Article
Oncology
Farhad Islami, Jordan Baeker Bispo, Hyunjung Lee, Daniel Wiese, K. Robin Yabroff, Priti Bandi, Kirsten Sloan, Alpa V. Patel, Elvan C. Daniels, Arif H. Kamal, Carmen E. Guerra, William L. Dahut, Ahmedin Jemal
Summary: The American Cancer Society has published a report on cancer disparities in the United States, highlighting the significant variations in cancer occurrence and outcomes based on race, ethnicity, socioeconomic factors, and geographic location. Black and American Indian/Alaska Native individuals face higher cancer mortality rates, and education level and residential area also contribute to these disparities. The report emphasizes the importance of addressing social determinants of health and implementing equitable policies and interventions to reduce cancer disparities.
CA-A CANCER JOURNAL FOR CLINICIANS
(2023)
Article
Oncology
Farhad Islami, Carmen E. Guerra, Adair Minihan, K. Robin Yabroff, Stacey A. Fedewa, Kirsten Sloan, Tracy L. Wiedt, Blake Thomson, Rebecca L. Siegel, Nigar Nargis, Robert A. Winn, Lisa Lacasse, Laura Makaroff, Elvan C. Daniels, Alpa Patel, William G. Cance, Ahmedin Jemal
Summary: This report provides comprehensive data on disparities in cancer occurrence, risk factors, and access to preventive measures and screening in the US. Policy recommendations are made to reduce these inequalities, emphasizing the need for broad implementation of evidence-based interventions to address social inequities and systemic racism.
CA-A CANCER JOURNAL FOR CLINICIANS
(2022)
Article
Surgery
Siobhan O. Nnorom, Oluwasegun Akinyemi, Joseph Tran, Hana Baig, Edward E. Cornwell III, Wayne A. Frederick, Lori L. Wilson
Summary: Race/ethnicity and socioeconomic status have different impacts on the survival rate of breast cancer patients, with lower survival rates for Black women. Only in the most prosperous quartile do Black women achieve a similar outcome to the poorest quartile White women.
AMERICAN JOURNAL OF SURGERY
(2022)
Article
Surgery
Arash Azin, Houman Tahmasebi, Amanpreet Brar, Sam Azin, Gary Ko, Andrea Covelli, Tulin Cil
Summary: The objective of this study was to investigate the impact of race/ethnicity and socioeconomic status on breast cancer outcomes. The results showed that Non-Hispanic Black and Hispanic patients were more likely to present with advanced stage disease compared to Non-Hispanic White patients. Additionally, Non-Hispanic Black and Hispanic patients were less likely to undergo breast-reconstruction. Furthermore, Non-Hispanic Black patients had increased hazard for all-cause mortality, and all-cause mortality increased with worsening socioeconomic status.
AMERICAN JOURNAL OF SURGERY
(2023)
Article
Endocrinology & Metabolism
Sara J. Cromer, James Meigs, Deborah J. Wexler
Summary: Participants from different races/ethnicities or socioeconomic status may not benefit equally in intensive lifestyle interventions for type 2 diabetes. Black and Hispanic participants had less weight loss compared to White participants, while participants with lower educational attainment benefited more from the interventions.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Medicine, General & Internal
Christoph Lee, Weiwei Zhu, Tracy Onega, Louise M. Henderson, Karla Kerlikowske, Brian L. Sprague, Garth H. Rauscher, Ellen S. O'Meara, Anna N. A. Tosteson, Jennifer S. Haas, Roberta DiFlorio-Alexander, Celia Kaplan, Diana L. Miglioretti
Summary: In this cross-sectional study, women of minority race/ethnicity and lower socioeconomic status experienced lower DBT access during the early adoption period and persistently lower DBT use when available over time. Future efforts should address racial/ethnic, educational, and financial barriers to DBT screening.
Article
Health Care Sciences & Services
Daniel Quan, Lucia Luna Wong, Anita Shallal, Raghav Madan, Abel Hamdan, Heaveen Ahdi, Amir Daneshvar, Manasi Mahajan, Mohamed Nasereldin, Meredith Van Harn, Ijeoma Nnodim Opara, Marcus Zervos
Summary: Racial and socioeconomic disparities impact clinical outcomes for COVID-19 patients, with higher neighborhood income associated with lower rates of IMV and ICU admission. Policies targeting neighborhood disadvantage may help mitigate COVID-19 disparities in the Black community.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2021)
Article
Oncology
Robert M. Cooper, Joanie Chung, Tiffany Hogan, Reina Haque
Summary: The study suggests that disparities in overall mortality risk after cancer diagnoses persist even in a cohort with health insurance, and that SES is an important driver of this disparity.
CANCER CAUSES & CONTROL
(2021)
Article
Health Care Sciences & Services
Jodi K. McCloskey, Jennifer L. Ellis, Connie S. Uratsu, Melanie L. Drace, James D. Ralston, Elizabeth A. Bayliss, Richard W. Grant
Summary: Communities of color have higher rates of SARS-COV-2 infection compared to non-Latino White communities, even after controlling for medical and social factors.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Nicholas R. Lenze, Douglas Farquhar, Siddharth Sheth, Jose P. Zevallos, Jeffrey Blumberg, Catherine Lumley, Samip Patel, Trevor Hackman, Mark C. Weissler, Wendell G. Yarbrough, Adam M. Zanation, Andrew F. Olshan
Summary: A study of HPV-negative head and neck squamous cell carcinoma patients found that racial disparities in diagnosis and survival are primarily influenced by socioeconomic status, with low SES serving as a target for interventions aimed at mitigating these disparities.
Review
Biochemistry & Molecular Biology
Swetha Balaji, Antu K. Antony, Harry Tonchev, Giorgia Scichilone, Mohammed Morsy, Hania Deen, Imaduddin Mirza, Mohamed M. Ali, Abeer M. Mahmoud
Summary: Breast cancer is the most common cancer globally, but the reduction in mortality rates through early detection and treatment has not been consistent among racial groups. Cardiac effects of breast cancer therapies contribute to non-metastatic breast cancer mortality, particularly among historically marginalized racial/ethnic backgrounds. Anthracyclines, the first-line treatments for breast cancer, have dose-dependent cardiotoxicity and racial/ethnic minorities face additional challenges in cardio-oncology due to socioeconomic factors and limited healthcare access.
Article
Oncology
Hsiao-Ching Huang, Mary H. Smart, Ashwini Zolekar, Huiwen Deng, Colin C. Hubbard, Kent F. Hoskins, Naomi Y. Ko, Jenny S. Guadamuz, Gregory S. Calip
Summary: The purpose of this study was to investigate the impact of socioeconomic status and rurality on cancer-specific mortality among women with metastatic breast cancer by race/ethnicity. The results showed that socioeconomic status and rurality had the greatest adverse impacts on Black women with HR-negative mBC.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Baoyi Zhang, Jianrong Li, Mabel Tang, Chao Cheng
Summary: A previous study found that racial disparities in prostate cancer fluctuated during 2004-2011 but substantially improved afterwards, while socioeconomic disparities consistently increased during 2004-2018. Efforts should be made to improve treatment plans for financially vulnerable patients and update treatment guidelines for prostate cancer.
Article
Surgery
Ambria S. Moten, Payton Grande, Ashley Hendrix, Martin D. Fleming
Summary: This study found racial disparities in the treatment and survival of breast cancer patients in the Midsouth. Black patients were less likely to undergo surgery and hormone therapy, but more likely to receive radiation and chemotherapy. Among Black patients, the risk of mortality was lower for those who underwent mastectomy and received hormone therapy.
AMERICAN JOURNAL OF SURGERY
(2023)
Article
Oncology
Austin D. Williams, Meghan Buckley, Robin M. Ciocca, Jennifer L. Sabol, Sharon L. Larson, Ned Z. Carp
Summary: This study examined the disparities in breast cancer diagnosis and mortality among Black and white women in Pennsylvania at different income levels. The results showed that there were no differences in breast cancer diagnosis between Black and white women at all income levels, but Black women had a higher mortality rate than white women, even when adjusted for income.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Editorial Material
Multidisciplinary Sciences
Teresa A. Zimmers
Summary: Certain cancers can cause weakness and wasting in individuals. A mouse model has shown that tumors can block molecules that typically protect muscle innervation and mass. This discovery may lead to potential therapies for this deadly condition.
Article
Endocrinology & Metabolism
Fabrizio Pin, Alexander J. Jones, Joshua R. Huot, Ashok Narasimhan, Teresa A. Zimmers, Lynda F. Bonewald, Andrea Bonetto
Summary: This study demonstrates that patients with ovarian cancer exhibit evidence of cachexia and increased bone turnover, with high levels of RANKL potentially causing skeletal muscle atrophy and bone resorption. Treatment with antiresorptive and anti-RANKL therapies benefits muscle mass and function in cancer cachexia.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Review
Nutrition & Dietetics
Omnia U. Gaafer, Teresa A. Zimmers
Summary: Cancer cachexia is a complex syndrome involving metabolic changes and wasting of peripheral tissues, with challenges in defining appropriate nutrition interventions and lack of effective therapies. The influence of tumors on neural mechanisms and the need for multimodal interventions are highlighted, along with the increasing efforts in diagnosing and staging cachexia. Despite differences in treatment recommendations, clinical trial activity and preclinical models continue to evolve for a better understanding and management of cancer cachexia.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2021)
Article
Geriatrics & Gerontology
Jose M. Garcia, Richard F. Dunne, Kristen Santiago, Lisa Martin, Morris J. Birnbaum, Jeffrey Crawford, Andrew E. Hendifar, Martin Kochanczyk, Cassadie Moravek, Doris Piccinin, Vincent Picozzi, Eric J. Roeland, Wendy K. D. Selig, Teresa A. Zimmers
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Geriatrics & Gerontology
Xiaoling Zhong, Ashok Narasimhan, Libbie M. Silverman, Andrew R. Young, Safi Shahda, Sheng Liu, Jun Wan, Yunlong Liu, Leonidas G. Koniaris, Teresa A. Zimmers
Summary: Cachexia in patients with pancreatic ductal adenocarcinoma displays sex-specific phenotypes, with male patients experiencing earlier and more severe cachexia. The reproductive hormone and cytokine Activin plays a significant role in muscle wasting in male patients.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Cell Biology
Audrey Loumaye, Pascale Lause, Xiaoling Zhong, Teresa A. Zimmers, Laure B. Bindels, Jean-Paul Thissen
Summary: This study investigated the effects of Activin A (ActA) on human skeletal muscle (SM) and in mouse models of cancer-induced cachexia (CC). The results showed that ActA induces myotube atrophy and inhibits the expression and activity of MEF2C, leading to the decrease in MyHC-beta/slow, the main myosin isoform in human muscle cells. Animal models of CC exhibited a decline in MEF2C expression and SM mass, which were both attenuated by ActA inhibition. This study reveals a novel interaction between ActA signaling and MEF2C transcriptional activity in SM atrophy in CC models.
Editorial Material
Cell Biology
Federica Cirillo, Teresa A. Zimmers, Laura Mangiavini
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biology
Julia E. Lefler, Catherine B. MarElia-Bennett, Katie A. Thies, Blake E. Hildreth, Sudarshana M. Sharma, Jason R. Pitarresi, Lu Han, Caroline Everett, Christopher Koivisto, Maria C. Cuitino, Cynthia Timmers, Elizabeth O'Quinn, Melodie Parrish, Martin J. Romeo, Amanda J. Linke, G. Aaron Hobbs, Gustavo Leone, Denis C. Guttridge, Teresa A. Zimmers, Gregory B. Lesinski, Michael C. Ostrowski
Summary: Disruption of the STAT3 signaling axis in stromal fibroblasts through genetic ablation of Stat3 slows tumor progression, increases survival, and reshapes the immune-suppressive tumor micro-environment in a PDAC mouse model. Loss of the tumor suppressor PTEN in pancreatic CAFs leads to increased STAT3 phosphorylation and promotes secretion of CXCL1.
LIFE SCIENCE ALLIANCE
(2022)
Article
Biochemistry & Molecular Biology
Daenique H. A. Jengelley, Meijing Wang, Ashok Narasimhan, Joseph E. Rupert, Andrew R. Young, Xiaoling Zhong, Daniel J. Horan, Alexander G. Robling, Leonidas G. Koniaris, Teresa A. Zimmers
Summary: Musculoskeletal diseases can harm overall health and survival, with the Interleukin-6 family of cytokines, particularly IL-6, playing a role. Oncostatin M (OSM) has negative effects on muscle, bone, and the heart, causing muscle atrophy, bone loss, and cardiac dysfunction.
Review
Immunology
Daniel Sharygin, Leonidas G. Koniaris, Clark Wells, Teresa A. Zimmers, Tewfik Hamidi
Summary: The cell surface antigen CD14 acts as a co-receptor for toll-like receptors (TLRs) in macrophages and monocytes, but also has roles in disease responses in epithelial and endothelial cells. CD14 expression is altered in various non-immune cell types in response to disease states, and soluble CD14 can initiate signaling in these cells. This review examines CD14's role in innate immunity and its potential functions in non-immune cells and associated human diseases.
Article
Biochemistry & Molecular Biology
Tiebing Liang, Janaiah Kota, Kent E. Williams, Romil Saxena, Samer Gawrieh, Xiaoling Zhong, Teresa A. Zimmers, Naga Chalasani
Summary: MicroRNA-29a (miR-29a) is a fibro-inflammatory molecule that is associated with liver pathological conditions. The effects of a high-fat diet (HFD) combined with different levels of ethanol (EtOH) consumption on miR-29a expression and liver pathobiology were investigated. The study found that miR-29a was up-regulated with increasing levels of EtOH consumption and was associated with less severe liver injury. A high-fat diet and increasing concentrations of EtOH had progressive adverse effects on the liver, without any beneficial effects of low-dose EtOH consumption.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Oncology
Daenique H. Jengelley, Ashok Narasimhan, Joseph E. Rupert, Xiaoling Zhong, Andrew R. Young, Leonidas G. Koniaris, Teresa A. Zimmers
Meeting Abstract
Oncology
Brittany R. Counts, Ashok Narasimhan, Tara S. Umberger, Emma H. Doud, Amber L. Mosley, Teresa A. Zimmers
Meeting Abstract
Oncology
Daniel Runco, Linda Dimeglio, Charles Vanderpool, Danielle Halsey, Teresa Zimmers
PEDIATRIC BLOOD & CANCER
(2022)
Meeting Abstract
Endocrinology & Metabolism
Fabrizio Pin, Alexander J. Jones, Joshua R. Huot, Narasimhan Ashok, Teresa A. Zimmers, Lynda F. Bonewald, Andrea Bonetto
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)