Review
Biochemistry & Molecular Biology
Yuexuan Wang, Yu Han, Yuzhen Jin, Qiang He, Zhicheng Wang
Summary: This study discusses the pathogenesis of cancer and the impact of radiotherapy on cancer. It has been found that epigenetic modification plays an important role in the occurrence and development of cancer. Radiation therapy affects the epigenetic modifications of DNA, chromatin, etc., which in turn affects the treatment outcomes. Therefore, studying the interaction between radiotherapy and epigenetic modifications can help us better understand cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Benjamin J. Bernard, Nupur Nigam, Kyunghee Burkitt, Vassiliki Saloura
Summary: Chromatin modifiers are enzymes that alter chromatin structure through various post-translational modifications, influencing transcription. SMYD3, a chromatin modifier implicated in cancer, has been shown to methylate not only histones but also non-histone substrates, impacting cancer prognosis and function. Ongoing efforts to develop inhibitors of SMYD3 for therapeutic use are underway, aiming to advance future discovery and treatment in cancer research.
CLINICAL EPIGENETICS
(2021)
Review
Cell Biology
Tanjing Song, Suli Lv, Neng Li, Xuefeng Zhao, Xianyun Ma, Yingying Yan, Weixia Wang, Lidong Sun
Summary: m6A machinery, a crucial RNA modification mechanism, is involved in the regulation of RNA processing and function. Recent studies have demonstrated that m6A machinery can be recruited to chromatin by various factors, leading to direct regulation of chromatin biology such as transcription, DNA damage repair, and DNA recombination.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2022)
Review
Oncology
Francisco Gimeno-Valiente, Gerardo Lopez-Rodas, Josefa Castillo, Luis Franco
Summary: This review focuses on the interconnections between epigenetics and alternative splicing in the development of cancer. It discusses the mechanisms involved in these interconnections and the potential diagnostic and therapeutic tools that can be derived from them. The reversible nature of epigenetic alterations and the possibility of correcting aberrant alternative splicing offer promising therapeutic possibilities for cancer treatment.
Article
Pharmacology & Pharmacy
Motoki Isono, Masataka Nakano, Tatsuki Fukami, Miki Nakajima
Summary: The study elucidated the mechanism by which m6A modification regulates the expression of CYP2B6, demonstrating that METTL3/14 upregulates CYP2B6 expression by altering the chromatin status.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Oncology
Yuhao Zhao, Mao Yang, Shijia Wang, Sk Jahir Abbas, Junzhe Zhang, Yongsheng Li, Rong Shao, Yingbin Liu
Summary: This review focuses on the mechanistic insights of DNA, histone, and RNA methylation in regulating the progression of pancreatic cancer. The roles of methylation regulators in modulating gene expression associated with cell proliferation, invasion, and apoptosis are discussed. Recent clinical trials on methylation drug targeting are also explored. Understanding the novel regulatory mechanisms of methylation modification may offer alternative opportunities to improve therapeutic efficacy in combating this devastating disease.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cell Biology
Aidan J. Levinsky, Gregor McEdwards, Nasha Sethna, Mark A. Currie
Summary: H3K9 methyltransferases play crucial roles in genome stability, cell type-specific gene expression, and non-histone methylation. They are involved in histone modification and regulate the methylation of various non-histone targets, contributing to genome regulation and cellular functions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Saikat Bhattacharya, Divya Reddy, Ning Zhang, Hua Li, Jerry L. L. Workman
Summary: The methyltransferase SETD2 plays a crucial role in regulating transcription, splicing, and other processes through the deposition of the H3K36me3 histone mark. Its stability is controlled by proteasome-mediated degradation to maintain low levels. Excessive SETD2 leads to upregulation of cell cycle-associated pathways, resulting in increased cell proliferation and migration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Medicine, Research & Experimental
Yangdan Liu, Dongsheng Wen, Chiakang Ho, Li Yu, Danning Zheng, Steven O'Reilly, Ya Gao, Qingfeng Li, Yifan Zhang
Summary: Fibrosis, caused by excessive deposition of extracellular matrix, is a common and serious condition leading to organ failure and death. Recent advances in epigenetics have provided new insights into the mechanism of fibrogenesis and potential therapeutic strategies for organ fibrosis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Hiroaki Tachiwana, Noriko Saitoh
Summary: LncRNAs are a class of non-coding RNAs widely present in mammalian cells, involved in regulating cellular functions. Their dysregulation in cancer is closely related to disease development and they have diagnostic and therapeutic potential.
CURRENT MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Valeria Pietropaolo, Carla Prezioso, Ugo Moens
Summary: Tumor viruses such as HTLV-1, HCV, MCPyV, HR-HPVs, EBV, KSHV, and HBV play a role in approximately 15% of all human cancers, using similar mechanisms to convey cancer hallmarks to infected cells. Perturbed gene expression and epigenetic processes, including DNA methylation and histone modification, are key mechanisms in virus-induced carcinogenesis. Increasing evidence shows that oncoviruses cause epigenetic modifications which are crucial in cancer development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Lidia Borkiewicz
Summary: Cancer development and progression are governed by complex genetic and epigenetic changes, with histone 3 trimethylation of lysine 27 (H3K27me3) playing a significant role in silencing tumor suppressor genes in breast cancer. This review highlights the importance of H3K27me3 status in breast cancer biology and potential therapeutic implications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Biochemistry & Molecular Biology
Eleni Skourti, Paraminder Dhillon
Summary: This Special Issue of The FEBS Journal, Cancer Epigenetics, features a collection of review articles that focus on the functions of a broad spectrum of epigenetic modulators in cancer. The topics explored in these articles range from the roles of transposable elements and chromatin architecture in cancer, to the effects of altered epigenetics on transcription and advanced cancer cell phenotypes. The potential of epigenetics for targeted cancer therapeutics is also discussed.
Review
Oncology
Richard Sean Lee, Kirti Sad, Dorelle V. Fawwal, Jennifer Marie Spangle
Summary: Breast cancer is a frequent and deadly disease in women, with histone-modifying enzymes playing a role in treatment response and patient outcomes. Epigenetic changes to chromatin affect the tumor environment and can be targeted for breast cancer treatment. Understanding these mechanisms may improve therapeutic interventions and patient outcomes.
Review
Genetics & Heredity
Reza Khayami, David Goltzman, Shafaat A. Rabbani, Mohammad Amin Kerachian
Summary: This review discusses the role of vitamin D and epigenetic factors in colorectal cancer. Vitamin D exerts anticancer effects through interactions with genes, the tumor microenvironment, microbiota, and other factors. Epigenetic factors also play a significant role in regulating the actions of vitamin D.
Article
Biology
Wei-Ta Chen, Nancy D. Ebelt, Travis H. Stracker, Blerta Xhemalce, Carla L. Van den Berg, Kyle M. Miller
Review
Genetics & Heredity
Samantha B. Shelton, Calder Reinsborough, Blerta Xhemalce
Article
Chemistry, Multidisciplinary
Nathan S. Abell, Marvin Mercado, Tatiana Caneque, Raphael Rodriguez, Blerta Xhemalce
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Article
Biochemistry & Molecular Biology
Joshua D. Bryant, Shannon R. Sweeney, Enrique Sentandreu, Minhye Shin, Helene Ipas, Blerta Xhemalce, Jessica Momb, Stefano Tiziani, Dean R. Appling
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Cell Biology
Samantha B. Shelton, Nakul M. Shah, Nathan S. Abell, Sravan K. Devanathan, Marvin Mercado, Blerta Xhemalce
Article
Genetics & Heredity
Calder W. Reinsborough, Helene Ipas, Nathan S. Abell, Ryan M. Nottingham, Jun Yao, Sravan K. Devanathan, Samantha B. Shelton, Alan M. Lambowitz, Blerta Xhemalce
Article
Multidisciplinary Sciences
Samantha B. Shelton, Blerta Xhemalce
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2019)
Article
Cell Biology
Jae Jin Kim, Seo Yun Lee, Fade Gong, Anna M. Battenhouse, Daniel R. Boutz, Aarti Bashyal, Samantha T. Refvik, Cheng-Ming Chiang, Blerta Xhemalce, Tanya T. Paull, Jennifer S. Brodbelt, Edward M. Marcotte, Kyle M. Miller
GENES & DEVELOPMENT
(2019)
Article
Biochemistry & Molecular Biology
Jae Jin Kim, Seo Yun Lee, Ji-Hye Choi, Hyun Goo Woo, Blerta Xhemalce, Kyle M. Miller
Review
Biotechnology & Applied Microbiology
Turja K. Debnath, Blerta Xhemalce
Summary: Nearly 200 distinct chemical modifications of RNAs have been discovered, and high throughput sequencing techniques have enabled the analysis of less abundant RNA species, such as cellular messenger RNAs. New methods to enrich and identify RNA modifications at base resolution have been implemented to meet the growing biomedical interest in proteins associated with RNA modifications. Modification-specific (bio)chemical approaches play a crucial role in exploring the epitranscriptome, with their advantages and shortcomings being discussed.
BRIEFINGS IN FUNCTIONAL GENOMICS
(2021)
Article
Biochemistry & Molecular Biology
Calder W. Reinsborough, Helene Ipas, Nathan S. Abell, Ellen B. Gouws, J. Paige Williams, Marvin Mercado, Carla Van den Berg, Blerta Xhemalce
Summary: BCDIN3D plays a crucial role in regulating metabolic pathways in cancer, with a connection to increased glycolysis and reduced glucose metabolism capacity, while also regulating ALDOC expression. This connection may be relevant to breast cancer, obesity, and T2D.
Article
Cell Biology
Michael J. McFadden, Alexa B. R. McIntyre, Haralambos Mourelatos, Nathan S. Abell, Nandan S. Gokhale, Helene Ipas, Blerta Xhemalce, Christopher E. Mason, Stacy M. Horner
Summary: The RNA base modification N6-methyladenosine (m(6)A) plays a role in post-transcriptional control of ISG translation during type I IFN response for antiviral restriction. m(6)A and m(6)A methyltransferase proteins METTL3, METTL14, along with m(6)A reader YTHDF1, significantly affect the expression of IFITM1. The m(6)A methyltransferase complex promotes the antiviral activity of type I IFN.
Editorial Material
Biotechnology & Applied Microbiology
Blerta Xhemalce
BRIEFINGS IN FUNCTIONAL GENOMICS
(2021)
Article
Cell Biology
Ramhari Kumbhar, Anthony Sanchez, Jullian Perren, Fade Gong, David Corujo, Frank Medina, Sravan K. Devanathan, Blerta Xhemalce, Andreas Matouschek, Marcus Buschbeck, Bethany A. Buck-Koehntop, Kyle M. Miller
Summary: This study uncovers the crucial factors involved in the recognition of DNA lesion sites by the histone demethylase KDM5A, including a noncanonical poly(ADP-ribose) binding region and the histone variant macroH2A1.2. These factors are essential for KDM5A's functions at DNA damage sites and play key roles in DNA repair processes.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Emmanouil Zacharioudakis, Poonam Agarwal, Alexandra Bartoli, Nathan Abell, Lavaniya Kunalingam, Valerie Bergoglio, Blerta Xhemalce, Kyle M. Miller, Rapha L. Rodriguez
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2017)
