, was found to be broadly distributed in endothelial cells and was localized at the endothelial-SMC interface in MEJs. Mice lacking endothelial laminin isoform showed increased TRPV4 localization at the endothelial-SMC interface in MEJs.
Article
Biochemistry & Molecular Biology
Jennifer L. Bailey, David H. Burk, Susan J. Burke, Scott D. Reed, Sujoy Ghosh, Carrie M. Elks
Summary: This study found that adipocyte-specific LAMA4 deletion is protective in an obesogenic environment, even though overall adiposity is increased. Laminin alpha 4 was found to be highly expressed in human and murine adipocytes.
Review
Genetics & Heredity
Liam Shaw, Conor J. Sugden, Kevin J. Hamill
Summary: Laminins play crucial roles in cell adhesion, signaling, and migration, forming functional networks through extracellular interactions. Pathogenic point mutations can lead to clinical syndromes, shedding light on the roles of laminins in tissue function through genotype-phenotype comparisons.
FRONTIERS IN GENETICS
(2021)