Article
Genetics & Heredity
Madhumala K. Sadanandappa, Shivaprasad H. Sathyanarayana, Shu Kondo, Giovanni Bosco
Summary: The study reveals that adult Drosophila females modify their oviposition behavior in response to parasitic wasps, including retention of matured follicles and increased apoptosis of developing follicles, leading to reduced egg-laying. The neuroendocrine signaling involving neuropeptide F (NPF) and its cognate receptor, NPFR, mediates the parasitoid-induced egg-lay depression and germline physiological modifications. Female fruit flies use multimodal sensory integration and brain-derived NPF signaling to engage in parasite-specific cellular and behavioral survival strategies.
Article
Biochemistry & Molecular Biology
Jana Lubec, Ahmed M. Hussein, Predrag Kalaba, Daniel Daba Feyissa, Edgar Arias-Sandoval, Anita Cybulska-Klosowicz, Mekite Bezu, Tamara Stojanovic, Volker Korz, Jovana Malikovic, Nilima Y. Aher, Martin Zehl, Vladimir Dragacevic, Johann Jakob Leban, Claudia Sagheddu, Judith Wackerlig, Marco Pistis, Merce Correa, Thierry Langer, Ernst Urban, Harald Hoeger, Gert Lubec
Summary: The worldwide increase in cognitive decline calls for the search of pharmacological treatment. Current dopamine transporter (DAT) inhibitors have unwanted side effects due to lack of specificity. A highly specific DAT inhibitor, S-CE-123, was synthesized and tested for its potential to enhance cognitive functions in rats. S-CE-123 showed good bioavailability and improved the performance of aged rats.
Article
Neurosciences
Aryeh Zolin, Raphael Cohn, Rich Pang, Andrew F. Siliciano, Adrienne L. Fairhall, Vanessa Ruta
Summary: By recording from the dopaminergic reinforcement pathways of the Drosophila mushroom body during active odor navigation, the researchers revealed how the ongoing motor-associated activity relates to goal-directed behavior. Dopaminergic neurons correlate with different behavioral variables depending on the animal's specific navigational strategy, reflecting actions most relevant to odor pursuit. This multiplexing of context-dependent representations within the mushroom body dopaminergic pathways allows them to influence both ongoing and future behavior.
NATURE NEUROSCIENCE
(2021)
Article
Entomology
Md Zeeshan Ali, Anushree Anushree, Anwar L. Bilgrami, Aarif Ahsan, Mohammad Shamsul Ola, Rizwanul Haque, Jawaid Ahsan
Summary: Phenylacetaldehyde (PAH), an aromatic odorant, serves as an important food and courtship cue for adult fruit flies. Our study found that larvae are attracted to PAH in a dose-dependent manner and can be trained with PAH as a marker for positive and negative reinforcement. Unlike adult flies, larvae primarily sense PAH through odorant receptors. This study provides valuable insights into how larvae perceive and process PAH odorant at the neural level.
JOURNAL OF INSECT SCIENCE
(2023)
Article
Agronomy
Xuemin Jiang, Jian Shi, Haoran Yang, Zhangwu Zhao
Summary: In this study, it was found that the neuropeptide F plays a significant role in the feeding regulation of Ostrinia furnacalis larvae. It regulates the structure and function of acetylcholine, which in turn stimulates the downstream PI3K and CREB signaling pathways, ultimately affecting larval feeding amount.
PEST MANAGEMENT SCIENCE
(2023)
Article
Agronomy
Jian Shi, Lei He, Juan Du, Chen-Zhu Wang, Zhangwu Zhao
Summary: This study identified a gustatory receptor, Gr43a, in Ostrinia furnacalis larvae, which plays a role in discriminating between nutritious and non-nutritious substances. The Gr43a is negatively regulated by the neuropeptide F system and offers insight into feeding strategies for animals to meet nutritional needs and gratification.
PEST MANAGEMENT SCIENCE
(2023)
Article
Biology
Louise Bestea, Emmanuelle Briard, Julie Carcaud, Jean-Christophe Sandoz, Rodrigo Velarde, Martin Giurfa, Maria Gabriela DE BRITO SANCHEZ
Summary: This study focuses on the short neuropeptide F (sNPF) and investigates its regulatory role in the acquisition and formation of color memories. The results show that increasing sNPF levels can enhance color learning and memory in partially starved foragers.
Article
Biology
Nobuhiro Yamagata, Takahiro Ezaki, Takahiro Takahashi, Hongyang Wu, Hiromu Tanimoto
Summary: Regulation of reward signaling in the brain is crucial for appropriate judgement of the environment and self. In Drosophila, inhibitory input to the presynaptic terminals of dopamine neurons mediate reward signals and control memory specificity. The disruption of GABA signaling reduces memory specificity and causes optimistic cognitive bias.
Article
Biochemistry & Molecular Biology
Kaixia Li, Shan Yu, Yihua Yang, Ya-Zhou He, Yidong Wu
Summary: This study investigates the feeding behavior of cotton bollworm larvae and the underlying mechanisms after exposure to Cry1Ac protein. It is found that the feeding cessation response to Cry1Ac in cotton bollworm larvae is closely associated with midgut epithelial damage and downregulation of NPF and NPFR expression. These findings provide insights into the mechanism of feeding cessation in response to Bt intoxication and the mode of action of the Cry1Ac toxin in target pests.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Psychology, Experimental
Emily A. Lang, Camilla van Geen, Ellen Tedeschi, Caroline B. Marvin, Daphna Shohamy
Summary: Curiosity drives learning, while temporal dynamics of the learning environment impact curiosity and learning processes. The timing of information delivery influences participants' behavior and memory, and pupil dilation reflects emotional responses.
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-GENERAL
(2022)
Editorial Material
Biochemistry & Molecular Biology
Marco Milan
Summary: A new study reveals that the developing wing primordium of Drosophila has the ability to regenerate in response to various types of damage. This regeneration is dependent on the activation of a pro-regenerative gene regulatory network in two distinct cell populations within the blastema.
Article
Multidisciplinary Sciences
Dingbang Ma, Nicholas Herndon, Jasmine Quynh Le, Katharine C. Abruzzi, Kai Zinn, Michael Rosbash
Summary: Our recent single-cell sequencing of adult Drosophila circadian neurons revealed unexpected heterogeneity and cell-specific expression of neuron communication molecules. Similar heterogeneity was observed in adult brain dopaminergic neurons. The common features of these neurons play essential roles in neuronal identity, connectivity, and the complex behavioral repertoire of Drosophila.
Article
Food Science & Technology
Elize A. Santos Musachio, Marcia Rosula Poetini, Dieniffer Espinosa Janner, Eliana Jardim Fernandes, Luana Barreto Meichtry, Mustafa Munir Mustafa Dahleh, Gustavo Petri Guerra, Marina Prigol
Summary: This study exposed Drosophila melanogaster larvae to Bisphenol F (BPF) and Bisphenol S (BPS) at different concentrations and found that they caused oxidative stress and affected metabolism. The larvae showed increased activity of cytochrome P-450 (CYP450) and glutathione S-transferase (GST), as well as increased levels of reactive species and lipid peroxidation. Mitochondrial and cell viability decreased at higher concentrations of BPF and BPS, and the number of pupae formed was reduced. This suggests that the presence of toxic metabolites and oxidative stress hindered the complete development of Drosophila melanogaster.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Robotics
Weize Zhang, Peng Pan, Xin Wang, Yixu Chen, Yong Rao, Xinyu Liu
Summary: This study investigates the neural response of Drosophila larvae to touch stimulation using force-controlled robotic mechanical stimulation and single-neuron fluorescence imaging. The findings reveal the relationship between the activation threshold of neurons and the change in transmission signal under touch stimulation.
IEEE ROBOTICS AND AUTOMATION LETTERS
(2021)
Article
Multidisciplinary Sciences
Hongjie Li, Jasper Janssens, Maxime De Waegeneer, Sai Saroja Kolluru, Kristofer Davie, Vincent Gardeux, Wouter Saelens, Fabrice David, Maria Brbic, Jure Leskovec, Colleen N. McLaughlin, Qijing Xie, Robert C. Jones, Katja Brueckner, Jiwon Shim, Sudhir Gopal Tattikota, Frank Schnorrer, Katja Rust, Todd G. Nystul, Zita Carvalho-Santos, Carlos Ribeiro, Soumitra Pal, Sharvani Mahadevaraju, Teresa M. Przytycka, Aaron M. Allen, Stephen F. Goodwin, Cameron W. Berry, Margaret T. Fuller, Helen White-Cooper, Erika L. Matunis, Stephen DiNardo, Anthony Galenza, Lucy Erin O'Brien, Julian A. T. Dow, Heinrich Jasper, Brian Oliver, Norbert Perrimon, Bart Deplancke, Stephen R. Quake, Liqun Luo, Stein Aerts
Summary: This study presents a single-cell atlas of the fruit fly Drosophila melanogaster, including 580,000 nuclei and annotations of over 250 distinct cell types. It serves as a valuable resource for the Drosophila community and provides a reference for studying genetic perturbations and disease models at single-cell resolution.
Article
Biochemistry & Molecular Biology
Sunitha Narasimha, Konstantin O. Nagornov, Laure Menin, Antonio Mucciolo, Astrid Rohwedder, Bruno M. Humbel, Martin Stevens, Andreas S. Thum, Yury O. Tsybin, Roshan K. Vijendravarma
Editorial Material
Biochemistry & Molecular Biology
Tilman Triphan, Andreas S. Thum
Article
Neurosciences
Andreas S. Thum, Bertram Gerber
CURRENT OPINION IN NEUROBIOLOGY
(2019)
Article
Multidisciplinary Sciences
Radostina Lyutova, Mareike Selcho, Maximilian Pfeuffer, Dennis Segebarth, Jens Habenstein, Astrid Rohwedder, Felix Frantzmann, Christian Wegener, Andreas S. Thum, Dennis Pauls
NATURE COMMUNICATIONS
(2019)
Article
Genetics & Heredity
Benita Bruenner, Juliane Saumweber, Merve Samur, Denise Weber, Isabell Schumann, Deepthi Mahishi, Astrid Rohwedder, Andreas S. Thum
JOURNAL OF NEUROGENETICS
(2020)
Review
Biology
Mareike Selcho, Dennis Pauls
CURRENT OPINION IN INSECT SCIENCE
(2019)
Article
Neurosciences
Claire Eschbach, Akira Fushiki, Michael Winding, Casey M. Schneider-Mizell, Mei Shao, Rebecca Arruda, Katharina Eichler, Javier Valdes-Aleman, Tomoko Ohyama, Andreas S. Thum, Bertram Gerber, Richard D. Fetter, James W. Truman, Ashok Litwin-Kumar, Albert Cardona, Marta Zlatic
NATURE NEUROSCIENCE
(2020)
Article
Neurosciences
Michael Schleyer, Alice Weiglein, Juliane Thoener, Martin Strauch, Volker Hartenstein, Melisa Kantar Weigelt, Sarah Schuller, Timo Saumweber, Katharina Eichler, Astrid Rohwedder, Dorit Merhof, Marta Zlatic, Andreas S. Thum, Bertram Gerber
JOURNAL OF NEUROSCIENCE
(2020)
Article
Multidisciplinary Sciences
Ilenia Meloni, Divya Sachidanandan, Andreas S. Thum, Robert J. Kittel, Caroline Murawski
SCIENTIFIC REPORTS
(2020)
Article
Biology
Sven Dannhauser, Thomas J. Lux, Chun Hu, Mareike Selcho, Jeremy T-C Chen, Nadine Ehmann, Divya Sachidanandan, Sarah Stopp, Dennis Pauls, Matthias Pawlak, Tobias Langenhan, Peter Soba, Heike L. Rittner, Robert J. Kittel
Article
Biochemistry & Molecular Biology
Dennis Pauls, Mareike Selcho, Johanna Raederscheidt, Kelechi M. Amatobi, Agnes Fekete, Markus Krischke, Christiane Hermann-Luibl, Ayten Gizem Ozbek-Unal, Nadine Ehmann, Pavel M. Itskov, Robert J. Kittel, Charlotte Helfrich-Foerster, Ronald P. Kuehnlein, Martin J. Mueller, Christian Wegener
Summary: Animals need to balance competitive behaviors to maintain internal homeostasis, which typically involves neuroendocrine signaling. In this study using Drosophila, it was found that AKH signals via two divergent pathways to balance activity levels under ad libitum access to food, with one pathway increasing activity during the day through the octopaminergic system, and the other preventing high activity levels during the night by signaling to the fat body. This regulation also involves feedback signaling from octopaminergic neurons to AKH-producing cells.
Article
Multidisciplinary Sciences
Isabell Schumann, Michael Berger, Nadine Nowag, Yannick Schaefer, Juliane Saumweber, Henrike Scholz, Andreas S. Thum
Summary: Chemosensory signals play crucial roles in guiding vertebrates and invertebrates towards optimal food sources while avoiding harmful substances. Ethanol, a substance naturally found in the environment of Drosophila melanogaster, influences the behavior and fitness of larvae. Moderate ethanol concentrations enhance larval fitness, while higher concentrations result in increased mortality. Ethanol also serves as a positive teaching signal in learning and memory processes. Limited understanding of how larvae perceive and process ethanol at the genetic and neuronal level points to the importance of standardized assays described in this study.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Luis Hernandez-Nunez, Alicia Chen, Gonzalo Budelli, Matthew E. Berck, Vincent Richter, Anna Rist, Andreas S. Thum, Albert Cardona, Mason Klein, Paul Garrity, Aravinthan D. T. Samuel
Summary: This study reveals the interaction between warming cells and cooling cells in larval Drosophila, which is crucial for maintaining thermal homeostasis. The integration of warming and cooling pathways through ionotropic receptors allows for the flexible regulation of body temperature set point. The cross-inhibition computation between warming and cooling cells orchestrates homeostatic thermoregulation in larvae.
Article
Neurosciences
Nino Mancini, Sia Hranova, Julia Weber, Alice Weiglein, Michael Schleyer, Denise Weber, Andreas S. Thum, Bertram Gerber