Epigenetics and Psychiatry

Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression

(2013) Sam A Golden et al.   NATURE MEDICINE

Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation

(2013) Pamela J Kennedy et al.   NATURE NEUROSCIENCE

L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors

(2013) C. Nasca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decreased expression of synapse-related genes and loss of synapses in major depressive disorder

(2012) Hyo Jung Kang et al.   NATURE MEDICINE

HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity

(2012) Mitsumasa Kurita et al.   NATURE NEUROSCIENCE

Transcriptional and epigenetic mechanisms of addiction

(2011) Alfred J. Robison et al.   NATURE REVIEWS NEUROSCIENCE

The role of BDNF and its receptors in depression and antidepressant drug action: Reactivation of developmental plasticity

(2010) Eero Castrén et al.   Developmental Neurobiology

MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212

(2010) Heh-In Im et al.   NATURE NEUROSCIENCE

Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens

(2010) Quincey LaPlant et al.   NATURE NEUROSCIENCE

Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons

(2010) Jian Feng et al.   NATURE NEUROSCIENCE

Analysis of the GAD1 promoter: Trans-acting factors and DNA methylation converge on the 5′ untranslated region

(2010) Ying Chen et al.   NEUROPHARMACOLOGY

Transcriptional regulation of type-2 metabotropic glutamate receptors: an epigenetic path to novel treatments for chronic pain

(2010) Santina Chiechio et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Chronic Cocaine-Induced H3 Acetylation and Transcriptional Activation of CaMKIIα in the Nucleus Accumbens Is Critical for Motivation for Drug Reinforcement

(2009) Lei Wang et al.   NEUROPSYCHOPHARMACOLOGY

An upregulation of DNA-methyltransferase 1 and 3a expressed in telencephalic GABAergic neurons of schizophrenia patients is also detected in peripheral blood lymphocytes

(2009) A. Zhubi et al.   SCHIZOPHRENIA RESEARCH

Long-lasting depression-like behavior and epigenetic changes of BDNF gene expression induced by perinatal exposure to methylmercury

(2008) Natalia Onishchenko et al.   JOURNAL OF NEUROCHEMISTRY

Histone Deacetylase Inhibitors Decrease Cocaine But Not Sucrose Self-Administration in Rats

(2008) P. Romieu et al.   JOURNAL OF NEUROSCIENCE

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

Decoding the Epigenetic Language of Neuronal Plasticity

(2008) Emiliana Borrelli et al.   NEURON

Defective group-II metaboropic glutamate receptors in the hippocampus of spontaneously depressed rats

(2008) F. Matrisciano et al.   NEUROPHARMACOLOGY

The effects of sodium butyrate, an inhibitor of histone deacetylase, on the cocaine- and sucrose-maintained self-administration in rats

(2008) Jie Sun et al.   NEUROSCIENCE LETTERS

Major Depressive Disorder

(2008) R.H. Belmaker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Selective Loss of Brain-Derived Neurotrophic Factor in the Dentate Gyrus Attenuates Antidepressant Efficacy

(2007) Megumi Adachi et al.   BIOLOGICAL PSYCHIATRY